ATE235045T1 - Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen - Google Patents
Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionenInfo
- Publication number
- ATE235045T1 ATE235045T1 AT00927110T AT00927110T ATE235045T1 AT E235045 T1 ATE235045 T1 AT E235045T1 AT 00927110 T AT00927110 T AT 00927110T AT 00927110 T AT00927110 T AT 00927110T AT E235045 T1 ATE235045 T1 AT E235045T1
- Authority
- AT
- Austria
- Prior art keywords
- particles
- numbers
- photon counts
- fluorescent molecules
- photon
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004364 calculation method Methods 0.000 abstract 1
- 238000005315 distribution function Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/457—Correlation spectrometry, e.g. of the intensity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J2003/2866—Markers; Calibrating of scan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Spectrometry And Color Measurement (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13165799P | 1999-04-29 | 1999-04-29 | |
| EP99112104A EP1063502A1 (de) | 1999-06-23 | 1999-06-23 | Verfahren zur Charakterisierung fluoreszierender Moleküle oder anderer Teilchen unter Verwendung von erzeugenden Funktionen |
| US09/338,439 US6376843B1 (en) | 1999-06-23 | 1999-06-23 | Method of characterizing fluorescent molecules or other particles using generating functions |
| EP99125745 | 1999-12-23 | ||
| US18156400P | 2000-02-10 | 2000-02-10 | |
| PCT/EP2000/003890 WO2000066985A1 (en) | 1999-04-29 | 2000-04-29 | A method of characterizing fluorescent molecules or other particles using generating functions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE235045T1 true ATE235045T1 (de) | 2003-04-15 |
Family
ID=56290015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00927110T ATE235045T1 (de) | 1999-04-29 | 2000-04-29 | Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1175602B1 (de) |
| JP (1) | JP3559525B2 (de) |
| AT (1) | ATE235045T1 (de) |
| AU (1) | AU4559600A (de) |
| DE (1) | DE60001731T2 (de) |
| DK (1) | DK1175602T3 (de) |
| WO (1) | WO2000066985A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6690463B2 (en) * | 2000-02-10 | 2004-02-10 | Evotec Biosystems Ag | Fluorescence intensity and lifetime distribution analysis |
| AU2002256658A1 (en) * | 2001-03-09 | 2002-09-24 | Gnothis Holding Sa | Determination of analytes by means of fluorescence correlation spectroscopy |
| DE10117723A1 (de) * | 2001-04-09 | 2002-10-17 | Evotec Ag | Probenträger, insbesondere für biochemische Reaktionen |
| US6658143B2 (en) * | 2002-04-29 | 2003-12-02 | Amersham Biosciences Corp. | Ray-based image analysis for biological specimens |
| EP1670943B1 (de) | 2003-09-30 | 2013-11-13 | Evotec International GmbH | Diagnostische und therapeutische verwendung einer sulfotransferase für alzheimer-krankheit |
| JP3793531B2 (ja) | 2003-10-07 | 2006-07-05 | オリンパス株式会社 | 蛍光寿命測定装置 |
| JP2008508893A (ja) | 2004-08-11 | 2008-03-27 | エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー | 形質膜atpアーゼの診断及び治療への使用 |
| JPWO2006062127A1 (ja) * | 2004-12-10 | 2008-06-12 | シスメックス株式会社 | 免疫システム異常疾患の診断支援情報出力装置及び診断支援情報出力プログラム |
| EP1888783B1 (de) | 2005-05-27 | 2011-10-26 | EVOTEC Neurosciences GmbH | Kcnn3 als diagnostisches und therapeutisches target für alzheimer-krankheit |
| ATE534751T1 (de) | 2005-05-30 | 2011-12-15 | Takeda Pharmaceutical | Verwendung von prkx zur diagnose und therapie von alzheimer krankheit |
| EP1891234B1 (de) | 2005-06-01 | 2014-12-10 | Evotec International GmbH | Verwendung von slc39a12-proteinen als zielmoleküle in der diagnose von und beim screening von medikamenten zur behandlung von alzheimer-krankheit |
| JP2008546379A (ja) | 2005-06-16 | 2008-12-25 | エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー | 神経変性疾患のための診断および治療の標的adarb2タンパク質 |
| JP2009278866A (ja) * | 2006-09-04 | 2009-12-03 | Olympus Corp | Dnaに於けるdna結合性タンパク質の結合部位の検出方法 |
| EP2053397A1 (de) | 2007-10-25 | 2009-04-29 | EVOTEC Neurosciences GmbH | PPM1E-Proteine und Nukleinsäuren als Targets für neurodegenerative Erkrankungen |
| EP2389568A4 (de) * | 2009-01-21 | 2013-11-20 | Rare Light Inc | Interferometrische korrelationsverfahren, vorrichtungen und systeme für kosteneffiziente und robuste spektroskopie |
| EP2543989A4 (de) * | 2010-03-01 | 2017-11-01 | Olympus Corporation | Vorrichtung für optische analyse, verfahren für optische analyse und computerprogramm für optische analyse |
| WO2012014778A1 (ja) | 2010-07-26 | 2012-02-02 | オリンパス株式会社 | 発光プローブを用いて溶液中の希薄粒子を検出する方法 |
| EP2602613B1 (de) | 2010-09-10 | 2017-02-22 | Olympus Corporation | Optisches analyseverfahren unter verwendung der optischen intensität eines einzelnen lichtemittierenden partikels |
| WO2012032955A1 (ja) | 2010-09-10 | 2012-03-15 | オリンパス株式会社 | 複数の波長帯域の光計測を用いた光分析方法 |
| JP5737704B2 (ja) * | 2010-09-27 | 2015-06-17 | 株式会社ライフテック | 蛍光一粒子検出方法および検出システム |
| EP2620763A4 (de) | 2010-10-19 | 2015-05-27 | Olympus Corp | Optische analyse zum beobachten von polarisationsdaten einzelner lichtemittierender teilchen, verfahren für optische analysen und computerprogramm für optische analysen |
| EP2631631B1 (de) | 2010-11-25 | 2016-01-20 | Olympus Corporation | Photometrische analysevorrichtung und photometrisches analyseverfahren unter verwendung von wellenlängeneigenschaften eines aus einem einzigen leuchtenden teilchen emittierten lichts |
| EP2667183A4 (de) | 2011-01-20 | 2017-05-10 | Olympus Corporation | Lichtanalyseverfahren und lichtanalysevorrichtung mit erkennung von licht aus einzelnen lichtemittierenden teilchen |
| EP2669376B1 (de) | 2011-01-26 | 2017-08-16 | Olympus Corporation | Verfahren zur identifizierung von polymorphismen von nukleinsäuremolekülen |
| WO2012102260A1 (ja) | 2011-01-26 | 2012-08-02 | オリンパス株式会社 | 核酸分子の多型識別方法 |
| CN103460026B (zh) | 2011-03-29 | 2015-06-10 | 奥林巴斯株式会社 | 利用单个发光粒子检测的光分析装置、光分析方法以及光分析用计算机程序 |
| JP5885738B2 (ja) | 2011-04-13 | 2016-03-15 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
| JP6013328B2 (ja) | 2011-04-18 | 2016-10-25 | オリンパス株式会社 | 標的粒子の定量方法 |
| JP6013335B2 (ja) | 2011-08-11 | 2016-10-25 | オリンパス株式会社 | 標的粒子の計数方法 |
| JP6013337B2 (ja) | 2011-08-15 | 2016-10-25 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
| CN103765195B (zh) | 2011-08-26 | 2018-06-01 | 奥林巴斯株式会社 | 利用光分析的单个粒子检测装置、单个粒子检测方法以及单个粒子检测用计算机程序 |
| CN103765196B (zh) | 2011-08-26 | 2016-03-02 | 奥林巴斯株式会社 | 利用单个发光粒子检测的光分析装置及光分析方法 |
| EP2752654A4 (de) | 2011-08-30 | 2015-04-15 | Olympus Corp | Optisches analysegerät mit einzelnachweis lichtemittierender teilchen, optisches analyseverfahren und computerprogramm für optische analysen |
| CN103765194B (zh) | 2011-08-30 | 2016-02-17 | 奥林巴斯株式会社 | 目标粒子的检测方法 |
| JP5941923B2 (ja) | 2011-11-10 | 2016-06-29 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
| DE102012100098B4 (de) * | 2012-01-06 | 2021-09-16 | Becker & Hickl Gmbh | Verfahren zur Aufzeichnung von zeitlichen Änderungen der Zeitfunktion eines optischen Signals mit räumlicher Auflösung entlang einer Linie im Raum |
| WO2013121905A1 (ja) | 2012-02-17 | 2013-08-22 | オリンパス株式会社 | 単一粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
| CN104115003B (zh) | 2012-02-22 | 2016-03-23 | 奥林巴斯株式会社 | 目标粒子的检测方法 |
| WO2013140890A1 (ja) | 2012-03-21 | 2013-09-26 | オリンパス株式会社 | 標的核酸分子の検出方法 |
| CN104246479B (zh) | 2012-04-18 | 2016-10-19 | 奥林巴斯株式会社 | 利用光分析的单个粒子检测装置、单个粒子检测方法以及单个粒子检测用计算机程序 |
| JP5940651B2 (ja) | 2012-04-18 | 2016-06-29 | オリンパス株式会社 | 標的粒子の検出方法 |
| CN104541152B (zh) * | 2012-06-15 | 2017-08-25 | 卢米尼克斯股份有限公司 | 使用拟合选择标准的高斯残差的图像归一化装置、系统和方法 |
| DE102013213362A1 (de) * | 2013-07-08 | 2015-01-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Identifizierung und Quantifizierung von emittierenden Teilchen in Systemen |
| WO2015015951A1 (ja) | 2013-07-31 | 2015-02-05 | オリンパス株式会社 | 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム |
| WO2015052965A1 (ja) | 2013-10-07 | 2015-04-16 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析装置、光分析方法及び光分析用コンピュータプログラム |
| EP2871461A1 (de) | 2013-11-06 | 2015-05-13 | F. Hoffmann-La Roche AG | Verfahren zur Untersuchung einer Vielzahl von kultivierten Zellen auf Anwesenheit von periodischen Strukturen von mindestens einer Zielkomponente in den kultivierten Zellen |
| WO2017098597A1 (ja) | 2015-12-09 | 2017-06-15 | オリンパス株式会社 | 単一発光粒子検出を用いた光分析方法及び光分析装置 |
| DE102019000066B4 (de) * | 2019-01-09 | 2020-10-08 | Becker & Hickl Gmbh | Verfahren zur Visualisierung von Fluoreszenz-Lifetime-Imaging-Daten |
| EP4204778A4 (de) * | 2020-08-27 | 2024-09-25 | The Research Foundation for The State University of New York | System und verfahren für eingebettete diffuse korrelationsspektroskopie |
| CN115048835B (zh) * | 2022-06-09 | 2024-10-18 | 山西大学 | 一种等离子体中粒子瞬态分布的成像方法 |
| KR102593306B1 (ko) * | 2023-03-21 | 2023-10-25 | 부경대학교 산학협력단 | 저투수성 매체 내 형광 추적자 농도분포 추정 장치 및 방법 |
| JP7739535B1 (ja) * | 2024-06-19 | 2025-09-16 | 浜松ホトニクス株式会社 | 信号処理方法、信号処理装置、及び信号処理システム |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1595422A (en) * | 1977-04-28 | 1981-08-12 | Nat Res Dev | Scaning microscopes |
| US5866911A (en) * | 1994-07-15 | 1999-02-02 | Baer; Stephen C. | Method and apparatus for improving resolution in scanned optical system |
| EP0836090A1 (de) * | 1996-10-12 | 1998-04-15 | Evotec BioSystems GmbH | Probenanalyseverfahren durch Bestimmung der spezifischen Helligkeitsverteilung von Teilchen |
| JP3830167B2 (ja) * | 1996-11-27 | 2006-10-04 | マックス−プランク−ゲゼルシャフト ツル フェルデルング デァ ヴィッセンシャフテン エー.フォオ.,ベルリン | 試料媒体にある標的粒子の所定の特性を決定するための方法および装置 |
-
2000
- 2000-04-29 DK DK00927110T patent/DK1175602T3/da active
- 2000-04-29 JP JP2000615574A patent/JP3559525B2/ja not_active Expired - Lifetime
- 2000-04-29 DE DE60001731T patent/DE60001731T2/de not_active Expired - Lifetime
- 2000-04-29 WO PCT/EP2000/003890 patent/WO2000066985A1/en not_active Ceased
- 2000-04-29 EP EP00927110A patent/EP1175602B1/de not_active Expired - Lifetime
- 2000-04-29 AT AT00927110T patent/ATE235045T1/de not_active IP Right Cessation
- 2000-04-29 AU AU45596/00A patent/AU4559600A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000066985A1 (en) | 2000-11-09 |
| DK1175602T3 (da) | 2003-05-26 |
| DE60001731T2 (de) | 2004-02-05 |
| AU4559600A (en) | 2000-11-17 |
| EP1175602B1 (de) | 2003-03-19 |
| WO2000066985A9 (en) | 2002-02-14 |
| EP1175602A1 (de) | 2002-01-30 |
| JP2002543414A (ja) | 2002-12-17 |
| JP3559525B2 (ja) | 2004-09-02 |
| DE60001731D1 (de) | 2003-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE235045T1 (de) | Verfahren zur erfassung von fluoreszierenden molekülen oder anderen teilchen mittels erzeugenden funktionen | |
| AU2001239258A1 (en) | Fluorescence intensity and lifetime distribution analysis | |
| WO2004011903A3 (en) | Monitoring molecular interactions using photon arrival-time interval distribution analysis | |
| DE69722800D1 (de) | Probenanalyseverfahren mittels bestimmung einer funktion der spezifischen helligkeit | |
| IL252832A0 (en) | Use of biomarkers for detecting ovarian cancer | |
| KR970048450A (ko) | 뇨중 유형성분 분석장치 및 그 방법 | |
| WO2013140350A3 (fr) | Procede et appareil de caracterisation d'echantillons par mesure de la diffusion lumineuse et de la fluorescence. | |
| ATE215694T1 (de) | Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten | |
| ATE310582T1 (de) | Verfahren und vorrichtung zur bestimmung des volumens einer flüssigkeitsprobe | |
| RU2012135462A (ru) | Устройство детектирования и способ детектирования | |
| RU2012156874A (ru) | Способ и устройство для обнаружения биологического материала | |
| MX2025009080A (es) | Analizador de concentracion en el punto de atencion | |
| DE60315715D1 (de) | Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs | |
| WO2005040759A3 (en) | Apparatus and methods for detecting target analyte | |
| RU2008110930A (ru) | Способ мониторинга и контроля процессов смещения | |
| DE60102797D1 (de) | Fluoreszenzintensitätsanalyse unter verwendung einer vielzahl von verteilungen: konkurrierende bestimmung von diffusionszeiten und molekularer helligkeit | |
| DE602006020140D1 (de) | Hitzeinduzierbare tetrahymena-promotoren und deren verwendung | |
| AR005521A1 (es) | Metodo para vigilar un proceso microbiologico en una fuente de fluidos que tiene poblacion microbiologica. | |
| CN104198456A (zh) | 荧光分光光度法测定钻石荧光强度及荧光颜色的方法 | |
| CN105928909A (zh) | 一种水质检测方法 | |
| CN211374503U (zh) | 光谱检测装置 | |
| CA2586654A1 (en) | Use of asc as a marker for colorectal cancer | |
| ATE266855T1 (de) | Verfahren zur reaktorfüllstandsmessung | |
| CN203432909U (zh) | 一种多探头荧光传感装置 | |
| ATE250229T1 (de) | Probenanalyse |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |