DE69332524T2 - Synthese von N-substituierten Oligomeren - Google Patents

Synthese von N-substituierten Oligomeren

Info

Publication number
DE69332524T2
DE69332524T2 DE69332524T DE69332524T DE69332524T2 DE 69332524 T2 DE69332524 T2 DE 69332524T2 DE 69332524 T DE69332524 T DE 69332524T DE 69332524 T DE69332524 T DE 69332524T DE 69332524 T2 DE69332524 T2 DE 69332524T2
Authority
DE
Germany
Prior art keywords
oligomers
substituted
poly
nsgs
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332524T
Other languages
English (en)
Other versions
DE69332524D1 (de
Inventor
N Zuckermann
Janice M Kerr
Brian Kent
H Moos
J Simon
A Goff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69332524D1 publication Critical patent/DE69332524D1/de
Publication of DE69332524T2 publication Critical patent/DE69332524T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
DE69332524T 1992-09-24 1993-09-24 Synthese von N-substituierten Oligomeren Expired - Lifetime DE69332524T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95085392A 1992-09-24 1992-09-24
PCT/US1993/009117 WO1994006451A1 (en) 1992-09-24 1993-09-24 Synthesis of n-substituted oligomers

Publications (2)

Publication Number Publication Date
DE69332524D1 DE69332524D1 (de) 2003-01-16
DE69332524T2 true DE69332524T2 (de) 2003-04-24

Family

ID=25490930

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332524T Expired - Lifetime DE69332524T2 (de) 1992-09-24 1993-09-24 Synthese von N-substituierten Oligomeren

Country Status (17)

Country Link
US (1) US20020115612A1 (de)
EP (2) EP1258492A1 (de)
JP (3) JP3461505B2 (de)
KR (1) KR0168709B1 (de)
AT (1) ATE228532T1 (de)
AU (1) AU679945B2 (de)
BG (1) BG99521A (de)
BR (1) BR9307092A (de)
CA (1) CA2144067A1 (de)
DE (1) DE69332524T2 (de)
FI (1) FI951356A (de)
HK (1) HK1049173A1 (de)
HU (1) HUT72614A (de)
NO (1) NO950682L (de)
NZ (1) NZ256952A (de)
PL (1) PL308204A1 (de)
WO (1) WO1994006451A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5536853A (en) * 1994-04-11 1996-07-16 Chiron Corporation Opiate receptor ligands
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
DE69530119T2 (de) * 1994-12-30 2003-09-25 Chiron Corp Verfahren zur kontrollierten synthese von beliebigen peptidmischungen kodierende polynukleotidmischungen
US5481020A (en) * 1994-12-30 1996-01-02 Chiron Corporation Opiate receptor ligands
US5891742A (en) * 1995-01-19 1999-04-06 Chiron Corporation Affinity selection of ligands by mass spectroscopy
US5627210A (en) * 1995-02-06 1997-05-06 Chiron Corporation Branched combinatorial libraries
US5747458A (en) * 1995-06-07 1998-05-05 Chiron Corporation Urokinase receptor ligands
US5958792A (en) * 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US6277583B1 (en) 1996-02-07 2001-08-21 Conjuchem, Inc. Affinity labeling libraries and applications thereof
JP4320054B2 (ja) 1996-08-13 2009-08-26 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド ポリヌクレオチド送達のための組成物および方法
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
ES2329955T3 (es) * 1997-04-28 2009-12-02 Novartis Vaccines And Diagnostics, Inc. Aparato para la sintesis de oligomeros, especialmente peptoides, con reciclado de reactivos.
US6197332B1 (en) * 1997-08-13 2001-03-06 Chiron Corporation Lipid-conjugated polyamide compounds and related compositions and methods thereof
DE69839946D1 (de) 1997-11-07 2008-10-09 Conjuchem Biotechnologies Inc Methoden zum Screening von Affinitätsmarker-Bibliotheken
DE69921102T2 (de) 1998-03-05 2006-02-02 Chiron Corp., Emeryville Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
WO2000043547A1 (en) 1999-01-20 2000-07-27 Northwestern University Dna mobility modifier
US7422861B2 (en) 2000-12-23 2008-09-09 Novartis Vaccines And Diagnostics, Inc. Oligonucleotide transfection screening method
US7664553B2 (en) * 2005-04-27 2010-02-16 Cardiac Pacemakers, Inc. System and method for enabling communications with implantable medical devices
WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
WO2007085357A1 (en) * 2006-01-30 2007-08-02 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
DE102006039615A1 (de) * 2006-08-24 2008-03-13 Leibniz-Institut Für Pflanzenbiochemie Esterelongationsverfahren zum sequenzgesteuerten Aufbau alternierender Peptid-Peptoid-Polymere (Peptid-Peptoid-Polymere)
DK2117578T3 (en) 2007-01-22 2015-07-20 Orthotrophix Inc Peptide composition and method for promoting cartilage formation
JP4997038B2 (ja) * 2007-07-27 2012-08-08 株式会社ブリヂストン 更生タイヤ用トレッド及び更生タイヤ
CA2714853A1 (en) * 2008-02-08 2009-08-27 Northwestern University Selective poly-n-substituted glycine antibiotics
US20130065833A1 (en) * 2010-03-19 2013-03-14 Northwestern University Alkylated sp-b peptoid compounds and related lung surfactant compositions
US9764953B2 (en) 2013-03-20 2017-09-19 The Regents Of The University Of California Peptoids useful for the mineralization of apatite
AU2016338410B2 (en) 2015-10-14 2021-07-15 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
US10329321B2 (en) 2016-02-09 2019-06-25 Alexander Krantz Site-selective functionalization of proteins using traceless affinity labels
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
EP3703676A4 (de) 2017-11-04 2021-12-15 Advanced Proteome Therapeutics, Inc. Zusammensetzung und verfahren zur modifizierung von polypeptiden
KR20240007491A (ko) 2022-07-08 2024-01-16 문정현 수평유지하는 유모차

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1037474A (en) * 1964-04-21 1966-07-27 British Nylon Spinners Ltd N-substituted polyamides and filaments therefrom
US3634364A (en) * 1969-09-26 1972-01-11 Grace W R & Co Polyminodiacetic acid and polysarcosine homopolymers
DE2447305C3 (de) * 1973-10-05 1979-09-13 Miyoshi Yushi K.K., Tokio Verfahren zur Herstellung chelatbildender Polymerisate
WO1986005518A1 (en) * 1985-03-15 1986-09-25 James Summerton Stereoregular polynucleotide-binding polymers
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs

Also Published As

Publication number Publication date
PL308204A1 (en) 1995-07-24
JP3596752B2 (ja) 2004-12-02
EP0671928B1 (de) 2002-11-27
HK1049173A1 (zh) 2003-05-02
KR950703349A (ko) 1995-09-20
HU9500855D0 (en) 1995-05-29
HUT72614A (en) 1996-05-28
EP0671928A4 (de) 1997-04-23
JP2000239242A (ja) 2000-09-05
US20020115612A1 (en) 2002-08-22
FI951356A0 (fi) 1995-03-22
WO1994006451A1 (en) 1994-03-31
FI951356A (fi) 1995-04-26
AU679945B2 (en) 1997-07-17
NO950682L (no) 1995-04-18
ATE228532T1 (de) 2002-12-15
JP2003012622A (ja) 2003-01-15
JPH08501565A (ja) 1996-02-20
EP1258492A1 (de) 2002-11-20
EP0671928A1 (de) 1995-09-20
JP3461505B2 (ja) 2003-10-27
NZ256952A (en) 1997-07-27
DE69332524D1 (de) 2003-01-16
CA2144067A1 (en) 1994-03-31
AU5292093A (en) 1994-04-12
BG99521A (en) 1996-01-31
NO950682D0 (no) 1995-02-23
KR0168709B1 (ko) 1999-01-15
BR9307092A (pt) 1999-03-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US