TR201912820A2 - Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇ - Google Patents

Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇

Info

Publication number
TR201912820A2
TR201912820A2 TR2019/12820A TR201912820A TR201912820A2 TR 201912820 A2 TR201912820 A2 TR 201912820A2 TR 2019/12820 A TR2019/12820 A TR 2019/12820A TR 201912820 A TR201912820 A TR 201912820A TR 201912820 A2 TR201912820 A2 TR 201912820A2
Authority
TR
Turkey
Prior art keywords
acid
carnosol
carnosic
extract
rosmarinic acid
Prior art date
Application number
TR2019/12820A
Other languages
English (en)
Inventor
Karadeni̇z Bülent
Pelvan Ebru
Saklar Ayyildiz Sena
Original Assignee
Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak filed Critical Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak
Priority to TR2019/12820A priority Critical patent/TR201912820A2/tr
Priority to EP20756966.6A priority patent/EP4021607B1/en
Priority to PCT/IB2020/057159 priority patent/WO2021038340A1/en
Priority to US17/638,067 priority patent/US20220313655A1/en
Priority to ES20756966T priority patent/ES2972699T3/es
Publication of TR201912820A2 publication Critical patent/TR201912820A2/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
    • B01D11/0265—Applying ultrasound

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

Buluş Biberiye bitkisinin antioksidan özelliğe sahip etken maddeleri olarak tanımlanan diterpenler olan karnosik asit ve karnosol ile fenolik asit olan rozmarinik asitin, kolon kromatografi yöntemiyle, fraksiyonlanarak ayrılması yöntemi ile ilgilidir. Üretim prosesi; uygun çözgen içinde elde edilen biberiye ekstresinin uygun dolgu maddesiyle doldurulmuş kolondan çözgen geçirerek karnosik asit ve karnosolce zengin kısmın ayrılmasını ve sonrasında kurutularak, deodorize toz ürün elde edilmesini kapsar. Proses sırasında yüksek antioksidan aktiviteye sahip rozmarinik asit içeren ekstre de elde edilmektedir. Buluş, bu şekliyle asitlendirme, çöktürme, membran filtrasyonu ve deodorizasyon gibi ek işlemlere gerek duymadan ve tek seferde elde edilen karnosik asit ve karnosolce zengin ekstrenin, rozmarinik asit içeren ekstrenin gıda, ilaç ve kozmetik uygulamalarında kullanımına izin verir.
TR2019/12820A 2019-08-26 2019-08-26 Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇ TR201912820A2 (tr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
TR2019/12820A TR201912820A2 (tr) 2019-08-26 2019-08-26 Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇
EP20756966.6A EP4021607B1 (en) 2019-08-26 2020-07-29 Carnosic acid, carnosol and rosmarinic acid isolation method
PCT/IB2020/057159 WO2021038340A1 (en) 2019-08-26 2020-07-29 Carnosic acid, carnosol and rosmarinic acid isolation method
US17/638,067 US20220313655A1 (en) 2019-08-26 2020-07-29 Carnosic acid, carnosol and rosmarinic acid isolation method
ES20756966T ES2972699T3 (es) 2019-08-26 2020-07-29 Procedimiento de aislamiento de ácido carnósico, de carnosol y de ácido rosmarínico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2019/12820A TR201912820A2 (tr) 2019-08-26 2019-08-26 Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇

Publications (1)

Publication Number Publication Date
TR201912820A2 true TR201912820A2 (tr) 2021-03-22

Family

ID=72086927

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/12820A TR201912820A2 (tr) 2019-08-26 2019-08-26 Karnosi̇k asi̇t, karnosol ve rozmari̇ni̇k asi̇t i̇zolasyon yöntemi̇

Country Status (5)

Country Link
US (1) US20220313655A1 (tr)
EP (1) EP4021607B1 (tr)
ES (1) ES2972699T3 (tr)
TR (1) TR201912820A2 (tr)
WO (1) WO2021038340A1 (tr)

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* Cited by examiner, † Cited by third party
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CN113461531A (zh) * 2021-06-09 2021-10-01 湖南鑫利生物科技有限公司 一种提取迷迭香酸的方法
CN114736123B (zh) * 2021-12-28 2023-10-03 海南舒普生物科技有限公司 一种高纯度迷迭香酸的提取方法
CN114773425B (zh) * 2022-06-07 2024-01-26 晨光生物科技集团股份有限公司 一种液液萃取分离鼠尾草酸和熊果酸的方法与应用
CN115724901A (zh) * 2022-12-09 2023-03-03 湖南一科生物科技有限公司 一种从迷迭香中提取迷迭香酸、鼠尾草酸和熊果酸的方法

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US3950266A (en) 1973-11-28 1976-04-13 Rutgers Research And Educational Foundation Method of producing an antioxidant composition from rosemary and sage
ATE111434T1 (de) 1990-10-06 1994-09-15 Nestle Sa Verfahren zur gewinnung von carnosäure.
CA2220223C (en) 1995-05-05 2008-07-29 Hauser Inc. High purity carnosic acid from rosemary and sage extracts by ph-controlled precipitation
US6855349B2 (en) 1998-12-07 2005-02-15 Kemin Industries, Inc. Method for simultaneous extraction of essential oils and antioxidants from Labiatae species and the extract products thereof
SI20143B (sl) 1999-02-16 2008-04-30 Vitiva Prizvodnja In Storitve D.D. Postopek za pridobivanje naravnih antioksidantov iz rastlin
CN102199092A (zh) * 2010-03-26 2011-09-28 禹州市森源本草天然产物有限公司 一种从迷迭香获得两种抗氧化剂的生产工艺
ES2581592T3 (es) 2010-10-25 2016-09-06 Kalamazoo Holdings, Inc. Procedimiento sencillo para producir y separar composiciones aromatizantes antioxidantes solubles en aceite y solubles en agua de hierbas de Labiatae usando disolventes verdes
CN102115442B (zh) * 2011-01-05 2013-10-16 曾健青 一种从迷迭香叶提取物中分离鼠尾草酸的方法
CN102432469B (zh) 2011-12-08 2013-02-20 长沙卫一生物科技有限公司 一种从迷迭香中提取分离迷迭香酸和熊果酸的方法
CN103319495B (zh) * 2013-07-20 2016-03-02 高政 高纯度鼠尾草酚的制备方法
CN104939267B (zh) * 2014-03-25 2019-07-23 湖南今汉药业有限公司 一种迷迭香提取组合物及其作为保鲜剂的应用
CN108070453A (zh) 2016-11-11 2018-05-25 长沙卫生物科技有限公司 一种从迷迭香中提取分离迷迭香精油、迷迭香酸、熊果酸和鼠尾草酸的方法
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Also Published As

Publication number Publication date
US20220313655A1 (en) 2022-10-06
EP4021607B1 (en) 2023-11-15
WO2021038340A1 (en) 2021-03-04
ES2972699T3 (es) 2024-06-14
EP4021607A1 (en) 2022-07-06

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