DE69404353T2 - Verfahren zur Herstellung von halbsynthetischen Glykosaminoglykanen, die in 3-Position mit nukleophilen Radikalen substituierte alpha-L-Galakturonsäure enthalten - Google Patents

Verfahren zur Herstellung von halbsynthetischen Glykosaminoglykanen, die in 3-Position mit nukleophilen Radikalen substituierte alpha-L-Galakturonsäure enthalten

Info

Publication number
DE69404353T2
DE69404353T2 DE69404353T DE69404353T DE69404353T2 DE 69404353 T2 DE69404353 T2 DE 69404353T2 DE 69404353 T DE69404353 T DE 69404353T DE 69404353 T DE69404353 T DE 69404353T DE 69404353 T2 DE69404353 T2 DE 69404353T2
Authority
DE
Germany
Prior art keywords
semi
galacturonic acid
acid substituted
production
containing alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69404353T
Other languages
English (en)
Other versions
DE69404353D1 (de
Inventor
Fabrizio Ungarelli
Silvano Piani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Application granted granted Critical
Publication of DE69404353D1 publication Critical patent/DE69404353D1/de
Publication of DE69404353T2 publication Critical patent/DE69404353T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69404353T 1993-03-29 1994-03-18 Verfahren zur Herstellung von halbsynthetischen Glykosaminoglykanen, die in 3-Position mit nukleophilen Radikalen substituierte alpha-L-Galakturonsäure enthalten Expired - Fee Related DE69404353T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000126A IT1264102B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (2)

Publication Number Publication Date
DE69404353D1 DE69404353D1 (de) 1997-09-04
DE69404353T2 true DE69404353T2 (de) 1997-11-13

Family

ID=11338860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404353T Expired - Fee Related DE69404353T2 (de) 1993-03-29 1994-03-18 Verfahren zur Herstellung von halbsynthetischen Glykosaminoglykanen, die in 3-Position mit nukleophilen Radikalen substituierte alpha-L-Galakturonsäure enthalten

Country Status (18)

Country Link
US (1) US5410039A (de)
EP (1) EP0618235B1 (de)
JP (1) JP2726620B2 (de)
KR (1) KR100191885B1 (de)
AT (1) ATE155798T1 (de)
AU (1) AU664938B2 (de)
CA (1) CA2114863C (de)
DE (1) DE69404353T2 (de)
DK (1) DK0618235T3 (de)
ES (1) ES2105382T3 (de)
FI (1) FI105100B (de)
GR (1) GR3024710T3 (de)
IL (1) IL108690A (de)
IT (1) IT1264102B1 (de)
NO (1) NO305993B1 (de)
NZ (1) NZ250816A (de)
TW (1) TW266216B (de)
ZA (1) ZA94892B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2002243630A1 (en) 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
JP4828795B2 (ja) * 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2017154938A1 (ja) * 2016-03-09 2017-09-14 株式会社糖鎖工学研究所 硫酸基および／またはリン酸基を有する糖の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground

Also Published As

Publication number Publication date
ES2105382T3 (es) 1997-10-16
CA2114863A1 (en) 1994-09-30
NO941129D0 (no) 1994-03-28
FI105100B (fi) 2000-06-15
EP0618235A1 (de) 1994-10-05
JPH06322002A (ja) 1994-11-22
JP2726620B2 (ja) 1998-03-11
GR3024710T3 (en) 1997-12-31
CA2114863C (en) 1999-07-20
ITBO930126A1 (it) 1994-09-29
IT1264102B1 (it) 1996-09-10
DK0618235T3 (da) 1998-01-26
ITBO930126A0 (it) 1993-03-29
ZA94892B (en) 1994-08-23
AU664938B2 (en) 1995-12-07
IL108690A0 (en) 1994-05-30
NO941129L (no) 1994-09-30
TW266216B (de) 1995-12-21
FI941432A0 (fi) 1994-03-28
ATE155798T1 (de) 1997-08-15
US5410039A (en) 1995-04-25
DE69404353D1 (de) 1997-09-04
KR100191885B1 (ko) 1999-06-15
KR940021583A (ko) 1994-10-19
AU5508494A (en) 1994-10-06
EP0618235B1 (de) 1997-07-23
NO305993B1 (no) 1999-08-30
FI941432A (fi) 1994-09-30
NZ250816A (en) 1996-02-27
IL108690A (en) 1998-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee