DE69331629T2 - Nachweissystem mit fluorometer - Google Patents

Nachweissystem mit fluorometer

Info

Publication number
DE69331629T2
DE69331629T2 DE69331629T DE69331629T DE69331629T2 DE 69331629 T2 DE69331629 T2 DE 69331629T2 DE 69331629 T DE69331629 T DE 69331629T DE 69331629 T DE69331629 T DE 69331629T DE 69331629 T2 DE69331629 T2 DE 69331629T2
Authority
DE
Germany
Prior art keywords
time
detection
histogram
compile
photon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69331629T
Other languages
English (en)
Other versions
DE69331629D1 (de
Inventor
Marlin Studholme
Arthur Blau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperion Inc
Original Assignee
Hyperion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperion Inc filed Critical Hyperion Inc
Application granted granted Critical
Publication of DE69331629D1 publication Critical patent/DE69331629D1/de
Publication of DE69331629T2 publication Critical patent/DE69331629T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Geophysics And Detection Of Objects (AREA)
DE69331629T 1992-03-23 1993-03-22 Nachweissystem mit fluorometer Expired - Fee Related DE69331629T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/855,238 US5323008A (en) 1992-03-23 1992-03-23 Fluorometer detection system
PCT/US1993/002540 WO1993019358A1 (en) 1992-03-23 1993-03-22 Fluorometer detection system

Publications (2)

Publication Number Publication Date
DE69331629D1 DE69331629D1 (de) 2002-04-04
DE69331629T2 true DE69331629T2 (de) 2002-08-14

Family

ID=25320715

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331629T Expired - Fee Related DE69331629T2 (de) 1992-03-23 1993-03-22 Nachweissystem mit fluorometer

Country Status (8)

Country Link
US (1) US5323008A (de)
EP (1) EP0632887B1 (de)
JP (2) JPH07505467A (de)
AT (1) ATE213832T1 (de)
CA (2) CA2538701C (de)
DE (1) DE69331629T2 (de)
ES (1) ES2173093T3 (de)
WO (1) WO1993019358A1 (de)

Cited By (4)

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DE102005027896A1 (de) * 2005-06-16 2006-12-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zum optischen Messen einer Probe
DE102006048346A1 (de) * 2006-10-12 2008-04-17 Eppendorf Ag Verfahren zur Vorrichtung zur quantitativen Echtzeitanalyse von fluoreszierenden Proben
DE102008018475A1 (de) * 2008-04-11 2009-10-15 Carl Zeiss Ag Vorrichtung und Verfahren zur Lumineszenzmessung
DE102012113024A1 (de) * 2012-12-21 2014-06-26 Hamilton Bonaduz Ag Optische Messvorrichtung

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US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5426306A (en) * 1993-10-21 1995-06-20 Associated Universities, Inc. Fast repetition rate (FRR) fluorometer and method for measuring fluorescence and photosynthetic parameters
JP3364333B2 (ja) * 1994-09-19 2003-01-08 浜松ホトニクス株式会社 減衰特性測定装置
US5919140A (en) * 1995-02-21 1999-07-06 Massachusetts Institute Of Technology Optical imaging using time gated scattered light
DE19634873A1 (de) * 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System zur Unterscheidung fluoreszierender Molekülgruppen durch zeitaufgelöste Fluoreszenzmessung
AU732703B2 (en) * 1996-11-20 2001-04-26 Crucell Holland B.V. An improved method for the production and purification of adenoviral vectors
DE19702914C2 (de) * 1997-01-28 1998-12-24 Max Planck Gesellschaft Verfahren und Anordnung zum Bestimmen vorgegebener Eigenschaften von Zielpartikeln eines Probenmediums
US5994707A (en) * 1997-03-18 1999-11-30 Physical Optics Corporation Modular fiber optic fluorometer and method of use thereof
DE19718016A1 (de) * 1997-04-29 1998-11-05 Drexhage Karl Heinz Verfahren zur optischen Detektion von Analytmolekülen in einem natürlichen biologischen Medium
US6097025A (en) * 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
WO2000006990A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
JPH11132953A (ja) * 1997-10-29 1999-05-21 Bunshi Bio Photonics Kenkyusho:Kk 蛍光寿命測定方法および装置
US6121053A (en) * 1997-12-10 2000-09-19 Brookhaven Science Associates Multiple protocol fluorometer and method
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
AU2775899A (en) * 1998-02-20 1999-09-06 Ljl Biosystems, Inc. Broad range light detection system
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
AU6139199A (en) * 1998-09-11 2000-04-03 Spectrx, Inc. Multi-modal optical tissue diagnostic system
AU3005400A (en) 1999-02-23 2000-09-14 Ljl Biosystems, Inc. Frequency-domain light detection device
JP2001070227A (ja) * 1999-07-07 2001-03-21 Fuji Photo Film Co Ltd 蛍光観察装置
JP2001078175A (ja) * 1999-07-07 2001-03-23 Fuji Photo Film Co Ltd 蛍光観察装置
US6402986B1 (en) 1999-07-16 2002-06-11 The Trustees Of Boston University Compositions and methods for luminescence lifetime comparison
US6690463B2 (en) 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
US6447995B1 (en) 2000-10-04 2002-09-10 Genvec, Inc. Utilizing intrinsic fluorescence to detect adenovirus
ATE403142T1 (de) * 2000-12-21 2008-08-15 Evotec Ag Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln
US20030136921A1 (en) * 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
JP4074136B2 (ja) * 2002-05-29 2008-04-09 浜松ホトニクス株式会社 蛍光寿命分布画像測定装置およびその測定方法
US20030224354A1 (en) * 2002-05-30 2003-12-04 Introgen Therapeutics Inc. Quantifying viral particles with intrinsic fluorescence
JP4188653B2 (ja) * 2002-10-01 2008-11-26 浜松ホトニクス株式会社 蛍光測定装置
US7371524B2 (en) * 2003-06-17 2008-05-13 Hannjorg Hereth Substituted azaporphyrins as fluorescence labels
US7812324B2 (en) * 2004-10-18 2010-10-12 Macquarie University Fluorescence detection
US7391512B2 (en) * 2004-12-22 2008-06-24 Avago Technologies General Ip Pte. Ltd. Integrated optoelectronic system for measuring fluorescence or luminescence emission decay
JP4652868B2 (ja) * 2005-03-30 2011-03-16 独立行政法人産業技術総合研究所 蛍光分析方法
US7839500B2 (en) * 2005-05-30 2010-11-23 Jerker Widengren Apparatus, method and computer program for spectroscopic measurements and analysis
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
KR100885927B1 (ko) * 2007-10-16 2009-02-26 광주과학기술원 형광수명 측정 방법 및 장치
WO2009089315A1 (en) * 2008-01-08 2009-07-16 Kinase Scientific, Llc Method to detect hemolytic streptococcus and optoelectronically determine results
US8104512B2 (en) * 2008-09-25 2012-01-31 Masco Corporation Of Indiana Spout tip retention method
EP2414504A4 (de) * 2009-04-03 2013-08-28 Illumina Inc Vorrichtungen und verfahren zur erwärmung biologischer proben
US8987685B2 (en) * 2009-09-09 2015-03-24 Pcr Max Limited Optical system for multiple reactions
DE102010047237B4 (de) * 2010-08-13 2021-07-01 Leica Microsystems Cms Gmbh Verfahren zum Trennen von Detektionssignalen im Strahlengang einer optischen Einrichtung
US9557243B2 (en) 2012-03-14 2017-01-31 Axonoptics Llc Integrated optics reflectometer
US9222850B2 (en) * 2013-03-14 2015-12-29 Axonoptics, Llc Integrated optics reflectometer
US9140648B2 (en) 2013-03-12 2015-09-22 Ecolab Usa Inc. Fluorometer with multiple detection channels
US8970724B2 (en) * 2013-03-15 2015-03-03 National Security Technologies, Llc Mach-zehnder based optical marker/comb generator for streak camera calibration
RU2751176C1 (ru) * 2020-12-28 2021-07-09 Акционерное общество "Специальное конструкторско-технологическое бюро Кольцова" Многопозиционное переключающее устройство
EP4278181A1 (de) * 2021-01-15 2023-11-22 Ventana Medical Systems, Inc. Lagerstabile haptene in käfigform

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US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
US4198567A (en) * 1977-10-25 1980-04-15 Peter Eneroth Method and apparatus for discrimination between scattered excitation radiation and low level fast decaying fluorescent radiation
NL7712535A (nl) * 1977-11-15 1979-05-17 Philips Nv Kleurenbeeldbuis.
US4877965A (en) * 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
US4895156A (en) * 1986-07-02 1990-01-23 Schulze John E Sensor system using fluorometric decay measurements
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US4716363A (en) * 1987-05-08 1987-12-29 Hewlett-Packard Company Exponential decay time constant measurement using frequency of offset phase-locked loop: system and method
US4857735A (en) * 1987-10-23 1989-08-15 Noller Hans G Light emitting diode spectrophotometer
US5071249A (en) * 1988-10-05 1991-12-10 Hamamatsu Photonics K.K. Light waveform measuring apparatus
US5151869A (en) * 1990-02-16 1992-09-29 The Boc Group, Inc. Frequency domain fluorometry using coherent sampling
US5196709A (en) * 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005027896A1 (de) * 2005-06-16 2006-12-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zum optischen Messen einer Probe
DE102005027896B4 (de) * 2005-06-16 2012-03-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum optischen Messen einer Probe
DE102006048346A1 (de) * 2006-10-12 2008-04-17 Eppendorf Ag Verfahren zur Vorrichtung zur quantitativen Echtzeitanalyse von fluoreszierenden Proben
DE102008018475A1 (de) * 2008-04-11 2009-10-15 Carl Zeiss Ag Vorrichtung und Verfahren zur Lumineszenzmessung
US9007579B2 (en) 2008-04-11 2015-04-14 Carl Zeiss Microscopy Gmbh Device and method for measuring luminescence
DE102012113024A1 (de) * 2012-12-21 2014-06-26 Hamilton Bonaduz Ag Optische Messvorrichtung
US9588039B2 (en) 2012-12-21 2017-03-07 Hamilton Bonaduz Ag Optical measuring device

Also Published As

Publication number Publication date
CA2538701C (en) 2006-11-28
ATE213832T1 (de) 2002-03-15
CA2132707A1 (en) 1993-09-30
CA2132707C (en) 2006-06-13
US5323008A (en) 1994-06-21
EP0632887B1 (de) 2002-02-27
JP2002323448A (ja) 2002-11-08
JPH07505467A (ja) 1995-06-15
EP0632887A1 (de) 1995-01-11
EP0632887A4 (de) 1995-11-22
CA2538701A1 (en) 1993-09-30
ES2173093T3 (es) 2002-10-16
WO1993019358A1 (en) 1993-09-30
DE69331629D1 (de) 2002-04-04

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee