DE69127791T2 - Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten - Google Patents

Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten

Info

Publication number
DE69127791T2
DE69127791T2 DE69127791T DE69127791T DE69127791T2 DE 69127791 T2 DE69127791 T2 DE 69127791T2 DE 69127791 T DE69127791 T DE 69127791T DE 69127791 T DE69127791 T DE 69127791T DE 69127791 T2 DE69127791 T2 DE 69127791T2
Authority
DE
Germany
Prior art keywords
compound
formula
pharmaceutically acceptable
acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127791T
Other languages
German (de)
English (en)
Other versions
DE69127791D1 (de
Inventor
Koichiro Hagihara
Toru Hayakawa
Haruhiko Kikuchi
Setsuko Mino
Hiroaki Satoh
Nobuhiro Yahata
Makoto Yanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Pharma Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Application granted granted Critical
Publication of DE69127791D1 publication Critical patent/DE69127791D1/de
Publication of DE69127791T2 publication Critical patent/DE69127791T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69127791T 1990-07-31 1991-07-24 Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten Expired - Lifetime DE69127791T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP20145390 1990-07-31
JP29200090 1990-10-31
JP41854990 1990-12-28
JP8447391 1991-03-26

Publications (2)

Publication Number Publication Date
DE69127791D1 DE69127791D1 (de) 1997-11-06
DE69127791T2 true DE69127791T2 (de) 1998-02-05

Family

ID=27466980

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127791T Expired - Lifetime DE69127791T2 (de) 1990-07-31 1991-07-24 Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten

Country Status (8)

Country Link
US (1) US5187166A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0469449B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR0171407B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9103195A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2047848C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69127791T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2108700T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW203051B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9121170D0 (en) * 1991-10-05 1991-11-20 Smithkline Beecham Plc Pharmaceuticals
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
TW251287B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1993-04-30 1995-07-11 Nissei Co Ltd
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
CA2160420A1 (en) 1994-10-20 1996-04-21 Haruhiko Kikuchi 5-ht4 receptor agonists
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
WO2000004020A1 (en) * 1998-07-17 2000-01-27 Agouron Pharmaceuticals, Inc. Compounds, compositions, and methods for stimulating neuronal growth and elongation
WO2000006575A2 (en) * 1998-07-28 2000-02-10 Smithkline Beecham Plc Azabicyclic compounds
GB9819032D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
JP3585796B2 (ja) 1999-12-17 2004-11-04 新光電気工業株式会社 多層配線基板の製造方法、及び半導体装置
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
DE60330456D1 (de) * 2002-07-05 2010-01-21 Targacept Inc N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung
AU2003254016A1 (en) 2002-07-19 2004-02-09 Catholic Healthcare West Methods and compositions relating to chimeric nicotinic receptor subunits
US7098331B2 (en) 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
DK1678172T3 (da) * 2003-10-15 2010-04-06 Targacept Inc Azabicykliske forbindelser til lindring af smerte og behandling af sygdomme i centralnervesystemet
WO2005099698A1 (ja) * 2004-04-15 2005-10-27 Eisai R & D Management Co., Ltd. 安定化された４－アミノ－５－クロロ－Ｎ－［（１Ｒ，３ｒ，５Ｓ）－８－メチル－８－アザビシクロ［３．２．１］オクタ－３－イル]－２－［１－メチルブタ－２－インイルオキシ］ベンズアミド含有組成物
US7384929B2 (en) * 2004-09-20 2008-06-10 Targacept, Inc. N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
KR20080035649A (ko) * 2005-08-22 2008-04-23 타가셉트 인코포레이티드 헤테로아릴로 치환된 디아자트리시클로알칸, 그 제조방법및 용도
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
WO2007134038A2 (en) * 2006-05-09 2007-11-22 Astrazeneca Ab Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
AR062860A1 (es) * 2006-09-15 2008-12-10 Astrazeneca Ab Combinaciones terapeuticas 482
WO2008091588A1 (en) * 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US20100247617A1 (en) * 2007-07-31 2010-09-30 Targacept, Inc. Transdermal Administration Of (2S)-(4E)-N-Methyl-5-(3-(5-Isopropoxypyridin)yl)-4-Penten-2-Amine
KR101565469B1 (ko) * 2007-10-01 2015-11-03 코멘티스, 인코포레이티드 알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1ｈ-인돌-3-카르복실레이트 유도체
CN102648202A (zh) 2009-12-07 2012-08-22 塔加西普特公司 作为神经元烟碱乙酰胆碱受体配体的3,6-二氮杂双环[3.1.1]庚烷
TWI471095B (zh) 2009-12-21 2015-02-01 Nippon Soda Co 環胺化合物及殺蟎劑
AR081721A1 (es) * 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
EP2574188A4 (en) 2010-05-20 2015-09-02 Targacept Inc NOVEL PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OLEFIN AMINES
US8242276B2 (en) * 2010-06-30 2012-08-14 Hoffmann-La Roche Inc. Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
CN103159765B (zh) * 2011-12-15 2015-06-24 北京嘉林药业股份有限公司 一种适于产业化的吲地司琼纯化方法
JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
AR101131A1 (es) 2014-07-11 2016-11-23 Comentis Inc QUINUCLIDINAS PARA LA MODULACIÓN DE ACTIVIDAD DE a7
HUE055175T2 (hu) 2014-09-29 2021-11-29 Takeda Pharmaceuticals Co Az 1-(1-metil-1H-pirazol-4-il)-N-((1R,5S,7S)-9-metil-3-oxa-9-azabiciklo[3.3.1] nonan-7-il)-1H-indol-3-karboxamid kristályos formája

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2970144A (en) * 1957-12-11 1961-01-31 Smith Kline French Lab Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0102195A3 (en) * 1982-08-03 1984-04-11 Beecham Group Plc Substituted aza bicycloalkyl derivatives with dopamine antagonist activity
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
ES8609309A1 (es) * 1984-01-25 1986-07-16 Glaxo Group Ltd Un nuevo procedimiento para la preparacion de nuevos derivados. de carbazolona.
GB8607163D0 (en) * 1986-03-22 1986-04-30 Beecham Group Plc Chemical compound
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
GB8829079D0 (en) * 1988-12-13 1989-01-25 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
ES2108700T3 (es) 1998-01-01
BR9103195A (pt) 1992-05-05
US5187166A (en) 1993-02-16
EP0469449B1 (en) 1997-10-01
CA2047848A1 (en) 1992-02-01
TW203051B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-04-01
DE69127791D1 (de) 1997-11-06
KR920002596A (ko) 1992-02-28
CA2047848C (en) 2001-06-05
KR0171407B1 (ko) 1999-02-01
EP0469449A1 (en) 1992-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NISSHIN PHARMA INC., TOKIO/TOKYO, JP