ATE403142T1 - Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln - Google Patents
Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikelnInfo
- Publication number
- ATE403142T1 ATE403142T1 AT01986914T AT01986914T ATE403142T1 AT E403142 T1 ATE403142 T1 AT E403142T1 AT 01986914 T AT01986914 T AT 01986914T AT 01986914 T AT01986914 T AT 01986914T AT E403142 T1 ATE403142 T1 AT E403142T1
- Authority
- AT
- Austria
- Prior art keywords
- counting
- photons
- histogram
- molecules
- signal
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title 1
- 238000001069 Raman spectroscopy Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00128142 | 2000-12-21 | ||
EP00128092 | 2000-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE403142T1 true ATE403142T1 (de) | 2008-08-15 |
Family
ID=26071680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01986914T ATE403142T1 (de) | 2000-12-21 | 2001-12-20 | Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln |
Country Status (6)
Country | Link |
---|---|
US (2) | US20040099813A1 (de) |
EP (1) | EP1344043B1 (de) |
AT (1) | ATE403142T1 (de) |
DE (1) | DE60135148D1 (de) |
DK (1) | DK1344043T3 (de) |
WO (1) | WO2002050516A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7810380B2 (en) * | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
US8020433B2 (en) * | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
EP1424548A1 (de) * | 2002-09-27 | 2004-06-02 | Evotec OAI AG | Partikel-Detektionsverfahren und Mikroskopiereinrichtung zur Partikel-Detektion |
EP1617221A4 (de) * | 2003-04-23 | 2006-08-02 | Olympus Corp | Screening-verfahren für eine zur bindung an einen rezeptor fähige substanz |
JP2007516843A (ja) * | 2003-10-20 | 2007-06-28 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 分子相互作用を検出するためのナノスケール変換システム |
WO2005107404A2 (en) * | 2004-05-03 | 2005-11-17 | The Penn State Research Foundation | Methods and systems for nanoparticle enhancement of signals |
US20080286880A1 (en) * | 2004-07-07 | 2008-11-20 | The Penn State Research Foundation | Methods and Systems for Nanoparticle Enhancement of Signals |
DE102005008196B4 (de) * | 2005-02-22 | 2019-08-29 | Leica Microsystems Cms Gmbh | Verfahren zum Erkennen von Dunkelzuständen bei der spektroskopischen oder mikroskopischen Untersuchung von fluoreszenten Proben und Vorrichtung zur spektroskopischen oder mikroskopischen Untersuchung von fluoreszenten Proben |
EP2051062B1 (de) * | 2007-10-16 | 2011-02-16 | Gwangju Institute of Science and Technology | Vorrichtung zur Messung der Fluoreszenzlebenszeit |
US8676744B2 (en) * | 2007-10-25 | 2014-03-18 | Lawrence Livermore National Security, Llc | Physics-based, Bayesian sequential detection method and system for radioactive contraband |
DE102008004549B4 (de) * | 2008-01-15 | 2013-04-18 | PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung | Vorrichtung und Verfahren zur simultanen zeitaufgelösten Einzelphotonenregistrierung aus einer Mehrzahl von Detektionskanälen |
EP2250530A1 (de) * | 2008-02-25 | 2010-11-17 | The University of Melbourne | Verfahren zur herstellung einer einzelphotonenquelle |
WO2009149498A1 (en) | 2008-06-10 | 2009-12-17 | Xtralis Technologies Ltd | Particle detection |
EP2186827A1 (de) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Ersatzmarkergerichtetes cDNA-Klonen von selektiv induzierten mRNAs |
DE102010005723A1 (de) * | 2010-01-26 | 2011-07-28 | WITec Wissenschaftliche Instrumente und Technologie GmbH, 89081 | Raman-Vorrichtung, insbesondere Raman-Mikroskop mit einer Vorrichtung zur Detektion eines Raman-Signals einer Probe |
DE102010047237B4 (de) * | 2010-08-13 | 2021-07-01 | Leica Microsystems Cms Gmbh | Verfahren zum Trennen von Detektionssignalen im Strahlengang einer optischen Einrichtung |
WO2012103423A2 (en) * | 2011-01-28 | 2012-08-02 | Cornell University | Computer-implemented platform for automated fluorescence imaging and kinetic analysis |
DE102011052686B4 (de) * | 2011-08-12 | 2013-09-05 | Leica Microsystems Cms Gmbh | Einrichtung und Verfahren zum Verteilen von Beleuchtungslicht und Detektionslicht in einem Mikroskop in Abhängigkeit des jeweiligen Polarisierungszustands und Mikroskop mit einer solchen Einrichtung |
US8982338B2 (en) * | 2012-05-31 | 2015-03-17 | Thermo Scientific Portable Analytical Instruments Inc. | Sample analysis |
AU2013306373B2 (en) * | 2012-08-20 | 2017-09-07 | Illumina, Inc. | Method and system for fluorescence lifetime based sequencing |
EP2924487B1 (de) * | 2012-11-26 | 2019-11-13 | Osaka University | Optisches mikroskop und autofokusvorrichtung für optisches mikroskop |
RU2530468C1 (ru) * | 2013-05-17 | 2014-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородский государственный технический университет им. Р.Е. Алексеева" (НГТУ) | Способ измерения параметров однофотонных источников излучения инфракрасного диапазона |
CN104165852B (zh) * | 2014-08-25 | 2016-09-28 | 广西师范大学 | 一种简单快速测定氟离子的共振瑞利散射能量转移光谱法 |
CA2959073A1 (en) | 2014-09-23 | 2016-03-31 | Tearlab Research, Inc. | Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest |
DE102016214469A1 (de) * | 2016-08-04 | 2018-02-08 | Schaeffler Technologies AG & Co. KG | Drehmomentübertragungseinrichtung |
CN111122540A (zh) * | 2019-12-25 | 2020-05-08 | 桂林电子科技大学 | 基于时间相关单光子探测技术的多功能光纤探针系统 |
GB2609456A (en) * | 2021-08-02 | 2023-02-08 | Advanced Instr Ltd | An apparatus and method for calculating a number of photons associated with bound fluorescent molecules |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL49776A (en) * | 1976-06-13 | 1979-05-31 | Elscint Ltd | Method and appararus for differentiating of normal and abnormal mammalian cells |
US5380663A (en) * | 1984-12-24 | 1995-01-10 | Caribbean Microparticles Corporation | Automated system for performance analysis and fluorescence quantitation of samples |
US5504337A (en) * | 1990-10-10 | 1996-04-02 | Joseph R. Lakowicz | Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry |
US5323008A (en) * | 1992-03-23 | 1994-06-21 | Diatron Corporation | Fluorometer detection system |
ATE252729T1 (de) * | 1996-11-27 | 2003-11-15 | Max Planck Gesellschaft | Verfahren und anordnung zum bestimmen vorgegebener eigenschaften von zielpartikeln eines probenmediums |
US6049380A (en) * | 1997-11-12 | 2000-04-11 | Regents Of The University Of California | Single molecule identification using selected fluorescence characteristics |
-
2001
- 2001-12-20 WO PCT/EP2001/015108 patent/WO2002050516A2/en active IP Right Grant
- 2001-12-20 EP EP01986914A patent/EP1344043B1/de not_active Expired - Lifetime
- 2001-12-20 DK DK01986914T patent/DK1344043T3/da active
- 2001-12-20 AT AT01986914T patent/ATE403142T1/de not_active IP Right Cessation
- 2001-12-20 US US10/451,653 patent/US20040099813A1/en not_active Abandoned
- 2001-12-20 DE DE60135148T patent/DE60135148D1/de not_active Expired - Lifetime
-
2006
- 2006-11-30 US US11/565,054 patent/US20070085025A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK1344043T3 (da) | 2008-11-24 |
DE60135148D1 (de) | 2008-09-11 |
US20070085025A1 (en) | 2007-04-19 |
EP1344043B1 (de) | 2008-07-30 |
WO2002050516A3 (en) | 2002-09-19 |
US20040099813A1 (en) | 2004-05-27 |
WO2002050516A8 (en) | 2002-07-25 |
WO2002050516A2 (en) | 2002-06-27 |
EP1344043A2 (de) | 2003-09-17 |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |