ATE403142T1 - Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln - Google Patents
Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikelnInfo
- Publication number
- ATE403142T1 ATE403142T1 AT01986914T AT01986914T ATE403142T1 AT E403142 T1 ATE403142 T1 AT E403142T1 AT 01986914 T AT01986914 T AT 01986914T AT 01986914 T AT01986914 T AT 01986914T AT E403142 T1 ATE403142 T1 AT E403142T1
- Authority
- AT
- Austria
- Prior art keywords
- counting
- photons
- histogram
- molecules
- signal
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title 1
- 238000001069 Raman spectroscopy Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00128092 | 2000-12-21 | ||
| EP00128142 | 2000-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE403142T1 true ATE403142T1 (de) | 2008-08-15 |
Family
ID=26071680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01986914T ATE403142T1 (de) | 2000-12-21 | 2001-12-20 | Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040099813A1 (de) |
| EP (1) | EP1344043B1 (de) |
| AT (1) | ATE403142T1 (de) |
| DE (1) | DE60135148D1 (de) |
| DK (1) | DK1344043T3 (de) |
| WO (1) | WO2002050516A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8020433B2 (en) * | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
| US7810380B2 (en) | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
| EP1424548A1 (de) * | 2002-09-27 | 2004-06-02 | Evotec OAI AG | Partikel-Detektionsverfahren und Mikroskopiereinrichtung zur Partikel-Detektion |
| WO2004095028A1 (ja) * | 2003-04-23 | 2004-11-04 | Olympus Corporation | 受容体に結合可能な物質をスクリーニングする方法 |
| WO2005040755A2 (en) * | 2003-10-20 | 2005-05-06 | The Regents Of The University Of California | Nanoscale transduction systems for detecting molecular interactions |
| WO2005107404A2 (en) * | 2004-05-03 | 2005-11-17 | The Penn State Research Foundation | Methods and systems for nanoparticle enhancement of signals |
| US20080286880A1 (en) * | 2004-07-07 | 2008-11-20 | The Penn State Research Foundation | Methods and Systems for Nanoparticle Enhancement of Signals |
| DE102005008196B4 (de) * | 2005-02-22 | 2019-08-29 | Leica Microsystems Cms Gmbh | Verfahren zum Erkennen von Dunkelzuständen bei der spektroskopischen oder mikroskopischen Untersuchung von fluoreszenten Proben und Vorrichtung zur spektroskopischen oder mikroskopischen Untersuchung von fluoreszenten Proben |
| EP2051062B1 (de) * | 2007-10-16 | 2011-02-16 | Gwangju Institute of Science and Technology | Vorrichtung zur Messung der Fluoreszenzlebenszeit |
| US8676744B2 (en) * | 2007-10-25 | 2014-03-18 | Lawrence Livermore National Security, Llc | Physics-based, Bayesian sequential detection method and system for radioactive contraband |
| DE102008004549B4 (de) * | 2008-01-15 | 2013-04-18 | PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung | Vorrichtung und Verfahren zur simultanen zeitaufgelösten Einzelphotonenregistrierung aus einer Mehrzahl von Detektionskanälen |
| AU2009219098A1 (en) * | 2008-02-25 | 2009-09-03 | The University Of Melbourne | A method of fabricating a single photon source |
| MY162695A (en) | 2008-06-10 | 2017-07-14 | Xtralis Technologies Ltd | Particle detection |
| EP2186827A1 (de) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Ersatzmarkergerichtetes cDNA-Klonen von selektiv induzierten mRNAs |
| DE102010005723A1 (de) * | 2010-01-26 | 2011-07-28 | WITec Wissenschaftliche Instrumente und Technologie GmbH, 89081 | Raman-Vorrichtung, insbesondere Raman-Mikroskop mit einer Vorrichtung zur Detektion eines Raman-Signals einer Probe |
| DE102010047237B4 (de) * | 2010-08-13 | 2021-07-01 | Leica Microsystems Cms Gmbh | Verfahren zum Trennen von Detektionssignalen im Strahlengang einer optischen Einrichtung |
| WO2012103423A2 (en) * | 2011-01-28 | 2012-08-02 | Cornell University | Computer-implemented platform for automated fluorescence imaging and kinetic analysis |
| DE102011052686B4 (de) * | 2011-08-12 | 2013-09-05 | Leica Microsystems Cms Gmbh | Einrichtung und Verfahren zum Verteilen von Beleuchtungslicht und Detektionslicht in einem Mikroskop in Abhängigkeit des jeweiligen Polarisierungszustands und Mikroskop mit einer solchen Einrichtung |
| US8982338B2 (en) * | 2012-05-31 | 2015-03-17 | Thermo Scientific Portable Analytical Instruments Inc. | Sample analysis |
| CA3040684C (en) | 2012-08-20 | 2023-02-07 | Hod Finkelstein | Method and system for fluorescence lifetime based sequencing |
| WO2014080932A1 (ja) * | 2012-11-26 | 2014-05-30 | 国立大学法人大阪大学 | 光学顕微鏡、および、光学顕微鏡のオートフォーカス装置 |
| RU2530468C1 (ru) * | 2013-05-17 | 2014-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородский государственный технический университет им. Р.Е. Алексеева" (НГТУ) | Способ измерения параметров однофотонных источников излучения инфракрасного диапазона |
| CN104165852B (zh) * | 2014-08-25 | 2016-09-28 | 广西师范大学 | 一种简单快速测定氟离子的共振瑞利散射能量转移光谱法 |
| AU2015320685B2 (en) | 2014-09-23 | 2021-01-28 | Tearlab Research, Inc. | Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest |
| DE102016214469A1 (de) * | 2016-08-04 | 2018-02-08 | Schaeffler Technologies AG & Co. KG | Drehmomentübertragungseinrichtung |
| CN111122540A (zh) * | 2019-12-25 | 2020-05-08 | 桂林电子科技大学 | 基于时间相关单光子探测技术的多功能光纤探针系统 |
| GB2609456A (en) * | 2021-08-02 | 2023-02-08 | Advanced Instr Ltd | An apparatus and method for calculating a number of photons associated with bound fluorescent molecules |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL49776A (en) * | 1976-06-13 | 1979-05-31 | Elscint Ltd | Method and appararus for differentiating of normal and abnormal mammalian cells |
| US5380663A (en) * | 1984-12-24 | 1995-01-10 | Caribbean Microparticles Corporation | Automated system for performance analysis and fluorescence quantitation of samples |
| WO1992007245A1 (en) * | 1990-10-10 | 1992-04-30 | The University Of Maryland | Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry |
| US5323008A (en) * | 1992-03-23 | 1994-06-21 | Diatron Corporation | Fluorometer detection system |
| JP3830167B2 (ja) * | 1996-11-27 | 2006-10-04 | マックス−プランク−ゲゼルシャフト ツル フェルデルング デァ ヴィッセンシャフテン エー.フォオ.,ベルリン | 試料媒体にある標的粒子の所定の特性を決定するための方法および装置 |
| US6049380A (en) * | 1997-11-12 | 2000-04-11 | Regents Of The University Of California | Single molecule identification using selected fluorescence characteristics |
-
2001
- 2001-12-20 DE DE60135148T patent/DE60135148D1/de not_active Expired - Lifetime
- 2001-12-20 DK DK01986914T patent/DK1344043T3/da active
- 2001-12-20 AT AT01986914T patent/ATE403142T1/de not_active IP Right Cessation
- 2001-12-20 EP EP01986914A patent/EP1344043B1/de not_active Expired - Lifetime
- 2001-12-20 WO PCT/EP2001/015108 patent/WO2002050516A2/en not_active Ceased
- 2001-12-20 US US10/451,653 patent/US20040099813A1/en not_active Abandoned
-
2006
- 2006-11-30 US US11/565,054 patent/US20070085025A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1344043A2 (de) | 2003-09-17 |
| EP1344043B1 (de) | 2008-07-30 |
| WO2002050516A3 (en) | 2002-09-19 |
| DK1344043T3 (da) | 2008-11-24 |
| WO2002050516A8 (en) | 2002-07-25 |
| US20070085025A1 (en) | 2007-04-19 |
| US20040099813A1 (en) | 2004-05-27 |
| DE60135148D1 (de) | 2008-09-11 |
| WO2002050516A2 (en) | 2002-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |