ATE235045T1 - Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen - Google Patents
Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionenInfo
- Publication number
- ATE235045T1 ATE235045T1 AT00927110T AT00927110T ATE235045T1 AT E235045 T1 ATE235045 T1 AT E235045T1 AT 00927110 T AT00927110 T AT 00927110T AT 00927110 T AT00927110 T AT 00927110T AT E235045 T1 ATE235045 T1 AT E235045T1
- Authority
- AT
- Austria
- Prior art keywords
- particles
- numbers
- photon counts
- fluorescent molecules
- photon
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004364 calculation method Methods 0.000 abstract 1
- 238000005315 distribution function Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/457—Correlation spectrometry, e.g. of the intensity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J2003/2866—Markers; Calibrating of scan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Spectrometry And Color Measurement (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13165799P | 1999-04-29 | 1999-04-29 | |
US09/338,439 US6376843B1 (en) | 1999-06-23 | 1999-06-23 | Method of characterizing fluorescent molecules or other particles using generating functions |
EP99112104A EP1063502A1 (de) | 1999-06-23 | 1999-06-23 | Verfahren zur Charakterisierung fluoreszierender Moleküle oder anderer Teilchen unter Verwendung von erzeugenden Funktionen |
EP99125745 | 1999-12-23 | ||
US18156400P | 2000-02-10 | 2000-02-10 | |
PCT/EP2000/003890 WO2000066985A1 (en) | 1999-04-29 | 2000-04-29 | A method of characterizing fluorescent molecules or other particles using generating functions |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE235045T1 true ATE235045T1 (de) | 2003-04-15 |
Family
ID=56290015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00927110T ATE235045T1 (de) | 1999-04-29 | 2000-04-29 | Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1175602B1 (de) |
JP (1) | JP3559525B2 (de) |
AT (1) | ATE235045T1 (de) |
AU (1) | AU4559600A (de) |
DE (1) | DE60001731T2 (de) |
DK (1) | DK1175602T3 (de) |
WO (1) | WO2000066985A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6690463B2 (en) * | 2000-02-10 | 2004-02-10 | Evotec Biosystems Ag | Fluorescence intensity and lifetime distribution analysis |
AU2002256658A1 (en) * | 2001-03-09 | 2002-09-24 | Gnothis Holding Sa | Determination of analytes by means of fluorescence correlation spectroscopy |
DE10117723A1 (de) * | 2001-04-09 | 2002-10-17 | Evotec Ag | Probenträger, insbesondere für biochemische Reaktionen |
US6658143B2 (en) * | 2002-04-29 | 2003-12-02 | Amersham Biosciences Corp. | Ray-based image analysis for biological specimens |
US20060223065A1 (en) | 2003-09-30 | 2006-10-05 | Evotec Neuroscience Gmbh | Diagnostic and therapeutic use of a sulfotransferase for neurodegenerative diseases |
JP3793531B2 (ja) | 2003-10-07 | 2006-07-05 | オリンパス株式会社 | 蛍光寿命測定装置 |
EP1776591B1 (de) | 2004-08-11 | 2013-10-16 | Evotec International GmbH | Diagnostische und therapeutische verwendung einer plasmamembran-atpase |
JPWO2006062127A1 (ja) * | 2004-12-10 | 2008-06-12 | シスメックス株式会社 | 免疫システム異常疾患の診断支援情報出力装置及び診断支援情報出力プログラム |
WO2006125830A2 (en) | 2005-05-27 | 2006-11-30 | Evotec Neurosciences Gmbh | Kcnn3 as diagnostic and therapeutic target for neurodegenerative diseases |
US8114620B2 (en) | 2005-05-30 | 2012-02-14 | Takeda Pharmaceutical Company Limited | Diagnostic and therapeutic target PRKX proteins for neurodegenerative diseases |
JP2008545424A (ja) | 2005-06-01 | 2008-12-18 | エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー | 神経変性疾患用の診断・治療標的slc39a12タンパク質 |
EP1891241B1 (de) | 2005-06-16 | 2011-01-12 | EVOTEC Neurosciences GmbH | Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen |
JP2009278866A (ja) * | 2006-09-04 | 2009-12-03 | Olympus Corp | Dnaに於けるdna結合性タンパク質の結合部位の検出方法 |
EP2053397A1 (de) | 2007-10-25 | 2009-04-29 | EVOTEC Neurosciences GmbH | PPM1E-Proteine und Nukleinsäuren als Targets für neurodegenerative Erkrankungen |
WO2010090872A2 (en) * | 2009-01-21 | 2010-08-12 | Rare Light, Inc. | Correlation interferometric methods, devices and systems for low cost and rugged spectroscopy |
WO2011108369A1 (ja) | 2010-03-01 | 2011-09-09 | オリンパス株式会社 | 光分析装置、光分析方法並びに光分析用コンピュータプログラム |
JP5877155B2 (ja) | 2010-07-26 | 2016-03-02 | オリンパス株式会社 | 発光プローブを用いて溶液中の希薄粒子を検出する方法 |
CN103097878B (zh) | 2010-09-10 | 2015-07-22 | 奥林巴斯株式会社 | 使用单个发光颗粒的光强度的光学分析方法 |
JP5893564B2 (ja) | 2010-09-10 | 2016-03-23 | オリンパス株式会社 | 複数の波長帯域の光計測を用いた光分析方法 |
JP5737704B2 (ja) * | 2010-09-27 | 2015-06-17 | 株式会社ライフテック | 蛍光一粒子検出方法および検出システム |
JP5907882B2 (ja) | 2010-10-19 | 2016-04-26 | オリンパス株式会社 | 単一発光粒子の偏光特性を観測する光分析装置、光分析方法及びそのための光分析用コンピュータプログラム |
WO2012070414A1 (ja) | 2010-11-25 | 2012-05-31 | オリンパス株式会社 | 単一発光粒子の光の波長特性を用いた光分析装置及び光分析方法 |
CN103328955B (zh) | 2011-01-20 | 2017-10-20 | 奥林巴斯株式会社 | 利用来自单个发光粒子的光的检测的光分析方法和光分析装置 |
JP5856984B2 (ja) | 2011-01-26 | 2016-02-10 | オリンパス株式会社 | 核酸分子の多型識別方法 |
EP2669376B1 (de) | 2011-01-26 | 2017-08-16 | Olympus Corporation | Verfahren zur identifizierung von polymorphismen von nukleinsäuremolekülen |
WO2012133292A1 (ja) | 2011-03-29 | 2012-10-04 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法並びに光分析用コンピュータプログラム |
CN103477210B (zh) | 2011-04-13 | 2015-09-23 | 奥林巴斯株式会社 | 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序 |
JP6013328B2 (ja) | 2011-04-18 | 2016-10-25 | オリンパス株式会社 | 標的粒子の定量方法 |
WO2013021687A1 (ja) | 2011-08-11 | 2013-02-14 | オリンパス株式会社 | 標的粒子の検出方法 |
WO2013024650A1 (ja) | 2011-08-15 | 2013-02-21 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
WO2013031309A1 (ja) | 2011-08-26 | 2013-03-07 | オリンパス株式会社 | 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム |
JP6013338B2 (ja) | 2011-08-26 | 2016-10-25 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
JP6010035B2 (ja) | 2011-08-30 | 2016-10-19 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
WO2013031365A1 (ja) | 2011-08-30 | 2013-03-07 | オリンパス株式会社 | 標的粒子の検出方法 |
EP2778658A4 (de) | 2011-11-10 | 2015-12-02 | Olympus Corp | Spektroskopievorrichtung, spektroskopieverfahren und spektroskopie-computerprogramm mit erkennung einzelner lichtemittierender teilchen |
DE102012100098B4 (de) * | 2012-01-06 | 2021-09-16 | Becker & Hickl Gmbh | Verfahren zur Aufzeichnung von zeitlichen Änderungen der Zeitfunktion eines optischen Signals mit räumlicher Auflösung entlang einer Linie im Raum |
CN104115001B (zh) | 2012-02-17 | 2016-08-24 | 奥林巴斯株式会社 | 利用单个粒子检测的光分析装置、光分析方法 |
JP5940644B2 (ja) | 2012-02-22 | 2016-06-29 | オリンパス株式会社 | 標的粒子の検出方法 |
JP6095645B2 (ja) | 2012-03-21 | 2017-03-15 | オリンパス株式会社 | 標的核酸分子の検出方法 |
WO2013157283A1 (ja) | 2012-04-18 | 2013-10-24 | オリンパス株式会社 | 標的粒子の検出方法 |
WO2013157319A1 (ja) | 2012-04-18 | 2013-10-24 | オリンパス株式会社 | 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム |
CN104541152B (zh) * | 2012-06-15 | 2017-08-25 | 卢米尼克斯股份有限公司 | 使用拟合选择标准的高斯残差的图像归一化装置、系统和方法 |
DE102013213362A1 (de) | 2013-07-08 | 2015-01-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Identifizierung und Quantifizierung von emittierenden Teilchen in Systemen |
WO2015015951A1 (ja) | 2013-07-31 | 2015-02-05 | オリンパス株式会社 | 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム |
JP6313776B2 (ja) | 2013-10-07 | 2018-04-18 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
EP2871461A1 (de) * | 2013-11-06 | 2015-05-13 | F. Hoffmann-La Roche AG | Verfahren zur Untersuchung einer Vielzahl von kultivierten Zellen auf Anwesenheit von periodischen Strukturen von mindestens einer Zielkomponente in den kultivierten Zellen |
JPWO2017098597A1 (ja) | 2015-12-09 | 2018-10-11 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析方法及び光分析装置 |
DE102019000066B4 (de) * | 2019-01-09 | 2020-10-08 | Becker & Hickl Gmbh | Verfahren zur Visualisierung von Fluoreszenz-Lifetime-Imaging-Daten |
WO2022047101A1 (en) * | 2020-08-27 | 2022-03-03 | The Research Foundation For The State University Of New York | System and method for embedded diffuse correlation spectroscopy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1595422A (en) * | 1977-04-28 | 1981-08-12 | Nat Res Dev | Scaning microscopes |
US5866911A (en) * | 1994-07-15 | 1999-02-02 | Baer; Stephen C. | Method and apparatus for improving resolution in scanned optical system |
EP0836090A1 (de) * | 1996-10-12 | 1998-04-15 | Evotec BioSystems GmbH | Probenanalyseverfahren durch Bestimmung der spezifischen Helligkeitsverteilung von Teilchen |
DK0941466T3 (da) * | 1996-11-27 | 2004-03-01 | Max Planck Gesellschaft | Metode og anordning til bestemmelse af forudbestemte egenskaber af målpartikler i et prøvemedium |
-
2000
- 2000-04-29 AU AU45596/00A patent/AU4559600A/en not_active Abandoned
- 2000-04-29 AT AT00927110T patent/ATE235045T1/de not_active IP Right Cessation
- 2000-04-29 DE DE60001731T patent/DE60001731T2/de not_active Expired - Lifetime
- 2000-04-29 EP EP00927110A patent/EP1175602B1/de not_active Expired - Lifetime
- 2000-04-29 JP JP2000615574A patent/JP3559525B2/ja not_active Expired - Lifetime
- 2000-04-29 WO PCT/EP2000/003890 patent/WO2000066985A1/en active IP Right Grant
- 2000-04-29 DK DK00927110T patent/DK1175602T3/da active
Also Published As
Publication number | Publication date |
---|---|
WO2000066985A9 (en) | 2002-02-14 |
JP3559525B2 (ja) | 2004-09-02 |
EP1175602B1 (de) | 2003-03-19 |
JP2002543414A (ja) | 2002-12-17 |
DE60001731T2 (de) | 2004-02-05 |
AU4559600A (en) | 2000-11-17 |
DK1175602T3 (da) | 2003-05-26 |
EP1175602A1 (de) | 2002-01-30 |
WO2000066985A1 (en) | 2000-11-09 |
DE60001731D1 (de) | 2003-04-24 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |