DE69123106T2 - Polypeptid, das zur Interaktion mit Thrombin fähig ist - Google Patents

Polypeptid, das zur Interaktion mit Thrombin fähig ist

Info

Publication number
DE69123106T2
DE69123106T2 DE69123106T DE69123106T DE69123106T2 DE 69123106 T2 DE69123106 T2 DE 69123106T2 DE 69123106 T DE69123106 T DE 69123106T DE 69123106 T DE69123106 T DE 69123106T DE 69123106 T2 DE69123106 T2 DE 69123106T2
Authority
DE
Germany
Prior art keywords
thrombin
gla
amino acid
polypeptide
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69123106T
Other languages
English (en)
Other versions
DE69123106D1 (de
Inventor
Michitaka Zushi
Komakazu Gomi
Shuji Yamamoto
Koji Suzuki
Akio Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of DE69123106D1 publication Critical patent/DE69123106D1/de
Application granted granted Critical
Publication of DE69123106T2 publication Critical patent/DE69123106T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69123106T 1990-08-03 1991-08-05 Polypeptid, das zur Interaktion mit Thrombin fähig ist Expired - Fee Related DE69123106T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20497890 1990-08-03

Publications (2)

Publication Number Publication Date
DE69123106D1 DE69123106D1 (de) 1996-12-19
DE69123106T2 true DE69123106T2 (de) 1997-04-10

Family

ID=16499445

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123106T Expired - Fee Related DE69123106T2 (de) 1990-08-03 1991-08-05 Polypeptid, das zur Interaktion mit Thrombin fähig ist

Country Status (9)

Country Link
US (1) US5574007A (de)
EP (1) EP0474273B1 (de)
KR (1) KR930008093B1 (de)
AT (1) ATE145241T1 (de)
AU (1) AU632958B2 (de)
CA (1) CA2048425C (de)
DE (1) DE69123106T2 (de)
ES (1) ES2093674T3 (de)
HK (1) HK1000968A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
CA2292759A1 (en) * 1997-06-05 1998-12-10 Abbott Laboratories Reagents and methods useful for detecting diseases of the urinary tract
WO2003033515A1 (en) * 2001-10-15 2003-04-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
US20060083733A1 (en) * 2002-01-18 2006-04-20 Fumihide Nishio High-concentration preparation of soluble thrombomodulin
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
KR101013697B1 (ko) * 2002-05-01 2011-02-10 바이엘 쉐링 파마 악티엔게젤샤프트 항응고제로서의 조직 인자 표적화된 신규 트롬보모둘린융합 단백질
US7579000B2 (en) * 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
MX2009003384A (es) * 2006-10-06 2009-04-08 Asahi Kasei Pharma Corp Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada.
WO2008117735A1 (ja) 2007-03-23 2008-10-02 Asahi Kasei Pharma Corporation 高純度可溶性トロンボモジュリンの製造方法
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
JP5722314B2 (ja) 2010-04-30 2015-05-20 旭化成ファーマ株式会社 高純度可溶性トロンボモジュリン及びその製造方法
HUE050698T2 (hu) 2011-11-15 2020-12-28 Asahi Kasei Pharma Corp Gyógyszer szepszis kezelésére és/vagy javítására
CN112608965B (zh) * 2021-01-15 2022-08-05 华东理工大学 利用深海链霉菌生产怡莱霉素e的培养基及其制备方法
CN113429459B (zh) * 2021-06-16 2022-07-26 昆明医科大学第一附属医院 一种抗血小板多肽及其药物组合物与其应用
WO2023172783A2 (en) * 2022-01-07 2023-09-14 The Government Of The United States, As Represented By The Secretary Of The Army Hemostatic composition containing recombinant human clotting factors, and method of producing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816493A1 (de) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha 3' End deletierte DNS, kodierend für ein Peptid das die Wirkung des Protein C mit Thrombin beschleunigt und Verfahren zu dessen Herstellung
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
WO1991004276A1 (fr) * 1989-09-25 1991-04-04 Asahi Kasei Kogyo Kabushiki Kaisha Polypetpides de thrombomoduline humaine physiologiquement actifs et isoles

Also Published As

Publication number Publication date
DE69123106D1 (de) 1996-12-19
EP0474273A3 (en) 1992-04-08
EP0474273B1 (de) 1996-11-13
CA2048425A1 (en) 1992-02-04
CA2048425C (en) 1998-04-21
ATE145241T1 (de) 1996-11-15
US5574007A (en) 1996-11-12
HK1000968A1 (en) 1998-05-15
AU632958B2 (en) 1993-01-14
KR930008093B1 (ko) 1993-08-25
KR920004419A (ko) 1992-03-27
EP0474273A2 (de) 1992-03-11
ES2093674T3 (es) 1997-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee