DE69132370D1 - Methode zur herstellung von eicosapentansäuren - Google Patents
Methode zur herstellung von eicosapentansäurenInfo
- Publication number
- DE69132370D1 DE69132370D1 DE69132370T DE69132370T DE69132370D1 DE 69132370 D1 DE69132370 D1 DE 69132370D1 DE 69132370 T DE69132370 T DE 69132370T DE 69132370 T DE69132370 T DE 69132370T DE 69132370 D1 DE69132370 D1 DE 69132370D1
- Authority
- DE
- Germany
- Prior art keywords
- diatoms
- epa
- pct
- depletion
- silicate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 241000206761 Bacillariophyta Species 0.000 abstract 4
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 4
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 4
- 239000008157 edible vegetable oil Substances 0.000 abstract 3
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Birds (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/496,572 US5244921A (en) | 1990-03-21 | 1990-03-21 | Eicosapentaenoic acids and methods for their production |
PCT/US1991/002052 WO1991014427A1 (en) | 1990-03-21 | 1991-03-20 | Eicosapentaenoic acids and methods for their production |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69132370D1 true DE69132370D1 (de) | 2000-09-21 |
DE69132370T2 DE69132370T2 (de) | 2001-03-29 |
Family
ID=23973229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132370T Expired - Fee Related DE69132370T2 (de) | 1990-03-21 | 1991-03-20 | Methode zur herstellung von eicosapentansäuren |
Country Status (7)
Country | Link |
---|---|
US (2) | US5244921A (de) |
EP (1) | EP0521104B1 (de) |
JP (1) | JPH05505726A (de) |
AT (1) | ATE195420T1 (de) |
CA (1) | CA2078664A1 (de) |
DE (1) | DE69132370T2 (de) |
WO (1) | WO1991014427A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060094089A1 (en) * | 1988-09-07 | 2006-05-04 | Martek Biosciences Corporation | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
US6451567B1 (en) | 1988-09-07 | 2002-09-17 | Omegatech, Inc. | Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms |
US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
US5985348A (en) * | 1995-06-07 | 1999-11-16 | Omegatech, Inc. | Milk products having high concentrations of omega-3 highly unsaturated fatty acids |
EP1787532A3 (de) | 1991-01-24 | 2010-03-31 | Martek Biosciences Corporation | Gemische von mikrobiellen Ölen und deren Verwendungen |
US6410281B1 (en) | 1992-07-10 | 2002-06-25 | Omegatech, Inc. | Reducing corrosion in a fermentor by providing sodium with a non-chloride sodium salt |
US6255505B1 (en) | 1996-03-28 | 2001-07-03 | Gist-Brocades, B.V. | Microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
JP3096654B2 (ja) * | 1997-04-01 | 2000-10-10 | クロレラ工業株式会社 | 高度不飽和脂肪酸含有クロレラの製造方法 |
JP4623829B2 (ja) * | 1998-08-18 | 2011-02-02 | メタボリックス,インコーポレイテッド | トランスジェニック微生物のポリヒドロキシアルカノエート産生 |
US6166231A (en) * | 1998-12-15 | 2000-12-26 | Martek Biosciences Corporation | Two phase extraction of oil from biomass |
GB9916537D0 (en) | 1999-07-14 | 1999-09-15 | Univ Hull | Culture of microorganisms for the synthesis of a polyunsaturated fatty acid |
HUP0301794A3 (en) * | 2000-01-28 | 2011-04-28 | Martek Biosciences Corp | Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors |
EP1276885B1 (de) * | 2000-04-21 | 2007-09-12 | Martek Biosciences Corporation | Trophische umwandlung von obligat phototropischen algen durch metabolische manipulation |
EP1780283A1 (de) | 2000-04-21 | 2007-05-02 | Martek Biosciences Corporation | Trophische Umwandlung von obligat phototropischen Algen durch metabolische Manipulation |
GB2377455A (en) * | 2001-02-09 | 2003-01-15 | Univ Hull | Method of culturing crypthecodinium cohnii |
FR2822701B1 (fr) * | 2001-04-03 | 2005-03-18 | Lvmh Rech | Utilisation d'un extrait d'algue phaeodactylum comme agent cosmetique favorisant l'activite du proteasome des cellules de la peau et composition cosmetique le contenant |
GB0113348D0 (en) * | 2001-06-01 | 2001-07-25 | Mars Uk Ltd | Skin diet |
EP1304029A1 (de) | 2001-10-19 | 2003-04-23 | Dsm N.V. | Polyungesättigte Fettsäuren in Eier |
ES2712854T3 (es) | 2002-06-19 | 2019-05-16 | Dsm Ip Assets Bv | Aceite microbiano y procedimientos para su procesamiento |
CA2395622A1 (fr) * | 2002-07-22 | 2004-01-22 | Edwin Bourget | Procede d'enrichissement en lipides et en acides gras omega-3 dans les cultures d'algues |
GB0301701D0 (en) * | 2003-01-24 | 2003-02-26 | Ensay Ltd | Psoriasis and Eicosapentaenoic acid |
US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
WO2005021735A1 (en) * | 2003-09-01 | 2005-03-10 | Novozymes A/S | Method for increasing yield of biomass of and/or components of biomass from marine microorganisms |
US20100021555A1 (en) * | 2004-10-15 | 2010-01-28 | Karl Geiringer | Compositions containing high omega-3 and low saturated fatty acid levels |
US7198937B2 (en) * | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
US7588931B2 (en) | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
US8685679B2 (en) * | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
EP1899453B1 (de) | 2005-06-07 | 2013-12-18 | Ocean Nutrition Canada Limited | Eukaryotische mikroorganismen zur herstellung von lipiden und antioxidantien |
GB0604647D0 (en) | 2006-03-08 | 2006-04-19 | Shchepinov Mikhail | Stabilized food supplements and their derivatives |
JP5242949B2 (ja) * | 2006-05-31 | 2013-07-24 | 独立行政法人水産総合研究センター | 藻類へのケイ酸成分供給方法 |
US8877465B2 (en) | 2006-07-05 | 2014-11-04 | Photonz Corporation Limited | Production of ultrapure EPA and polar lipids from largely heterotrophic culture |
WO2008004088A2 (en) * | 2006-07-05 | 2008-01-10 | Centre National De La Recherche Scientifique (C.N.R.S.) | Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding |
US9023616B2 (en) | 2006-08-01 | 2015-05-05 | Dsm Nutritional Products Ag | Oil producing microbes and method of modification thereof |
WO2008036654A2 (en) * | 2006-09-18 | 2008-03-27 | The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Algal medium chain length fatty acids and hydrocarbons |
WO2008060571A2 (en) * | 2006-11-13 | 2008-05-22 | Aurora Biofuels, Inc. | Methods and compositions for production and purification of biofuel from plants and microalgae |
US8221743B2 (en) | 2006-12-22 | 2012-07-17 | Novozymes A/S | Use of polypeptides against diseases caused by protozoans |
WO2009046231A1 (en) | 2007-10-03 | 2009-04-09 | E. I. Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
US8343753B2 (en) * | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
US20100303989A1 (en) | 2008-10-14 | 2010-12-02 | Solazyme, Inc. | Microalgal Flour |
US8207363B2 (en) * | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
PT2418270E (pt) | 2009-04-10 | 2014-08-06 | Electric Power Dev Co | Microalga pertencente ao género navicula, processo para a produção de óleo através da cultura da microalga e óleo colhido a partir da microalga |
JP5636039B2 (ja) * | 2009-04-14 | 2014-12-03 | ソラザイム、インクSolazyme Inc | 新規微細藻類食物組成物 |
US8865452B2 (en) * | 2009-06-15 | 2014-10-21 | Aurora Algae, Inc. | Systems and methods for extracting lipids from wet algal biomass |
US9101942B2 (en) * | 2009-06-16 | 2015-08-11 | Aurora Algae, Inc. | Clarification of suspensions |
US8747930B2 (en) * | 2009-06-29 | 2014-06-10 | Aurora Algae, Inc. | Siliceous particles |
US8765983B2 (en) * | 2009-10-30 | 2014-07-01 | Aurora Algae, Inc. | Systems and methods for extracting lipids from and dehydrating wet algal biomass |
JP5920890B2 (ja) | 2010-01-19 | 2016-05-18 | ディーエスエム アイピー アセッツ ビー.ブイ. | エイコサペンタエン酸生成微生物、脂肪酸組成物、ならびにそれらを作る方法およびそれらの使用 |
ES2784774T3 (es) * | 2010-04-14 | 2020-09-30 | Corbion Biotech Inc | Composiciones alimenticias de harina de microalgas ricas en lípidos |
CN103282474A (zh) | 2010-04-22 | 2013-09-04 | 纳幕尔杜邦公司 | 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法 |
US8769868B2 (en) | 2010-06-09 | 2014-07-08 | Photonz Corporation Limited | Compositions comprising eicosapentaenoic acid suitable for high purification |
MY163938A (en) | 2010-06-14 | 2017-11-15 | Io-Mega Holding Corp | Method for the production of algae derived oils |
US20120040076A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
WO2012021703A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | A sustainable aquaculture feeding strategy |
CA2805882A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Dupont De Nemours And Company | Improved aquaculture meat products |
AU2011293180B2 (en) | 2010-08-26 | 2017-03-02 | E. I. Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
NZ588781A (en) * | 2010-10-22 | 2013-08-30 | Photonz Corp Ltd | Method of provision of silicate to culture media |
US8926844B2 (en) | 2011-03-29 | 2015-01-06 | Aurora Algae, Inc. | Systems and methods for processing algae cultivation fluid |
US8569530B2 (en) | 2011-04-01 | 2013-10-29 | Aurora Algae, Inc. | Conversion of saponifiable lipids into fatty esters |
JP2014513964A (ja) | 2011-05-06 | 2014-06-19 | ソラザイム、インク | キシロースを代謝する遺伝子操作微生物 |
US9222112B2 (en) | 2011-07-21 | 2015-12-29 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
WO2014105576A1 (en) | 2012-12-24 | 2014-07-03 | Qualitas Health, Ltd. | Eicosapentaenoic acid (epa) formulations |
US10098371B2 (en) | 2013-01-28 | 2018-10-16 | Solazyme Roquette Nutritionals, LLC | Microalgal flour |
JP6300220B2 (ja) * | 2013-03-04 | 2018-03-28 | 国立大学法人山口大学 | 微細藻類を用いた脂質の製造方法 |
PT2970926T (pt) | 2013-03-13 | 2018-03-22 | Dsm Nutritional Products Ag | Modificação genética de microrganismos |
US9266973B2 (en) | 2013-03-15 | 2016-02-23 | Aurora Algae, Inc. | Systems and methods for utilizing and recovering chitosan to process biological material |
EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
US9879218B2 (en) | 2013-08-01 | 2018-01-30 | Fermentalg | Methods for the production of diatom biomass |
FR3009619B1 (fr) | 2013-08-07 | 2017-12-29 | Roquette Freres | Compositions de biomasse de microalgues riches en proteines de qualite sensorielle optimisee |
EP3200604B1 (de) | 2014-10-02 | 2021-11-03 | Evonik Operations GmbH | Verfahren zur herstellung eines futtermittels |
CA2958457C (en) | 2014-10-02 | 2022-10-25 | Evonik Industries Ag | Process for producing a pufa-containing biomass which has high cell stability |
CN106793803B (zh) | 2014-10-02 | 2021-03-09 | 赢创运营有限公司 | 通过挤压含pufa的生物质来制备含pufa的饲料的方法 |
US11464244B2 (en) | 2014-10-02 | 2022-10-11 | Evonik Operations Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
AR104042A1 (es) | 2015-03-26 | 2017-06-21 | Mara Renewables Corp | Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto |
CN107849514A (zh) | 2015-07-13 | 2018-03-27 | 玛拉可再生能源公司 | 增强木糖的微藻代谢 |
JP6625370B2 (ja) * | 2015-08-24 | 2019-12-25 | 岡山県 | 藻類の培養密度を向上させるための組成物およびその利用 |
US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
RU2661116C1 (ru) * | 2017-12-13 | 2018-07-11 | Общество с ограниченной ответственностью "СОЛИКСАНТ" | Штамм одноклеточной микроводоросли Eustigmatos magnus - продуцент эйкозапентаеновой кислоты |
NO20201076A1 (en) | 2020-10-01 | 2022-04-04 | Finnfjord As | Process for cultivation of diatoms |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2725677A (en) * | 1952-01-16 | 1955-12-06 | Carnegie Inst Of Washington | Method of effectuating high density mass culture of algae or other microorganisms |
US4670285A (en) * | 1982-08-06 | 1987-06-02 | The University Of Toronto Innovations Foundation | Infant formula |
JPS5946225A (ja) * | 1982-09-09 | 1984-03-15 | Kogyo Kaihatsu Kenkyusho | 抗動脈硬化剤の製造方法 |
JPS6034156A (ja) * | 1983-08-08 | 1985-02-21 | Hayashibara Biochem Lab Inc | エイコサペンタエン酸包接化合物及びこれを含有した飲食物 |
JPS60133094A (ja) * | 1983-12-21 | 1985-07-16 | 日清製油株式会社 | 高純度エイコサペンタエン酸の製造法 |
JPS63185390A (ja) * | 1987-01-27 | 1988-07-30 | Suntory Ltd | 藻類によるエイコサペンタエン酸の製造方法 |
AU2122688A (en) * | 1987-07-20 | 1989-02-13 | Maricultura, Incorporated | Microorganism production of omega-3 (n-3) lipids |
-
1990
- 1990-03-21 US US07/496,572 patent/US5244921A/en not_active Expired - Lifetime
-
1991
- 1991-03-20 US US07/934,485 patent/US5567732A/en not_active Expired - Lifetime
- 1991-03-20 WO PCT/US1991/002052 patent/WO1991014427A1/en active IP Right Grant
- 1991-03-20 EP EP91907423A patent/EP0521104B1/de not_active Expired - Lifetime
- 1991-03-20 CA CA002078664A patent/CA2078664A1/en not_active Abandoned
- 1991-03-20 JP JP91507375A patent/JPH05505726A/ja active Pending
- 1991-03-20 DE DE69132370T patent/DE69132370T2/de not_active Expired - Fee Related
- 1991-03-20 AT AT91907423T patent/ATE195420T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2078664A1 (en) | 1991-09-22 |
WO1991014427A1 (en) | 1991-10-03 |
EP0521104A1 (de) | 1993-01-07 |
US5567732A (en) | 1996-10-22 |
ATE195420T1 (de) | 2000-09-15 |
EP0521104B1 (de) | 2000-08-16 |
US5244921A (en) | 1993-09-14 |
JPH05505726A (ja) | 1993-08-26 |
EP0521104A4 (en) | 1993-03-24 |
DE69132370T2 (de) | 2001-03-29 |
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