ES2052166T3 - Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos. - Google Patents

Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos.

Info

Publication number
ES2052166T3
ES2052166T3 ES90250249T ES90250249T ES2052166T3 ES 2052166 T3 ES2052166 T3 ES 2052166T3 ES 90250249 T ES90250249 T ES 90250249T ES 90250249 T ES90250249 T ES 90250249T ES 2052166 T3 ES2052166 T3 ES 2052166T3
Authority
ES
Spain
Prior art keywords
derivatives
carbon atoms
homo
medicines
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90250249T
Other languages
English (en)
Inventor
Gerald Dr Kirsch
Guenter Dr Neef
Katica Schwarz
Matthias Dr Braeutigam
Ruth Dr Thieroff-Eckerdt
Petra Rach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2052166T3 publication Critical patent/ES2052166T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

EL INVENTO SE REFIERE A UN NUEVO DERIVADO 24 TAMINA D DE FORMULA (I). TRATA DE UN PROCEDIMIENTO PARA LA PRODUCCION DEL COMPUESTO DE FORMULA (I) COMO MEDICAMENTO; RESEÑA LA ACCION DIFERENCIADORA DE LAS VELULAS Y LA ACCION INHIBIDORA DE POLIFERACION DEL COMPUESTO DE FORMULA (I) Y DESGLOSA PREPARADO FARMACEUTICOS QUE CONTIENEN EL COMPUESTO DE FOMRULA (I). SIENDO A Y B HIDROGENO Y COMUNMENTE UN DOBLE ENLACE; R1 HIDROGENO , UN GRUPO HIDROXY O UN GRUPO ACILOXI DE C1 A 6; R (AL CUADRADO) Y R3 INDEPENDIENTES UNO DE OTRO UN GRUPO ALQUILO LINEAL O RAMIFICADO DE C1 A 4, UN GRUPO TRIFLUOROMETILO O UN ANILLO CARBOCICLICO SATURADO CON C25 Y FORMADO POR C3 A 9 Y R5 HIDROGENO O UN GRUPO ACILO DE C1 A 8 Y N 1, 2, 3, 4 O 5.
ES90250249T 1989-10-02 1990-10-01 Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos. Expired - Lifetime ES2052166T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3933034A DE3933034A1 (de) 1989-10-02 1989-10-02 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2052166T3 true ES2052166T3 (es) 1994-07-01

Family

ID=6390762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90250249T Expired - Lifetime ES2052166T3 (es) 1989-10-02 1990-10-01 Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos.

Country Status (18)

Country Link
US (1) US5665716A (es)
EP (1) EP0421561B1 (es)
JP (1) JPH03246273A (es)
CN (2) CN1031705C (es)
AT (1) ATE103893T1 (es)
AU (1) AU639717B2 (es)
CA (1) CA2026671C (es)
DD (1) DD299178A5 (es)
DE (2) DE3933034A1 (es)
DK (1) DK0421561T3 (es)
ES (1) ES2052166T3 (es)
FI (1) FI93643C (es)
HU (1) HU210032B (es)
IE (1) IE71227B1 (es)
IL (1) IL95872A (es)
NO (1) NO178923C (es)
PT (1) PT95473B (es)
ZA (1) ZA907876B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
DE4200783C2 (de) * 1992-01-10 1997-02-06 Schering Ag (5Z,7E,22E)-(1S,3R,24S)-24-Benzyl-9,10-secochola-5,7,10(19),22-tetraen-1,3,24-triol, Verfahren zur Herstellung und Pharmazeutische Präparate
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
DE4328217C2 (de) * 1993-08-21 1996-01-11 Lohmann Therapie Syst Lts Therapeutisches System zur Behandlung der Psoriasis
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO2002006218A2 (en) * 2000-07-18 2002-01-24 Bone Care International, Inc. STABILIZED 1α-HYDROXY VITAMIN D
DE10156596A1 (de) * 2001-11-13 2003-05-28 Schering Ag Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
EP1470220B1 (en) * 2002-01-10 2011-10-05 Teva Pharmaceutical Industries, Ltd. Selective enzymatic esterification and solvolysis of epimeric vitamin d analog and separation of the epimers
EP1461314A1 (en) * 2002-06-13 2004-09-29 Teva Pharmaceutical Industries Limited Epimerization of analogs of vitamin d
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
KR20090039833A (ko) * 2006-08-29 2009-04-22 테바 파마슈티컬 인더스트리즈 리미티드 비타민 ｄ 및 코르티코스테로이드를 포함하는 약학 조성물
US8716334B2 (en) 2008-06-17 2014-05-06 Ben Gurion University Of The Negev Research And Development Authority Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
SG2014006324A (en) 2009-01-27 2014-03-28 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
HK1222819A1 (zh) 2013-05-29 2017-07-14 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197949A1 (en) * 1984-10-04 1986-10-22 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
WO1987003282A1 (fr) * 1985-11-21 1987-06-04 Taisho Pharmaceutical Co., Ltd. Derive de la vitamine d3
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives

Also Published As

Publication number Publication date
PT95473B (pt) 1997-07-31
DE59005254D1 (de) 1994-05-11
DK0421561T3 (da) 1994-07-25
NO904269D0 (no) 1990-10-01
AU639717B2 (en) 1993-08-05
DE3933034A1 (de) 1991-04-11
HUT55751A (en) 1991-06-28
CA2026671A1 (en) 1991-04-03
CN1053103C (zh) 2000-06-07
JPH03246273A (ja) 1991-11-01
ATE103893T1 (de) 1994-04-15
ZA907876B (en) 1992-04-29
CN1051907A (zh) 1991-06-05
NO904269L (no) 1991-04-03
IL95872A (en) 1995-03-15
IE903520A1 (en) 1991-04-10
NO178923B (no) 1996-03-25
PT95473A (pt) 1991-06-25
CN1031705C (zh) 1996-05-01
AU6371590A (en) 1991-04-11
EP0421561A3 (en) 1991-06-12
FI904850A0 (fi) 1990-10-02
HU210032B (en) 1995-01-30
US5665716A (en) 1997-09-09
EP0421561A2 (de) 1991-04-10
IE71227B1 (en) 1997-02-12
IL95872A0 (en) 1991-07-18
NO178923C (no) 1996-07-03
EP0421561B1 (de) 1994-04-06
HU906284D0 (en) 1991-03-28
CN1106666A (zh) 1995-08-16
FI93643B (fi) 1995-01-31
FI93643C (fi) 1995-05-10
DD299178A5 (de) 1992-04-02
CA2026671C (en) 1998-12-08

Similar Documents

Publication Publication Date Title
ES2052166T3 (es) Derivados de 24-homo-vitamina-d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos.
MX9300821A (es) Compuestos hipolipidemicos.
ES2040261T3 (es) Procedimiento para preparar acidos 6-fluor-4-oxo-1,4-dihidroquinolina-3-carboxilicos sustituidos y acidos 9-fluor-3-metil-7-oxo-2,3-dihidro-7h-pirido(1,2,3-de)(1,4)benzoxazina-6-carboxilico sustituidos.
ES2079719T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su utilizacion y agentes que los contienen en calidad de anticoagulantes.
ES542323A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
ES2089497T3 (es) Derivados de 23-oxa en la serie de la vitamina d, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos.
DE3588095D1 (de) Polypeptid, dessen Verfahren zur Herstellung und dieses enthaltende pharmazeutische Zusammensetzung und deren Benutzung
ES510599A0 (es) Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos.
ZA824438B (en) Novel 2-aryl-3,4-diazabicyclo-(4.n.o)alk-2-en-5-ones their preparation,and drugs containing them
DK0474712T3 (da) Anvendelse af lysolecitinderivater til fremstilling af et farmaceutisk præparat
ZA806399B (en) New 2-hydroxyalkyl-3,4,5-trihydroxypiperidine compounds, their production and their medicinal use
ES2032582T3 (es) Procedimiento para preparar derivados de la oxima del 1,2,5,6,-tetrahidropiridin -3-carboxialdehido.
MX9300840A (es) Compuestos farmaceuticos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DE3574969D1 (de) Aetheroxidderivate von zyklopropylphenolen.
ES2143973T3 (es) Procedimiento para la preparacion de acidos 7-(3-amino- asi como 3-aminometil-1-pirrolidinil)-3-quinoloncarboxilicos asi como -naftiridoncarboxilicos.
ES2038776T3 (es) Procedimiento de preparacion de derivados de la oxima del 1,2,5,6-tetrahidropiridin-3-carboxaldehido.
AR245688A1 (es) Compuestos trigliceridos de amonio cuaternario, su preparacion y su uso.
IL60323A0 (en) Pseudotrisaccharide compounds,their preparation and their medicinal use
IT1230595B (it) Perossiacidi immido derivati
MX9303392A (es) Derivados de imidazo benzoxazin-1-ona substituidos y proceso para su preparacion.
FR2446841A1 (fr) Procede de preparation de 1a,3b-dihydroxy-d5-steroides
MX174093B (es) 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA
MX25747A (es) 3'-desamino-4' -desoxi-4' -amino-8-fluoroantraciclinas y procedimiento para su preparacion.
BR8103727A (pt) Processos para a producaco de um ester de acido dimetacrilico sua aplicacao e composicoes vedantes ou adesivas a base do mesmo

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 421561

Country of ref document: ES