ES2081417T3 - Procedimiento para la preparacion de acido 5-(2,4-difluorofenil)-salicilico. - Google Patents

Procedimiento para la preparacion de acido 5-(2,4-difluorofenil)-salicilico.

Info

Publication number
ES2081417T3
ES2081417T3 ES91121785T ES91121785T ES2081417T3 ES 2081417 T3 ES2081417 T3 ES 2081417T3 ES 91121785 T ES91121785 T ES 91121785T ES 91121785 T ES91121785 T ES 91121785T ES 2081417 T3 ES2081417 T3 ES 2081417T3
Authority
ES
Spain
Prior art keywords
preparation
acid
salicilico
difluorofenil
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121785T
Other languages
English (en)
Inventor
Claudio Giordano
Laura Coppi
Francesco Minisci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI910027A external-priority patent/IT1244361B/it
Priority claimed from ITMI911094A external-priority patent/IT1247507B/it
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Application granted granted Critical
Publication of ES2081417T3 publication Critical patent/ES2081417T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Abstract

SE DESCRIBE EL PROCESO PARA LA PREPARACION DEL ACIDO SALICILICO 5-(2,4-DIFLUOROFENIL) QUE COMPRENDE LA REACCION DE UN DERIVADO ORGANOMETALICO CON UN BENCENO IDONEAMENTE SUSTITUIDO EN PRESENCIA DE UN CATALIZADOR BASADO EN LA TRANSICION DE UN METAL.
ES91121785T 1991-01-08 1992-01-01 Procedimiento para la preparacion de acido 5-(2,4-difluorofenil)-salicilico. Expired - Lifetime ES2081417T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI910027A IT1244361B (it) 1991-01-08 1991-01-08 Processo per la preparazione dell'acido 5-(2,4-difluorofenil)- salicilico
ITMI911094A IT1247507B (it) 1991-04-19 1991-04-19 Processo per la preparazione dell'acido 5(2,4 difluorofenil) salicilico

Publications (1)

Publication Number Publication Date
ES2081417T3 true ES2081417T3 (es) 1996-03-16

Family

ID=26330657

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121785T Expired - Lifetime ES2081417T3 (es) 1991-01-08 1992-01-01 Procedimiento para la preparacion de acido 5-(2,4-difluorofenil)-salicilico.

Country Status (11)

Country Link
US (2) US5312975A (es)
EP (1) EP0494419B1 (es)
JP (1) JP3106259B2 (es)
AT (1) ATE131149T1 (es)
CA (1) CA2058646C (es)
DE (1) DE69206423T2 (es)
DK (1) DK0494419T3 (es)
ES (1) ES2081417T3 (es)
FI (1) FI103788B (es)
GR (1) GR3018569T3 (es)
IL (1) IL100353A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3336507B2 (ja) * 1992-04-28 2002-10-21 イハラケミカル工業株式会社 非対称ビアリール誘導体の製造方法
IT1291356B1 (it) * 1997-05-13 1999-01-07 Zambon Spa Processo per la rimozione di metalli pesanti
JP4238405B2 (ja) * 1999-02-09 2009-03-18 東ソー株式会社 置換スチレン誘導体又は置換ビアリール誘導体の製造方法
FR2826963B1 (fr) * 2001-07-04 2006-01-27 Rhodia Chimie Sa Preparation d'organozinciques aromatiques et composition pour ce faire
GB2415193A (en) * 2004-06-19 2005-12-21 F2 Chemicals Ltd Fluorinated arylboronic acids
JP4852879B2 (ja) * 2005-05-10 2012-01-11 ダイキン工業株式会社 含フッ素ポリマーおよび含フッ素化合物の製造方法
EP3363796B1 (en) * 2015-10-16 2021-04-07 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
US9733226B1 (en) 2016-02-02 2017-08-15 Ripetime Limited Apparatus and method for measuring a gas
JP7175464B2 (ja) * 2017-08-30 2022-11-21 学校法人関西学院 二ヨウ化ホウ素化合物、それから得られるボロン酸およびボロン酸エステル等、ならびにそれらの製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096370A (en) * 1959-03-30 1963-07-02 American Potash & Chem Corp Reactions of boron halides and tetrasubstituted boron compounds
GB1175212A (en) * 1967-03-09 1969-12-23 Merck & Co Inc Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives
US3992459A (en) * 1975-05-01 1976-11-16 Merck & Co., Inc. Preparation of biphenyl compounds
US4225730A (en) * 1978-05-11 1980-09-30 Merck & Co., Inc. Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid
IT1190926B (it) * 1982-07-22 1988-02-24 Zambon Spa Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico
DE3502986A1 (de) * 1985-01-30 1986-07-31 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verfahren zum abtrennen von caesiumionen aus waessrigen loesungen
DE3816120A1 (de) * 1988-05-11 1989-11-23 Bayer Ag Verfahren zur herstellung von unsymmetrischen biarylverbindungen
US4912276A (en) * 1988-10-25 1990-03-27 Eastman Kodak Company Preparation of biaryl compounds
IT1244036B (it) * 1990-12-19 1994-06-28 Zambon Spa Processo per la preparazione del 4-nitro-benzoato di 4-(2,4- difluorofenil)-fenile
US5239114A (en) * 1990-12-19 1993-08-24 Zambon Group S.P.A. Process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitrobenzoate
IT1250736B (it) * 1991-08-01 1995-04-21 Zambon Spa Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura
CA2370600A1 (en) * 1999-04-26 2000-11-02 Center For Molecular Medicine And Immunology Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity

Also Published As

Publication number Publication date
DK0494419T3 (da) 1996-01-08
DE69206423D1 (de) 1996-01-18
US5412143A (en) 1995-05-02
US5312975A (en) 1994-05-17
FI103788B1 (fi) 1999-09-30
DE69206423T2 (de) 1996-05-02
EP0494419A3 (en) 1992-12-09
FI920069A (fi) 1992-07-09
FI103788B (fi) 1999-09-30
JP3106259B2 (ja) 2000-11-06
JPH0585986A (ja) 1993-04-06
IL100353A (en) 1997-06-10
ATE131149T1 (de) 1995-12-15
GR3018569T3 (en) 1996-03-31
EP0494419B1 (en) 1995-12-06
FI920069A0 (fi) 1992-01-08
CA2058646A1 (en) 1992-07-09
CA2058646C (en) 2000-07-18
EP0494419A2 (en) 1992-07-15

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