DE69127791T2 - Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten - Google Patents
Diazabicyclononyl-Derivate als 5-HT3 Rezeptor AntagonistenInfo
- Publication number
- DE69127791T2 DE69127791T2 DE69127791T DE69127791T DE69127791T2 DE 69127791 T2 DE69127791 T2 DE 69127791T2 DE 69127791 T DE69127791 T DE 69127791T DE 69127791 T DE69127791 T DE 69127791T DE 69127791 T2 DE69127791 T2 DE 69127791T2
- Authority
- DE
- Germany
- Prior art keywords
- diazabicyclononyl
- derivatives
- receptor antagonists
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20145390 | 1990-07-31 | ||
JP29200090 | 1990-10-31 | ||
JP41854990 | 1990-12-28 | ||
JP8447391 | 1991-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69127791D1 DE69127791D1 (de) | 1997-11-06 |
DE69127791T2 true DE69127791T2 (de) | 1998-02-05 |
Family
ID=27466980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69127791T Expired - Lifetime DE69127791T2 (de) | 1990-07-31 | 1991-07-24 | Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten |
Country Status (8)
Country | Link |
---|---|
US (1) | US5187166A (de) |
EP (1) | EP0469449B1 (de) |
KR (1) | KR0171407B1 (de) |
BR (1) | BR9103195A (de) |
CA (1) | CA2047848C (de) |
DE (1) | DE69127791T2 (de) |
ES (1) | ES2108700T3 (de) |
TW (1) | TW203051B (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9121170D0 (en) * | 1991-10-05 | 1991-11-20 | Smithkline Beecham Plc | Pharmaceuticals |
US5344831A (en) * | 1992-01-31 | 1994-09-06 | Nisshin Flour Milling Co., Ltd. | Diazabicyclo derivatives |
TW251287B (de) * | 1993-04-30 | 1995-07-11 | Nissei Co Ltd | |
JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
CA2160420A1 (en) | 1994-10-20 | 1996-04-21 | Haruhiko Kikuchi | 5-ht4 receptor agonists |
US7214686B2 (en) * | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
ATE268772T1 (de) * | 1998-07-17 | 2004-06-15 | Agouron Pharma | Verbindungen und zusammensetzungen um neurales wachstum und streckung zu stimulieren |
WO2000006575A2 (en) * | 1998-07-28 | 2000-02-10 | Smithkline Beecham Plc | Azabicyclic compounds |
GB9819032D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
JP3585796B2 (ja) | 1999-12-17 | 2004-11-04 | 新光電気工業株式会社 | 多層配線基板の製造方法、及び半導体装置 |
IT1317841B1 (it) * | 2000-02-18 | 2003-07-15 | Univ Degli Studi Milano | Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica. |
MXPA05000370A (es) * | 2002-07-05 | 2005-04-19 | Targacept Inc | Compuestos n-aril diazaespiraciclicos y metodos de preparacion y usos de los mismos. |
WO2004009775A2 (en) | 2002-07-19 | 2004-01-29 | Targacept, Inc. | Methods and compositions relating to chimeric nicotinic receptor subunits |
US7098331B2 (en) * | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
EP1678172B1 (de) * | 2003-10-15 | 2009-12-09 | Targacept, Inc. | Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems |
EP1736156A4 (de) * | 2004-04-15 | 2010-06-16 | Eisai R&D Man Co Ltd | Stabilisierte 4-amino-5-chloro-n-¼(1r,3r,5s)-8-methyl-8- azabicyclo¼3.2.1 oct-3-yl -2-¼1-methylbut-2-ynyloxy -benzamid enthaltende zusammensetzung |
CN101044134A (zh) * | 2004-09-20 | 2007-09-26 | 塔加西普特公司 | 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物 |
US7459469B2 (en) * | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
DE602006017235D1 (de) * | 2005-08-22 | 2010-11-11 | Targacept Inc | Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung |
WO2007134038A2 (en) * | 2006-05-09 | 2007-11-22 | Astrazeneca Ab | Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine |
TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型 |
WO2008034041A2 (en) * | 2006-09-15 | 2008-03-20 | Astrazeneca Ab | Therapeutic combinations |
EP2112923A1 (de) * | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasale, orale und sublinguale verabreichung von metanikotin-analogen |
CA2695214A1 (en) * | 2007-07-31 | 2009-02-05 | Targacept, Inc. | Transdermal administration of (2s)-(4e)-n-methyl-5-(3-(5-is0pr0p0xypyridin)yl)-4-penten-2-amine |
WO2009046025A1 (en) * | 2007-10-01 | 2009-04-09 | Comentis, Inc. | Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
AU2010328419A1 (en) | 2009-12-07 | 2012-06-21 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
TWI471095B (zh) | 2009-12-21 | 2015-02-01 | Nippon Soda Co | 環胺化合物及殺蟎劑 |
AR081721A1 (es) * | 2010-02-25 | 2012-10-17 | Nippon Soda Co | Compuesto de amina ciclica y acaricida |
WO2011146009A1 (en) | 2010-05-20 | 2011-11-24 | Targacept Inc. | New process for the preparation of aryl substituted olefinic amines |
US8242276B2 (en) | 2010-06-30 | 2012-08-14 | Hoffmann-La Roche Inc. | Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt |
CN103159765B (zh) * | 2011-12-15 | 2015-06-24 | 北京嘉林药业股份有限公司 | 一种适于产业化的吲地司琼纯化方法 |
JOP20130213B1 (ar) * | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
AR101131A1 (es) | 2014-07-11 | 2016-11-23 | Comentis Inc | QUINUCLIDINAS PARA LA MODULACIÓN DE ACTIVIDAD DE a7 |
JP7055017B2 (ja) | 2014-09-29 | 2022-04-15 | 武田薬品工業株式会社 | 結晶形の1-(1-メチル-1h-ピラゾール-4-イル)-n-((1r,5s,7s)-9-メチル-3-オキサ-9-アザビシクロ[3.3.1]ノナン-7-イル)-1h-インドール-3-カルボキサミド |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2970144A (en) * | 1957-12-11 | 1961-01-31 | Smith Kline French Lab | Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol |
US4352802A (en) * | 1980-06-10 | 1982-10-05 | Beecham Group Limited | Bicyclo[3.3.1]nonyl-benzamide |
AU1508183A (en) * | 1982-06-04 | 1983-12-08 | Beecham Group Plc | Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane |
FI74707C (fi) * | 1982-06-29 | 1988-03-10 | Sandoz Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror. |
JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
EP0102195A3 (de) * | 1982-08-03 | 1984-04-11 | Beecham Group Plc | Substituierte Azabicycloalkyl-Derivate mit dopaminantagonistischer Wirkung |
DE3445377A1 (de) * | 1983-12-23 | 1985-07-04 | Sandoz-Patent-GmbH, 7850 Lörrach | Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen |
FR2561244B1 (fr) * | 1984-01-25 | 1988-03-04 | Glaxo Group Ltd | Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant |
GB8607163D0 (en) * | 1986-03-22 | 1986-04-30 | Beecham Group Plc | Chemical compound |
HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
DE3827253A1 (de) * | 1987-08-20 | 1989-03-02 | Sandoz Ag | Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen |
GB8829079D0 (en) * | 1988-12-13 | 1989-01-25 | Beecham Group Plc | Novel compounds |
-
1991
- 1991-07-16 US US07/730,699 patent/US5187166A/en not_active Expired - Lifetime
- 1991-07-24 DE DE69127791T patent/DE69127791T2/de not_active Expired - Lifetime
- 1991-07-24 ES ES91112397T patent/ES2108700T3/es not_active Expired - Lifetime
- 1991-07-24 EP EP91112397A patent/EP0469449B1/de not_active Expired - Lifetime
- 1991-07-25 CA CA002047848A patent/CA2047848C/en not_active Expired - Lifetime
- 1991-07-25 BR BR919103195A patent/BR9103195A/pt not_active Application Discontinuation
- 1991-07-29 TW TW080105897A patent/TW203051B/zh not_active IP Right Cessation
- 1991-07-30 KR KR1019910013073A patent/KR0171407B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW203051B (de) | 1993-04-01 |
EP0469449A1 (de) | 1992-02-05 |
CA2047848A1 (en) | 1992-02-01 |
EP0469449B1 (de) | 1997-10-01 |
DE69127791D1 (de) | 1997-11-06 |
KR920002596A (ko) | 1992-02-28 |
US5187166A (en) | 1993-02-16 |
KR0171407B1 (ko) | 1999-02-01 |
BR9103195A (pt) | 1992-05-05 |
CA2047848C (en) | 2001-06-05 |
ES2108700T3 (es) | 1998-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NISSHIN PHARMA INC., TOKIO/TOKYO, JP |