YU42893A - Inhibitori hiv proteaze korisni za tretiranje aids-a - Google Patents

Inhibitori hiv proteaze korisni za tretiranje aids-a

Info

Publication number
YU42893A
YU42893A YU42893A YU42893A YU42893A YU 42893 A YU42893 A YU 42893A YU 42893 A YU42893 A YU 42893A YU 42893 A YU42893 A YU 42893A YU 42893 A YU42893 A YU 42893A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
heterocycle
aryl
cycloalkyl
unsaturated heterocycle
Prior art date
Application number
YU42893A
Other languages
English (en)
Inventor
J.E. Munroe
W.J. Hornback
Original Assignee
Eli Lilly And Company Indianapolis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company Indianapolis filed Critical Eli Lilly And Company Indianapolis
Publication of YU42893A publication Critical patent/YU42893A/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01G—PRELIMINARY TREATMENT OF FIBRES, e.g. FOR SPINNING
    • D01G1/00—Severing continuous filaments or long fibres, e.g. stapling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
    • D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
    • D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
    • D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
    • D02J1/22—Stretching or tensioning, shrinking or relaxing, e.g. by use of overfeed and underfeed apparatus, or preventing stretch
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/402—Amides imides, sulfamic acids
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
    • D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
    • D10B2331/02—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

INHIBITORI HIV PROTEAZE KORISNI ZA TRETIRANJE AIDS-A, pronalaskom je dat postupak za dobijanje jedinjenja formule 1 gde: R je C1-C6 alik, cikloalkil, hetrocikl, nezasićeni heterocikl, aril, cikloalkil (C1-C4) alkil, heterocikl (C1-C4) alkil, nezasićeni heterocikl (C1-C4) alkil, aril (C1-C4) alkil, ili struktura formule -A- (CH2)q-R0, gde A je -O-, -NH-, ili -S-q je 0, 1, 2 ili 3; R0 je cikloalkil, aril, heterocikl ili nezasićeni heterocikl; X je gde: R1 je aril, cikloalkil, heterocikl ili nezasićeni heterocikl; R2 je vodonik, ili C1-C4; R3 je aminokiselinski bočni niz, -CH2CH3, -CH2CH2CH3, -CH2(CH2)2CH3, -C(CH3)3, cijano (C1-C4) alkil, nezasićeni heterocikl (C1-C4)alkil, aril (C1-C4) alkil ili struktura formule -(CH2)s- A0-(CH2)R-R4 ili -CH2-C(O)-NR2(CH2)R-R5, gde s je 1,2,3 ili 4; R je 0,1,2 ili 3; A0 je -O-, -NH- ili -S-; R4 je C1-C6 alkil, cikloalkil, aril, heterocikl, ili nezasićeni heterocikl; R5 je cikloalkil, aril, heterocikl ini nezasićeni heterocikl; j je 0,1,2,3 ili 4; k je 0 ili 1; i Y je -O-, -N(R2)- ili -S-; ili njegova farmaceutski prihvaljiva so. Dobijena jedinjenja imaju farmaceutsku aktivnost i naročito su pogodna za tretiranje obolelih od AIDS-a.
YU42893A 1992-06-19 1993-06-21 Inhibitori hiv proteaze korisni za tretiranje aids-a YU42893A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90144792A 1992-06-19 1992-06-19

Publications (1)

Publication Number Publication Date
YU42893A true YU42893A (sh) 1996-07-24

Family

ID=25414213

Family Applications (1)

Application Number Title Priority Date Filing Date
YU42893A YU42893A (sh) 1992-06-19 1993-06-21 Inhibitori hiv proteaze korisni za tretiranje aids-a

Country Status (21)

Country Link
US (1) US5578608A (sh)
EP (1) EP0575097B1 (sh)
JP (1) JP3195462B2 (sh)
KR (2) KR940000634A (sh)
CN (1) CN1082035A (sh)
AU (1) AU663958B2 (sh)
BR (1) BR9302389A (sh)
CA (1) CA2098165A1 (sh)
CO (1) CO4130200A1 (sh)
CZ (1) CZ113393A3 (sh)
DE (1) DE69329606T2 (sh)
ES (1) ES2152241T3 (sh)
FI (1) FI932847A (sh)
HU (1) HUT67571A (sh)
IL (1) IL105973A0 (sh)
MX (1) MX9303572A (sh)
NO (1) NO932130L (sh)
NZ (1) NZ247837A (sh)
PL (1) PL299369A1 (sh)
TW (1) TW218873B (sh)
YU (1) YU42893A (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
RU2126794C1 (ru) 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
NZ264143A (en) * 1993-08-09 1996-11-26 Lilly Co Eli Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production
EP0812839A1 (en) * 1994-12-08 1997-12-17 LG Chemical Limited Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof
KR0125117B1 (ko) * 1994-06-15 1997-12-05 성재갑 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법
US5696134A (en) * 1993-11-30 1997-12-09 Lg Chemical Limited Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
KR0159652B1 (ko) * 1995-10-26 1998-12-01 성재갑 항 에이즈 효과를 갖는 비가역적 인간 면역 결핍 바이러스 프로테아제 저해제 및 그의 제조방법
US5693847A (en) * 1995-04-19 1997-12-02 Vertex Pharmaceuticals Incorporated Heteroatom functionalized α-methyl ketones
US7431956B2 (en) 2003-06-20 2008-10-07 Sensient Imaging Technologies, Inc. Food grade colored fluids for printing on edible substrates
CN101005769B (zh) 2004-06-10 2011-03-16 森辛特成像科技公司 用于在食用基底上打印的食品级喷墨油墨
US9113647B2 (en) 2008-08-29 2015-08-25 Sensient Colors Llc Flavored and edible colored waxes and methods for precision deposition on edible substrates
WO2014075676A1 (en) * 2012-11-15 2014-05-22 V-Biotek Holding Aps Amines from trigonella foemum - graecum

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
JPS60193979A (ja) * 1984-03-15 1985-10-02 Mitsui Toatsu Chem Inc Ν−（ω−グリシドキシアルキル）置換アミド化合物及びその製造方法
US5155227A (en) * 1984-07-19 1992-10-13 University Of Florida Compounds for site-enhanced delivery of radionuclides
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
EP0538396A1 (en) * 1990-07-06 1993-04-28 Smithkline Beecham Corporation Inhibitors of retroviral proteases
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂

Also Published As

Publication number Publication date
DE69329606D1 (de) 2000-12-07
KR940005620A (ko) 1994-03-21
CA2098165A1 (en) 1993-12-20
BR9302389A (pt) 1994-01-11
NO932130L (no) 1993-12-20
AU4135493A (en) 1993-12-23
TW218873B (sh) 1994-01-11
FI932847A0 (fi) 1993-06-18
KR940000634A (ko) 1994-01-03
NZ247837A (en) 1995-04-27
JPH0656812A (ja) 1994-03-01
HU9301795D0 (en) 1993-09-28
EP0575097A1 (en) 1993-12-22
EP0575097B1 (en) 2000-11-02
AU663958B2 (en) 1995-10-26
FI932847A (fi) 1993-12-20
IL105973A0 (en) 1993-10-20
MX9303572A (es) 1994-01-31
ES2152241T3 (es) 2001-02-01
US5578608A (en) 1996-11-26
JP3195462B2 (ja) 2001-08-06
PL299369A1 (en) 1993-12-27
CO4130200A1 (es) 1995-02-13
CN1082035A (zh) 1994-02-16
DE69329606T2 (de) 2001-05-03
HUT67571A (en) 1995-04-28
NO932130D0 (no) 1993-06-10
CZ113393A3 (en) 1994-03-16

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