DE69334197D1 - Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik - Google Patents
Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und DiagnostikInfo
- Publication number
- DE69334197D1 DE69334197D1 DE69334197T DE69334197T DE69334197D1 DE 69334197 D1 DE69334197 D1 DE 69334197D1 DE 69334197 T DE69334197 T DE 69334197T DE 69334197 T DE69334197 T DE 69334197T DE 69334197 D1 DE69334197 D1 DE 69334197D1
- Authority
- DE
- Germany
- Prior art keywords
- vaccines
- diagnostics
- useful
- helicobacter pylori
- pylori cytotoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101710112752 Cytotoxin Proteins 0.000 title 1
- 241000590002 Helicobacter pylori Species 0.000 title 1
- 231100000599 cytotoxic agent Toxicity 0.000 title 1
- 239000002619 cytotoxin Substances 0.000 title 1
- 229940037467 helicobacter pylori Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITFI920052 | 1992-03-02 | ||
ITFI920052A IT1262895B (it) | 1992-03-02 | 1992-03-02 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. |
WOPCT/EP93/00158 | 1993-01-25 | ||
EPPCT/EP93/00158 | 1993-01-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69334197D1 true DE69334197D1 (de) | 2008-02-14 |
DE69334197T2 DE69334197T2 (de) | 2008-12-11 |
Family
ID=26069992
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69334197T Expired - Lifetime DE69334197T2 (de) | 1992-03-02 | 1993-03-02 | Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik |
DE69333110T Expired - Lifetime DE69333110T2 (de) | 1992-03-02 | 1993-03-02 | Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333110T Expired - Lifetime DE69333110T2 (de) | 1992-03-02 | 1993-03-02 | Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose |
Country Status (7)
Country | Link |
---|---|
US (3) | US6077706A (de) |
EP (1) | EP0967279B1 (de) |
JP (4) | JP3368902B2 (de) |
AU (1) | AU3630093A (de) |
CA (2) | CA2383007A1 (de) |
DE (2) | DE69334197T2 (de) |
WO (1) | WO1993018150A1 (de) |
Families Citing this family (92)
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US5721349A (en) * | 1992-02-26 | 1998-02-24 | Vanderbilt University | Vacuolating toxin-deficient H. pylori |
CA2117490C (en) * | 1992-02-26 | 2009-01-06 | Timothy L. Cover | Purified vacuolating toxin from helicobacter pylori and methods to use same |
US5928865A (en) * | 1992-03-02 | 1999-07-27 | Chiron S.P.A. | Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof |
IT1262896B (it) * | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
MX9301706A (es) * | 1992-04-13 | 1994-05-31 | Oravax Inc | Composicion de vacuna para el tratamiento de la infeccion por helicobacter. |
US5403924A (en) * | 1992-10-13 | 1995-04-04 | Vanderbilt University | Taga gene and methods for detecting predisposition to peptic ulceration |
US5733740A (en) * | 1992-10-13 | 1998-03-31 | Vanderbilt University | Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma |
US6290962B1 (en) * | 1992-11-03 | 2001-09-18 | Oravax, Inc. | Urease-based vaccine and treatment for helicobacter infection |
US5972336A (en) * | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
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US6258359B1 (en) | 1993-05-19 | 2001-07-10 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides |
GB9313279D0 (en) * | 1993-06-28 | 1993-08-11 | Medical Res Council | Protection against infection with helicobacter pylori |
US6406703B1 (en) | 1993-07-27 | 2002-06-18 | Csl Limited | Treatment of H. pylori associated gastroduodenal disease |
ATE244578T1 (de) * | 1993-07-27 | 2003-07-15 | Csl Ltd | Behandlung eines durch helicobakter verursachten gastroduodenalen krankheit |
US5750119A (en) * | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
US5997873A (en) | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
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GB2303855B (en) * | 1994-07-01 | 1998-10-28 | Rican Limited | Helicobacter pylori antigenic protein preparation and immunoassays |
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US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
JPH11502418A (ja) * | 1995-10-09 | 1999-03-02 | パストゥール メリユ セリュム エ ヴァサン | ヘリコバクターのラクトフェリン受容体 |
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FR2637612B1 (fr) * | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
AU640118B2 (en) | 1988-12-19 | 1993-08-19 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | Meningococcal class 1 outer-membrane protein vaccine |
GB8928625D0 (en) * | 1989-12-19 | 1990-02-21 | 3I Res Expl Ltd | H.pylori dna probes |
US5292658A (en) * | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
DE69233083T2 (de) * | 1991-08-27 | 2003-12-18 | Hoffmann La Roche | Primers und Sondern zum Nachweis von Hepatitis C |
US5354854A (en) * | 1991-11-07 | 1994-10-11 | The Curators Of The University Of Missouri | Expression system for use in plants to suppress foreign expression and method |
US5721349A (en) * | 1992-02-26 | 1998-02-24 | Vanderbilt University | Vacuolating toxin-deficient H. pylori |
IT1262895B (it) * | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
US5403924A (en) * | 1992-10-13 | 1995-04-04 | Vanderbilt University | Taga gene and methods for detecting predisposition to peptic ulceration |
US5733740A (en) * | 1992-10-13 | 1998-03-31 | Vanderbilt University | Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma |
US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
US6902903B1 (en) * | 1996-12-19 | 2005-06-07 | Chiron Corporation | Helicobacter pylori diagnostics |
AU5810201A (en) * | 2000-05-10 | 2001-11-20 | Aventis Pasteur | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
-
1993
- 1993-03-02 EP EP99202698A patent/EP0967279B1/de not_active Expired - Lifetime
- 1993-03-02 DE DE69334197T patent/DE69334197T2/de not_active Expired - Lifetime
- 1993-03-02 JP JP51530993A patent/JP3368902B2/ja not_active Expired - Lifetime
- 1993-03-02 WO PCT/EP1993/000472 patent/WO1993018150A1/en active IP Right Grant
- 1993-03-02 AU AU36300/93A patent/AU3630093A/en not_active Abandoned
- 1993-03-02 CA CA002383007A patent/CA2383007A1/en active Pending
- 1993-03-02 DE DE69333110T patent/DE69333110T2/de not_active Expired - Lifetime
- 1993-03-02 CA CA002131729A patent/CA2131729C/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/470,260 patent/US6077706A/en not_active Expired - Lifetime
-
2000
- 2000-04-26 JP JP2000126695A patent/JP3408494B2/ja not_active Expired - Lifetime
- 2000-04-26 JP JP2000126696A patent/JP2000333686A/ja active Pending
-
2001
- 2001-08-02 US US09/921,157 patent/US20040048353A1/en not_active Abandoned
-
2003
- 2003-07-08 US US10/615,668 patent/US7700755B2/en not_active Expired - Fee Related
-
2005
- 2005-09-09 JP JP2005263068A patent/JP2006055168A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2131729A1 (en) | 1993-09-16 |
JP2006055168A (ja) | 2006-03-02 |
US6077706A (en) | 2000-06-20 |
US20050276819A1 (en) | 2005-12-15 |
JPH07504565A (ja) | 1995-05-25 |
CA2131729C (en) | 2008-02-12 |
CA2383007A1 (en) | 1993-09-16 |
JP2000350591A (ja) | 2000-12-19 |
US7700755B2 (en) | 2010-04-20 |
JP2000333686A (ja) | 2000-12-05 |
JP3408494B2 (ja) | 2003-05-19 |
JP3368902B2 (ja) | 2003-01-20 |
DE69333110T2 (de) | 2004-05-06 |
US20040048353A1 (en) | 2004-03-11 |
EP0967279A1 (de) | 1999-12-29 |
EP0967279B1 (de) | 2008-01-02 |
DE69333110D1 (de) | 2003-08-28 |
WO1993018150A1 (en) | 1993-09-16 |
AU3630093A (en) | 1993-10-05 |
DE69334197T2 (de) | 2008-12-11 |
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