DE68928853T2 - Befestigung von sequenzspezifischen proben - Google Patents

Befestigung von sequenzspezifischen proben

Info

Publication number
DE68928853T2
DE68928853T2 DE68928853T DE68928853T DE68928853T2 DE 68928853 T2 DE68928853 T2 DE 68928853T2 DE 68928853 T DE68928853 T DE 68928853T DE 68928853 T DE68928853 T DE 68928853T DE 68928853 T2 DE68928853 T2 DE 68928853T2
Authority
DE
Germany
Prior art keywords
nucleotides
binding
nucleic acid
target sequence
tail
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68928853T
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English (en)
Other versions
DE68928853D1 (de
Inventor
Randall Saiki
Henry Erlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of DE68928853D1 publication Critical patent/DE68928853D1/de
Application granted granted Critical
Publication of DE68928853T2 publication Critical patent/DE68928853T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
DE68928853T 1988-05-20 1989-05-18 Befestigung von sequenzspezifischen proben Expired - Lifetime DE68928853T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19700088A 1988-05-20 1988-05-20
US34749589A 1989-05-04 1989-05-04
PCT/US1989/002170 WO1989011548A1 (en) 1988-05-20 1989-05-18 Immobilized sequence-specific probes

Publications (2)

Publication Number Publication Date
DE68928853D1 DE68928853D1 (de) 1998-12-24
DE68928853T2 true DE68928853T2 (de) 1999-08-05

Family

ID=26892463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928853T Expired - Lifetime DE68928853T2 (de) 1988-05-20 1989-05-18 Befestigung von sequenzspezifischen proben

Country Status (8)

Country Link
EP (1) EP0451141B1 (de)
JP (1) JP2897959B2 (de)
AT (1) ATE173508T1 (de)
AU (1) AU632494B2 (de)
CA (1) CA1340864C (de)
DE (1) DE68928853T2 (de)
IL (1) IL90358A (de)
WO (1) WO1989011548A1 (de)

Families Citing this family (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567809A (en) * 1986-03-13 1996-10-22 Hoffmann-La Roche Inc. Methods and reagents for HLA DRbeta DNA typing
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5871928A (en) * 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
EP0415755B1 (de) * 1989-09-01 1995-12-20 Life Technologies Inc. Verfahren zur Überprüfung der Kontamination von oligonukleotidabhängigen Nukleinsäure-Amplifikationsreaktionen
US5232829A (en) * 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
CA2032331A1 (en) * 1990-01-22 1991-07-23 Annie L. Wu Method and kits for detecting human leukocyte antigen dna
GB9002625D0 (en) * 1990-02-06 1990-04-04 Univ Singapore Human leukocyte antigen typing
AU7692691A (en) * 1990-03-07 1991-10-10 F. Hoffmann-La Roche Ag Method for diagnosis of lyme disease
CA2037349C (en) * 1990-03-26 2008-06-17 James G. Wetmur Branch migration of nucleotides
US5650302A (en) * 1990-05-01 1997-07-22 Amgen Inc. Method for reducing carryover contamination in an amplification procedure
HU218095B (hu) * 1990-05-01 2000-05-28 Amgen Inc. Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban
FR2663949A1 (fr) * 1990-06-29 1992-01-03 Genset Sa Perfectionnements a un procede d'amplification enzymatique in vitro.
ATE176002T1 (de) * 1990-07-24 1999-02-15 Hoffmann La Roche Verringerung von nicht spezifischer amplifikation während einer (in vitro) nukleinsäure amplifikation unter verwendung von modifizierten nukleinsäure basen
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
AU8920191A (en) * 1990-10-31 1992-05-26 George D. Cimino Methods and compositions for minimizing inhibition of nucleic acid amplification
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
EP0511559A1 (de) * 1991-04-30 1992-11-04 F.Hoffmann-La Roche & Co. Aktiengesellschaft Reagens für eine Oligonukleotidprobe
US5273883A (en) * 1991-05-07 1993-12-28 Hoffmann-La Roche Inc. Methods and reagents for γ-globin typing
US5220004A (en) * 1991-05-07 1993-06-15 Cetus Corporation Methods and reagents for G -65 -globin typing
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5464744A (en) * 1992-09-24 1995-11-07 Norval B. Galloway Methods and compositions for reducing false positive signals in an RNA amplification system
US5583211A (en) * 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5554501A (en) * 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5861242A (en) * 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
JP3954092B2 (ja) 1993-06-25 2007-08-08 アフィメトリックス インコーポレイテッド 核酸配列のハイブリダイゼーションと配列決定
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
AU7551094A (en) * 1993-07-23 1995-02-20 Hyseq, Inc. Method for screening unknown organisms
FR2709761B1 (fr) * 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6156501A (en) * 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US7375198B2 (en) 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
JP2000513921A (ja) * 1995-03-04 2000-10-24 ベーリンガー マンハイム ゲーエムベーハー 核酸の配列特異的検出
US5968740A (en) * 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US6326140B1 (en) 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
ATE216431T1 (de) * 1996-08-12 2002-05-15 Univ California Systemen zum erzeugen und analysieren von stimulus-reaktion ausgangssignalmatrizen
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US6458584B1 (en) 1996-12-23 2002-10-01 University Of Chicago Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable
EP0951569A2 (de) * 1996-12-23 1999-10-27 University Of Chicago Kundengerichtete oligonukleotidchips als vielfaeltige biosensoren
CA2389358C (en) 1996-12-31 2008-07-15 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
DE19708758A1 (de) * 1997-03-04 1998-09-17 Christoph Prof Dr Wagener Verfahren zum Nachweis von mutierten Allelen
US6489455B2 (en) 1997-05-21 2002-12-03 Clontech Laboratories, Inc. Methods of assaying differential expression
US5994076A (en) * 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US6308170B1 (en) 1997-07-25 2001-10-23 Affymetrix Inc. Gene expression and evaluation system
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
AU3659199A (en) * 1998-04-20 1999-11-08 Affymetrix, Inc. Methods for reducing non-specific binding to a nucleic acid probe array
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US6664045B1 (en) 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
CN1334871A (zh) * 1998-12-10 2002-02-06 宝酒造株式会社 将dna固定在载体上的方法
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
JP4598960B2 (ja) 1999-05-19 2010-12-15 エッペンドルフ アレイ テクノロジーズ エスアー （エーアーテー） 生物学的サンプルから得られた標的化合物のチップ上での同定及び／又は定量方法
US7144700B1 (en) 1999-07-23 2006-12-05 Affymetrix, Inc. Photolithographic solid-phase polymer synthesis
EP1305444A2 (de) * 2000-02-28 2003-05-02 Variom Biotechnology AG Verfahren zur immobilisierung von nukleinsäuren
US6833240B2 (en) 2000-03-08 2004-12-21 Mcgill University Very low density lipoprotein receptor polymorphisms and uses therefor
US7205104B2 (en) 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7875442B2 (en) 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
EP1136567A1 (de) 2000-03-24 2001-09-26 Advanced Array Technologies S.A. Methode und Kit zum Auffinden, Nachweis und/oder Quantifizieren von Transkriptionsfaktoren
US7407748B2 (en) 2000-03-24 2008-08-05 Eppendorf Array Technologies S.A. Method and kit for the determination of cellular activation profiles
EP1136566A1 (de) * 2000-03-24 2001-09-26 Facultés Universitaires Notre-Dame de la Paix Methode und Kit zum Nachweis und/oder Quantifizierung von homologen Sequenzen mittels Arrays
US7202026B2 (en) 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
DE10015097A1 (de) 2000-03-28 2001-10-04 Giesecke & Devrient Gmbh Im Stichtiefdruck bedruckter Datenträger
US6511277B1 (en) 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
AU2001278517A1 (en) 2000-08-03 2002-02-18 F. Hoffman-La Roche Ag Nucleic acid binding compounds containing pyrazolo(3,4-d)pyrimidine analogues of purin-2,6-diamine and their uses
US6422249B1 (en) 2000-08-10 2002-07-23 Affymetrix Inc. Cartridge washing system and methods
JP2004510433A (ja) 2000-10-06 2004-04-08 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク Ｄｎａおよびｒｎａを解読するための大量並行方法
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
GB0119719D0 (en) * 2001-08-13 2001-10-03 Solexa Ltd DNA sequence analysis
DE10154291B4 (de) * 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
ATE467115T1 (de) 2002-03-15 2010-05-15 Affymetrix Inc System und verfahren zur abtastung von biologischen materialien
WO2003091393A2 (en) * 2002-04-23 2003-11-06 Applera Corporation Nucleic “acid molecules encoding human proteins, and uses thereof”
JP2004041109A (ja) * 2002-07-12 2004-02-12 Toshiba Corp 核酸検出方法およびそれに使用されるプライマー
JP3917640B2 (ja) * 2002-07-26 2007-05-23 株式会社東芝 核酸プローブ固定化基体を用いた標的核酸の存在を検出する方法
US20040086856A1 (en) * 2002-07-26 2004-05-06 Masayoshi Takahashi Nucleic acid probe-immobilized substrate and method of detecting the presence of target nucleic acid by using the same
US7482117B2 (en) 2002-12-20 2009-01-27 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
CA2463719A1 (en) 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
EP2392581A3 (de) 2003-04-25 2012-03-07 North Carolina State University Nukleinsäurensequenzen, die für Proteine an der Zelloberfläche von Lactobacillus acidophilus kodieren und deren Verwendung
ATE504645T1 (de) 2003-06-23 2011-04-15 Univ North Carolina State Für fructooligosaccharid-nutzende verbindungen codierende nukleinsäuren aus lactobacillus acidophilus und verwendungen davon
CA2860272C (en) 2003-11-26 2017-12-19 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
GB0403039D0 (en) * 2004-02-11 2004-03-17 Health Prot Agency TB resistance assay
US7459289B2 (en) 2004-03-08 2008-12-02 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
EP1745154B1 (de) 2004-05-07 2012-08-01 Celera Corporation Genetische polymorphismen assoziiert mit leberfibrose, verfahren zur detektion und verwendung davon
US7338763B2 (en) 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US7858763B2 (en) 2004-06-04 2010-12-28 Council Of Scientific And Industrial Research Transforming growth factor beta 1 (TGFβ1) haplotypes and prediction of susceptibility for immunological disorders
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称ｐｃｒを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
JP5341350B2 (ja) 2004-11-16 2013-11-13 トラスティーズ オブ ボストン ユニバーシティ 高血圧および血管新生におけるエンドセリン−１／アンジオテンシンｉｉ二重レセプター（ｄｅａｒ）の役割
EP1816195A4 (de) * 2004-11-19 2009-06-03 Wakunaga Pharma Co Ltd Nukleinsäurefragmente zum nachweis von nukleinsäure und verfahren zum nachweis von nukleinsäure
JP2006166911A (ja) * 2004-11-19 2006-06-29 Wakunaga Pharmaceut Co Ltd 核酸検出用核酸断片および核酸検出方法
GB0500996D0 (en) * 2005-01-18 2005-02-23 Delfts Diagnostic Labaratory B Detection method and materials therefor
US7495092B2 (en) 2005-01-14 2009-02-24 North Carolina State University Compositions comprising promoter sequences and methods of use
KR20070112801A (ko) 2005-02-14 2007-11-27 유니버시티 오브 아이오와 리써치 파운데이션 연령­관련 황반 변성의 치료 및 진단용 방법 및 시약
CA2600794C (en) 2005-03-11 2014-08-12 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
JP5238250B2 (ja) * 2005-03-31 2013-07-17 国立大学法人名古屋大学 核酸マイクロアレイ、その製造方法および核酸マイクロアレイ用基材
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
US7595151B2 (en) 2005-07-01 2009-09-29 Arbor Vita Corporation Methods and compositions for diagnosis and treatment of influenza
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
WO2007053719A2 (en) 2005-10-31 2007-05-10 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
US7982029B2 (en) 2005-10-31 2011-07-19 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
CA2638773A1 (en) * 2006-01-24 2007-08-02 The University Of British Columbia Vasopressin pathway polymorphisms as indicators of subject outcome in critically ill subjects
US20100021891A1 (en) 2006-06-12 2010-01-28 Bernard Lerer Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
WO2008008986A2 (en) 2006-07-13 2008-01-17 University Of Iowa Research Foundation Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration
US7993833B2 (en) 2006-09-11 2011-08-09 Celera Corporation Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof
EP2084297A4 (de) 2006-10-20 2010-10-20 Celera Corp Mit venenthrombose assoziierte genetische polymorphismen, nachweisverfahren und verwendungen dafür
DE112007002932B4 (de) 2006-12-01 2015-08-06 The Trustees Of Columbia University In The City Of New York Vierfarben DNA-Sequenzierung mittels Synthese unter Verwendung von abspaltbaren, reversiblen, fluoreszierenden Nucleotidterminatoren
AU2008260029B2 (en) 2007-05-31 2015-02-12 Yale University A genetic lesion associated with cancer
CA2694832A1 (en) 2007-08-06 2009-02-12 Orion Genomics Llc Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene
EP2913398B1 (de) 2007-08-27 2017-07-12 Life Technologies Corporation Verfahren für PCR
EP2725107B1 (de) 2007-10-19 2018-08-29 The Trustees of Columbia University in the City of New York DNA-Sequenzierung mit nichtfluoreszierenden, reversiblen Nukleotidterminatoren und spaltbaren, fluoreszierenden ddNTPs und Nukleinsäuren die Inosine mit reversiblen Terminatorgruppe
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
EP2065474A1 (de) 2007-11-28 2009-06-03 Siemens Healthcare Diagnostics GmbH Verfahren für die Prognose der Therapiereaktion zur endokrinen Behandlung
WO2009070640A2 (en) 2007-11-28 2009-06-04 Great Basin Scientific Methods and compositions for amplifying a detectable signal
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
WO2009140685A2 (en) 2008-05-16 2009-11-19 Bristol-Myers Squibb Company Methods for identifying subjects with an increased likelihood of responding to dpp-iv inhibitors
EP2878680B1 (de) 2008-07-09 2016-06-08 Celera Corporation Mit kardiovaskulären Krankheiten assoziierte, genetische Polymorphismen, Verfahren zum Nachweis und Verwendungen davon
RU2582250C2 (ru) * 2008-10-01 2016-04-20 Конинклейке Филипс Электроникс Н.В. Способ тестирования и контроль качества нуклеиновых кислот на подложке
EP2334810B1 (de) 2008-10-01 2016-11-09 Koninklijke Philips N.V. Verfahren zur immobilisierung von nukleinsäuren auf einem träger
ES2544265T3 (es) 2009-02-11 2015-08-28 Orion Genomics, Llc Combinaciones de polimorfismos para determinar la expresión específica de alelo de IGF2
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
CA2766210A1 (en) 2009-06-25 2010-12-29 Yale University Single nucleotide polymorphisms in brca1 and cancer risk
US20110104154A1 (en) 2009-10-30 2011-05-05 Alcon Research, Ltd. Single nucleotide polymorphisms and genes associated with age-related macular degeneration
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
WO2012040619A2 (en) 2010-09-24 2012-03-29 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
ES2589455T3 (es) 2011-08-31 2016-11-14 F. Hoffmann-La Roche Ag Método para predecir el riesgo de hipertensión asociado a la terapia antiangiogénesis
KR20140064923A (ko) 2011-08-31 2014-05-28 에프. 호프만-라 로슈 아게 혈관신생 억제제에 대한 반응성
JP6465655B2 (ja) 2011-10-28 2019-02-06 アイテック ベンチャーズ ピーティーワイ エルティーディーＩｔｅｋ Ｖｅｎｔｕｒｅｓ Ｐｔｙ Ｌｔｄ 発作障害及び運動障害に関連する遺伝子及びその変異
AU2012342682A1 (en) 2011-11-23 2014-05-22 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
MY154507A (en) 2012-03-19 2015-06-22 Malaysian Palm Oil Board Gene Controlling Shell Phenotype in Palm
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Ｉｌ－３３媒介性障害のための治療及び診断方法
EP3221471B1 (de) 2014-11-18 2019-07-17 Aqua Gen AS Verfahren zur vorhersage der resistenz von regenbogen-forellen gegen anstekende pankreas-nekrosis
WO2017070096A1 (en) 2015-10-18 2017-04-27 Affymetrix, Inc. Multiallelic genotyping of single nucleotide polymorphisms and indels
US11781133B2 (en) 2015-12-28 2023-10-10 Pathogendx, Inc. Microarray based multiplex pathogen analysis and uses thereof
US11851705B2 (en) 2015-12-28 2023-12-26 PathogenDX Inc Microarray based multiplex pathogen analysis for plants, agriculture, food, and water
US10894985B2 (en) 2016-01-12 2021-01-19 Sitokine Limited Methods for predicting response to treatment
WO2017182623A1 (en) 2016-04-22 2017-10-26 Aquagen As A qtl for omega-3 fatty acid content in fish
US20200308660A1 (en) 2016-06-29 2020-10-01 Tine Sa Quantitative trait loci affecting fatty acid composition in milk
US10337070B2 (en) 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
KR20200037867A (ko) 2017-08-25 2020-04-09 조에티스 서비시즈 엘엘씨 핵산 프로브, uv 광을 사용하여 핵산을 고형 지지체에 고정화시키는 방법, 고정화된 핵산 프로브를 포함하는 고형 지지체 및 고형 지지체를 포함하는 시험 장치
MA51741A (fr) 2018-02-09 2021-05-19 Hoffmann La Roche Procédés thérapeutiques et de diagnostic pour des maladies inflammatoires médiées par des mastocytes
JP2021516995A (ja) * 2018-03-08 2021-07-15 パソジェンディーエックス，インク． マイクロアレイベースの多重病原体分析およびその使用
CA3142662A1 (en) 2019-06-06 2020-12-10 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
EP3839066B1 (de) 2019-12-18 2021-12-08 AquaGen AS Sexuelle reifung bei der regenbogenforelle
US20230110203A1 (en) 2020-03-13 2023-04-13 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
JPS6091999A (ja) * 1983-10-25 1985-05-23 Fujirebio Inc ポリヌクレオチドの測定方法
IL79112A (en) * 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
WO1988002785A2 (en) * 1986-10-14 1988-04-21 Beckman Instruments, Inc. Improved nucleic acid hybridization technique and kit therefor

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EP0451141A1 (de) 1991-10-16
AU632494B2 (en) 1993-01-07
WO1989011548A1 (en) 1989-11-30
IL90358A (en) 1993-08-18
DE68928853D1 (de) 1998-12-24
ATE173508T1 (de) 1998-12-15
JP2897959B2 (ja) 1999-05-31
CA1340864C (en) 1999-12-28
AU3754289A (en) 1989-12-12
EP0451141B1 (de) 1998-11-18
IL90358A0 (en) 1989-12-15
JPH03504328A (ja) 1991-09-26

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