DE69022943T2 - Verfahren zur Herstellung von Phenylessigsäurederivaten aus Thienopyridin und Zwischenprodukte von alpha-Bromphenylessigsäuren. - Google Patents

Verfahren zur Herstellung von Phenylessigsäurederivaten aus Thienopyridin und Zwischenprodukte von alpha-Bromphenylessigsäuren.

Info

Publication number
DE69022943T2
DE69022943T2 DE69022943T DE69022943T DE69022943T2 DE 69022943 T2 DE69022943 T2 DE 69022943T2 DE 69022943 T DE69022943 T DE 69022943T DE 69022943 T DE69022943 T DE 69022943T DE 69022943 T2 DE69022943 T2 DE 69022943T2
Authority
DE
Germany
Prior art keywords
thienopyridine
intermediates
alpha
preparation
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022943T
Other languages
English (en)
Other versions
DE69022943D1 (de
Inventor
Michel Bouisset
Joel Radisson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69022943D1 publication Critical patent/DE69022943D1/de
Application granted granted Critical
Publication of DE69022943T2 publication Critical patent/DE69022943T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
    • C07C51/23—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups
    • C07C51/235—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups of —CHO groups or primary alcohol groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69022943T 1989-09-29 1990-06-26 Verfahren zur Herstellung von Phenylessigsäurederivaten aus Thienopyridin und Zwischenprodukte von alpha-Bromphenylessigsäuren. Expired - Lifetime DE69022943T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912787A FR2652575B1 (fr) 1989-09-29 1989-09-29 Procede de preparation d'acides alpha-bromo phenylacetiques.

Publications (2)

Publication Number Publication Date
DE69022943D1 DE69022943D1 (de) 1995-11-16
DE69022943T2 true DE69022943T2 (de) 1996-04-25

Family

ID=9385964

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022943T Expired - Lifetime DE69022943T2 (de) 1989-09-29 1990-06-26 Verfahren zur Herstellung von Phenylessigsäurederivaten aus Thienopyridin und Zwischenprodukte von alpha-Bromphenylessigsäuren.

Country Status (28)

Country Link
US (1) US5036156A (de)
EP (1) EP0420706B1 (de)
JP (1) JP3176612B2 (de)
KR (1) KR910006201A (de)
AT (1) ATE128961T1 (de)
AU (1) AU627590B2 (de)
CA (1) CA2019301C (de)
DD (1) DD295851A5 (de)
DE (1) DE69022943T2 (de)
DK (1) DK0420706T3 (de)
ES (1) ES2078956T3 (de)
FI (1) FI903210A0 (de)
FR (1) FR2652575B1 (de)
GR (1) GR3017939T3 (de)
HU (1) HU207325B (de)
IE (1) IE70432B1 (de)
IL (1) IL94801A0 (de)
LV (1) LV11683B (de)
MA (1) MA21878A1 (de)
NO (1) NO902714L (de)
NZ (1) NZ234160A (de)
OA (1) OA09453A (de)
PL (1) PL285788A1 (de)
PT (1) PT94486B (de)
RU (1) RU1836373C (de)
TN (1) TNSN90089A1 (de)
YU (1) YU124590A (de)
ZA (1) ZA904830B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189170A (en) * 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
ATE129496T1 (de) * 1990-01-25 1995-11-15 Sanofi Sa Herstellung von 2-(2'-thienyl)alkylaminen und deren derivaten zur synthese von 4,5,6,7- thieno(3,2-c>pyridinderivaten.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
JP3127332B2 (ja) * 1993-05-10 2001-01-22 本田技研工業株式会社 自動二輪車用制動装置
JP3231169B2 (ja) * 1993-12-30 2001-11-19 本田技研工業株式会社 自動２輪車用制動装置
HU225503B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225504B1 (en) * 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
ATE349451T1 (de) * 2001-01-24 2007-01-15 Cadila Healthcare Ltd Verfahren zur herstellung von clopidogrel
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
WO2004074215A1 (en) * 2003-02-03 2004-09-02 Sunil Sadanand Nadkarni Process for preparation of clopidogrel, its salts and pharmaceutical compositions
EP1603920A1 (de) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorphe und amorphe form (s)-(+)-clopidogrel-bisulfat
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
ATE455778T1 (de) 2003-11-03 2010-02-15 Cadila Healthcare Ltd Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
US20060223845A1 (en) * 2005-02-24 2006-10-05 Eran Turgeman Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
WO2006130852A1 (en) * 2005-06-02 2006-12-07 Dr. Reddy's Laboratories Ltd. Recovery of clopidogrel bisulfate
EP1942110A4 (de) * 2005-09-08 2010-08-04 Zhejiang Huahai Pharm Co Ltd Herstellung von clopidogrel und seinen analogen methyltetrahydrothienopyridinacetatverbindungen
EP1980563A1 (de) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat
JP2009532508A (ja) * 2007-04-18 2009-09-10 テバ ファーマシューティカル インダストリーズ リミティド クロピドグレルの改良された調製方法
EP2107061A1 (de) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Herstellungsverfahren für optisch angereichertes Clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
KR100990949B1 (ko) * 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
CN102186858A (zh) * 2008-10-24 2011-09-14 桑多斯股份公司 制备s-氯吡格雷的方法
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN101974016A (zh) * 2010-10-14 2011-02-16 天津药物研究院 酰胺类化合物及其制备方法和用途
CN102250114B (zh) * 2011-04-27 2014-02-26 青岛黄海制药有限责任公司 一种氯吡格雷及其硫酸盐的制备方法
CN102268012B (zh) * 2011-08-24 2014-04-09 天津药物研究院 噻唑衍生物、其制备方法和用途
CN103387497A (zh) * 2012-05-10 2013-11-13 深圳信立泰药业股份有限公司 一种氯吡格雷及其中间体α-溴代邻氯苯乙酸甲酯和噻吩乙胺基取代乙酸甲酯盐的制备方法
CN103450005B (zh) * 2012-06-01 2016-07-06 深圳信立泰药业股份有限公司 一种氯吡格雷及其中间体α-溴代邻氯苯乙酸和α-噻吩乙胺基取代乙酸盐酸盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2778851A (en) * 1953-09-03 1957-01-22 Dow Chemical Co Preparation of alpha-chloro-alpha-methyl aliphatic acids and acid-chlorides
US4268442A (en) * 1978-11-14 1981-05-19 Sagami Chemical Research Center Process for preparing aromatic acetic acid
JPS5935370B2 (ja) * 1978-11-14 1984-08-28 財団法人相模中央化学研究所 芳香族酢酸の製造方法
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
AU5754690A (en) 1991-04-11
JP3176612B2 (ja) 2001-06-18
IE902179A1 (en) 1991-04-10
DD295851A5 (de) 1991-11-14
IL94801A0 (en) 1991-04-15
AU627590B2 (en) 1992-08-27
HU903995D0 (en) 1990-11-28
LV11683A (lv) 1997-02-20
IE70432B1 (en) 1996-11-27
RU1836373C (ru) 1993-08-23
JPH03120286A (ja) 1991-05-22
ES2078956T3 (es) 1996-01-01
FR2652575B1 (fr) 1992-01-24
HUT55338A (en) 1991-05-28
PT94486A (pt) 1991-05-22
EP0420706A3 (en) 1992-03-04
PT94486B (pt) 1997-02-28
ZA904830B (en) 1992-02-26
FI903210A0 (fi) 1990-06-26
KR910006201A (ko) 1991-04-27
GR3017939T3 (en) 1996-02-29
MA21878A1 (fr) 1990-12-31
CA2019301C (en) 2000-09-05
ATE128961T1 (de) 1995-10-15
PL285788A1 (en) 1991-08-12
US5036156A (en) 1991-07-30
EP0420706B1 (de) 1995-10-11
TNSN90089A1 (fr) 1991-03-05
OA09453A (fr) 1992-10-15
NZ234160A (en) 1992-08-26
HU207325B (en) 1993-03-29
DE69022943D1 (de) 1995-11-16
DK0420706T3 (da) 1996-02-05
NO902714D0 (no) 1990-06-19
EP0420706A2 (de) 1991-04-03
YU124590A (en) 1991-10-31
FR2652575A1 (fr) 1991-04-05
LV11683B (en) 1997-08-20
NO902714L (no) 1991-04-02
CA2019301A1 (en) 1991-03-29

Similar Documents

Publication Publication Date Title
DE69022943D1 (de) Verfahren zur Herstellung von Phenylessigsäurederivaten aus Thienopyridin und Zwischenprodukte von alpha-Bromphenylessigsäuren.
DE69118765D1 (de) Verfahren zur Herstellung eines N-Phenylacetylderivats von Tetrahydrothieno[3,2-c]pyridin und Zwischenprodukt der Synthese
ATE133950T1 (de) 2-thienylglycidsäurederivat, verfahren zu seiner herstellung und seine verwendung als synthesezwischenprodukt
EP0403252A3 (de) Verfahren zur Herstellung von Epoxyestern und dadurch erhaltene Zwischenprodukte
DE69030897D1 (de) Verfahren zur Herstellung von 1,5-Benzothiazepin-Derivaten
ES8200681A1 (es) Procedimiento para la preparacion de derivados de 5,11-dihi-dro-6h-pirido(2,3-b)(1,4)-benzodiazepin-6-ona
ATE60058T1 (de) Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3- phosphocholinen.
DE58909406D1 (de) Verfahren zur Herstellung von 4,5,6,7-Tetrahydrothieno-[3,2-c]-Pyridinen.
ATE16696T1 (de) Verfahren zur herstellung von 3-alkyl-6-methylbeta-resorcylsaeureestern.
JPS5679668A (en) 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation
IL85135A (en) Preparation of 3-phenylthiazolo(3,2-a)benzimidazole 2-alkanoic acids
DE69407938T2 (de) Verfahren zur herstellung von alpha-hydroximinophenylacetonitril
DE69906009D1 (de) Verfahren zur Herstellung von 2-Alkyliden-4-Bromacetessigsäureestern
JPS57156447A (en) Ether compound and its synthesis
JPS5610190A (en) Preparation of benzopyranopyridine derivative
JPS56123992A (en) Thiazinoimidazole derivative and its preparation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR