DE69001493T2 - Verwendung von 5-methyltetrahydrofolsaeure, 5-formyltetrahydrofolsaeure sowie deren pharmazeutisch geeigneten salzen zur herstellung von arzneimitteln mit gesteuerter freigabe zur verwendung in der therapie depressiver stoerungen sowie die auf diese weise hergestellten arzneimittel. - Google Patents
Verwendung von 5-methyltetrahydrofolsaeure, 5-formyltetrahydrofolsaeure sowie deren pharmazeutisch geeigneten salzen zur herstellung von arzneimitteln mit gesteuerter freigabe zur verwendung in der therapie depressiver stoerungen sowie die auf diese weise hergestellten arzneimittel.Info
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- DE69001493T2 DE69001493T2 DE9090101570T DE69001493T DE69001493T2 DE 69001493 T2 DE69001493 T2 DE 69001493T2 DE 9090101570 T DE9090101570 T DE 9090101570T DE 69001493 T DE69001493 T DE 69001493T DE 69001493 T2 DE69001493 T2 DE 69001493T2
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8919261A IT1229517B (it) | 1989-01-31 | 1989-01-31 | Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69001493D1 DE69001493D1 (de) | 1993-06-09 |
| DE69001493T2 true DE69001493T2 (de) | 1993-08-26 |
Family
ID=11156204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE9090101570T Expired - Lifetime DE69001493T2 (de) | 1989-01-31 | 1990-01-26 | Verwendung von 5-methyltetrahydrofolsaeure, 5-formyltetrahydrofolsaeure sowie deren pharmazeutisch geeigneten salzen zur herstellung von arzneimitteln mit gesteuerter freigabe zur verwendung in der therapie depressiver stoerungen sowie die auf diese weise hergestellten arzneimittel. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5538734A (enExample) |
| EP (1) | EP0382019B1 (enExample) |
| JP (1) | JPH0757727B2 (enExample) |
| AT (1) | ATE88895T1 (enExample) |
| DE (1) | DE69001493T2 (enExample) |
| DK (1) | DK0382019T3 (enExample) |
| ES (1) | ES2055175T3 (enExample) |
| GR (1) | GR3007790T3 (enExample) |
| IT (1) | IT1229517B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660835A (en) * | 1995-02-24 | 1997-08-26 | East Carolina University | Method of treating adenosine depletion |
| US20020032160A1 (en) * | 1995-02-24 | 2002-03-14 | Nyce Jonathan W. | Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels |
| CA2243981C (en) * | 1996-01-31 | 2005-09-06 | South Alabama Medical Science Foundation | Food and vitamin preparations containing the natural isomer of reduced folates |
| GB2336534A (en) * | 1998-04-24 | 1999-10-27 | Alec James Coppen | Anti-depressant - Folic Acid Combination |
| ES2292238T3 (es) * | 1998-04-24 | 2008-03-01 | Scarista Limited | Tratamiento de la depresion y preparaciones farmaceuticas para el mismo. |
| EP1102578A4 (en) * | 1998-08-03 | 2005-05-18 | Epigenesis Pharmaceuticals Inc | NEW ANALGICAL, ANTIINFLAMMATORY AND WOUND HEALING ACTIVE SUBSTANCE |
| WO2000023089A1 (en) * | 1998-10-19 | 2000-04-27 | Merck Patent Gmbh | Natural formulation for the treatment and prevention of depression, containing st john's wort and derivatives of dihydro- and tetrahydrofolic acid |
| AU6202299A (en) * | 1998-10-30 | 2000-05-22 | Merck Patent Gmbh | Compositions for the treatment and prevention of neurological and pathopsychological diseases |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| EP1349554A2 (en) * | 2000-12-14 | 2003-10-08 | Tufts University | Compositions and methods for treating an arthritic condition |
| AU2002303427A1 (en) * | 2001-04-24 | 2002-11-05 | East Carolina University | Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease |
| US20050070487A1 (en) * | 2001-04-24 | 2005-03-31 | Nyce Jonathan W. | Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent |
| JP2005530820A (ja) * | 2002-06-17 | 2005-10-13 | エピジェネシス ファーマシューティカルズ リミティド ライアビリティー カンパニー | 二水和デヒドロエピアンドロステロン及びその組成物を用いた喘息又は慢性閉塞性肺疾患の治療方法 |
| US7405207B2 (en) * | 2002-06-17 | 2008-07-29 | Epigenesis Pharmaceuticals, Inc. | Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof |
| US20050026890A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026848A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026882A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
| US20090274676A1 (en) * | 2003-07-31 | 2009-11-05 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20090263381A1 (en) * | 2003-07-31 | 2009-10-22 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease |
| US20110209699A1 (en) * | 2003-07-31 | 2011-09-01 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050085430A1 (en) * | 2003-07-31 | 2005-04-21 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026881A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease |
| US20090285900A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050113318A1 (en) * | 2003-07-31 | 2005-05-26 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026884A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20090285899A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026883A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050043282A1 (en) * | 2003-07-31 | 2005-02-24 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050101545A1 (en) * | 2003-07-31 | 2005-05-12 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026880A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease |
| WO2011006147A1 (en) * | 2009-07-10 | 2011-01-13 | Scott Iii Linzy O | Methods and compositions for treating thyroid-related medical conditions with reduced folates |
| US8372451B2 (en) * | 2010-02-12 | 2013-02-12 | Alexander Vuckovic, M.D., Llc | Compositions and methods for treating depression |
| WO2018144088A1 (en) | 2016-11-03 | 2018-08-09 | Alexander Vuckovic, M.D., Llc | Compositions and methods for treating depression |
| HUE068578T2 (hu) | 2017-03-31 | 2025-01-28 | Merck Patent Gmbh | 5-Metil-(6S)-tetrahidrofolsav kristályos nátriumsója |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1572137A (en) * | 1977-02-22 | 1980-07-23 | Bioresearch Sas Del Dr Livio C | Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts |
| GB2072504B (en) * | 1980-03-27 | 1983-10-26 | Coppen A J | Pharmaceutical compositions |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
| IT1204612B (it) * | 1987-05-14 | 1989-03-10 | Bioresearch Spa | Pteridine atte alla preparazione di composizioni farmaceutiche ad attivita' antiamnesica |
| IT1229203B (it) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
-
1989
- 1989-01-31 IT IT8919261A patent/IT1229517B/it active
-
1990
- 1990-01-26 DK DK90101570.1T patent/DK0382019T3/da active
- 1990-01-26 DE DE9090101570T patent/DE69001493T2/de not_active Expired - Lifetime
- 1990-01-26 ES ES90101570T patent/ES2055175T3/es not_active Expired - Lifetime
- 1990-01-26 AT AT90101570T patent/ATE88895T1/de not_active IP Right Cessation
- 1990-01-26 EP EP90101570A patent/EP0382019B1/en not_active Expired - Lifetime
- 1990-01-31 JP JP2019369A patent/JPH0757727B2/ja not_active Expired - Lifetime
-
1993
- 1993-05-06 GR GR920403210T patent/GR3007790T3/el unknown
-
1995
- 1995-02-09 US US08/386,188 patent/US5538734A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5538734A (en) | 1996-07-23 |
| GR3007790T3 (enExample) | 1993-08-31 |
| DK0382019T3 (da) | 1993-06-07 |
| IT8919261A0 (it) | 1989-01-31 |
| IT1229517B (it) | 1991-09-03 |
| DE69001493D1 (de) | 1993-06-09 |
| JPH0757727B2 (ja) | 1995-06-21 |
| EP0382019B1 (en) | 1993-05-05 |
| ES2055175T3 (es) | 1994-08-16 |
| ATE88895T1 (de) | 1993-05-15 |
| JPH02240021A (ja) | 1990-09-25 |
| EP0382019A1 (en) | 1990-08-16 |
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: KNOLL FARMACEUTICI S.P.A., MUGGIO, MAILAND/MILANO, |
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| 8327 | Change in the person/name/address of the patent owner |
Owner name: KNOLL-RAVIZZA FARMACEUTICI S.P.A., CAMPOVERDE DI A |