ES2102830T3 - Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. - Google Patents
Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco.Info
- Publication number
- ES2102830T3 ES2102830T3 ES94906446T ES94906446T ES2102830T3 ES 2102830 T3 ES2102830 T3 ES 2102830T3 ES 94906446 T ES94906446 T ES 94906446T ES 94906446 T ES94906446 T ES 94906446T ES 2102830 T3 ES2102830 T3 ES 2102830T3
- Authority
- ES
- Spain
- Prior art keywords
- tumors
- agents
- drug resistance
- alkyl piperidines
- diaryl alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PIPERIDINAS DIARIALQUILO DE LA FORMULA (1) SE OPONEN A LA RESISTENCIA A LA DROGA EN TUMORES RESISTENTES A MULTIDROGAS. ESTOS COMPUESTOS APARENTEMENTE FUNCIONAN MEDIANTE LA INHIBICION DE UNA BOMBA DE UNA P-GLICOPROTEINA QUE SE ACTIVA EN EL ULTIMO ESTADO DE DESARROLLO DEL TUMOR Y QUE ESTA INHERENTEMENTE PRESENTE EN TUMORES DE CIERTOS ORIGENES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US656993A | 1993-01-21 | 1993-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102830T3 true ES2102830T3 (es) | 1997-08-01 |
Family
ID=21721516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94906446T Expired - Lifetime ES2102830T3 (es) | 1993-01-21 | 1993-12-17 | Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5648365A (es) |
EP (1) | EP0680470B1 (es) |
JP (1) | JP3398748B2 (es) |
KR (1) | KR100377280B1 (es) |
AT (1) | ATE150748T1 (es) |
AU (1) | AU679723B2 (es) |
CA (1) | CA2152794C (es) |
DE (1) | DE69309310T2 (es) |
DK (1) | DK0680470T3 (es) |
ES (1) | ES2102830T3 (es) |
FI (1) | FI112474B (es) |
GR (1) | GR3023188T3 (es) |
HU (1) | HUT72078A (es) |
IL (1) | IL108369A (es) |
MX (1) | MX9400563A (es) |
NO (1) | NO305166B1 (es) |
NZ (1) | NZ261414A (es) |
TW (1) | TW243445B (es) |
WO (1) | WO1994017040A1 (es) |
ZA (1) | ZA94317B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ249040A (en) * | 1992-02-06 | 1997-06-24 | Merrell Dow Pharma | Triphenyl azacycloalkane derivatives; treatment of drug resistance |
WO2001007034A1 (en) * | 1999-07-23 | 2001-02-01 | Colorado State University Research Foundation | Multidrug resistance pump inhibitors and uses thereof |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
KR100656490B1 (ko) | 2001-11-26 | 2006-12-12 | 삼성에스디아이 주식회사 | 풀칼라 유기전계 발광표시소자 및 그의 제조방법 |
US8153184B2 (en) * | 2001-11-26 | 2012-04-10 | Samsung Mobile Display Co., Ltd. | Organic EL display device and method of manufacturing the same |
WO2014124222A1 (en) | 2013-02-08 | 2014-08-14 | General Mills, Inc. | Reduced sodium food products |
CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
US4035372A (en) * | 1976-08-13 | 1977-07-12 | G. D. Searle & Co. | 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines |
EP0235463A3 (en) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
NZ234110A (en) * | 1989-06-19 | 1993-01-27 | Wellcome Found | Dibenzoazepine, -oxepine and -cycloheptane substituted alkylidene amines; pharmaceutical compositions containing such compounds or various other aryl substituted amines |
GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
DE69128820T2 (de) * | 1990-08-14 | 1998-06-10 | Hoechst Marion Roussel Inc | Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon |
NZ249040A (en) * | 1992-02-06 | 1997-06-24 | Merrell Dow Pharma | Triphenyl azacycloalkane derivatives; treatment of drug resistance |
-
1993
- 1993-12-17 DK DK94906446.3T patent/DK0680470T3/da active
- 1993-12-17 KR KR1019950702950A patent/KR100377280B1/ko not_active IP Right Cessation
- 1993-12-17 CA CA002152794A patent/CA2152794C/en not_active Expired - Fee Related
- 1993-12-17 ES ES94906446T patent/ES2102830T3/es not_active Expired - Lifetime
- 1993-12-17 JP JP51701194A patent/JP3398748B2/ja not_active Expired - Fee Related
- 1993-12-17 EP EP94906446A patent/EP0680470B1/en not_active Expired - Lifetime
- 1993-12-17 DE DE69309310T patent/DE69309310T2/de not_active Expired - Fee Related
- 1993-12-17 AT AT94906446T patent/ATE150748T1/de not_active IP Right Cessation
- 1993-12-17 NZ NZ261414A patent/NZ261414A/en unknown
- 1993-12-17 AU AU60148/94A patent/AU679723B2/en not_active Ceased
- 1993-12-17 HU HU9502195A patent/HUT72078A/hu unknown
- 1993-12-17 WO PCT/US1993/012300 patent/WO1994017040A1/en active IP Right Grant
- 1993-12-17 US US08/481,538 patent/US5648365A/en not_active Expired - Fee Related
-
1994
- 1994-01-17 ZA ZA94317A patent/ZA94317B/xx unknown
- 1994-01-18 TW TW083100396A patent/TW243445B/zh active
- 1994-01-19 IL IL10836994A patent/IL108369A/en not_active IP Right Cessation
- 1994-01-20 MX MX9400563A patent/MX9400563A/es not_active IP Right Cessation
-
1995
- 1995-07-20 NO NO952885A patent/NO305166B1/no not_active IP Right Cessation
- 1995-07-20 FI FI953506A patent/FI112474B/fi active
-
1997
- 1997-04-21 GR GR970400848T patent/GR3023188T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5648365A (en) | 1997-07-15 |
NO952885L (no) | 1995-09-20 |
AU6014894A (en) | 1994-08-15 |
NO952885D0 (no) | 1995-07-20 |
IL108369A0 (en) | 1994-04-12 |
IL108369A (en) | 1999-08-17 |
AU679723B2 (en) | 1997-07-10 |
EP0680470A1 (en) | 1995-11-08 |
DE69309310T2 (de) | 1997-11-06 |
FI112474B (fi) | 2003-12-15 |
ATE150748T1 (de) | 1997-04-15 |
FI953506A (fi) | 1995-07-20 |
MX9400563A (es) | 1994-07-29 |
JPH08505870A (ja) | 1996-06-25 |
HU9502195D0 (en) | 1995-09-28 |
NZ261414A (en) | 1997-06-24 |
EP0680470B1 (en) | 1997-03-26 |
CA2152794A1 (en) | 1994-08-04 |
DK0680470T3 (es) | 1997-04-28 |
JP3398748B2 (ja) | 2003-04-21 |
WO1994017040A1 (en) | 1994-08-04 |
CA2152794C (en) | 1999-04-06 |
DE69309310D1 (de) | 1997-04-30 |
KR100377280B1 (ko) | 2003-07-18 |
GR3023188T3 (en) | 1997-07-30 |
HUT72078A (en) | 1996-03-28 |
NO305166B1 (no) | 1999-04-12 |
KR960700230A (ko) | 1996-01-19 |
FI953506A0 (fi) | 1995-07-20 |
TW243445B (es) | 1995-03-21 |
ZA94317B (en) | 1994-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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