DE69132497D1 - Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung - Google Patents

Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung

Info

Publication number
DE69132497D1
DE69132497D1 DE69132497T DE69132497T DE69132497D1 DE 69132497 D1 DE69132497 D1 DE 69132497D1 DE 69132497 T DE69132497 T DE 69132497T DE 69132497 T DE69132497 T DE 69132497T DE 69132497 D1 DE69132497 D1 DE 69132497D1
Authority
DE
Germany
Prior art keywords
production
paf
benzimidazole derivatives
nitrogen atom
amelioration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132497T
Other languages
English (en)
Other versions
DE69132497T2 (de
Inventor
Mark Whittaker
Andrew Miller
Stephen Arthur Bowles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909017878A external-priority patent/GB9017878D0/en
Priority claimed from GB909018040A external-priority patent/GB9018040D0/en
Priority claimed from GB919112214A external-priority patent/GB9112214D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of DE69132497D1 publication Critical patent/DE69132497D1/de
Application granted granted Critical
Publication of DE69132497T2 publication Critical patent/DE69132497T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69132497T 1990-08-15 1991-08-15 Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung Expired - Fee Related DE69132497T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909017878A GB9017878D0 (en) 1990-08-15 1990-08-15 Compounds
GB909018040A GB9018040D0 (en) 1990-08-16 1990-08-16 Compounds
GB919112214A GB9112214D0 (en) 1991-06-06 1991-06-06 Compounds
PCT/GB1991/001392 WO1992003423A1 (en) 1990-08-15 1991-08-15 Benzimidazole derivatives, process for their preparation and application

Publications (2)

Publication Number Publication Date
DE69132497D1 true DE69132497D1 (de) 2001-01-25
DE69132497T2 DE69132497T2 (de) 2001-06-13

Family

ID=27265233

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132497T Expired - Fee Related DE69132497T2 (de) 1990-08-15 1991-08-15 Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung

Country Status (18)

Country Link
US (1) US5180723A (de)
EP (1) EP0543858B1 (de)
JP (2) JP2976004B2 (de)
KR (1) KR0185959B1 (de)
AT (1) ATE198197T1 (de)
AU (2) AU655595B2 (de)
CA (1) CA2088761C (de)
DE (1) DE69132497T2 (de)
ES (1) ES2153820T3 (de)
FI (1) FI103409B1 (de)
GR (1) GR3035511T3 (de)
HK (1) HK1012336A1 (de)
HU (1) HUT67289A (de)
IE (1) IE70217B1 (de)
NO (2) NO301228B1 (de)
NZ (1) NZ239409A (de)
PT (1) PT98673B (de)
WO (1) WO1992003423A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides
PT98674B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9200209D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9201755D0 (en) * 1992-01-28 1992-03-11 British Bio Technology Compounds
GB9202791D0 (en) * 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4206042A1 (de) * 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazopyridine
DE4327256A1 (de) * 1993-08-13 1995-02-16 Bayer Ag Sulfonylbenzyl-substituierte Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
GB9323162D0 (en) * 1993-11-10 1994-01-05 British Bio Technology 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
GB2298138B (en) * 1993-11-10 1997-07-09 British Biotech Pharm 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists
EP0775134A4 (de) 1994-08-04 1997-08-13 Synaptic Pharma Corp Neue benzimidazolderivate
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
ES2106682B1 (es) * 1995-09-08 1998-07-01 Uriach & Cia Sa J Nuevos derivados azo del acido 5-aminosalicilico.
ES2104513B1 (es) * 1995-10-11 1998-07-01 Uriach & Cia Sa J Nuevos derivados del acido 5-aminosalicilico.
DK0790998T3 (da) * 1995-09-08 2001-02-05 Uriach & Cia Sa J Azo-derivater af 5-aminosalicylsyre til behandling af inflammatorisk tarmsygdom
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US6858630B2 (en) 1999-12-06 2005-02-22 Smithkline Beecham Corporation Naphthimidazole derivatives and their use as thrombopoietin mimetics
AU2079901A (en) * 1999-12-06 2001-06-12 Smithkline Beecham Corporation Thrombopoietin mimetics
ES2165803B1 (es) 2000-04-10 2003-09-16 Uriach & Cia Sa J Nueva sal de un derivado azo del acido 5-aminosalicilico
CN1571765B (zh) * 2001-10-17 2012-09-26 克洛达股份有限公司 芳香族烷氧基化醇和脂肪族羧酸的酯
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US7829589B2 (en) * 2005-06-10 2010-11-09 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
EP1893569A4 (de) * 2005-06-10 2009-08-05 Elixir Pharmaceuticals Inc Sulfonamidverbindungen und ihre verwendungen
RU2453312C1 (ru) * 2010-11-10 2012-06-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее антиагрегантную и антитромбогенную активности
CA2856642C (en) * 2011-11-23 2019-09-17 Cell Therapy Limited Platelet lysate gel
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6715600A (de) * 1966-12-02 1968-06-04
US4612323A (en) * 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
US5157026A (en) * 1989-05-30 1992-10-20 Merck & Co., Inc. Oxo-purines as angiotensin II antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
PT98674B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides

Also Published As

Publication number Publication date
EP0543858B1 (de) 2000-12-20
GR3035511T3 (en) 2001-06-29
JPH06500316A (ja) 1994-01-13
AU655595B2 (en) 1995-01-05
US5180723A (en) 1993-01-19
EP0543858A1 (de) 1993-06-02
FI930634A (fi) 1993-04-05
NO930498D0 (no) 1993-02-12
NO972615D0 (no) 1997-06-06
HU9300389D0 (en) 1993-04-28
PT98673A (pt) 1992-07-31
NO301228B1 (no) 1997-09-29
AU8426891A (en) 1992-03-17
JP2976004B2 (ja) 1999-11-10
NO972615L (no) 1997-06-06
HUT67289A (en) 1995-03-28
AU5309094A (en) 1994-03-17
NO930498L (no) 1993-04-14
PT98673B (pt) 1999-01-29
ATE198197T1 (de) 2001-01-15
FI103409B (fi) 1999-06-30
HK1012336A1 (en) 1999-07-30
AU658337B2 (en) 1995-04-06
DE69132497T2 (de) 2001-06-13
NZ239409A (en) 1994-05-26
IE70217B1 (en) 1996-10-30
KR930701413A (ko) 1993-06-11
KR0185959B1 (en) 1999-05-01
FI103409B1 (fi) 1999-06-30
ES2153820T3 (es) 2001-03-16
JPH11315070A (ja) 1999-11-16
CA2088761C (en) 1999-11-16
JP3120075B2 (ja) 2000-12-25
CA2088761A1 (en) 1992-02-16
FI930634A0 (fi) 1993-02-12
IE912875A1 (en) 1992-02-26
WO1992003423A1 (en) 1992-03-05

Similar Documents

Publication Publication Date Title
DE69132497D1 (de) Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung
ATE172195T1 (de) Imidazopyridinderivate, verfahren zu deren herstellung und deren anwendung
DE69201948D1 (de) Verwendung von 1,3-oxathiolanalogen von nukleosiden zur herstellung eines arzneimittels zur behandlung von hepatitis-b.
NO933200L (no) Substituerte cykloheksanderivater, fremgangsmåte til fremstilling derav og anvendelsen av forbindelsene til behandling av sykdommer
HUT57763A (en) Process for producing 2,9-disubstituted-4h-pyrido(1,2-a)pyrimidine-4-one derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DE68904586D1 (de) Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung.
ATE126228T1 (de) Antihistaminische und nicht sedierende benzimidazolderivate, verfahren zu deren herstellung und deren anwendung als arzneimittel.
DK132188A (da) Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika
ATE131822T1 (de) Benzimidazolderivate, verfahren zu deren herstellung und deren anwendung als arzneimittel
DE3769563D1 (de) Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung.
ATE365162T1 (de) Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
DE69112432D1 (de) Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung.
ATE22557T1 (de) Bicyclo(4.2.0)oktatriene-1,3,5 derivate, verfahren zu deren herstellung und deren therapeutische anwendung.
DE69619088D1 (de) Quinoxalin-Derivate zur Behandlung von Tinnitus
DE68907857D1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ZA923502B (en) 1-amidoocthydropyrido[2,1-c][1,4]oxazine compounds, processes for preparing these and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee