DE69131589D1 - Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung - Google Patents

Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung

Info

Publication number
DE69131589D1
DE69131589D1 DE69131589T DE69131589T DE69131589D1 DE 69131589 D1 DE69131589 D1 DE 69131589D1 DE 69131589 T DE69131589 T DE 69131589T DE 69131589 T DE69131589 T DE 69131589T DE 69131589 D1 DE69131589 D1 DE 69131589D1
Authority
DE
Germany
Prior art keywords
ribosome
processes
production
inactivating proteins
precursor forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131589T
Other languages
English (en)
Other versions
DE69131589T2 (de
Inventor
Terence A Walsh
Timothy D Hey
Alice E R Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
Dow AgroSciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow AgroSciences LLC filed Critical Dow AgroSciences LLC
Publication of DE69131589D1 publication Critical patent/DE69131589D1/de
Application granted granted Critical
Publication of DE69131589T2 publication Critical patent/DE69131589T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DE69131589T 1990-06-11 1991-06-10 Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung Expired - Lifetime DE69131589T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/535,636 US5248606A (en) 1990-06-11 1990-06-11 Dna encoding inactive precursor and active forms of maize ribosome inactivating protein

Publications (2)

Publication Number Publication Date
DE69131589D1 true DE69131589D1 (de) 1999-10-14
DE69131589T2 DE69131589T2 (de) 2000-05-04

Family

ID=24135102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131589T Expired - Lifetime DE69131589T2 (de) 1990-06-11 1991-06-10 Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung

Country Status (10)

Country Link
US (1) US5248606A (de)
EP (1) EP0466222B1 (de)
JP (1) JPH04279599A (de)
CN (1) CN1062172A (de)
AT (1) ATE184289T1 (de)
AU (1) AU638133B2 (de)
BR (1) BR9102418A (de)
CA (1) CA2044201A1 (de)
DE (1) DE69131589T2 (de)
HU (1) HUT58800A (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672683A (en) * 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US5635384A (en) * 1990-06-11 1997-06-03 Dowelanco Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
DE4040954C2 (de) * 1990-12-20 2001-05-17 Max Planck Gesellschaft Verfahren zur Erzeugung von pathogen-resistenten Pflanzen
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
RU2126794C1 (ru) * 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
GB9304905D0 (en) * 1992-03-16 1993-04-28 Zeneca Ltd Processes
WO1993025688A1 (en) * 1992-06-16 1993-12-23 Whittier Institute For Diabetes And Endocrinology Recombinant production of saporin-containing proteins
US5332808A (en) * 1992-09-08 1994-07-26 North Carolina State University DNA encoding a ribosome inactivating protein
KR970001565B1 (ko) * 1993-08-28 1997-02-11 장기하 섬자리공 항바이러스성 단백질(pip) 유전자 및 이를 발현하는 미생물
EG23907A (en) * 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
JPH0856655A (ja) * 1994-08-16 1996-03-05 Frontier:Kk 細胞致死剤および細胞死抑制剤
CA2252799C (en) * 1996-04-30 2008-09-16 De Novo Enzyme Corporation Antiviral ricin-like proteins
US7060789B1 (en) 1999-10-04 2006-06-13 Twinstrand Therapeutics Inc. Ricin-like toxins for treatment of cancer
US7247715B2 (en) 1997-04-30 2007-07-24 Twinstrand Therapeutics Inc. Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
CA2288943C (en) 1997-04-30 2011-02-01 De Novo Enzyme Corporation Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
EP0948347A4 (de) * 1997-07-16 2000-08-30 Sophie Chen Anti-virale und anti-tumor wirkstoffe
WO2000039291A1 (en) * 1998-12-31 2000-07-06 Rutgers, The State University Virus-resistant transgenic plants expressing l3
US6531125B1 (en) 1999-03-02 2003-03-11 Twinstrand Therapeutics Inc. Antiviral ricin-like proteins
AU2006201828B2 (en) * 2000-10-14 2009-07-16 British American Tobacco (Investments) Limited Plant cell death system
GB0025225D0 (en) * 2000-10-14 2000-11-29 Cambridge Advanced Tech Plant cell death system
US7629309B2 (en) 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US7560424B2 (en) 2001-04-30 2009-07-14 Zystor Therapeutics, Inc. Targeted therapeutic proteins
US20050191626A1 (en) * 2001-05-11 2005-09-01 Kazunari Taira Method for forming a stable complex comprising a transcription product and translation product of a dna encoding a desired polypeptide, a nucleic acid construct used for the method, a complex formed by the method, and screening of a functional protein and mrna or dna encoding the protein using the method
US20030072761A1 (en) 2001-10-16 2003-04-17 Lebowitz Jonathan Methods and compositions for targeting proteins across the blood brain barrier
JP4914224B2 (ja) 2004-02-10 2012-04-11 バイオマリン ファーマシューティカル インコーポレイテッド 酸性αグルコシダーゼおよびそのフラグメント
EP3778652A1 (de) 2008-05-07 2021-02-17 BioMarin Pharmaceutical Inc. Auf lysosomen gerichtete peptide und verwendungen davon
EP3075386B1 (de) 2009-06-17 2019-10-16 BioMarin Pharmaceutical Inc. Formulierungen für lysosomale enzyme
CN102234638B (zh) * 2010-04-27 2013-03-27 香港中文大学 修饰的玉米核糖体失活蛋白前体及其应用和蛋白纯化方法
CN110455903A (zh) * 2018-05-07 2019-11-15 天士力生物医药股份有限公司 一种注射用重组人尿激酶原杂质分析的梯度电泳检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE68703T1 (de) * 1984-02-08 1991-11-15 Cetus Corp Toxinkonjugate.
AU609380B2 (en) * 1985-11-29 1991-05-02 Consolidated Pharmaceuticals Limited Ricin-antibody conjugates
FR2601679B1 (fr) * 1986-07-15 1990-05-25 Sanofi Sa Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant
DE3724323C2 (de) * 1986-07-29 1995-07-20 Erba Farmitalia Ein neuer Inhibitor für die Proteinsynthese
US4869903A (en) * 1987-05-29 1989-09-26 Genelabs Incorporated Method of selectively inhibiting HIV
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IT1229216B (it) * 1989-03-31 1991-07-25 Italfarmaco Spa Proteine inibenti i ribosomi e loro derivati.
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins

Also Published As

Publication number Publication date
JPH04279599A (ja) 1992-10-05
CN1062172A (zh) 1992-06-24
HU911944D0 (en) 1991-12-30
US5248606A (en) 1993-09-28
EP0466222A1 (de) 1992-01-15
EP0466222B1 (de) 1999-09-08
BR9102418A (pt) 1992-01-14
AU7832991A (en) 1991-12-12
ATE184289T1 (de) 1999-09-15
AU638133B2 (en) 1993-06-17
HUT58800A (en) 1992-03-30
DE69131589T2 (de) 2000-05-04
CA2044201A1 (en) 1991-12-12

Similar Documents

Publication Publication Date Title
DE69131589D1 (de) Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung
DE3888274D1 (de) Vorrichtung zur intensiven und kontrollierten Herstellung von Mikroorganismen durch Photosynthese.
FI103278B1 (fi) Menetelmä biologisesti aktiivisen TGF- :n kaltaisen proteiinin tuottamiseksi
DE3769174D1 (de) Indolizin-derivate, verfahren zur herstellung und diese enthaltende zusammensetzungen.
DE60133802D1 (de) Verwendung von säurestabilen proteasen in tierfutter
DE69717356T2 (de) Verfahren zur Herstellung von Heteroübergang-Bipolartransistoren mit hoher Verstärkung
DE3863170D1 (de) Mesophasenpech zur herstellung von kohlenstoffkoerpern und verfahren zur herstellung derselben.
DE69406559T2 (de) Integriertes Verfahren zur Herstellung von Brenngas und Sauerstoff enthaltenden organischen Produkten
DE60029589D1 (de) Verfahren zur herstellung von azithromycin
ATE309369T1 (de) Heterologe herstellung von polyketiden
DE68907447D1 (de) Geblasene, einstueckige flasche und verfahren zur herstellung derselben.
DE122011100046I1 (de) In vitro kulturprozess fur verschiedene stadien von gewebeparasiten.
DE69131657T2 (de) Verfahren zur industriellen Herstellung von 4-Chloro-3-sulfamoyl-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-Benzamid
DE68919282T2 (de) Verfahren zur Herstellung von Cephalosporin und Zwischenverbindungen.
DE59207095D1 (de) Verfahren zur Herstellung von aktiviertem Protein C
DE60220658D1 (de) Verfahren zur produktion von 2,6-dihalogenopurinen
DE69313297D1 (de) Benzofuranone, benzodifurantrione und verfahren zur herstellung von benzodifurandionen
ATE86984T1 (de) Verfahren zur herstellung von 5,6-substituierten- 2,4-chinazolindiaminen und zwischenprodukten.
DE578388T1 (de) Verfahren zur fermentativen Herstellung von 10-Hydroxy-C18-Carbonsäure und Gamma-Dodekalaktonderivaten.
DE69908288D1 (de) Verfahren zur Herstellung von UCN-01
ATE259772T1 (de) Verfahren zum herstellen von trimethylhydroquinondiacetat und trimethylhydroquinon
DE59905165D1 (de) Verfahren zur Herstellung von Orthoestern
ATE85893T1 (de) Verwendung von somatostatin zur herstellung eines arzneimittels fuer die behandlung von rheumatoider arthritis.
DE59008852D1 (de) Verfahren zur Herstellung von 2-Acylamino-9-acyl-6-halogen-purinen.
DE69002841D1 (de) Verfahren und Anlage zur Herstellung von Kohlenoxyd.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition