CA2047848C - Azabicyclo derivatives - Google Patents

Azabicyclo derivatives

Info

Publication number
CA2047848C
CA2047848C CA002047848A CA2047848A CA2047848C CA 2047848 C CA2047848 C CA 2047848C CA 002047848 A CA002047848 A CA 002047848A CA 2047848 A CA2047848 A CA 2047848A CA 2047848 C CA2047848 C CA 2047848C
Authority
CA
Canada
Prior art keywords
formula
endo
dimethyl
diazabicyclo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002047848A
Other languages
English (en)
French (fr)
Other versions
CA2047848A1 (en
Inventor
Haruhiko Kikuchi
Hiroaki Satoh
Nobuhiro Yahata
Koichiro Hagihara
Toru Hayakawa
Setsuko Mino
Makoto Yanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Pharma Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Publication of CA2047848A1 publication Critical patent/CA2047848A1/en
Application granted granted Critical
Publication of CA2047848C publication Critical patent/CA2047848C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002047848A 1990-07-31 1991-07-25 Azabicyclo derivatives Expired - Lifetime CA2047848C (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP201453/1990 1990-07-31
JP20145390 1990-07-31
JP29200090 1990-10-31
JP292000/1990 1990-10-31
JP418549/1990 1990-12-28
JP41854990 1990-12-28
JP84473/1991 1991-03-26
JP8447391 1991-03-26

Publications (2)

Publication Number Publication Date
CA2047848A1 CA2047848A1 (en) 1992-02-01
CA2047848C true CA2047848C (en) 2001-06-05

Family

ID=27466980

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002047848A Expired - Lifetime CA2047848C (en) 1990-07-31 1991-07-25 Azabicyclo derivatives

Country Status (8)

Country Link
US (1) US5187166A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0469449B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR0171407B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9103195A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2047848C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69127791T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2108700T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW203051B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9121170D0 (en) * 1991-10-05 1991-11-20 Smithkline Beecham Plc Pharmaceuticals
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
TW251287B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1993-04-30 1995-07-11 Nissei Co Ltd
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
CA2160420A1 (en) * 1994-10-20 1996-04-21 Haruhiko Kikuchi 5-ht4 receptor agonists
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
EP1098897B1 (en) * 1998-07-17 2004-06-09 Agouron Pharmaceuticals, Inc. Compounds, compositions, and methods for stimulating neuronal growth and elongation
WO2000006575A2 (en) * 1998-07-28 2000-02-10 Smithkline Beecham Plc Azabicyclic compounds
GB9819032D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
JP3585796B2 (ja) 1999-12-17 2004-11-04 新光電気工業株式会社 多層配線基板の製造方法、及び半導体装置
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
BR0312414A (pt) * 2002-07-05 2005-05-10 Targacept Inc Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos
AU2003254016A1 (en) 2002-07-19 2004-02-09 Catholic Healthcare West Methods and compositions relating to chimeric nicotinic receptor subunits
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
ATE451368T1 (de) * 2003-10-15 2009-12-15 Targacept Inc Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems
US20070155780A1 (en) * 2004-04-15 2007-07-05 Hitoshi Nakata Stabilized composition containing 4-amino-5-chloro-n-[(1r, 3r, 5s)-8-methyl-8-azabicyclo[3.2.1]oct-3-y1]-2-[1-methylbut-2-ynyloxy]benzamide
CN101044134A (zh) * 2004-09-20 2007-09-26 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) * 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
CN101248073A (zh) * 2005-08-22 2008-08-20 塔加西普特公司 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用
US8017785B2 (en) * 2006-05-09 2011-09-13 Astrazeneca Ab Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
TW200829244A (en) * 2006-09-15 2008-07-16 Astrazeneca Ab Therapeutic combinations 482
WO2008091592A1 (en) * 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
AU2008282205A1 (en) * 2007-07-31 2009-02-05 Astrazeneca Ab Transdermal administration of (2S)-(4E)-N-methyl-5-(3-( 5-isopropoxypyridin)yl)-4-penten-2-amine
WO2009046025A1 (en) * 2007-10-01 2009-04-09 Comentis, Inc. Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease
US8802694B2 (en) 2009-12-07 2014-08-12 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
TWI471095B (zh) 2009-12-21 2015-02-01 Nippon Soda Co 環胺化合物及殺蟎劑
AR081721A1 (es) * 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
MX2012013193A (es) 2010-05-20 2012-12-17 Astrazeneca Ab Nuevo proceso para preparar aminas olefinicas sustituidas con arilo.
US8242276B2 (en) 2010-06-30 2012-08-14 Hoffmann-La Roche Inc. Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
CN103159765B (zh) * 2011-12-15 2015-06-24 北京嘉林药业股份有限公司 一种适于产业化的吲地司琼纯化方法
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
US9434724B2 (en) 2014-07-11 2016-09-06 Alpharmagen, Llc Quinuclidines for modulating alpha 7 activity
PT3201203T (pt) 2014-09-29 2021-08-09 Takeda Pharmaceuticals Co Forma cristalina de 1-(1-metil-1h-pirazol-4-il)-n-((1r,5s,7s)-9-metil-3-oxa-9-azabiciclo[3.3.1]nonan-7-il)-1hindol-3-carboxamida

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2970144A (en) * 1957-12-11 1961-01-31 Smith Kline French Lab Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0102195A3 (en) * 1982-08-03 1984-04-11 Beecham Group Plc Substituted aza bicycloalkyl derivatives with dopamine antagonist activity
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
IE57809B1 (en) * 1984-01-25 1993-04-21 Glaxo Group Ltd 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives
GB8607163D0 (en) * 1986-03-22 1986-04-30 Beecham Group Plc Chemical compound
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
GB8829079D0 (en) * 1988-12-13 1989-01-25 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
TW203051B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-04-01
DE69127791T2 (de) 1998-02-05
CA2047848A1 (en) 1992-02-01
US5187166A (en) 1993-02-16
KR0171407B1 (ko) 1999-02-01
EP0469449B1 (en) 1997-10-01
KR920002596A (ko) 1992-02-28
ES2108700T3 (es) 1998-01-01
DE69127791D1 (de) 1997-11-06
EP0469449A1 (en) 1992-02-05
BR9103195A (pt) 1992-05-05

Similar Documents

Publication Publication Date Title
CA2047848C (en) Azabicyclo derivatives
CN105814045B (zh) 作为tnf活性调节剂的咪唑并吡啶衍生物
CA2713173C (en) (dihydro)pyrrolo[2,1-.alpha.]isoquinolines
WO2004022558A2 (en) Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
IE920750A1 (en) New imidazopyridines as serotonergic 5-ht3 antagonists
ZA200502750B (en) (1H-Benzoimidazol-2-UL)-(Piperazinyl)-Methanone derivatives and realted compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders
EP0315390A2 (en) Novel 4-oxobenzotriazines and 4-oxoquinazolines
CN105814025A (zh) 用作tnf活性调节剂的四氢苯并咪唑衍生物
CN105814044B (zh) 作为tnf活性调节剂的四氢咪唑并吡啶衍生物
HUE029343T2 (en) Quinolylpyrrolo-pyrimidyl fused ring compounds and salts thereof
EP0297858A2 (en) Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
EP0496064B1 (en) Process for the preparation of substituted benzofuran derivatives
US5318977A (en) New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
RU2162470C2 (ru) 2,7-замещенные производные октагидропирроло[1,2-а]пиразина, способ лечения, фармацевтическая композиция, промежуточные соединения
JP3453394B2 (ja) ジヒドロベンゾフランカルボキサミド及びその製造方法
US5256656A (en) Azabicyclo derivatives
JP3615550B2 (ja) イミダゾ［１，５−ａ］インドール−３−オンのアザビシクロアルキル誘導体およびそれらの製造法
EP0558923B1 (en) Diazabicyclo derivatives as 5-HT3 antagonists
US6395905B1 (en) Tetrahydroindazole derivatives as ligands for GABA-A α 5 receptors
JP3251954B2 (ja) アザビシクロ誘導体
US5516782A (en) New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
JPH1087661A (ja) サブスタンスｐアンタゴニストとしてのテトラゾリル置換キヌクリジン
WO2001014385A1 (fr) Derives de dihydrobenzofuran, leur procede de preparation et agents
JP3657986B2 (ja) イミダゾ〔１，５−ａ〕インドール−３−オンのイミダゾリルアルキル誘導体およびそれらの製造法
MXPA01009550A (es) Sistema de anillo fusionado que contiene indol como antagonistas receptores muscarinicos aza-antraceno m4.

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry