KR910011259A - 뉴모시스토시스 치료 또는 예방에 사용하기 위한 플루오로퀴놀론 유도체로 구성된 약제 - Google Patents
뉴모시스토시스 치료 또는 예방에 사용하기 위한 플루오로퀴놀론 유도체로 구성된 약제 Download PDFInfo
- Publication number
- KR910011259A KR910011259A KR1019900020271A KR900020271A KR910011259A KR 910011259 A KR910011259 A KR 910011259A KR 1019900020271 A KR1019900020271 A KR 1019900020271A KR 900020271 A KR900020271 A KR 900020271A KR 910011259 A KR910011259 A KR 910011259A
- Authority
- KR
- South Korea
- Prior art keywords
- prevention
- radical
- treatment
- atom
- pneumocystosis
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하기 일반식 (I)의 플루오로퀴놀론 또는 그들이 염으로 구성된, 뉴모시스토시스(pneumocystosis)의 예방 또는 치료에 사용하기 위한 약제:상기식에서, X는 질소원자 또는 기=CR6-를 나타내고, R1은 C1-C4를 함유한 알킬 라디칼, 플루오로에틸, 시클로프로필 또는 디플루오로페닐 라디칼이거나, R1및 R6이 그들을 연결하는 원자들과 함께, 메탈라디칼로 치환되고 임의로산소원자를 함유한 6-원으로 구성된 헤테로사이클을 형성하고, R2, R3및 R4는 동일하거나 서로 다르며 수소원자 또는 메틸라디칼을 나타내고, R6은 수소 또는 불소원자이거나 전기된 바와 같은 헤테로시 클릭고리의 일부를 형성하고 R5는 수소원자, 또는 만일 R6이 불소원자라면, 수소원자 또는 아미노라디칼이다.
- 제1항에 있어서, 페플록삭신 (R1=Et, R2=Me, R3, R4, R5=H,X=CH) 에녹삭신(R1=Et, R2, R3, R4, R5=H, X=N), 노르플록삭신(R1=Et, R2, R3, R4, R5=H, X=CH), 오플로삭신(R1, R2이 화학식의 고리의 부분을 이루고 R2=Me, R3, R4, R5,=H) 스파르플록삭신(R1=시클로프로필, R2=H,R3, R4=Me, R5=N, X=CF) 플레록삭신(R1=2-플루오로에틸, R2=Me, R3, R4, R5=H, X=CF), 로메플록삭신(R1=Et, R2=Me, R3, R4, R5=H, X=CF) 또는 테마플록삭식(R1=2,4-디플루오로페닐, R2, R3=H R4=Me, R5=H, X=CH)또는 전술된 화합 물중 임의의 하나의 염인 약제.
- 제2항에 있어서, 페플록삭신(R1=Et,R2=Me, R3, R4, R5=H, X=CH) 오플록삭식(R1, R2이 화학식의 고리의 부분을 이루고, R2=Me, R3, R4, R5=H) 또는 테마플록삭신(R1=2,4-디플루오로페닐, R2,R3=H,R4=Me,R5=H,X=CH) 또는 전술된 화합물중 임의의 하나의 염인 약제.
- 제1항 내지 제3항 중 어느 한 항에 있어서, 동물의 예방 또는 치료에 사용하기 위한 약제.
- 제1항에 청구된 바와같은 화합물 및 제약학적으로 허용가능한 회석제 또는 담체로 구성된 제약학적 조성물로 구성된, 뉴모시스토시스의 예방 또는 치료에 사용하기 위한 약제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8916324A FR2655545B1 (fr) | 1989-12-11 | 1989-12-11 | Nouvelle application therapeutique des derives des fluoroquinolones. |
FR8916324 | 1989-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910011259A true KR910011259A (ko) | 1991-08-07 |
Family
ID=9388344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900020271A KR910011259A (ko) | 1989-12-11 | 1990-12-10 | 뉴모시스토시스 치료 또는 예방에 사용하기 위한 플루오로퀴놀론 유도체로 구성된 약제 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5179096A (ko) |
EP (1) | EP0437128B1 (ko) |
JP (1) | JPH03251532A (ko) |
KR (1) | KR910011259A (ko) |
AT (1) | ATE101518T1 (ko) |
AU (1) | AU626743B2 (ko) |
CA (1) | CA2031886A1 (ko) |
DE (1) | DE69006707T2 (ko) |
DK (1) | DK0437128T3 (ko) |
ES (1) | ES2062464T3 (ko) |
FR (1) | FR2655545B1 (ko) |
HU (1) | HU207947B (ko) |
IE (1) | IE64720B1 (ko) |
IL (1) | IL96618A (ko) |
PT (1) | PT96164B (ko) |
ZA (1) | ZA909886B (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT67395A (en) * | 1993-07-13 | 1995-04-28 | Somfai | Method for the n-cyclopropylation of primary and secondary aromatic amines |
US5707551A (en) * | 1994-12-22 | 1998-01-13 | Rhone-Poulenc Inc. | Nonaqueous suspension concentrates of highly water-soluble solids |
US5906962A (en) * | 1994-12-22 | 1999-05-25 | Rhodia Inc. | Non-aqueous suspension concentrates of highly water-soluble solids |
US6024979A (en) * | 1995-06-06 | 2000-02-15 | Solvay Animal Health, Inc. | Oral veterinary composition containing a fluoroquinolone antibacterial agent possessing superior absorption properties and an extended duration of therapeutic antimicrobial blood levels, and a method of treating a microbial infection in a ruminant |
US5686095A (en) * | 1995-10-23 | 1997-11-11 | Price, Jr.; Francis W. | Method of treating canker sores |
EP0908181B8 (en) * | 1996-05-20 | 2009-04-15 | Otsuka Pharmaceutical Co., Ltd. | Remedy for rosacea |
JPH10143977A (ja) | 1996-09-10 | 1998-05-29 | Sony Corp | ディスク装置およびそれを用いたビデオカメラ装置 |
US6060474A (en) * | 1998-11-05 | 2000-05-09 | New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Method for preventing scar tissue formation |
US6346391B1 (en) | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
RU2373937C9 (ru) * | 2003-02-10 | 2010-07-27 | Байер Шеринг Фарма Акциенгезельшафт | Лечение бактериальных заболеваний органов дыхания путем местного применения фторхинолонов |
US9415111B2 (en) * | 2006-08-11 | 2016-08-16 | Rutgers, The State University Of New Jersey | Dual-sensitizer-containing luminescent compounds, conjugates, and uses thereof |
US9221759B2 (en) | 2010-01-13 | 2015-12-29 | Rutgers, The State University Of New Jersey | Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency |
Family Cites Families (27)
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GB1598915A (en) * | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
US4292317A (en) * | 1977-09-20 | 1981-09-29 | Laboratorie Roger Bellon | 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them |
JPS5845426B2 (ja) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | 置換キノリンカルボン酸誘導体 |
JPS5630964A (en) * | 1979-08-22 | 1981-03-28 | Kyorin Pharmaceut Co Ltd | Novel substituted quinolinecarboxylic acid and its preparation |
JPS5746986A (en) * | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
US4620007A (en) * | 1980-09-03 | 1986-10-28 | Bayer Aktiengesellschaft | 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid |
DE3142854A1 (de) | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4670444B1 (en) * | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
NZ208470A (en) * | 1983-07-18 | 1988-06-30 | Abbott Lab | 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such |
AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
US4774246A (en) * | 1984-01-26 | 1988-09-27 | Abbott Laboratories | Quinoline antibacterial compounds |
EP0154780B1 (en) * | 1984-01-26 | 1990-04-11 | Abbott Laboratories | Quinoline antibacterial compounds |
DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
NO166131C (no) * | 1985-06-20 | 1991-06-05 | Daiichi Seiyaku Co | Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser. |
DE3608745A1 (de) * | 1985-07-24 | 1987-01-29 | Bayer Ag | Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin |
DE3537761A1 (de) * | 1985-10-24 | 1987-04-30 | Bayer Ag | Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure |
AU594983B2 (en) | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
DE3601566A1 (de) * | 1986-01-21 | 1987-07-23 | Bayer Ag | Pharmazeutische zubereitungen von ciprofloxacin |
DE3632222A1 (de) * | 1986-09-23 | 1988-04-07 | Bayer Ag | Topisch anwendbare zubereitungen von gyrase-inhibitoren |
DE3637649A1 (de) * | 1986-10-13 | 1988-04-14 | Uwe Dr Spohr | Verwendung von 4-chinolon-derivaten zur bekaempfung von protozoen und helminthen |
DE3704907A1 (de) * | 1987-02-17 | 1988-08-25 | Bayer Ag | Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden |
IT1231425B (it) * | 1987-10-05 | 1991-12-04 | Prodotti Antibiotici Spa | Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico |
DE3902079A1 (de) * | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
US4978661A (en) * | 1988-09-29 | 1990-12-18 | Innocenzo Caruso | Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis |
-
1989
- 1989-12-11 FR FR8916324A patent/FR2655545B1/fr not_active Expired - Fee Related
-
1990
- 1990-12-07 AU AU67862/90A patent/AU626743B2/en not_active Ceased
- 1990-12-10 AT AT90403501T patent/ATE101518T1/de not_active IP Right Cessation
- 1990-12-10 IE IE444990A patent/IE64720B1/en not_active IP Right Cessation
- 1990-12-10 HU HU908146A patent/HU207947B/hu not_active IP Right Cessation
- 1990-12-10 EP EP90403501A patent/EP0437128B1/fr not_active Expired - Lifetime
- 1990-12-10 CA CA002031886A patent/CA2031886A1/fr not_active Abandoned
- 1990-12-10 KR KR1019900020271A patent/KR910011259A/ko not_active Application Discontinuation
- 1990-12-10 DE DE69006707T patent/DE69006707T2/de not_active Expired - Fee Related
- 1990-12-10 DK DK90403501.1T patent/DK0437128T3/da active
- 1990-12-10 IL IL9661890A patent/IL96618A/en not_active IP Right Cessation
- 1990-12-10 ES ES90403501T patent/ES2062464T3/es not_active Expired - Lifetime
- 1990-12-10 ZA ZA909886A patent/ZA909886B/xx unknown
- 1990-12-11 PT PT96164A patent/PT96164B/pt not_active IP Right Cessation
- 1990-12-11 US US07/625,408 patent/US5179096A/en not_active Expired - Fee Related
- 1990-12-11 JP JP2409712A patent/JPH03251532A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH03251532A (ja) | 1991-11-11 |
AU626743B2 (en) | 1992-08-06 |
IL96618A0 (en) | 1991-09-16 |
FR2655545A1 (fr) | 1991-06-14 |
DE69006707T2 (de) | 1994-06-09 |
US5179096A (en) | 1993-01-12 |
HU207947B (en) | 1993-07-28 |
PT96164A (pt) | 1991-09-30 |
DE69006707D1 (de) | 1994-03-24 |
EP0437128A2 (fr) | 1991-07-17 |
ATE101518T1 (de) | 1994-03-15 |
ZA909886B (en) | 1991-09-25 |
ES2062464T3 (es) | 1994-12-16 |
IL96618A (en) | 1995-05-26 |
EP0437128B1 (fr) | 1994-02-16 |
DK0437128T3 (da) | 1994-03-14 |
HUT55991A (en) | 1991-07-29 |
FR2655545B1 (fr) | 1994-06-10 |
EP0437128A3 (en) | 1992-09-30 |
HU908146D0 (en) | 1991-06-28 |
AU6786290A (en) | 1991-06-13 |
CA2031886A1 (fr) | 1991-06-12 |
IE64720B1 (en) | 1995-08-23 |
PT96164B (pt) | 1998-04-30 |
IE904449A1 (en) | 1991-06-19 |
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