DE69033299T2 - Verwendung von Carnosolsäure wegen seiner anticarcinogenen und antiviralen Eigenschaften - Google Patents

Verwendung von Carnosolsäure wegen seiner anticarcinogenen und antiviralen Eigenschaften

Info

Publication number
DE69033299T2
DE69033299T2 DE69033299T DE69033299T DE69033299T2 DE 69033299 T2 DE69033299 T2 DE 69033299T2 DE 69033299 T DE69033299 T DE 69033299T DE 69033299 T DE69033299 T DE 69033299T DE 69033299 T2 DE69033299 T2 DE 69033299T2
Authority
DE
Germany
Prior art keywords
anticarcinogenic
carnosic acid
antiviral properties
carnosic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033299T
Other languages
English (en)
Other versions
DE69033299D1 (de
Inventor
Robert Aeschbach
Georges Philippossian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Publication of DE69033299D1 publication Critical patent/DE69033299D1/de
Application granted granted Critical
Publication of DE69033299T2 publication Critical patent/DE69033299T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
DE69033299T 1990-10-06 1990-10-06 Verwendung von Carnosolsäure wegen seiner anticarcinogenen und antiviralen Eigenschaften Expired - Fee Related DE69033299T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90119218A EP0480077B1 (de) 1990-10-06 1990-10-06 Verfahren zur Gewinnung von Carnosäure

Publications (2)

Publication Number Publication Date
DE69033299D1 DE69033299D1 (de) 1999-10-28
DE69033299T2 true DE69033299T2 (de) 2000-01-05

Family

ID=8204588

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69012566T Expired - Fee Related DE69012566T2 (de) 1990-10-06 1990-10-06 Verfahren zur Gewinnung von Carnosäure.
DE69033299T Expired - Fee Related DE69033299T2 (de) 1990-10-06 1990-10-06 Verwendung von Carnosolsäure wegen seiner anticarcinogenen und antiviralen Eigenschaften

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69012566T Expired - Fee Related DE69012566T2 (de) 1990-10-06 1990-10-06 Verfahren zur Gewinnung von Carnosäure.

Country Status (13)

Country Link
US (1) US5256700A (de)
EP (2) EP0480077B1 (de)
JP (2) JP2572173B2 (de)
AT (2) ATE111434T1 (de)
AU (1) AU634911B2 (de)
CA (1) CA2052745C (de)
DE (2) DE69012566T2 (de)
DK (2) DK0480077T3 (de)
ES (2) ES2137963T3 (de)
GR (1) GR3031421T3 (de)
IE (1) IE65512B1 (de)
NZ (1) NZ240094A (de)
ZA (1) ZA917484B (de)

Families Citing this family (38)

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EP0605509B1 (de) * 1991-09-20 1995-12-20 Norac Technologies Inc. Antioxidan-oleoreninzusammensetzung und verfahren zur herstellung
US5552158A (en) * 1993-02-23 1996-09-03 Norac Technologies Inc. Skin care composition
US5358752A (en) * 1993-02-23 1994-10-25 Norac Technologies Inc. Skin care composition
DE4418976C2 (de) * 1994-05-31 1996-12-12 Horst Walter Hendricks Phytotherapeutikum zur Behandlung von Infektionen des Herpes simplex-Virus (Typ 1 und Typ 2) und Verfahren zu seiner Herstellung
EP0824320A4 (de) * 1995-05-05 2000-06-07 Hauser Inc Carnosinsäure hoher reinheit aus rosmarin-und salbeiextrakten durch ph-gesteuerte fällung
CA2286801C (en) * 1997-04-16 2006-03-14 Lycored Natural Products Industries Ltd. A novel process to produce stabilized carnosic acid in high concentration
US6824789B2 (en) 1998-05-20 2004-11-30 Kemin Industries, Inc. Method of extracting antioxidants from lamiaceae species and the extract products thereof
US6855349B2 (en) 1998-12-07 2005-02-15 Kemin Industries, Inc. Method for simultaneous extraction of essential oils and antioxidants from Labiatae species and the extract products thereof
KR100326841B1 (ko) * 1999-06-14 2002-03-04 박명규 들깨잎으로부터 고순도 로즈마리닉산의 분리, 정제방법
JP2001122777A (ja) 1999-10-27 2001-05-08 Nagase & Co Ltd 抗潰瘍剤
US6180144B1 (en) * 2000-01-27 2001-01-30 The Goodyear Tire & Rubber Co Chewing gum base stabilized with carnosic acid
JP2001233835A (ja) * 2000-02-28 2001-08-28 Nagase & Co Ltd カルノジン酸誘導体およびそれを用いた神経成長因子合成促進剤
US6450935B1 (en) 2000-10-13 2002-09-17 Kemin Industries, Inc. Method for removing essential oils and antioxidants from extract products of lamiaceae species using rolled film evaporation
JP2003073266A (ja) * 2001-08-30 2003-03-12 Osaka Organic Chem Ind Ltd 癌細胞増殖阻害剤
JP3980952B2 (ja) * 2002-04-12 2007-09-26 森下仁丹株式会社 植物抽出エキスを含有する腸溶性の脂肪吸収抑制剤およびそれを含有する食品
CN1297259C (zh) * 2004-05-21 2007-01-31 北京华医神农医药科技有限公司 一种来源于迷迭香的总二萜酚及其制备方法和用途
JP2006008531A (ja) * 2004-06-22 2006-01-12 Nagase & Co Ltd 抗酸化酵素産生促進剤及びその製造方法。
KR100668689B1 (ko) * 2004-11-09 2007-01-15 한국생명공학연구원 라이노바이러스에 대한 항바이러스 조성물
US20060134025A1 (en) * 2004-12-17 2006-06-22 Colgate-Palmolive Company Oral compositions containing extracts of Rosmarinus and related methods
KR100697309B1 (ko) * 2005-04-12 2007-03-20 한국생명공학연구원 식물 추출물을 포함하는 항바이러스 조성물
US8022246B2 (en) * 2006-10-10 2011-09-20 The Burnham Institute For Medical Research Neuroprotective compositions and methods
CN103110188A (zh) * 2006-11-17 2013-05-22 生物合成技术公司 含有迷迭香提取物的卷烟过滤嘴以及通过使用所述过滤嘴减少由烟雾中有害物质引起的dna 损伤的方法
EP2094120A4 (de) * 2006-11-17 2012-12-12 Biosynthec Rosmarinextrakt enthaltender zigarettenfilter und verfahren zur verminderung des durch schädliche mittel im zigarettenrauch hervorgerufenen dna-schadens durch die verwendung dieses filters
EP1925301A1 (de) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Verwendung von tricyclischen Diterpenen und deren Derivaten zur Behandlung oder Vorbeugung von entzündlichen - und/oder Gelenkerkrankungen
EP1925302A1 (de) 2006-11-24 2008-05-28 DSMIP Assets B.V. Diätetische oder pharmazeutische Zubereitung enthaltend trizyklische Diterpene und ihre Derivate zur Behandlung von Depression
US8691247B2 (en) 2006-12-26 2014-04-08 Ad Lunam Labs Inc. Skin rejuvenation cream
FR2918560B1 (fr) * 2007-07-12 2009-10-09 Oreal Composition cosmetique contenant un derive de dibenzoylmethane et un compose phenanthrenol ; procede de photostabilisation du derive de dibenzoylmethane.
CN105193777B (zh) * 2009-01-19 2019-06-28 利科雷德有限公司 类胡萝卜素和多酚的协同组合
DE102009045994A1 (de) * 2009-10-26 2011-11-17 Evonik Degussa Gmbh Verfahren zur Herstellung eines carnosolsäurereichen Pflanzenextrakts
WO2012060861A1 (en) 2010-10-25 2012-05-10 Kalamazoo Holdings, Inc. Simple process to produce and separate water soluble and oil soluble antioxidative flavoring compositions from labiatae herbs using green solvents
CN102070440B (zh) * 2010-12-15 2013-05-01 广东省食品工业研究所 一种富含鼠尾草酸的液态提取物的制备方法
ITGE20110041A1 (it) * 2011-04-12 2012-10-13 Ct Di Sperimentazione Ed Assist Enza Agricola Metodo di ottenimento di acido carnosico e triterpeni, come composti puri o come fitocomplessi arricchiti, da piante della famiglia delle lamiaceae
US9801844B2 (en) * 2012-05-24 2017-10-31 The Research Foundation Of The City University Of New York Methods and compositions for the treatment of cancer
CN104058955A (zh) * 2014-07-02 2014-09-24 中国林业科学研究院林产化学工业研究所 一种常压柱层析从迷迭香提取物中分离纯化鼠尾草酸的方法
CN107759467B (zh) * 2017-10-27 2020-11-13 湖南鑫利生物科技有限公司 一种提高迷迭香脂溶性抗氧化剂中鼠尾草酸含量的制备方法
CN107827738A (zh) * 2017-10-27 2018-03-23 湖南鑫利生物科技有限公司 一种从迷迭香提取物中分离鼠尾草酸的方法
TR201912820A2 (tr) 2019-08-26 2021-03-22 Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇
CN111100642B (zh) * 2019-12-06 2021-01-01 湖南鑫利生物科技有限公司 一种制备迷迭香脂溶性抗氧化剂结晶粉末的方法

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US4450097A (en) * 1981-02-26 1984-05-22 Lion Corporation Antioxidative compound, method of extracting same from rosemary, and use of same
US4638095A (en) * 1984-08-10 1987-01-20 Research Corporation Isolation of a novel antioxidant rosmaridiphenol from Rosmarinus officinalis L.
IL80783A0 (en) * 1986-10-17 1987-02-27 Univ Bar Ilan Food supplements
US5102659A (en) * 1990-07-12 1992-04-07 Shaklee Corporation Natural antioxidant compositions

Also Published As

Publication number Publication date
DK0480077T3 (da) 1995-02-13
EP0480077A1 (de) 1992-04-15
DE69033299D1 (de) 1999-10-28
US5256700A (en) 1993-10-26
AU634911B2 (en) 1993-03-04
EP0480077B1 (de) 1994-09-14
GR3031421T3 (en) 2000-01-31
ZA917484B (en) 1992-06-24
CA2052745C (en) 2002-12-17
JPH04247054A (ja) 1992-09-03
IE65512B1 (en) 1995-11-01
EP0582318B1 (de) 1999-09-22
ATE184789T1 (de) 1999-10-15
EP0582318A1 (de) 1994-02-09
AU8458891A (en) 1992-04-09
DE69012566T2 (de) 1995-02-02
ATE111434T1 (de) 1994-09-15
DE69012566D1 (de) 1994-10-20
JP2880670B2 (ja) 1999-04-12
JP2572173B2 (ja) 1997-01-16
NZ240094A (en) 1994-02-25
CA2052745A1 (en) 1992-04-07
ES2137963T3 (es) 2000-01-01
ES2060883T3 (es) 1994-12-01
IE913285A1 (en) 1992-04-08
DK0582318T3 (da) 2000-03-20
JPH0873349A (ja) 1996-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee