DE69132812D1 - Pichia pastoris Säure-Phosphatase-Gen - Google Patents

Pichia pastoris Säure-Phosphatase-Gen

Info

Publication number
DE69132812D1
DE69132812D1 DE69132812T DE69132812T DE69132812D1 DE 69132812 D1 DE69132812 D1 DE 69132812D1 DE 69132812 T DE69132812 T DE 69132812T DE 69132812 T DE69132812 T DE 69132812T DE 69132812 D1 DE69132812 D1 DE 69132812D1
Authority
DE
Germany
Prior art keywords
pichia pastoris
acid phosphatase
phosphatase gene
pastoris acid
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132812T
Other languages
English (en)
Other versions
DE69132812T2 (de
Inventor
Richard G Buckholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of DE69132812D1 publication Critical patent/DE69132812D1/de
Application granted granted Critical
Publication of DE69132812T2 publication Critical patent/DE69132812T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/938—Pichia

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69132812T 1990-12-14 1991-12-13 Pichia pastoris Säure-Phosphatase-Gen Expired - Fee Related DE69132812T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/627,539 US5268273A (en) 1990-12-14 1990-12-14 Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same

Publications (2)

Publication Number Publication Date
DE69132812D1 true DE69132812D1 (de) 2001-12-20
DE69132812T2 DE69132812T2 (de) 2002-06-20

Family

ID=24515081

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132812T Expired - Fee Related DE69132812T2 (de) 1990-12-14 1991-12-13 Pichia pastoris Säure-Phosphatase-Gen

Country Status (22)

Country Link
US (1) US5268273A (de)
EP (1) EP0495208B1 (de)
JP (1) JP3437850B2 (de)
KR (1) KR0181179B1 (de)
CN (1) CN1062169A (de)
AR (1) AR245218A1 (de)
AT (1) ATE208822T1 (de)
AU (1) AU637734B2 (de)
CA (1) CA2055542C (de)
CS (1) CS378891A3 (de)
DE (1) DE69132812T2 (de)
FI (2) FI104493B (de)
HU (1) HU913926D0 (de)
IE (1) IE914354A1 (de)
IL (1) IL100363A0 (de)
MX (1) MX9102546A (de)
NO (1) NO314151B1 (de)
PL (1) PL292765A1 (de)
PT (1) PT99802A (de)
TW (1) TW201330B (de)
YU (1) YU193591A (de)
ZA (1) ZA919776B (de)

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US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
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US5521086A (en) * 1993-09-16 1996-05-28 Cephalon, Inc. Secretion sequence for the production of a heterologous protein in yeast
IT1266740B1 (it) * 1994-07-01 1997-01-14 Maria Paola Landini Materiale proteico ricombinante legante anticorpi contro il citomegalovirus umano, reagenti diagnostici derivati da tale
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
EP0788546B9 (de) 1994-10-18 2007-06-13 Dendreon Corporation Aus nematoden extrahierte serinprotease-inhibitoren und die koagulation hemmende proteine
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
AU2115897A (en) * 1996-02-01 1997-08-22 North American Vaccine, Inc. Expression of group b neisseria meningitidis outer membrane (mb3) protein from yeast and vaccines
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
EP1003889A1 (de) 1997-08-05 2000-05-31 Chiron Corporation Gensequenzen aus pichia pastoris und deren verwendung
US6451572B1 (en) * 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
AU2614500A (en) 1999-01-14 2000-08-01 Novozymes Biotech, Inc. Polypeptides having acid phosphatase activity and nucleic acids encoding same
CN100347303C (zh) * 1999-03-31 2007-11-07 康乃尔研究基金会有限公司 具有改良的肌醇六磷酸酶活性的磷酸酶
US6841370B1 (en) * 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
CN1320699A (zh) * 2000-04-27 2001-11-07 上海博德基因开发有限公司 一种新的多肽——人磷脂酶9和编码这种多肽的多核苷酸
CN1324948A (zh) * 2000-05-24 2001-12-05 上海博德基因开发有限公司 一种新的多肽——酸性磷酸酶14和编码这种多肽的多核苷酸
US6605450B1 (en) 2000-05-25 2003-08-12 Chiron Corporation Iron regulation of the PpSEC10 transcriptional regulatory region of Pichia pastoris and methods of use
CN1329020A (zh) * 2000-06-21 2002-01-02 上海博德基因开发有限公司 一种新的多肽——酸性磷酸酶家族蛋白11和编码这种多肽的多核苷酸
US7009045B2 (en) * 2000-07-14 2006-03-07 Archer-Daniels-Midland Company Transformation systems for flavinogenic yeast
EP1450627B1 (de) 2001-10-31 2012-09-05 Phytex, Llc Verwendung eines phytase-haltigen tierfutters
US7309505B2 (en) * 2002-09-13 2007-12-18 Cornell Research Foundation, Inc. Using mutations to improve Aspergillus phytases
WO2005012341A2 (en) * 2003-07-30 2005-02-10 Zymogenetics, Inc. Pichia methanolica secretory signal
US7919297B2 (en) 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
EP2069486A2 (de) 2006-08-03 2009-06-17 Cornell Research Foundation, Inc. Phytasen mit erhöhter wärmestabilität
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US8192734B2 (en) 2007-07-09 2012-06-05 Cornell University Compositions and methods for bone strengthening
US9200270B2 (en) * 2008-03-03 2015-12-01 Abbvie Inc. Methods for transforming yeast
US20090280103A1 (en) * 2008-04-04 2009-11-12 Martin Flueck Regulation of muscle repair
US20120156761A1 (en) 2009-07-02 2012-06-21 Verdezyne, Inc. Biological methods for preparing adipic acid
WO2011006126A2 (en) * 2009-07-09 2011-01-13 Verdezyne, Inc Engineered microorganisms with enhanced fermentation activity
US8889394B2 (en) * 2009-09-07 2014-11-18 Empire Technology Development Llc Multiple domain proteins
US8343752B2 (en) 2011-05-03 2013-01-01 Verdezyne, Inc. Biological methods for preparing adipic acid
US8728798B2 (en) 2011-05-03 2014-05-20 Verdezyne, Inc. Biological methods for preparing adipic acid
WO2013006733A2 (en) 2011-07-06 2013-01-10 Verdezyne, Inc. Biological methods for preparing a fatty dicarboxylic acid
ES2789299T3 (es) 2012-10-29 2020-10-26 Lonza Ag Secuencias de expresión
CN105189731A (zh) 2012-12-19 2015-12-23 沃德金有限公司 制备脂肪二羧酸的生物学方法
SG10201705057QA (en) 2012-12-19 2017-07-28 Verdezyne Inc Biological methods for preparing a fatty dicarboxylic acid
TWI638047B (zh) 2014-04-09 2018-10-11 史基普研究協會 藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中
CN104195059B (zh) * 2014-08-15 2016-08-24 陕西科技大学 多形汉逊酵母突变菌株及多形汉逊酵母生产d-阿拉伯糖醇的方法
US20180148744A1 (en) 2015-03-20 2018-05-31 Verdezyne, Inc. Biological methods for preparing 3-hydroxypropionic acid
US10988515B2 (en) 2017-01-13 2021-04-27 Bolt Threads, Inc. Elastomeric proteins
WO2019014267A1 (en) 2017-07-11 2019-01-17 Synthorx, Inc. INCORPORATION OF NON-NATURAL NUCLEOTIDES AND ASSOCIATED METHODS
EP3652300A4 (de) 2017-07-13 2021-06-23 Radici Chimica S.p.A. Biologische verfahren zur modifizierung des zellulären kohlenstoffflusses
AU2018309172B2 (en) 2017-08-03 2022-12-15 Synthorx, Inc. Cytokine conjugates for the treatment of autoimmune diseases
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
EP3923974A4 (de) 2019-02-06 2023-02-08 Synthorx, Inc. Il-2-konjugate und verfahren zur verwendung davon

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
JPS5974988A (ja) * 1982-10-20 1984-04-27 Suntory Ltd 酵母の誘導発現型プラスミドベクタ−およびその利用方法
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DK175327B1 (da) * 1984-10-01 2004-08-23 Integrated Genetics Inc Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4808537A (en) * 1984-10-30 1989-02-28 Phillips Petroleum Company Methanol inducible genes obtained from pichia and methods of use
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4895800A (en) * 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
JPH0655146B2 (ja) * 1985-12-27 1994-07-27 財団法人化学及血清療法研究所 シヤトルベクタ−
IL82935A0 (en) * 1986-08-12 1987-12-20 Phillips Petroleum Co Secretion of heterologous proteins from yeast
US5002876A (en) * 1986-09-22 1991-03-26 Phillips Petroleum Company Yeast production of human tumor necrosis factor
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
US5102789A (en) * 1989-03-15 1992-04-07 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of epideramal growth factor in pichia pastoris yeast cells
CA2000101A1 (en) * 1988-12-22 1990-06-22 Mary E. Digan Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene
JPH0671434B2 (ja) * 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法

Also Published As

Publication number Publication date
AU637734B2 (en) 1993-06-03
KR0181179B1 (ko) 1999-04-01
FI915893A (fi) 1992-06-15
IE914354A1 (en) 1992-06-17
YU193591A (sh) 1994-06-10
FI113474B (fi) 2004-04-30
TW201330B (de) 1993-03-01
EP0495208A3 (en) 1994-05-18
NO314151B1 (no) 2003-02-03
MX9102546A (es) 1992-07-01
ATE208822T1 (de) 2001-11-15
HU913926D0 (en) 1992-02-28
JPH0576371A (ja) 1993-03-30
CS378891A3 (en) 1992-06-17
NO914935L (no) 1992-06-15
DE69132812T2 (de) 2002-06-20
EP0495208A2 (de) 1992-07-22
NO914935D0 (no) 1991-12-13
CN1062169A (zh) 1992-06-24
AR245218A1 (es) 1993-12-30
ZA919776B (en) 1992-09-30
FI104493B (fi) 2000-02-15
IL100363A0 (en) 1992-09-06
PL292765A1 (en) 1992-08-24
US5268273A (en) 1993-12-07
AU8882391A (en) 1992-06-25
CA2055542C (en) 1999-08-31
PT99802A (pt) 1992-12-31
JP3437850B2 (ja) 2003-08-18
CA2055542A1 (en) 1992-06-15
KR920012442A (ko) 1992-07-27
FI915893A0 (fi) 1991-12-13
EP0495208B1 (de) 2001-11-14
FI19992503A (fi) 1999-11-24

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Legal Events

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8339 Ceased/non-payment of the annual fee