DE69215722D1 - Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen - Google Patents

Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen

Info

Publication number
DE69215722D1
DE69215722D1 DE69215722T DE69215722T DE69215722D1 DE 69215722 D1 DE69215722 D1 DE 69215722D1 DE 69215722 T DE69215722 T DE 69215722T DE 69215722 T DE69215722 T DE 69215722T DE 69215722 D1 DE69215722 D1 DE 69215722D1
Authority
DE
Germany
Prior art keywords
amplifiers
diseases
pharmaceutical compositions
compositions containing
liquid pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69215722T
Other languages
English (en)
Other versions
DE69215722T2 (de
DE69215722T3 (de
Inventor
Katsuro Tachibana
Shunro Tachibana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13099707&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69215722(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of DE69215722D1 publication Critical patent/DE69215722D1/de
Publication of DE69215722T2 publication Critical patent/DE69215722T2/de
Application granted granted Critical
Publication of DE69215722T3 publication Critical patent/DE69215722T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69215722T 1991-03-22 1992-03-19 Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen Expired - Fee Related DE69215722T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5897091 1991-03-22

Publications (3)

Publication Number Publication Date
DE69215722D1 true DE69215722D1 (de) 1997-01-23
DE69215722T2 DE69215722T2 (de) 1997-05-07
DE69215722T3 DE69215722T3 (de) 2001-03-08

Family

ID=13099707

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69215722T Expired - Fee Related DE69215722T3 (de) 1991-03-22 1992-03-19 Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen

Country Status (5)

Country Link
US (5) US5315998A (de)
EP (2) EP0732106A3 (de)
AT (1) ATE146073T1 (de)
CA (1) CA2063529A1 (de)
DE (1) DE69215722T3 (de)

Families Citing this family (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
ATE146073T1 (de) * 1991-03-22 1996-12-15 Katsuro Tachibana Verstärker zur ultraschalltherapie von erkrankungen sowie diesen enthaltende flüssige arzneimittelzusammensetzungen
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5713848A (en) * 1993-05-19 1998-02-03 Dubrul; Will R. Vibrating catheter
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
EP1550464A1 (de) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilisierte Mikrogasbläschen-Zusammensetzung für Echographie
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
CA2171303C (en) * 1993-09-09 2006-06-06 Werner Weitschies Active principles and gas containing microparticles
DE4330958A1 (de) * 1993-09-09 1995-03-16 Schering Ag Neue wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
WO1996022111A1 (en) * 1995-01-19 1996-07-25 Sound Science Limited Partnership Local delivery and monitoring of drugs
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5728062A (en) * 1995-11-30 1998-03-17 Pharmasonics, Inc. Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US5725494A (en) * 1995-11-30 1998-03-10 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced intraluminal therapy
US5735811A (en) * 1995-11-30 1998-04-07 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced fluid delivery
ES2247621T3 (es) * 1996-02-15 2006-03-01 Biosense Webster, Inc. Sonda de excavacion.
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
ATE248511T1 (de) * 1996-03-12 2003-09-15 Univ Nebraska Zusammensetzung zur zielortspezifischen verabreichung eines medikamentes und verfahren zur anwendung
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
JP2002515786A (ja) 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． 経皮輸送の超音波増強
BE1010407A4 (fr) 1996-07-04 1998-07-07 Undatim Ultrasonics Procede et installation de traitement des eaux.
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846218A (en) 1996-09-05 1998-12-08 Pharmasonics, Inc. Balloon catheters having ultrasonically driven interface surfaces and methods for their use
US6464660B2 (en) 1996-09-05 2002-10-15 Pharmasonics, Inc. Balloon catheters having ultrasonically driven interface surfaces and methods for their use
JP4139440B2 (ja) 1996-09-11 2008-08-27 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 造影剤及び血管拡張薬を用いる画像診断のための改良された方法
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6024717A (en) * 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
US6221038B1 (en) 1996-11-27 2001-04-24 Pharmasonics, Inc. Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6228046B1 (en) 1997-06-02 2001-05-08 Pharmasonics, Inc. Catheters comprising a plurality of oscillators and methods for their use
US5931805A (en) * 1997-06-02 1999-08-03 Pharmasonics, Inc. Catheters comprising bending transducers and methods for their use
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
EP1043949A2 (de) * 1997-12-31 2000-10-18 Pharmasonics, Inc. Verfahren und systeme zum verhindern von vaskulärer hyperplasia
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US7273458B2 (en) 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JPH11244283A (ja) * 1998-03-05 1999-09-14 Ge Yokogawa Medical Systems Ltd 超音波撮像方法および装置
US6135976A (en) * 1998-09-25 2000-10-24 Ekos Corporation Method, device and kit for performing gene therapy
US20040171980A1 (en) * 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6361554B1 (en) 1999-06-30 2002-03-26 Pharmasonics, Inc. Methods and apparatus for the subcutaneous delivery of acoustic vibrations
US6387116B1 (en) 1999-06-30 2002-05-14 Pharmasonics, Inc. Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts
AU6636000A (en) * 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
US6351663B1 (en) 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6439236B1 (en) 1999-10-25 2002-08-27 The Board Of Regents Of The University Of Nebraska Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles
US6443976B1 (en) 1999-11-30 2002-09-03 Akorn, Inc. Methods for treating conditions and illnesses associated with abnormal vasculature
US20040158317A1 (en) * 2000-07-18 2004-08-12 Pharmasonics, Inc. Coated stent with ultrasound therapy
US6514221B2 (en) * 2000-07-27 2003-02-04 Brigham And Women's Hospital, Inc. Blood-brain barrier opening
AU2001293112A1 (en) * 2000-09-25 2002-04-02 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US6964647B1 (en) 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US8235919B2 (en) * 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US6569099B1 (en) 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
IL141123A0 (en) * 2001-01-26 2002-02-10 Iger Yoni Method and apparatus for the delivery of substances to biological components
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
DE10108798A1 (de) * 2001-02-19 2002-09-26 Laser & Med Tech Gmbh Verfahren und Vorrichtung zur ultraschallgestützten transmembranen Medikamentenapplikation in vivo
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US8123789B2 (en) * 2002-04-29 2012-02-28 Rohit Khanna Central nervous system cooling catheter
DE60226251T2 (de) * 2001-07-10 2009-05-14 Sonogene, LLC, Glen Ellyn Verbesserung der transfektion von dna in die leber
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US7141044B2 (en) * 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
WO2003051208A1 (en) 2001-12-14 2003-06-26 Ekos Corporation Blood flow reestablishment determination
IL148299A (en) 2002-02-21 2014-04-30 Technion Res & Dev Foundation Ultrasonic to the heart
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
JP4243499B2 (ja) * 2002-06-11 2009-03-25 富士通株式会社 貼合せ基板製造装置及び貼合せ基板製造方法
AU2003257394A1 (en) * 2002-07-22 2004-03-03 Hans-Werner Bender Ultrasonic applicator device with a flat, flexible ultrasonic applicator and cavitation medium
US6921371B2 (en) * 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
WO2004041314A1 (en) * 2002-11-04 2004-05-21 Ashland Inc. Device and process for treating a liquid medium using ultrasound in preventing the growth of hyperproliferative or infected cells
JP2004182728A (ja) * 2002-11-22 2004-07-02 Katsuro Tachibana 歯あるいは歯周組織への導入用薬剤および歯あるいは歯周組織への薬剤導入装置
EP1599141A2 (de) * 2003-02-19 2005-11-30 Second Stage Ventures, Inc. Durch ultraschall verstärkte behandlung verbrannter haut mit kochsalzlösung
WO2004097017A2 (en) 2003-04-29 2004-11-11 Avi Biopharma, Inc. Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells
US7048863B2 (en) * 2003-07-08 2006-05-23 Ashland Licensing And Intellectual Property Llc Device and process for treating cutting fluids using ultrasound
WO2005056105A2 (de) * 2003-12-11 2005-06-23 Hans-Werner Bender Vorrichtung aus schallapplikator und trägerelement
US20060058708A1 (en) * 2003-12-24 2006-03-16 Gill Heart Method and apparatus for ultrasonically increasing the transportation of therapeutic substances through tissue
WO2005072409A2 (en) 2004-01-29 2005-08-11 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US7341569B2 (en) * 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
PT1761284E (pt) 2004-06-23 2012-12-12 Ashland Licensing & Intellectu Dispositivo e método para tratamento de fluídos utilizados em processo de revestimento por electrodeposição com ultra-sons
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
EP1828059B1 (de) 2004-11-17 2013-11-20 Ashland Licensing and Intellectual Property LLC Verfahren zur behandlung von bei der reifenherstellung verwendeten kühlflüssigkeiten
CN101076290B (zh) 2004-12-09 2011-11-23 铸造品股份有限公司 主动脉瓣修复
US20060264809A1 (en) * 2005-04-12 2006-11-23 Hansmann Douglas R Ultrasound catheter with cavitation promoting surface
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7785277B2 (en) * 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7717853B2 (en) * 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
US20110160621A1 (en) * 2005-06-24 2011-06-30 Henry Nita Methods and apparatus for dissolving intracranial blood clots
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US7967763B2 (en) * 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
AU2006287633A1 (en) * 2005-09-07 2007-03-15 The Foundry, Inc. Apparatus and method for disrupting subcutaneous structures
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) * 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US20090093737A1 (en) * 2007-10-09 2009-04-09 Cabochon Aesthetics, Inc. Ultrasound apparatus with treatment lens
GB0518273D0 (en) * 2005-09-08 2005-10-19 Univ Dundee Apparatus and method for sonoporation
US8257338B2 (en) * 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US9248317B2 (en) * 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US20080200864A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080195036A1 (en) * 2005-12-02 2008-08-14 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080200863A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US20080014627A1 (en) * 2005-12-02 2008-01-17 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US20080197517A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
WO2007102933A2 (en) * 2006-01-06 2007-09-13 Imarx Therapeutics, Inc Composition for ultrasound therapy and pharmaceutical liquid composition containing the same
US20070265560A1 (en) * 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
US8562547B2 (en) 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
US7431704B2 (en) * 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US20080097316A1 (en) * 2006-08-21 2008-04-24 Leonid Malinin Ultrasound catheter
JP2010501287A (ja) 2006-08-25 2010-01-21 ババエヴ，エイラズ 創傷治療用の可搬形の超音波器具
US20080089848A1 (en) * 2006-10-11 2008-04-17 Dimauro Thomas Intrathecal injection of microbubbles
US8192363B2 (en) * 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
WO2008079379A1 (en) * 2006-12-22 2008-07-03 Celleration, Inc. Apparatus to prevent applicator re-use
US8491521B2 (en) 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
US10182833B2 (en) * 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
EP2111261B1 (de) 2007-01-08 2015-04-15 Ekos Corporation Leistungsparameter für einen ultraschallkatheter
WO2008109739A1 (en) * 2007-03-07 2008-09-12 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
PT2152358E (pt) 2007-04-27 2011-06-07 Echo Therapeutics Inc Dispositivo de permeação da pele para detecção de analito ou distribuição transdérmica de droga
ES2471118T3 (es) 2007-06-22 2014-06-25 Ekos Corporation Método y aparato para el tratamiento de hemorragias intracraneales
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US20090093723A1 (en) * 2007-10-05 2009-04-09 Cabochon Aesthetics, Inc. Ultrasound device including dispenser
US20090093738A1 (en) * 2007-10-09 2009-04-09 Cabochon Aesthetics, Inc. Device and method for monitoring a treatment area
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
CN100560157C (zh) * 2007-11-13 2009-11-18 重庆市生力医疗设备有限公司 超声波药贴
US8262645B2 (en) * 2007-11-21 2012-09-11 Actuated Medical, Inc. Devices for clearing blockages in in-situ artificial lumens
US20090187137A1 (en) * 2007-12-14 2009-07-23 Kim Volz Ultrasound pulse shaping
US20090177122A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory skin disorders
DE102008038309A1 (de) * 2008-08-19 2010-02-25 Theuer, Axel E., Prof. Dr.-Ing. habil. Vorrichtung zur Zerstörung von Tumorzellen oder Erregern im Blutkreislauf
US20100106063A1 (en) * 2008-10-29 2010-04-29 Cabochon Aesthetics, Inc. Ultrasound Enhancing Target for Treating Subcutaneous Tissue
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US20100256596A1 (en) * 2009-04-07 2010-10-07 Cabochon Aesthetics, Inc. Fiber growth promoting implants for reducing the appearance of cellulite
WO2011003031A1 (en) 2009-07-03 2011-01-06 Ekos Corporation Power parameters for ultrasonic catheter
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US9375223B2 (en) 2009-10-06 2016-06-28 Cardioprolific Inc. Methods and devices for endovascular therapy
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
DE102010013703A1 (de) * 2010-04-01 2012-12-27 Oncowave Medical AG Apparat zur Diagnose und Therapie von malignen Tumoren
EP2608730B1 (de) 2010-08-27 2019-07-24 Ekos Corporation Vorrichtung zur behandlung intrakranialer blutungen
AU2011349578B2 (en) 2010-12-23 2016-06-30 Twelve, Inc. System for mitral valve repair and replacement
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
WO2012177942A2 (en) 2011-06-21 2012-12-27 Hanson Gifford, Iii Prosthetic heart valve devices and associated systems and methods
WO2013053099A1 (zh) * 2011-10-10 2013-04-18 Liu Zheng 微泡联合超声空化的肝创伤止血用途
AU2012325809B2 (en) 2011-10-19 2016-01-21 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
CA3090422C (en) 2011-10-19 2023-08-01 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US20140128734A1 (en) 2012-11-05 2014-05-08 Ekos Corporation Catheter systems and methods
US20160030725A1 (en) 2013-03-14 2016-02-04 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US9101745B2 (en) 2013-03-14 2015-08-11 Sonogene Llc Sonochemical induction of ABCA1 expression and compositions therefor
CA2910948C (en) 2013-05-20 2020-12-29 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
AU2014355072A1 (en) 2013-11-26 2016-06-02 Alliqua Biomedical, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
US10052394B2 (en) 2014-11-21 2018-08-21 General Electric Company Microbubble tether for diagnostic and therapeutic applications
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
WO2017035002A1 (en) 2015-08-21 2017-03-02 Twelve Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
EP3448316B1 (de) 2016-04-29 2023-03-29 Medtronic Vascular Inc. Herzklappenprothesenvorrichtungen mit angebundenen ankern
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US558512A (en) * 1896-04-21 Strainer for coffee-pots
US2961382A (en) * 1957-07-25 1960-11-22 Ortho Pharma Corp Urokinase-a plasmiogen activator and methods of obtaining the same
CA1083040A (en) * 1976-02-09 1980-08-05 Mostafa Fahim Topical application of medication by ultrasound with coupling agent
FR2445755A1 (fr) 1979-01-08 1980-08-01 Harmand Pierre Broche porte-outils pour usinage de precision
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4762915A (en) * 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US4750902A (en) * 1985-08-28 1988-06-14 Sonomed Technology, Inc. Endoscopic ultrasonic aspirators
US4797285A (en) * 1985-12-06 1989-01-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Lipsome/anthraquinone drug composition and method
ATE63124T1 (de) * 1986-03-14 1991-05-15 Fujisawa Pharmaceutical Co Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
US4948587A (en) * 1986-07-08 1990-08-14 Massachusetts Institute Of Technology Ultrasound enhancement of transbuccal drug delivery
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
US5718921A (en) * 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
US5040537A (en) * 1987-11-24 1991-08-20 Hitachi, Ltd. Method and apparatus for the measurement and medical treatment using an ultrasonic wave
DE3741199A1 (de) * 1987-12-02 1989-08-17 Schering Ag Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
WO1989006978A1 (en) * 1988-02-05 1989-08-10 Schering Aktiengesellschaft Berlin Und Bergkamen Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US4921478A (en) * 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
US5158071A (en) 1988-07-01 1992-10-27 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
US4920954A (en) * 1988-08-05 1990-05-01 Sonic Needle Corporation Ultrasonic device for applying cavitation forces
JPH02180275A (ja) * 1988-12-29 1990-07-13 Toshiro Tachibana 超音波発振素子付きカテーテル
US4936281A (en) * 1989-04-13 1990-06-26 Everest Medical Corporation Ultrasonically enhanced RF ablation catheter
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5069664A (en) * 1990-01-25 1991-12-03 Inter Therapy, Inc. Intravascular ultrasonic angioplasty probe
ES2077595T3 (es) * 1990-03-16 1995-12-01 Siemens Ag Cabeza de verificacion ultrasonica y procedimiento para su funcionamiento.
US5216130A (en) * 1990-05-17 1993-06-01 Albany Medical College Complex for in-vivo target localization
US5197946A (en) 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
CA2022019C (en) * 1990-07-26 1992-12-29 Michael Black Catheter
US5269291A (en) 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5916192A (en) * 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
ATE146073T1 (de) * 1991-03-22 1996-12-15 Katsuro Tachibana Verstärker zur ultraschalltherapie von erkrankungen sowie diesen enthaltende flüssige arzneimittelzusammensetzungen
US5277913A (en) * 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
CA2122834C (en) * 1991-11-04 1999-10-05 Henry Nita Ultrasonic ablation device adapted for guidewire passage
JPH05262673A (ja) * 1992-03-19 1993-10-12 Nippon Paint Co Ltd 超音波診断用造影剤
US5380273A (en) * 1992-05-19 1995-01-10 Dubrul; Will R. Vibrating catheter
US5713848A (en) * 1993-05-19 1998-02-03 Dubrul; Will R. Vibrating catheter
US5261291A (en) * 1992-08-17 1993-11-16 Schoch Paul T Ergonomic apparatus for controlling a vehicle
US5318014A (en) * 1992-09-14 1994-06-07 Coraje, Inc. Ultrasonic ablation/dissolution transducer
US5362309A (en) * 1992-09-14 1994-11-08 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis
JP2746021B2 (ja) * 1992-10-20 1998-04-28 富士写真光機株式会社 超音波プローブ
US5630837A (en) * 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
JP3294387B2 (ja) * 1993-07-21 2002-06-24 立花 克郎 超音波強度分布測定方法
CA2171303C (en) * 1993-09-09 2006-06-06 Werner Weitschies Active principles and gas containing microparticles
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US5628728A (en) * 1995-05-31 1997-05-13 Ekos Corporation Medicine applying tool
US5558092A (en) * 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5707608A (en) * 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5735811A (en) * 1995-11-30 1998-04-07 Pharmasonics, Inc. Apparatus and methods for ultrasonically enhanced fluid delivery
ES2247621T3 (es) * 1996-02-15 2006-03-01 Biosense Webster, Inc. Sonda de excavacion.
US5836896A (en) * 1996-08-19 1998-11-17 Angiosonics Method of inhibiting restenosis by applying ultrasonic energy
US6024718A (en) * 1996-09-04 2000-02-15 The Regents Of The University Of California Intraluminal directed ultrasound delivery device
US5817048A (en) * 1997-03-20 1998-10-06 Brown University Research Foundation Ultrasonic alternative to laser-based photodynamic therapy
US6723063B1 (en) * 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6676626B1 (en) * 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) * 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6001069A (en) * 1997-05-01 1999-12-14 Ekos Corporation Ultrasound catheter for providing a therapeutic effect to a vessel of a body
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6228046B1 (en) * 1997-06-02 2001-05-08 Pharmasonics, Inc. Catheters comprising a plurality of oscillators and methods for their use
JP4441000B2 (ja) * 1997-06-23 2010-03-24 克郎 立花 生体組織処理装置
US20010053384A1 (en) * 1997-07-07 2001-12-20 James F. Greenleaf Site-directed transfection with ultrasound and cavitation nuclei
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6113558A (en) * 1997-09-29 2000-09-05 Angiosonics Inc. Pulsed mode lysis method
US6007514A (en) * 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
US6896659B2 (en) * 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
US6508816B2 (en) * 1998-03-27 2003-01-21 John H. Shadduck Medical instrument working end creating very high pressure gradients
US6475183B1 (en) * 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US6135976A (en) * 1998-09-25 2000-10-24 Ekos Corporation Method, device and kit for performing gene therapy
US6296619B1 (en) * 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6524251B2 (en) * 1999-10-05 2003-02-25 Omnisonics Medical Technologies, Inc. Ultrasonic device for tissue ablation and sheath for use therewith
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
US20040019318A1 (en) * 2001-11-07 2004-01-29 Wilson Richard R. Ultrasound assembly for use with a catheter
AU2002359576A1 (en) * 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
WO2003047696A1 (en) * 2001-12-03 2003-06-12 Ekos Corporation Small vessel ultrasound catheter
WO2003072165A2 (en) * 2002-02-28 2003-09-04 Ekos Corporation Ultrasound assembly for use with a catheter
US7207989B2 (en) * 2003-10-27 2007-04-24 Biosense Webster, Inc. Method for ablating with needle electrode
US7341569B2 (en) * 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US20060264809A1 (en) * 2005-04-12 2006-11-23 Hansmann Douglas R Ultrasound catheter with cavitation promoting surface
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy

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USRE36939E (en) 2000-10-31
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DE69215722T2 (de) 1997-05-07
EP0732106A2 (de) 1996-09-18
US20030191446A1 (en) 2003-10-09
US6585678B1 (en) 2003-07-01
ATE146073T1 (de) 1996-12-15
US5315998A (en) 1994-05-31
EP0504881A2 (de) 1992-09-23
CA2063529A1 (en) 1992-09-23
EP0504881B1 (de) 1996-12-11
DE69215722T3 (de) 2001-03-08
EP0504881B2 (de) 2000-11-08

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