DE69206423T2 - Verfahren zur Herstellung von 5-(2,4-Difluorphenyl)-Salizylsäure. - Google Patents
Verfahren zur Herstellung von 5-(2,4-Difluorphenyl)-Salizylsäure.Info
- Publication number
- DE69206423T2 DE69206423T2 DE69206423T DE69206423T DE69206423T2 DE 69206423 T2 DE69206423 T2 DE 69206423T2 DE 69206423 T DE69206423 T DE 69206423T DE 69206423 T DE69206423 T DE 69206423T DE 69206423 T2 DE69206423 T2 DE 69206423T2
- Authority
- DE
- Germany
- Prior art keywords
- difluorophenyl
- preparation
- salicylic acid
- transition
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910027A IT1244361B (it) | 1991-01-08 | 1991-01-08 | Processo per la preparazione dell'acido 5-(2,4-difluorofenil)- salicilico |
| ITMI911094A IT1247507B (it) | 1991-04-19 | 1991-04-19 | Processo per la preparazione dell'acido 5(2,4 difluorofenil) salicilico |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69206423D1 DE69206423D1 (de) | 1996-01-18 |
| DE69206423T2 true DE69206423T2 (de) | 1996-05-02 |
Family
ID=26330657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69206423T Expired - Fee Related DE69206423T2 (de) | 1991-01-08 | 1992-01-01 | Verfahren zur Herstellung von 5-(2,4-Difluorphenyl)-Salizylsäure. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5312975A (de) |
| EP (1) | EP0494419B1 (de) |
| JP (1) | JP3106259B2 (de) |
| AT (1) | ATE131149T1 (de) |
| CA (1) | CA2058646C (de) |
| DE (1) | DE69206423T2 (de) |
| DK (1) | DK0494419T3 (de) |
| ES (1) | ES2081417T3 (de) |
| FI (1) | FI103788B (de) |
| GR (1) | GR3018569T3 (de) |
| IL (1) | IL100353A (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3336507B2 (ja) * | 1992-04-28 | 2002-10-21 | イハラケミカル工業株式会社 | 非対称ビアリール誘導体の製造方法 |
| IT1291356B1 (it) | 1997-05-13 | 1999-01-07 | Zambon Spa | Processo per la rimozione di metalli pesanti |
| JP4238405B2 (ja) * | 1999-02-09 | 2009-03-18 | 東ソー株式会社 | 置換スチレン誘導体又は置換ビアリール誘導体の製造方法 |
| FR2826963B1 (fr) * | 2001-07-04 | 2006-01-27 | Rhodia Chimie Sa | Preparation d'organozinciques aromatiques et composition pour ce faire |
| GB2415193A (en) * | 2004-06-19 | 2005-12-21 | F2 Chemicals Ltd | Fluorinated arylboronic acids |
| JP4852879B2 (ja) * | 2005-05-10 | 2012-01-11 | ダイキン工業株式会社 | 含フッ素ポリマーおよび含フッ素化合物の製造方法 |
| JP6807322B2 (ja) * | 2015-10-16 | 2021-01-06 | 武田薬品工業株式会社 | 複素環化合物の製造方法 |
| US9733226B1 (en) | 2016-02-02 | 2017-08-15 | Ripetime Limited | Apparatus and method for measuring a gas |
| JP7175464B2 (ja) * | 2017-08-30 | 2022-11-21 | 学校法人関西学院 | 二ヨウ化ホウ素化合物、それから得られるボロン酸およびボロン酸エステル等、ならびにそれらの製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3096370A (en) * | 1959-03-30 | 1963-07-02 | American Potash & Chem Corp | Reactions of boron halides and tetrasubstituted boron compounds |
| GB1175212A (en) * | 1967-03-09 | 1969-12-23 | Merck & Co Inc | Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives |
| US3992459A (en) * | 1975-05-01 | 1976-11-16 | Merck & Co., Inc. | Preparation of biphenyl compounds |
| US4225730A (en) * | 1978-05-11 | 1980-09-30 | Merck & Co., Inc. | Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid |
| IT1190926B (it) * | 1982-07-22 | 1988-02-24 | Zambon Spa | Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico |
| DE3502986A1 (de) * | 1985-01-30 | 1986-07-31 | Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe | Verfahren zum abtrennen von caesiumionen aus waessrigen loesungen |
| DE3816120A1 (de) * | 1988-05-11 | 1989-11-23 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen biarylverbindungen |
| US4912276A (en) * | 1988-10-25 | 1990-03-27 | Eastman Kodak Company | Preparation of biaryl compounds |
| US5239114A (en) * | 1990-12-19 | 1993-08-24 | Zambon Group S.P.A. | Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitrobenzoate |
| IT1244036B (it) * | 1990-12-19 | 1994-06-28 | Zambon Spa | Processo per la preparazione del 4-nitro-benzoato di 4-(2,4- difluorofenil)-fenile |
| IT1250736B (it) * | 1991-08-01 | 1995-04-21 | Zambon Spa | Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura |
| AU4972200A (en) * | 1999-04-26 | 2000-11-10 | Center For Molecular Medicine And Immunology | Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity |
-
1991
- 1991-12-12 IL IL100353A patent/IL100353A/xx not_active IP Right Cessation
- 1991-12-27 US US07/813,661 patent/US5312975A/en not_active Expired - Fee Related
- 1991-12-27 JP JP03361474A patent/JP3106259B2/ja not_active Expired - Fee Related
- 1991-12-31 CA CA002058646A patent/CA2058646C/en not_active Expired - Fee Related
-
1992
- 1992-01-01 DK DK91121785.9T patent/DK0494419T3/da active
- 1992-01-01 EP EP91121785A patent/EP0494419B1/de not_active Expired - Lifetime
- 1992-01-01 DE DE69206423T patent/DE69206423T2/de not_active Expired - Fee Related
- 1992-01-01 AT AT91121785T patent/ATE131149T1/de not_active IP Right Cessation
- 1992-01-01 ES ES91121785T patent/ES2081417T3/es not_active Expired - Lifetime
- 1992-01-08 FI FI920069A patent/FI103788B/fi active
-
1993
- 1993-12-30 US US08/174,316 patent/US5412143A/en not_active Expired - Fee Related
-
1995
- 1995-12-29 GR GR950403706T patent/GR3018569T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI103788B1 (fi) | 1999-09-30 |
| EP0494419B1 (de) | 1995-12-06 |
| FI920069A (fi) | 1992-07-09 |
| ES2081417T3 (es) | 1996-03-16 |
| GR3018569T3 (en) | 1996-03-31 |
| CA2058646C (en) | 2000-07-18 |
| JPH0585986A (ja) | 1993-04-06 |
| FI103788B (fi) | 1999-09-30 |
| EP0494419A2 (de) | 1992-07-15 |
| US5312975A (en) | 1994-05-17 |
| DE69206423D1 (de) | 1996-01-18 |
| DK0494419T3 (da) | 1996-01-08 |
| EP0494419A3 (en) | 1992-12-09 |
| IL100353A (en) | 1997-06-10 |
| US5412143A (en) | 1995-05-02 |
| FI920069A0 (fi) | 1992-01-08 |
| CA2058646A1 (en) | 1992-07-09 |
| JP3106259B2 (ja) | 2000-11-06 |
| ATE131149T1 (de) | 1995-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |