DE69115105D1 - Chirale Katalysatoren für die Reduktion von Ketonen und Verfahren zu ihrer Herstellung. - Google Patents

Chirale Katalysatoren für die Reduktion von Ketonen und Verfahren zu ihrer Herstellung.

Info

Publication number
DE69115105D1
DE69115105D1 DE69115105T DE69115105T DE69115105D1 DE 69115105 D1 DE69115105 D1 DE 69115105D1 DE 69115105 T DE69115105 T DE 69115105T DE 69115105 T DE69115105 T DE 69115105T DE 69115105 D1 DE69115105 D1 DE 69115105D1
Authority
DE
Germany
Prior art keywords
ketones
processes
reduction
preparation
chiral catalysts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69115105T
Other languages
English (en)
Other versions
DE69115105T2 (de
Inventor
Thomas J Blacklock
Todd K Jones
David J Mathre
Lyndon C Xavier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69115105D1 publication Critical patent/DE69115105D1/de
Application granted granted Critical
Publication of DE69115105T2 publication Critical patent/DE69115105T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
DE69115105T 1990-04-18 1991-04-18 Chirale Katalysatoren für die Reduktion von Ketonen und Verfahren zu ihrer Herstellung. Expired - Fee Related DE69115105T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/510,768 US5039802A (en) 1990-04-18 1990-04-18 Arylation process for preparation of chiral catalysts for ketone reduction

Publications (2)

Publication Number Publication Date
DE69115105D1 true DE69115105D1 (de) 1996-01-18
DE69115105T2 DE69115105T2 (de) 1996-07-25

Family

ID=24032117

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69131967T Expired - Fee Related DE69131967T2 (de) 1990-04-18 1991-04-18 Verfahren zur Herstellung von 1,1-Diarylprolinolen
DE69115105T Expired - Fee Related DE69115105T2 (de) 1990-04-18 1991-04-18 Chirale Katalysatoren für die Reduktion von Ketonen und Verfahren zu ihrer Herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69131967T Expired - Fee Related DE69131967T2 (de) 1990-04-18 1991-04-18 Verfahren zur Herstellung von 1,1-Diarylprolinolen

Country Status (5)

Country Link
US (1) US5039802A (de)
EP (3) EP0668266B1 (de)
JP (2) JP3262810B2 (de)
CA (1) CA2040606C (de)
DE (2) DE69131967T2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264574A (en) * 1992-04-03 1993-11-23 Merck & Co., Inc. Preparation of oxazaborolidine borane complex
JP2525127B2 (ja) * 1992-05-14 1996-08-14 ファイザー・インコーポレーテッド 鏡像体選択的オキサアザボロリジン
DE69305748T3 (de) * 1992-08-28 2004-07-29 Avecia Ltd., Blackley Enzymatisches asymetrisches reduktionsverfahren zur herstellung von 4h thieno (2,3-6) thiopyren derivaten.
JP3279671B2 (ja) * 1992-09-28 2002-04-30 鐘淵化学工業株式会社 チエノチオピラン誘導体の製造方法
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
DE4416963C1 (de) * 1994-05-13 1995-07-13 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Diarylprolinolen
US5495054A (en) * 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
JP3803126B2 (ja) * 1995-10-31 2006-08-02 第一アスビオファーマ株式会社 光学活性なトランス体ビニルスルフィドアルコールの製造方法
US5650521A (en) * 1995-12-29 1997-07-22 Guilford Pharmaceuticals Inc. Pyrrolidine derivatives
US5925666A (en) * 1995-12-29 1999-07-20 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods for treating compulsive disorders using pyrrolidine derivatives
US5747523A (en) * 1996-01-24 1998-05-05 Guilford Pharmaceuticals Inc. Substituted ethyl α,α-diarylmethyl ether derivatives
NZ504346A (en) 1997-12-19 2001-11-30 Warner Lambert Exp Ltd Process for the synthesis of 1,3-diols characterised by either reconcentration step with either trialkylborane or dialkylalkoxyborane or a mixture of both trialkylborane and dialkylalkoxyborane
FR2830191B1 (fr) 2001-09-28 2004-12-10 Oreal Composition tinctoriale comprenant une base d'oxydation du type diaminopyrazole, une base d'oxydation du type paraphenylenediamine a groupement amino cyclique et un coupleur
JP2004339207A (ja) * 2003-04-21 2004-12-02 Tosoh Corp 新規ラクタムアルコール誘導体、ラクタムアルコール誘導体から調製される不斉還元触媒溶液、その調製方法並びにそれを用いた光学活性アルコール類の製造方法
EP1787975A4 (de) * 2004-09-10 2008-07-09 San Ei Gen Ffi Inc Verfahren zur herstellung von weinlacton und zwischenprodukten davon und anwendung des lactons
WO2006074230A2 (en) * 2005-01-06 2006-07-13 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of making dorzolamide hydrochloride
JP5001252B2 (ja) * 2006-02-16 2012-08-15 壽製薬株式会社 光学活性アルコールを製造する方法
HUP0700486A2 (en) * 2007-07-23 2009-03-30 Mta Kemiai Kutatokoezpont Method for recovering diphenyl prolinol type catalysts carrying phasemarker groups and the recovered catalysts and their utilization
AU2010319983B2 (en) 2009-11-13 2015-03-12 Receptos Llc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
EP2498611B1 (de) 2009-11-13 2018-01-10 Celgene International II Sàrl Sphingosin-1-phosphatrezeptormodulatoren und verfahren für chirale synthese
MY169497A (en) * 2009-11-13 2019-04-15 Celgene Int Ii Sarl Selective heterocyclic sphingosine 1 phosphate receptor modulators
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
CN108101820B (zh) * 2018-02-10 2020-04-03 上海鑫凯化学科技有限公司 一种手性吡咯烷的合成工艺及中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3638M (fr) * 1964-05-29 1965-10-25 Roussel Uclaf Nouveau médicament actif sur le systeme nerveux central et doué notamment d'effet psychotonique.
DE3609152A1 (de) * 1986-03-19 1987-09-24 Bayer Ag Verfahren zur herstellung des (-)-antipoden des (e)-1-cyclohexyl-4,4-dimethyl- 3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ens
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones

Also Published As

Publication number Publication date
EP0962451A3 (de) 2002-07-31
EP0962451A2 (de) 1999-12-08
JP3262810B2 (ja) 2002-03-04
CA2040606A1 (en) 1991-10-19
DE69131967D1 (de) 2000-03-09
EP0453298A2 (de) 1991-10-23
EP0668266A1 (de) 1995-08-23
EP0668266B1 (de) 2000-02-02
JP3740050B2 (ja) 2006-01-25
EP0453298A3 (en) 1992-07-22
DE69115105T2 (de) 1996-07-25
DE69131967T2 (de) 2000-08-17
JPH04224556A (ja) 1992-08-13
JP2002193929A (ja) 2002-07-10
US5039802A (en) 1991-08-13
EP0453298B1 (de) 1995-12-06
CA2040606C (en) 2003-06-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee