FI103788B - Menetelmä 5-(2,4-difluorifenyyli)salisyylihapon valmistamiseksi - Google Patents

Menetelmä 5-(2,4-difluorifenyyli)salisyylihapon valmistamiseksi

Info

Publication number
FI103788B
FI103788B FI920069A FI920069A FI103788B FI 103788 B FI103788 B FI 103788B FI 920069 A FI920069 A FI 920069A FI 920069 A FI920069 A FI 920069A FI 103788 B FI103788 B FI 103788B
Authority
FI
Finland
Prior art keywords
difluorophenyl
preparation
salicylic acid
transition
reaction
Prior art date
Application number
FI920069A
Other languages
English (en)
Swedish (sv)
Other versions
FI103788B1 (fi
FI920069A (fi
FI920069A0 (fi
Inventor
Claudio Giordano
Laura Coppi
Francesco Minisci
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI910027A external-priority patent/IT1244361B/it
Priority claimed from ITMI911094A external-priority patent/IT1247507B/it
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of FI920069A0 publication Critical patent/FI920069A0/fi
Publication of FI920069A publication Critical patent/FI920069A/fi
Application granted granted Critical
Publication of FI103788B1 publication Critical patent/FI103788B1/fi
Publication of FI103788B publication Critical patent/FI103788B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
FI920069A 1991-01-08 1992-01-08 Menetelmä 5-(2,4-difluorifenyyli)salisyylihapon valmistamiseksi FI103788B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI910027A IT1244361B (it) 1991-01-08 1991-01-08 Processo per la preparazione dell'acido 5-(2,4-difluorofenil)- salicilico
ITMI911094A IT1247507B (it) 1991-04-19 1991-04-19 Processo per la preparazione dell'acido 5(2,4 difluorofenil) salicilico

Publications (4)

Publication Number Publication Date
FI920069A0 FI920069A0 (fi) 1992-01-08
FI920069A FI920069A (fi) 1992-07-09
FI103788B1 FI103788B1 (fi) 1999-09-30
FI103788B true FI103788B (fi) 1999-09-30

Family

ID=26330657

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920069A FI103788B (fi) 1991-01-08 1992-01-08 Menetelmä 5-(2,4-difluorifenyyli)salisyylihapon valmistamiseksi

Country Status (11)

Country Link
US (2) US5312975A (fi)
EP (1) EP0494419B1 (fi)
JP (1) JP3106259B2 (fi)
AT (1) ATE131149T1 (fi)
CA (1) CA2058646C (fi)
DE (1) DE69206423T2 (fi)
DK (1) DK0494419T3 (fi)
ES (1) ES2081417T3 (fi)
FI (1) FI103788B (fi)
GR (1) GR3018569T3 (fi)
IL (1) IL100353A (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3336507B2 (ja) * 1992-04-28 2002-10-21 イハラケミカル工業株式会社 非対称ビアリール誘導体の製造方法
IT1291356B1 (it) * 1997-05-13 1999-01-07 Zambon Spa Processo per la rimozione di metalli pesanti
JP4238405B2 (ja) * 1999-02-09 2009-03-18 東ソー株式会社 置換スチレン誘導体又は置換ビアリール誘導体の製造方法
FR2826963B1 (fr) * 2001-07-04 2006-01-27 Rhodia Chimie Sa Preparation d'organozinciques aromatiques et composition pour ce faire
GB2415193A (en) * 2004-06-19 2005-12-21 F2 Chemicals Ltd Fluorinated arylboronic acids
JP4852879B2 (ja) * 2005-05-10 2012-01-11 ダイキン工業株式会社 含フッ素ポリマーおよび含フッ素化合物の製造方法
EP3363796B1 (en) * 2015-10-16 2021-04-07 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
US9733226B1 (en) 2016-02-02 2017-08-15 Ripetime Limited Apparatus and method for measuring a gas
JP7175464B2 (ja) * 2017-08-30 2022-11-21 学校法人関西学院 二ヨウ化ホウ素化合物、それから得られるボロン酸およびボロン酸エステル等、ならびにそれらの製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096370A (en) * 1959-03-30 1963-07-02 American Potash & Chem Corp Reactions of boron halides and tetrasubstituted boron compounds
GB1175212A (en) * 1967-03-09 1969-12-23 Merck & Co Inc Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives
US3992459A (en) * 1975-05-01 1976-11-16 Merck & Co., Inc. Preparation of biphenyl compounds
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
IT1190926B (it) * 1982-07-22 1988-02-24 Zambon Spa Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico
DE3502986A1 (de) * 1985-01-30 1986-07-31 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verfahren zum abtrennen von caesiumionen aus waessrigen loesungen
DE3816120A1 (de) * 1988-05-11 1989-11-23 Bayer Ag Verfahren zur herstellung von unsymmetrischen biarylverbindungen
US4912276A (en) * 1988-10-25 1990-03-27 Eastman Kodak Company Preparation of biaryl compounds
IT1244036B (it) * 1990-12-19 1994-06-28 Zambon Spa Processo per la preparazione del 4-nitro-benzoato di 4-(2,4- difluorofenil)-fenile
US5239114A (en) * 1990-12-19 1993-08-24 Zambon Group S.P.A. Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitrobenzoate
IT1250736B (it) * 1991-08-01 1995-04-21 Zambon Spa Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura
CA2370600A1 (en) * 1999-04-26 2000-11-02 Center For Molecular Medicine And Immunology Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity

Also Published As

Publication number Publication date
DK0494419T3 (da) 1996-01-08
DE69206423D1 (de) 1996-01-18
US5412143A (en) 1995-05-02
US5312975A (en) 1994-05-17
FI103788B1 (fi) 1999-09-30
DE69206423T2 (de) 1996-05-02
EP0494419A3 (en) 1992-12-09
FI920069A (fi) 1992-07-09
JP3106259B2 (ja) 2000-11-06
JPH0585986A (ja) 1993-04-06
IL100353A (en) 1997-06-10
ATE131149T1 (de) 1995-12-15
GR3018569T3 (en) 1996-03-31
EP0494419B1 (en) 1995-12-06
FI920069A0 (fi) 1992-01-08
CA2058646A1 (en) 1992-07-09
CA2058646C (en) 2000-07-18
EP0494419A2 (en) 1992-07-15
ES2081417T3 (es) 1996-03-16

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