DE69309310D1 - Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine - Google Patents

Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine

Info

Publication number
DE69309310D1
DE69309310D1 DE69309310T DE69309310T DE69309310D1 DE 69309310 D1 DE69309310 D1 DE 69309310D1 DE 69309310 T DE69309310 T DE 69309310T DE 69309310 T DE69309310 T DE 69309310T DE 69309310 D1 DE69309310 D1 DE 69309310D1
Authority
DE
Germany
Prior art keywords
pct
diarylalkyl
piperidine
against multiple
resistant tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69309310T
Other languages
English (en)
Other versions
DE69309310T2 (de
Inventor
Sai Sunkara
Jules Freedman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69309310D1 publication Critical patent/DE69309310D1/de
Application granted granted Critical
Publication of DE69309310T2 publication Critical patent/DE69309310T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69309310T 1993-01-21 1993-12-17 Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine Expired - Fee Related DE69309310T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US656993A 1993-01-21 1993-01-21
PCT/US1993/012300 WO1994017040A1 (en) 1993-01-21 1993-12-17 Diarylalkyl piperidines useful as multi-drug resistant tumor agents

Publications (2)

Publication Number Publication Date
DE69309310D1 true DE69309310D1 (de) 1997-04-30
DE69309310T2 DE69309310T2 (de) 1997-11-06

Family

ID=21721516

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309310T Expired - Fee Related DE69309310T2 (de) 1993-01-21 1993-12-17 Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine

Country Status (20)

Country Link
US (1) US5648365A (de)
EP (1) EP0680470B1 (de)
JP (1) JP3398748B2 (de)
KR (1) KR100377280B1 (de)
AT (1) ATE150748T1 (de)
AU (1) AU679723B2 (de)
CA (1) CA2152794C (de)
DE (1) DE69309310T2 (de)
DK (1) DK0680470T3 (de)
ES (1) ES2102830T3 (de)
FI (1) FI112474B (de)
GR (1) GR3023188T3 (de)
HU (1) HUT72078A (de)
IL (1) IL108369A (de)
MX (1) MX9400563A (de)
NO (1) NO305166B1 (de)
NZ (1) NZ261414A (de)
TW (1) TW243445B (de)
WO (1) WO1994017040A1 (de)
ZA (1) ZA94317B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662602B2 (en) * 1992-02-06 1995-09-07 Merrell Dow Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives
AU6366000A (en) * 1999-07-23 2001-02-13 Colorado State University Research Foundation Multidrug resistance pump inhibitors and uses thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US20030109448A1 (en) * 2001-11-07 2003-06-12 Crowley Kathleen S. Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
KR100656490B1 (ko) 2001-11-26 2006-12-12 삼성에스디아이 주식회사 풀칼라 유기전계 발광표시소자 및 그의 제조방법
US8153184B2 (en) * 2001-11-26 2012-04-10 Samsung Mobile Display Co., Ltd. Organic EL display device and method of manufacturing the same
PT3732994T (pt) 2013-02-08 2022-12-02 Gen Mills Inc Produtos alimentares com reduzido teor de sódio
CN110372571B (zh) * 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049377B (de) * 1952-04-03 1959-01-29 Abbott Laboratories, North Chicago, 111. (V. St. A.) Verfahren zur Herstellung von substituierten Vinylpiperidinen
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US4035372A (en) * 1976-08-13 1977-07-12 G. D. Searle & Co. 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
EP0228893A3 (de) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Durch Aryloxyalkyl-Gruppen N-substituierte Arylalkyl heterozyklische Amine in Allergieheilverfahren
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
US4990511A (en) * 1988-08-03 1991-02-05 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
DE69003200T2 (de) * 1989-06-19 1994-01-20 Wellcome Found Arylsubstituierte Aminderivate verwendbar in der Krebstherapie.
GB9000305D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Anticholinergic agents
EP0467435A3 (en) * 1990-07-19 1992-04-01 Akzo N.V. Benzhydryl derivatives having calmodulin inhibitor properties
ES2112268T3 (es) * 1990-08-14 1998-04-01 Hoechst Marion Roussel Inc Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
AU662602B2 (en) * 1992-02-06 1995-09-07 Merrell Dow Pharmaceuticals Inc. Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives

Also Published As

Publication number Publication date
AU6014894A (en) 1994-08-15
CA2152794A1 (en) 1994-08-04
HU9502195D0 (en) 1995-09-28
JP3398748B2 (ja) 2003-04-21
IL108369A0 (en) 1994-04-12
US5648365A (en) 1997-07-15
GR3023188T3 (en) 1997-07-30
NO305166B1 (no) 1999-04-12
NO952885L (no) 1995-09-20
ZA94317B (en) 1994-08-18
EP0680470B1 (de) 1997-03-26
FI953506A0 (fi) 1995-07-20
NZ261414A (en) 1997-06-24
FI112474B (fi) 2003-12-15
IL108369A (en) 1999-08-17
HUT72078A (en) 1996-03-28
KR100377280B1 (ko) 2003-07-18
FI953506A (fi) 1995-07-20
DK0680470T3 (de) 1997-04-28
ATE150748T1 (de) 1997-04-15
DE69309310T2 (de) 1997-11-06
MX9400563A (es) 1994-07-29
AU679723B2 (en) 1997-07-10
CA2152794C (en) 1999-04-06
KR960700230A (ko) 1996-01-19
TW243445B (de) 1995-03-21
EP0680470A1 (de) 1995-11-08
JPH08505870A (ja) 1996-06-25
NO952885D0 (no) 1995-07-20
ES2102830T3 (es) 1997-08-01
WO1994017040A1 (en) 1994-08-04

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee