ES2152241T3 - Oxiranos 2,3-bis-carboxamidometil sustituidos como inhibidores de la proteasa del hiv y su uso para el tratamiento del sida. - Google Patents

Oxiranos 2,3-bis-carboxamidometil sustituidos como inhibidores de la proteasa del hiv y su uso para el tratamiento del sida.

Info

Publication number
ES2152241T3
ES2152241T3 ES93304504T ES93304504T ES2152241T3 ES 2152241 T3 ES2152241 T3 ES 2152241T3 ES 93304504 T ES93304504 T ES 93304504T ES 93304504 T ES93304504 T ES 93304504T ES 2152241 T3 ES2152241 T3 ES 2152241T3
Authority
ES
Spain
Prior art keywords
heterocicle
aril
rent
formula
hiv protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304504T
Other languages
English (en)
Inventor
John Edwin Munroe
William Joseph Hornback
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2152241T3 publication Critical patent/ES2152241T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01G—PRELIMINARY TREATMENT OF FIBRES, e.g. FOR SPINNING
    • D01G1/00—Severing continuous filaments or long fibres, e.g. stapling
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
    • D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
    • D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
    • D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
    • D02J1/22—Stretching or tensioning, shrinking or relaxing, e.g. by use of overfeed and underfeed apparatus, or preventing stretch
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/402—Amides imides, sulfamic acids
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
    • D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
    • D10B2331/02—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Textile Engineering (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

LA INVENCION SUMINISTRA NUEVOS INHIBIDORES DE LA PROTEASA DEL HIV DE LA FORMULA I EN LA QUE R ES ALQUIL C1-C6, CICLOALQUIL, HETEROCICLO, HETEROCICLO INSATURADO, ARIL, CICLOALQUIL (C1-C4)ALQUIL, HETEROCICLO(C1-C4)ALQUIL, HETEROCICLO (C1-C4)ALQUIL INSATURADO, ARIL (C1-C4)ALQUIL, O UNA ESTRUCTURA QUE TENGA LA FORMULA -A-(CH2)Q-R0, EN DONDE A ES -O-, -NH 2 O 3; R0 ES CICLOALQUIL, ARIL, HETEROCICLO O HETEROCICLO INSATURADO; X ES LA FORMULA II EN LA QUE: R1 ES ARIL, CICLOALQUIL, HETEROCICLO O HETEROCICLO INSATURADO; R2 ES HIDROGENO O ALQUIL C1-C4; R3 ES UNA CADENA LATERAL DE UN AMINOACIDO, -CH2CH3, -CH2CH2CH3, -CH2-(CHE2)2CH3, -C(CH3)3, CIANO (C1C4)ALQUIL, HETEROCICLO (C1-C4)ALQUIL INSATURADO, ARIL(C1-C4)ALQUIL O UNA ESTRUCTURA QUE TENGA LA FORMULA (CH2)S-A0-(CH2)R-R4 O BIEN -CH2-C(O)-NR2-(CH2)R-R5, EN DONDE S ES 1, 2, 3 O 4; R ES 0, 1, 2 O 3; A0 ES -O-, -NHHETEROCICLO O HETEROCICLO INSATURADO; R5 ES CICLOALQUIL, ARIL, HETEROCICLO O HETEROCICLO INSATURADO; J ES 0, 1, 2, 3 O 4; K ES 0 O 1; E Y ES-O-, -N(R2)ALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS.
ES93304504T 1992-06-19 1993-06-10 Oxiranos 2,3-bis-carboxamidometil sustituidos como inhibidores de la proteasa del hiv y su uso para el tratamiento del sida. Expired - Lifetime ES2152241T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90144792A 1992-06-19 1992-06-19

Publications (1)

Publication Number Publication Date
ES2152241T3 true ES2152241T3 (es) 2001-02-01

Family

ID=25414213

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304504T Expired - Lifetime ES2152241T3 (es) 1992-06-19 1993-06-10 Oxiranos 2,3-bis-carboxamidometil sustituidos como inhibidores de la proteasa del hiv y su uso para el tratamiento del sida.

Country Status (21)

Country Link
US (1) US5578608A (es)
EP (1) EP0575097B1 (es)
JP (1) JP3195462B2 (es)
KR (2) KR940005620A (es)
CN (1) CN1082035A (es)
AU (1) AU663958B2 (es)
BR (1) BR9302389A (es)
CA (1) CA2098165A1 (es)
CO (1) CO4130200A1 (es)
CZ (1) CZ113393A3 (es)
DE (1) DE69329606T2 (es)
ES (1) ES2152241T3 (es)
FI (1) FI932847A (es)
HU (1) HUT67571A (es)
IL (1) IL105973A0 (es)
MX (1) MX9303572A (es)
NO (1) NO932130L (es)
NZ (1) NZ247837A (es)
PL (1) PL299369A1 (es)
TW (1) TW218873B (es)
YU (1) YU42893A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
CA2130754C (en) 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
CZ184194A3 (en) * 1993-08-09 1995-03-15 Lilly Co Eli Aspartylprotease inhibitor and method of identifying thereof
KR0125117B1 (ko) * 1994-06-15 1997-12-05 성재갑 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법
EP0812839A1 (en) * 1994-12-08 1997-12-17 LG Chemical Limited Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof
US5696134A (en) * 1993-11-30 1997-12-09 Lg Chemical Limited Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
KR0159652B1 (ko) * 1995-10-26 1998-12-01 성재갑 항 에이즈 효과를 갖는 비가역적 인간 면역 결핍 바이러스 프로테아제 저해제 및 그의 제조방법
US5693847A (en) * 1995-04-19 1997-12-02 Vertex Pharmaceuticals Incorporated Heteroatom functionalized α-methyl ketones
US7431956B2 (en) 2003-06-20 2008-10-07 Sensient Imaging Technologies, Inc. Food grade colored fluids for printing on edible substrates
JP2008502370A (ja) 2004-06-10 2008-01-31 センシエント イメージング テクノロジーズ インコーポレイテッド 可食性基材への印刷に用いる食品用インクジェットインク液
US9113647B2 (en) 2008-08-29 2015-08-25 Sensient Colors Llc Flavored and edible colored waxes and methods for precision deposition on edible substrates
WO2014075676A1 (en) * 2012-11-15 2014-05-22 V-Biotek Holding Aps Amines from trigonella foemum - graecum

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
JPS60193979A (ja) * 1984-03-15 1985-10-02 Mitsui Toatsu Chem Inc Ν−（ω−グリシドキシアルキル）置換アミド化合物及びその製造方法
US5155227A (en) * 1984-07-19 1992-10-13 University Of Florida Compounds for site-enhanced delivery of radionuclides
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
WO1992000948A1 (en) * 1990-07-06 1992-01-23 Smithkline Beecham Corporation Inhibitors of retroviral proteases
IE913840A1 (en) * 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂

Also Published As

Publication number Publication date
CA2098165A1 (en) 1993-12-20
HU9301795D0 (en) 1993-09-28
HUT67571A (en) 1995-04-28
FI932847A (fi) 1993-12-20
MX9303572A (es) 1994-01-31
JPH0656812A (ja) 1994-03-01
KR940000634A (ko) 1994-01-03
IL105973A0 (en) 1993-10-20
US5578608A (en) 1996-11-26
EP0575097A1 (en) 1993-12-22
AU4135493A (en) 1993-12-23
NZ247837A (en) 1995-04-27
CZ113393A3 (en) 1994-03-16
EP0575097B1 (en) 2000-11-02
PL299369A1 (en) 1993-12-27
DE69329606D1 (de) 2000-12-07
YU42893A (sh) 1996-07-24
CN1082035A (zh) 1994-02-16
TW218873B (es) 1994-01-11
BR9302389A (pt) 1994-01-11
NO932130L (no) 1993-12-20
JP3195462B2 (ja) 2001-08-06
FI932847A0 (fi) 1993-06-18
DE69329606T2 (de) 2001-05-03
CO4130200A1 (es) 1995-02-13
KR940005620A (ko) 1994-03-21
NO932130D0 (no) 1993-06-10
AU663958B2 (en) 1995-10-26

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