FI112474B - Menetelmä kasvainlääkkeinä käyttökelpoisten diaryylialkyylipiperidiiniyhdisteiden valmistamiseksi - Google Patents
Menetelmä kasvainlääkkeinä käyttökelpoisten diaryylialkyylipiperidiiniyhdisteiden valmistamiseksi Download PDFInfo
- Publication number
- FI112474B FI112474B FI953506A FI953506A FI112474B FI 112474 B FI112474 B FI 112474B FI 953506 A FI953506 A FI 953506A FI 953506 A FI953506 A FI 953506A FI 112474 B FI112474 B FI 112474B
- Authority
- FI
- Finland
- Prior art keywords
- tumors
- formula
- preparation
- pct
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US656993A | 1993-01-21 | 1993-01-21 | |
| PCT/US1993/012300 WO1994017040A1 (en) | 1993-01-21 | 1993-12-17 | Diarylalkyl piperidines useful as multi-drug resistant tumor agents |
| US9312300 | 1993-12-17 | ||
| US656993 | 1996-05-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI953506A FI953506A (fi) | 1995-07-20 |
| FI953506A0 FI953506A0 (fi) | 1995-07-20 |
| FI112474B true FI112474B (fi) | 2003-12-15 |
Family
ID=21721516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI953506A FI112474B (fi) | 1993-01-21 | 1995-07-20 | Menetelmä kasvainlääkkeinä käyttökelpoisten diaryylialkyylipiperidiiniyhdisteiden valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5648365A (de) |
| EP (1) | EP0680470B1 (de) |
| JP (1) | JP3398748B2 (de) |
| KR (1) | KR100377280B1 (de) |
| AT (1) | ATE150748T1 (de) |
| AU (1) | AU679723B2 (de) |
| CA (1) | CA2152794C (de) |
| DE (1) | DE69309310T2 (de) |
| DK (1) | DK0680470T3 (de) |
| ES (1) | ES2102830T3 (de) |
| FI (1) | FI112474B (de) |
| GR (1) | GR3023188T3 (de) |
| HU (1) | HUT72078A (de) |
| IL (1) | IL108369A (de) |
| MX (1) | MX9400563A (de) |
| NO (1) | NO305166B1 (de) |
| NZ (1) | NZ261414A (de) |
| TW (1) | TW243445B (de) |
| WO (1) | WO1994017040A1 (de) |
| ZA (1) | ZA94317B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2135463T3 (es) * | 1992-02-06 | 1999-11-01 | Merrell Pharma Inc | Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina. |
| AU6366000A (en) * | 1999-07-23 | 2001-02-13 | Colorado State University Research Foundation | Multidrug resistance pump inhibitors and uses thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US20030109448A1 (en) * | 2001-11-07 | 2003-06-12 | Crowley Kathleen S. | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| KR100656490B1 (ko) | 2001-11-26 | 2006-12-12 | 삼성에스디아이 주식회사 | 풀칼라 유기전계 발광표시소자 및 그의 제조방법 |
| US8153184B2 (en) * | 2001-11-26 | 2012-04-10 | Samsung Mobile Display Co., Ltd. | Organic EL display device and method of manufacturing the same |
| DK3466930T3 (da) | 2013-02-08 | 2022-09-05 | Gen Mills Inc | Fødevareprodukt med reduceret natriumindhold |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4035372A (en) * | 1976-08-13 | 1977-07-12 | G. D. Searle & Co. | 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines |
| EP0235463A3 (de) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituierte Arylalkyl- und Arylalkylen-Piperidine und Anwendung als kardiovaskulär antihistaminische und antisekretorische Mittel |
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| NZ234110A (en) * | 1989-06-19 | 1993-01-27 | Wellcome Found | Dibenzoazepine, -oxepine and -cycloheptane substituted alkylidene amines; pharmaceutical compositions containing such compounds or various other aryl substituted amines |
| GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
| EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| DE69128820T2 (de) * | 1990-08-14 | 1998-06-10 | Hoechst Marion Roussel Inc | Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon |
| ES2135463T3 (es) * | 1992-02-06 | 1999-11-01 | Merrell Pharma Inc | Inversion de la resistencia multi-medicamento por medio de derivados de trifenil-piperidina. |
-
1993
- 1993-12-17 KR KR1019950702950A patent/KR100377280B1/ko not_active IP Right Cessation
- 1993-12-17 CA CA002152794A patent/CA2152794C/en not_active Expired - Fee Related
- 1993-12-17 HU HU9502195A patent/HUT72078A/hu unknown
- 1993-12-17 DK DK94906446.3T patent/DK0680470T3/da active
- 1993-12-17 WO PCT/US1993/012300 patent/WO1994017040A1/en active IP Right Grant
- 1993-12-17 AT AT94906446T patent/ATE150748T1/de not_active IP Right Cessation
- 1993-12-17 ES ES94906446T patent/ES2102830T3/es not_active Expired - Lifetime
- 1993-12-17 JP JP51701194A patent/JP3398748B2/ja not_active Expired - Fee Related
- 1993-12-17 US US08/481,538 patent/US5648365A/en not_active Expired - Fee Related
- 1993-12-17 DE DE69309310T patent/DE69309310T2/de not_active Expired - Fee Related
- 1993-12-17 EP EP94906446A patent/EP0680470B1/de not_active Expired - Lifetime
- 1993-12-17 AU AU60148/94A patent/AU679723B2/en not_active Ceased
- 1993-12-17 NZ NZ261414A patent/NZ261414A/en unknown
-
1994
- 1994-01-17 ZA ZA94317A patent/ZA94317B/xx unknown
- 1994-01-18 TW TW083100396A patent/TW243445B/zh active
- 1994-01-19 IL IL10836994A patent/IL108369A/en not_active IP Right Cessation
- 1994-01-20 MX MX9400563A patent/MX9400563A/es not_active IP Right Cessation
-
1995
- 1995-07-20 NO NO952885A patent/NO305166B1/no not_active IP Right Cessation
- 1995-07-20 FI FI953506A patent/FI112474B/fi active
-
1997
- 1997-04-21 GR GR970400848T patent/GR3023188T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0680470B1 (de) | 1997-03-26 |
| NZ261414A (en) | 1997-06-24 |
| CA2152794A1 (en) | 1994-08-04 |
| ES2102830T3 (es) | 1997-08-01 |
| KR960700230A (ko) | 1996-01-19 |
| CA2152794C (en) | 1999-04-06 |
| WO1994017040A1 (en) | 1994-08-04 |
| IL108369A (en) | 1999-08-17 |
| GR3023188T3 (en) | 1997-07-30 |
| TW243445B (de) | 1995-03-21 |
| IL108369A0 (en) | 1994-04-12 |
| JPH08505870A (ja) | 1996-06-25 |
| AU6014894A (en) | 1994-08-15 |
| NO952885D0 (no) | 1995-07-20 |
| US5648365A (en) | 1997-07-15 |
| MX9400563A (es) | 1994-07-29 |
| DK0680470T3 (de) | 1997-04-28 |
| ATE150748T1 (de) | 1997-04-15 |
| FI953506A (fi) | 1995-07-20 |
| DE69309310T2 (de) | 1997-11-06 |
| ZA94317B (en) | 1994-08-18 |
| EP0680470A1 (de) | 1995-11-08 |
| NO305166B1 (no) | 1999-04-12 |
| AU679723B2 (en) | 1997-07-10 |
| FI953506A0 (fi) | 1995-07-20 |
| HUT72078A (en) | 1996-03-28 |
| KR100377280B1 (ko) | 2003-07-18 |
| DE69309310D1 (de) | 1997-04-30 |
| HU9502195D0 (en) | 1995-09-28 |
| NO952885L (no) | 1995-09-20 |
| JP3398748B2 (ja) | 2003-04-21 |
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