DE69329606T2 - 2,3-Bis-Carboxaamidomethyl substituierte Oxirane als Inhibitoren der HIV-Protease und ihre Verwendung zur Behandlung von AIDS Protease - Google Patents
2,3-Bis-Carboxaamidomethyl substituierte Oxirane als Inhibitoren der HIV-Protease und ihre Verwendung zur Behandlung von AIDS ProteaseInfo
- Publication number
- DE69329606T2 DE69329606T2 DE69329606T DE69329606T DE69329606T2 DE 69329606 T2 DE69329606 T2 DE 69329606T2 DE 69329606 T DE69329606 T DE 69329606T DE 69329606 T DE69329606 T DE 69329606T DE 69329606 T2 DE69329606 T2 DE 69329606T2
- Authority
- DE
- Germany
- Prior art keywords
- protease
- carboxaamidomethyl
- aids
- inhibitors
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000030507 AIDS Diseases 0.000 title 1
- 108010010369 HIV Protease Proteins 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002924 oxiranes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01G—PRELIMINARY TREATMENT OF FIBRES, e.g. FOR SPINNING
- D01G1/00—Severing continuous filaments or long fibres, e.g. stapling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
- D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
- D02J1/22—Stretching or tensioning, shrinking or relaxing, e.g. by use of overfeed and underfeed apparatus, or preventing stretch
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
- D06M13/402—Amides imides, sulfamic acids
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
- D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/02—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Textile Engineering (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90144792A | 1992-06-19 | 1992-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69329606D1 DE69329606D1 (de) | 2000-12-07 |
DE69329606T2 true DE69329606T2 (de) | 2001-05-03 |
Family
ID=25414213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329606T Expired - Fee Related DE69329606T2 (de) | 1992-06-19 | 1993-06-10 | 2,3-Bis-Carboxaamidomethyl substituierte Oxirane als Inhibitoren der HIV-Protease und ihre Verwendung zur Behandlung von AIDS Protease |
Country Status (21)
Country | Link |
---|---|
US (1) | US5578608A (de) |
EP (1) | EP0575097B1 (de) |
JP (1) | JP3195462B2 (de) |
KR (2) | KR940000634A (de) |
CN (1) | CN1082035A (de) |
AU (1) | AU663958B2 (de) |
BR (1) | BR9302389A (de) |
CA (1) | CA2098165A1 (de) |
CO (1) | CO4130200A1 (de) |
CZ (1) | CZ113393A3 (de) |
DE (1) | DE69329606T2 (de) |
ES (1) | ES2152241T3 (de) |
FI (1) | FI932847A (de) |
HU (1) | HUT67571A (de) |
IL (1) | IL105973A0 (de) |
MX (1) | MX9303572A (de) |
NO (1) | NO932130L (de) |
NZ (1) | NZ247837A (de) |
PL (1) | PL299369A1 (de) |
TW (1) | TW218873B (de) |
YU (1) | YU42893A (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
RU2126794C1 (ru) | 1992-03-11 | 1999-02-27 | Нархекс Лимитед | Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы |
DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
CZ184194A3 (en) * | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
KR0125117B1 (ko) * | 1994-06-15 | 1997-12-05 | 성재갑 | 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법 |
KR0159652B1 (ko) * | 1995-10-26 | 1998-12-01 | 성재갑 | 항 에이즈 효과를 갖는 비가역적 인간 면역 결핍 바이러스 프로테아제 저해제 및 그의 제조방법 |
EP0812839A1 (de) * | 1994-12-08 | 1997-12-17 | LG Chemical Limited | Irreversible HIV-Protease-Inhibitoren und diese enthaltende Zusammensetzungen und Verfahren zu ihrer Herstellung |
US5696134A (en) * | 1993-11-30 | 1997-12-09 | Lg Chemical Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
US5693847A (en) * | 1995-04-19 | 1997-12-02 | Vertex Pharmaceuticals Incorporated | Heteroatom functionalized α-methyl ketones |
US7431956B2 (en) | 2003-06-20 | 2008-10-07 | Sensient Imaging Technologies, Inc. | Food grade colored fluids for printing on edible substrates |
US7431957B2 (en) | 2004-06-10 | 2008-10-07 | Sensient Imaging Technologies, Inc. | Food grade ink jet inks for printing on edible substrates |
US9113647B2 (en) | 2008-08-29 | 2015-08-25 | Sensient Colors Llc | Flavored and edible colored waxes and methods for precision deposition on edible substrates |
WO2014075676A1 (en) * | 2012-11-15 | 2014-05-22 | V-Biotek Holding Aps | Amines from trigonella foemum - graecum |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
JPS60193979A (ja) * | 1984-03-15 | 1985-10-02 | Mitsui Toatsu Chem Inc | Ν−(ω−グリシドキシアルキル)置換アミド化合物及びその製造方法 |
US5155227A (en) * | 1984-07-19 | 1992-10-13 | University Of Florida | Compounds for site-enhanced delivery of radionuclides |
FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
EP0361341A3 (de) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren |
WO1992000948A1 (en) * | 1990-07-06 | 1992-01-23 | Smithkline Beecham Corporation | Inhibitors of retroviral proteases |
IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
-
1993
- 1993-06-10 CA CA002098165A patent/CA2098165A1/en not_active Abandoned
- 1993-06-10 IL IL105973A patent/IL105973A0/xx unknown
- 1993-06-10 DE DE69329606T patent/DE69329606T2/de not_active Expired - Fee Related
- 1993-06-10 TW TW082104596A patent/TW218873B/zh active
- 1993-06-10 NZ NZ247837A patent/NZ247837A/en unknown
- 1993-06-10 ES ES93304504T patent/ES2152241T3/es not_active Expired - Lifetime
- 1993-06-10 CZ CZ931133A patent/CZ113393A3/cs unknown
- 1993-06-10 EP EP93304504A patent/EP0575097B1/de not_active Expired - Lifetime
- 1993-06-10 NO NO932130A patent/NO932130L/no unknown
- 1993-06-15 MX MX9303572A patent/MX9303572A/es unknown
- 1993-06-17 PL PL29936993A patent/PL299369A1/xx unknown
- 1993-06-17 JP JP14606193A patent/JP3195462B2/ja not_active Expired - Fee Related
- 1993-06-17 BR BR9302389A patent/BR9302389A/pt not_active Application Discontinuation
- 1993-06-18 KR KR1019930011216A patent/KR940000634A/ko not_active Application Discontinuation
- 1993-06-18 CO CO93392259A patent/CO4130200A1/es unknown
- 1993-06-18 FI FI932847A patent/FI932847A/fi not_active Application Discontinuation
- 1993-06-18 HU HU9301795A patent/HUT67571A/hu unknown
- 1993-06-18 AU AU41354/93A patent/AU663958B2/en not_active Ceased
- 1993-06-18 KR KR1019930011214A patent/KR940005620A/ko not_active Application Discontinuation
- 1993-06-19 CN CN93107424A patent/CN1082035A/zh active Pending
- 1993-06-21 YU YU42893A patent/YU42893A/sh unknown
-
1995
- 1995-01-17 US US08/372,722 patent/US5578608A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU9301795D0 (en) | 1993-09-28 |
AU4135493A (en) | 1993-12-23 |
DE69329606D1 (de) | 2000-12-07 |
KR940000634A (ko) | 1994-01-03 |
PL299369A1 (en) | 1993-12-27 |
TW218873B (de) | 1994-01-11 |
CA2098165A1 (en) | 1993-12-20 |
JPH0656812A (ja) | 1994-03-01 |
CN1082035A (zh) | 1994-02-16 |
EP0575097B1 (de) | 2000-11-02 |
NO932130D0 (no) | 1993-06-10 |
NZ247837A (en) | 1995-04-27 |
KR940005620A (ko) | 1994-03-21 |
NO932130L (no) | 1993-12-20 |
CZ113393A3 (en) | 1994-03-16 |
EP0575097A1 (de) | 1993-12-22 |
IL105973A0 (en) | 1993-10-20 |
FI932847A (fi) | 1993-12-20 |
JP3195462B2 (ja) | 2001-08-06 |
HUT67571A (en) | 1995-04-28 |
YU42893A (sh) | 1996-07-24 |
US5578608A (en) | 1996-11-26 |
MX9303572A (es) | 1994-01-31 |
AU663958B2 (en) | 1995-10-26 |
CO4130200A1 (es) | 1995-02-13 |
FI932847A0 (fi) | 1993-06-18 |
ES2152241T3 (es) | 2001-02-01 |
BR9302389A (pt) | 1994-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |