DE69107512T2 - Derivate von endogenen Mediatoren, ihre Salze, Verfahren zur Herstellung, Anwendungen und Zusammensetzungen, die diese enthalten. - Google Patents
Derivate von endogenen Mediatoren, ihre Salze, Verfahren zur Herstellung, Anwendungen und Zusammensetzungen, die diese enthalten.Info
- Publication number
- DE69107512T2 DE69107512T2 DE69107512T DE69107512T DE69107512T2 DE 69107512 T2 DE69107512 T2 DE 69107512T2 DE 69107512 T DE69107512 T DE 69107512T DE 69107512 T DE69107512 T DE 69107512T DE 69107512 T2 DE69107512 T2 DE 69107512T2
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- derivatives
- applications
- salts
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9006292A FR2662082B1 (fr) | 1990-05-15 | 1990-05-15 | Nouveaux derives de mediateurs endogenes, leurs sels, procede de preparation et applications. |
FR9101292A FR2671971B1 (fr) | 1991-01-30 | 1991-01-30 | Nouveaux derives de la serotonine, application a titre de medicament et compositions les renfermant. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69107512D1 DE69107512D1 (de) | 1995-03-30 |
DE69107512T2 true DE69107512T2 (de) | 1995-06-29 |
Family
ID=26228029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69107512T Expired - Lifetime DE69107512T2 (de) | 1990-05-15 | 1991-05-13 | Derivate von endogenen Mediatoren, ihre Salze, Verfahren zur Herstellung, Anwendungen und Zusammensetzungen, die diese enthalten. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5298491A (de) |
EP (1) | EP0457701B1 (de) |
JP (1) | JP2968623B2 (de) |
KR (1) | KR0138750B1 (de) |
AT (1) | ATE118758T1 (de) |
AU (1) | AU650265B2 (de) |
CA (1) | CA2042295A1 (de) |
DE (1) | DE69107512T2 (de) |
DK (1) | DK0457701T3 (de) |
ES (1) | ES2039313T3 (de) |
IE (1) | IE67888B1 (de) |
NO (1) | NO308663B1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer | |
JP2544704B2 (ja) * | 1992-04-10 | 1996-10-16 | フアイザー・インコーポレイテツド | 5−ht▲下1▼アゴニストとしてのアシルアミノインド―ル誘導体 |
TW251284B (de) * | 1992-11-02 | 1995-07-11 | Pfizer | |
FR2699918B1 (fr) * | 1992-12-30 | 1995-03-17 | Pf Medicament | Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments. |
NZ267453A (en) * | 1993-06-18 | 1997-03-24 | Nycomed Imaging As Substituted | Factor vii derived peptides |
AU729415B2 (en) | 1996-07-12 | 2001-02-01 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
FR2773489B1 (fr) * | 1998-01-15 | 2001-03-23 | Immunotech Sa | Nouvelle composition destinee a la voie oromuqueuse notamment pernasale |
KR100596641B1 (ko) * | 1998-12-11 | 2006-10-04 | 이승진 | 진단용 공중합성 미셀 및 그의 제조방법 |
US7163918B2 (en) * | 2000-08-22 | 2007-01-16 | New River Pharmaceuticals Inc. | Iodothyronine compositions |
US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
DK1523486T3 (da) | 2002-06-21 | 2008-03-03 | Suven Life Sciences Ltd | Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet |
EP1537113B9 (de) | 2002-06-21 | 2010-05-26 | Suven Life Sciences Limited | Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten |
KR100818508B1 (ko) | 2002-11-28 | 2008-03-31 | 수벤 라이프 사이언시스 리미티드 | 세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물 |
ES2425143T3 (es) | 2002-11-28 | 2013-10-11 | Suven Life Sciences Limited | N-Arilsulfonil-3-aminoalcoxiindoles |
KR100739987B1 (ko) | 2002-12-18 | 2007-07-16 | 수벤 라이프 사이언시스 리미티드 | 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2703325A (en) * | 1951-12-06 | 1955-03-01 | Upjohn Co | Preparation of 5-benzyloxytryptamines |
US3182071A (en) * | 1961-06-27 | 1965-05-04 | Warner Lambert Pharmaceutical | Acylated indole derivatives |
US3686213A (en) * | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
US4046636A (en) * | 1974-06-20 | 1977-09-06 | Syva Company | Diazepam enzyme conjugates |
US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
US4040907A (en) * | 1974-06-20 | 1977-08-09 | Syva Company | Iodothyronine enzyme conjugates |
DE2737802A1 (de) * | 1977-08-22 | 1979-03-08 | Henning Berlin Gmbh | Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung |
FR2437398A1 (fr) * | 1978-06-20 | 1980-04-25 | Commissariat Energie Atomique | Compose iode utilisable comme traceur en radio-immunologie |
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
ZW19381A1 (en) * | 1980-08-12 | 1983-03-09 | Glaxo Group Ltd | Heterocyclic compounds |
US4426453A (en) * | 1980-09-18 | 1984-01-17 | Amersham International Limited | Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds |
DE3368258D1 (en) * | 1982-07-16 | 1987-01-22 | Beecham Group Plc | 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them |
JPS60132935A (ja) * | 1983-12-20 | 1985-07-16 | Sumitomo Chem Co Ltd | フエニルセリン誘導体及びその製造方法 |
FR2562671B1 (fr) * | 1984-04-10 | 1986-07-25 | Immunotech Sa | Procede pour le dosage immunologique des monoamines |
DE3678805D1 (de) * | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
DE3628795A1 (de) * | 1986-08-25 | 1988-03-03 | Hoechst Ag | Neue thyroninderivate |
US5019586A (en) * | 1987-04-14 | 1991-05-28 | Glaxo Group Limited | Ketone derivatives |
GB8801306D0 (en) * | 1988-01-21 | 1988-02-17 | Ici Plc | Chemical compounds |
GB8802127D0 (en) * | 1988-02-01 | 1988-03-02 | Glaxo Group Ltd | Chemical compounds |
US4933324A (en) * | 1988-02-26 | 1990-06-12 | Shashoua Victor E | Fatty acid-neuroactive drug conjugate as a prodrug |
FR2662082B1 (fr) * | 1990-05-15 | 1994-12-23 | Immunotech Sa | Nouveaux derives de mediateurs endogenes, leurs sels, procede de preparation et applications. |
FR2671971B1 (fr) * | 1991-01-30 | 1994-01-28 | Immunotech | Nouveaux derives de la serotonine, application a titre de medicament et compositions les renfermant. |
-
1991
- 1991-05-10 CA CA002042295A patent/CA2042295A1/fr not_active Abandoned
- 1991-05-13 ES ES91430009T patent/ES2039313T3/es not_active Expired - Lifetime
- 1991-05-13 DK DK91430009.0T patent/DK0457701T3/da active
- 1991-05-13 EP EP91430009A patent/EP0457701B1/de not_active Expired - Lifetime
- 1991-05-13 US US07/699,027 patent/US5298491A/en not_active Expired - Lifetime
- 1991-05-13 AT AT91430009T patent/ATE118758T1/de not_active IP Right Cessation
- 1991-05-13 DE DE69107512T patent/DE69107512T2/de not_active Expired - Lifetime
- 1991-05-14 IE IE164991A patent/IE67888B1/en unknown
- 1991-05-14 NO NO911880A patent/NO308663B1/no unknown
- 1991-05-14 KR KR1019910007750A patent/KR0138750B1/ko not_active IP Right Cessation
- 1991-05-14 AU AU77045/91A patent/AU650265B2/en not_active Ceased
- 1991-05-15 JP JP3205013A patent/JP2968623B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5298491A (en) | 1994-03-29 |
DE69107512D1 (de) | 1995-03-30 |
ES2039313T3 (es) | 1995-04-16 |
AU650265B2 (en) | 1994-06-16 |
DK0457701T3 (da) | 1996-02-05 |
IE911649A1 (en) | 1991-11-20 |
EP0457701A1 (de) | 1991-11-21 |
KR910020034A (ko) | 1991-12-19 |
IE67888B1 (en) | 1996-05-01 |
JPH04288044A (ja) | 1992-10-13 |
ATE118758T1 (de) | 1995-03-15 |
NO308663B1 (no) | 2000-10-09 |
AU7704591A (en) | 1991-11-21 |
NO911880D0 (no) | 1991-05-14 |
KR0138750B1 (ko) | 1998-05-01 |
CA2042295A1 (fr) | 1991-11-16 |
JP2968623B2 (ja) | 1999-10-25 |
ES2039313T1 (es) | 1993-10-01 |
NO911880L (no) | 1991-11-18 |
EP0457701B1 (de) | 1995-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |