DE69309310T2 - Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine - Google Patents
Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidineInfo
- Publication number
- DE69309310T2 DE69309310T2 DE69309310T DE69309310T DE69309310T2 DE 69309310 T2 DE69309310 T2 DE 69309310T2 DE 69309310 T DE69309310 T DE 69309310T DE 69309310 T DE69309310 T DE 69309310T DE 69309310 T2 DE69309310 T2 DE 69309310T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- compound according
- tumors
- hydrogen atoms
- represent hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 25
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- 150000001875 compounds Chemical class 0.000 claims abstract description 44
- 239000003814 drug Substances 0.000 claims abstract description 8
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- -1 3,4-methylenedioxyphenyl group Chemical group 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 3
- 125000001041 indolyl group Chemical group 0.000 claims description 3
- 125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US656993A | 1993-01-21 | 1993-01-21 | |
| PCT/US1993/012300 WO1994017040A1 (en) | 1993-01-21 | 1993-12-17 | Diarylalkyl piperidines useful as multi-drug resistant tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69309310D1 DE69309310D1 (de) | 1997-04-30 |
| DE69309310T2 true DE69309310T2 (de) | 1997-11-06 |
Family
ID=21721516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69309310T Expired - Fee Related DE69309310T2 (de) | 1993-01-21 | 1993-12-17 | Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5648365A (enExample) |
| EP (1) | EP0680470B1 (enExample) |
| JP (1) | JP3398748B2 (enExample) |
| KR (1) | KR100377280B1 (enExample) |
| AT (1) | ATE150748T1 (enExample) |
| AU (1) | AU679723B2 (enExample) |
| CA (1) | CA2152794C (enExample) |
| DE (1) | DE69309310T2 (enExample) |
| DK (1) | DK0680470T3 (enExample) |
| ES (1) | ES2102830T3 (enExample) |
| FI (1) | FI112474B (enExample) |
| GR (1) | GR3023188T3 (enExample) |
| HU (1) | HUT72078A (enExample) |
| IL (1) | IL108369A (enExample) |
| MX (1) | MX9400563A (enExample) |
| NO (1) | NO305166B1 (enExample) |
| NZ (1) | NZ261414A (enExample) |
| TW (1) | TW243445B (enExample) |
| WO (1) | WO1994017040A1 (enExample) |
| ZA (1) | ZA94317B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2129144C (en) * | 1992-02-06 | 1999-07-13 | Jules Freedman | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
| AU6366000A (en) * | 1999-07-23 | 2001-02-13 | Colorado State University Research Foundation | Multidrug resistance pump inhibitors and uses thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| CA2465886A1 (en) * | 2001-11-07 | 2003-05-15 | Kathleen S. Crowley | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| KR100656490B1 (ko) | 2001-11-26 | 2006-12-12 | 삼성에스디아이 주식회사 | 풀칼라 유기전계 발광표시소자 및 그의 제조방법 |
| US8153184B2 (en) * | 2001-11-26 | 2012-04-10 | Samsung Mobile Display Co., Ltd. | Organic EL display device and method of manufacturing the same |
| ES2831028T3 (es) | 2013-02-08 | 2021-06-07 | Gen Mills Inc | Productos alimenticios reducidos en sodio |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4035372A (en) * | 1976-08-13 | 1977-07-12 | G. D. Searle & Co. | 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines |
| EP0228893A3 (en) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| KR920702620A (ko) * | 1989-06-19 | 1992-10-06 | 엠. 피. 잭슨 | 암치료에 유용하며 항히스타민성 특성을 갖는 약물 |
| GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
| EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| DE69128820T2 (de) * | 1990-08-14 | 1998-06-10 | Hoechst Marion Roussel Inc | Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon |
| CA2129144C (en) * | 1992-02-06 | 1999-07-13 | Jules Freedman | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
-
1993
- 1993-12-17 DK DK94906446.3T patent/DK0680470T3/da active
- 1993-12-17 JP JP51701194A patent/JP3398748B2/ja not_active Expired - Fee Related
- 1993-12-17 CA CA002152794A patent/CA2152794C/en not_active Expired - Fee Related
- 1993-12-17 WO PCT/US1993/012300 patent/WO1994017040A1/en not_active Ceased
- 1993-12-17 DE DE69309310T patent/DE69309310T2/de not_active Expired - Fee Related
- 1993-12-17 AU AU60148/94A patent/AU679723B2/en not_active Ceased
- 1993-12-17 AT AT94906446T patent/ATE150748T1/de not_active IP Right Cessation
- 1993-12-17 EP EP94906446A patent/EP0680470B1/en not_active Expired - Lifetime
- 1993-12-17 KR KR1019950702950A patent/KR100377280B1/ko not_active Expired - Fee Related
- 1993-12-17 NZ NZ261414A patent/NZ261414A/en unknown
- 1993-12-17 HU HU9502195A patent/HUT72078A/hu unknown
- 1993-12-17 ES ES94906446T patent/ES2102830T3/es not_active Expired - Lifetime
- 1993-12-17 US US08/481,538 patent/US5648365A/en not_active Expired - Fee Related
-
1994
- 1994-01-17 ZA ZA94317A patent/ZA94317B/xx unknown
- 1994-01-18 TW TW083100396A patent/TW243445B/zh active
- 1994-01-19 IL IL10836994A patent/IL108369A/en not_active IP Right Cessation
- 1994-01-20 MX MX9400563A patent/MX9400563A/es not_active IP Right Cessation
-
1995
- 1995-07-20 NO NO952885A patent/NO305166B1/no not_active IP Right Cessation
- 1995-07-20 FI FI953506A patent/FI112474B/fi active
-
1997
- 1997-04-21 GR GR970400848T patent/GR3023188T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ261414A (en) | 1997-06-24 |
| JPH08505870A (ja) | 1996-06-25 |
| TW243445B (enExample) | 1995-03-21 |
| NO952885L (no) | 1995-09-20 |
| AU679723B2 (en) | 1997-07-10 |
| HU9502195D0 (en) | 1995-09-28 |
| DK0680470T3 (enExample) | 1997-04-28 |
| DE69309310D1 (de) | 1997-04-30 |
| EP0680470B1 (en) | 1997-03-26 |
| ZA94317B (en) | 1994-08-18 |
| ES2102830T3 (es) | 1997-08-01 |
| JP3398748B2 (ja) | 2003-04-21 |
| NO305166B1 (no) | 1999-04-12 |
| AU6014894A (en) | 1994-08-15 |
| KR960700230A (ko) | 1996-01-19 |
| FI953506A0 (fi) | 1995-07-20 |
| GR3023188T3 (en) | 1997-07-30 |
| FI953506L (fi) | 1995-07-20 |
| HUT72078A (en) | 1996-03-28 |
| IL108369A (en) | 1999-08-17 |
| NO952885D0 (no) | 1995-07-20 |
| US5648365A (en) | 1997-07-15 |
| MX9400563A (es) | 1994-07-29 |
| EP0680470A1 (en) | 1995-11-08 |
| WO1994017040A1 (en) | 1994-08-04 |
| ATE150748T1 (de) | 1997-04-15 |
| KR100377280B1 (ko) | 2003-07-18 |
| FI112474B (fi) | 2003-12-15 |
| CA2152794A1 (en) | 1994-08-04 |
| CA2152794C (en) | 1999-04-06 |
| IL108369A0 (en) | 1994-04-12 |
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Legal Events
| Date | Code | Title | Description |
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| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |