DE69205851D1 - Verfahren zur Herstellung von (-)-(2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)propionat-methylester. - Google Patents

Verfahren zur Herstellung von (-)-(2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)propionat-methylester.

Info

Publication number
DE69205851D1
DE69205851D1 DE69205851T DE69205851T DE69205851D1 DE 69205851 D1 DE69205851 D1 DE 69205851D1 DE 69205851 T DE69205851 T DE 69205851T DE 69205851 T DE69205851 T DE 69205851T DE 69205851 D1 DE69205851 D1 DE 69205851D1
Authority
DE
Germany
Prior art keywords
methoxyphenyl
epoxy
preparation
methyl ester
propionate methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69205851T
Other languages
English (en)
Other versions
DE69205851T2 (de
Inventor
Lydia Zard
Arlette Tixidre
Guy Rossey
Alexander Wick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9409484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69205851(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE69205851D1 publication Critical patent/DE69205851D1/de
Publication of DE69205851T2 publication Critical patent/DE69205851T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69205851T 1991-02-08 1992-02-03 Verfahren zur Herstellung von (-)-(2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)propionat-methylester. Expired - Lifetime DE69205851T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919101427A FR2672600B1 (fr) 1991-02-08 1991-02-08 Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Publications (2)

Publication Number Publication Date
DE69205851D1 true DE69205851D1 (de) 1995-12-14
DE69205851T2 DE69205851T2 (de) 1996-05-23

Family

ID=9409484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69205851T Expired - Lifetime DE69205851T2 (de) 1991-02-08 1992-02-03 Verfahren zur Herstellung von (-)-(2R,3S)-2,3-Epoxy-3-(4-Methoxyphenyl)propionat-methylester.

Country Status (9)

Country Link
US (1) US5169779A (de)
EP (1) EP0498706B2 (de)
JP (1) JP3126056B2 (de)
AT (1) ATE130040T1 (de)
DE (1) DE69205851T2 (de)
DK (1) DK0498706T3 (de)
ES (1) ES2082391T3 (de)
FR (1) FR2672600B1 (de)
GR (1) GR3018311T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249777B (it) 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
ES2050067B1 (es) * 1992-06-08 1994-12-16 Menarini Lab Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva con un alcohol bifuncional catalizada enzimaticamente en medio organico.
WO1993025704A1 (en) * 1992-06-08 1993-12-23 Laboratorios Menarini S.A. A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
ES2048653B1 (es) * 1992-06-08 1994-12-16 Menarini Lab Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.
NL9202208A (nl) * 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
FI93741C (fi) * 1993-03-24 1995-05-26 Orion Yhtymae Oy Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
US5559229A (en) * 1995-06-01 1996-09-24 Acic (Canada) Inc. Method for the manufacture of benzothiazepine
AU7551998A (en) * 1997-06-11 1998-12-30 Tanabe Seiyaku Co., Ltd. Process for preparing optically active phenyloxirane compounds
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
CN114874156A (zh) * 2022-06-20 2022-08-09 巨鑫生物制药股份有限公司 一种合成地尔硫卓中间体(2s)-顺-羟基内酰胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IT1217765B (it) * 1988-06-02 1990-03-30 Montedison Spa Processo per la risoluzione enzimatica degli isomeri ottici di derivati racemi esterei dell,acido 3 mercapto 2 alchilpropionico
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi

Also Published As

Publication number Publication date
JPH0576389A (ja) 1993-03-30
ATE130040T1 (de) 1995-11-15
DK0498706T3 (da) 1996-02-12
JP3126056B2 (ja) 2001-01-22
GR3018311T3 (en) 1996-03-31
US5169779A (en) 1992-12-08
DE69205851T2 (de) 1996-05-23
ES2082391T3 (es) 1996-03-16
EP0498706A1 (de) 1992-08-12
FR2672600B1 (fr) 1994-10-14
FR2672600A1 (fr) 1992-08-14
EP0498706B1 (de) 1995-11-08
EP0498706B2 (de) 2000-05-31

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8332 No legal effect for de
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR