FI930634A - Benzimidazolderivat, foerfarande foer framstaellning daerav och deras anvaendning - Google Patents

Benzimidazolderivat, foerfarande foer framstaellning daerav och deras anvaendning Download PDF

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Publication number
FI930634A
FI930634A FI930634A FI930634A FI930634A FI 930634 A FI930634 A FI 930634A FI 930634 A FI930634 A FI 930634A FI 930634 A FI930634 A FI 930634A FI 930634 A FI930634 A FI 930634A
Authority
FI
Finland
Prior art keywords
benzimidazolderivat
foerfarande foer
foer framstaellning
och deras
deras anvaendning
Prior art date
Application number
FI930634A
Other languages
English (en)
Other versions
FI103409B (fi
FI103409B1 (fi
FI930634A0 (fi
Inventor
Mark Whittaker
Andrew Miller
Stephen Arthur Bowles
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909017878A external-priority patent/GB9017878D0/en
Priority claimed from GB909018040A external-priority patent/GB9018040D0/en
Priority claimed from GB919112214A external-priority patent/GB9112214D0/en
Application filed by British Bio Technology filed Critical British Bio Technology
Publication of FI930634A0 publication Critical patent/FI930634A0/fi
Publication of FI930634A publication Critical patent/FI930634A/fi
Application granted granted Critical
Publication of FI103409B publication Critical patent/FI103409B/fi
Publication of FI103409B1 publication Critical patent/FI103409B1/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI930634A 1990-08-15 1993-02-12 Menetelmä farmaseuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi FI103409B1 (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9017878 1990-08-15
GB909017878A GB9017878D0 (en) 1990-08-15 1990-08-15 Compounds
GB9018040 1990-08-16
GB909018040A GB9018040D0 (en) 1990-08-16 1990-08-16 Compounds
GB9112214 1991-06-06
GB919112214A GB9112214D0 (en) 1991-06-06 1991-06-06 Compounds
GB9101392 1991-08-15
PCT/GB1991/001392 WO1992003423A1 (en) 1990-08-15 1991-08-15 Benzimidazole derivatives, process for their preparation and application

Publications (4)

Publication Number Publication Date
FI930634A0 FI930634A0 (fi) 1993-02-12
FI930634A true FI930634A (fi) 1993-04-05
FI103409B FI103409B (fi) 1999-06-30
FI103409B1 FI103409B1 (fi) 1999-06-30

Family

ID=27265233

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930634A FI103409B1 (fi) 1990-08-15 1993-02-12 Menetelmä farmaseuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi

Country Status (18)

Country Link
US (1) US5180723A (fi)
EP (1) EP0543858B1 (fi)
JP (2) JP2976004B2 (fi)
KR (1) KR0185959B1 (fi)
AT (1) ATE198197T1 (fi)
AU (2) AU655595B2 (fi)
CA (1) CA2088761C (fi)
DE (1) DE69132497T2 (fi)
ES (1) ES2153820T3 (fi)
FI (1) FI103409B1 (fi)
GR (1) GR3035511T3 (fi)
HK (1) HK1012336A1 (fi)
HU (1) HUT67289A (fi)
IE (1) IE70217B1 (fi)
NO (2) NO301228B1 (fi)
NZ (1) NZ239409A (fi)
PT (1) PT98673B (fi)
WO (1) WO1992003423A1 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides
PT98674B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9200209D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9201755D0 (en) * 1992-01-28 1992-03-11 British Bio Technology Compounds
GB9202791D0 (en) * 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4206042A1 (de) * 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazopyridine
DE4327256A1 (de) * 1993-08-13 1995-02-16 Bayer Ag Sulfonylbenzyl-substituierte Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
GB9323162D0 (en) * 1993-11-10 1994-01-05 British Bio Technology 4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
GB2298138B (en) * 1993-11-10 1997-07-09 British Biotech Pharm 4-(1h-2-methylimidazo 4,5-c pyridinylmethyl)phenyl sulphonamide carboxylic acid derivatives as antagonists
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
ES2106682B1 (es) * 1995-09-08 1998-07-01 Uriach & Cia Sa J Nuevos derivados azo del acido 5-aminosalicilico.
ES2104513B1 (es) * 1995-10-11 1998-07-01 Uriach & Cia Sa J Nuevos derivados del acido 5-aminosalicilico.
DK0790998T3 (da) * 1995-09-08 2001-02-05 Uriach & Cia Sa J Azo-derivater af 5-aminosalicylsyre til behandling af inflammatorisk tarmsygdom
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US6858630B2 (en) 1999-12-06 2005-02-22 Smithkline Beecham Corporation Naphthimidazole derivatives and their use as thrombopoietin mimetics
AU2079901A (en) * 1999-12-06 2001-06-12 Smithkline Beecham Corporation Thrombopoietin mimetics
ES2165803B1 (es) 2000-04-10 2003-09-16 Uriach & Cia Sa J Nueva sal de un derivado azo del acido 5-aminosalicilico
CN1571765B (zh) * 2001-10-17 2012-09-26 克洛达股份有限公司 芳香族烷氧基化醇和脂肪族羧酸的酯
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US7829589B2 (en) * 2005-06-10 2010-11-09 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
EP1893569A4 (en) * 2005-06-10 2009-08-05 Elixir Pharmaceuticals Inc SULPHONAMIDE COMPOUNDS AND ITS USES
RU2453312C1 (ru) * 2010-11-10 2012-06-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее антиагрегантную и антитромбогенную активности
CA2856642C (en) * 2011-11-23 2019-09-17 Cell Therapy Limited Platelet lysate gel
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6715600A (fi) * 1966-12-02 1968-06-04
US4612323A (en) * 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
US4914108A (en) * 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
US5157026A (en) * 1989-05-30 1992-10-20 Merck & Co., Inc. Oxo-purines as angiotensin II antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
PT98674B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides

Also Published As

Publication number Publication date
EP0543858B1 (en) 2000-12-20
GR3035511T3 (en) 2001-06-29
JPH06500316A (ja) 1994-01-13
AU655595B2 (en) 1995-01-05
US5180723A (en) 1993-01-19
EP0543858A1 (en) 1993-06-02
NO930498D0 (no) 1993-02-12
NO972615D0 (no) 1997-06-06
HU9300389D0 (en) 1993-04-28
PT98673A (pt) 1992-07-31
NO301228B1 (no) 1997-09-29
AU8426891A (en) 1992-03-17
JP2976004B2 (ja) 1999-11-10
NO972615L (no) 1997-06-06
HUT67289A (en) 1995-03-28
AU5309094A (en) 1994-03-17
NO930498L (no) 1993-04-14
DE69132497D1 (de) 2001-01-25
PT98673B (pt) 1999-01-29
ATE198197T1 (de) 2001-01-15
FI103409B (fi) 1999-06-30
HK1012336A1 (en) 1999-07-30
AU658337B2 (en) 1995-04-06
DE69132497T2 (de) 2001-06-13
NZ239409A (en) 1994-05-26
IE70217B1 (en) 1996-10-30
KR930701413A (ko) 1993-06-11
KR0185959B1 (en) 1999-05-01
FI103409B1 (fi) 1999-06-30
ES2153820T3 (es) 2001-03-16
JPH11315070A (ja) 1999-11-16
CA2088761C (en) 1999-11-16
JP3120075B2 (ja) 2000-12-25
CA2088761A1 (en) 1992-02-16
FI930634A0 (fi) 1993-02-12
IE912875A1 (en) 1992-02-26
WO1992003423A1 (en) 1992-03-05

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HC Name/ company changed in application

Owner name: BRITISH BIOTECH PHARMACEUTICALS LIMITED

MA Patent expired