DE68907762D1 - Arzneizubereitung mit gesteuerter wirkstofffreisetzung und verfahren zu deren herstellung. - Google Patents

Arzneizubereitung mit gesteuerter wirkstofffreisetzung und verfahren zu deren herstellung.

Info

Publication number
DE68907762D1
DE68907762D1 DE8989302767T DE68907762T DE68907762D1 DE 68907762 D1 DE68907762 D1 DE 68907762D1 DE 8989302767 T DE8989302767 T DE 8989302767T DE 68907762 T DE68907762 T DE 68907762T DE 68907762 D1 DE68907762 D1 DE 68907762D1
Authority
DE
Germany
Prior art keywords
production
active substance
medicine preparation
substance release
controlled active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989302767T
Other languages
English (en)
Other versions
DE68907762T2 (de
DE68907762T3 (de
Inventor
Masayoshi Samejima
Kazuo Noda
Yoshiyuki Hirakawa
Hiroyuki Yoshino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13722933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68907762(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of DE68907762D1 publication Critical patent/DE68907762D1/de
Publication of DE68907762T2 publication Critical patent/DE68907762T2/de
Publication of DE68907762T3 publication Critical patent/DE68907762T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE68907762T 1988-03-31 1989-03-21 Arzneizubereitung mit gesteuerter Wirkstofffreisetzung und Verfahren zu deren Herstellung. Expired - Fee Related DE68907762T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8060488 1988-03-31

Publications (3)

Publication Number Publication Date
DE68907762D1 true DE68907762D1 (de) 1993-09-02
DE68907762T2 DE68907762T2 (de) 1993-11-11
DE68907762T3 DE68907762T3 (de) 2003-11-20

Family

ID=13722933

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68907762T Expired - Fee Related DE68907762T3 (de) 1988-03-31 1989-03-21 Arzneizubereitung mit gesteuerter Wirkstofffreisetzung und Verfahren zu deren Herstellung.

Country Status (21)

Country Link
US (1) US5068112A (de)
EP (1) EP0335560B2 (de)
KR (1) KR950007202B1 (de)
AT (1) ATE91888T1 (de)
AU (1) AU610711B2 (de)
BG (1) BG50712A3 (de)
CA (1) CA1339078C (de)
DE (1) DE68907762T3 (de)
DK (1) DK156289A (de)
ES (1) ES2059729T5 (de)
FI (1) FI101344B (de)
FR (1) FR2629344B1 (de)
HK (1) HK76195A (de)
HU (1) HU201882B (de)
IE (1) IE64348B1 (de)
IL (1) IL89695A0 (de)
NO (1) NO178136C (de)
PH (1) PH25791A (de)
PT (1) PT90153B (de)
RU (1) RU1836083C (de)
ZA (1) ZA892131B (de)

Families Citing this family (59)

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FI101344B (fi) † 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseut tisesti aktiivista ainetta
US5330766A (en) * 1989-01-06 1994-07-19 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US6350462B1 (en) * 1990-12-26 2002-02-26 Olympus Optical Co., Ltd. Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
JP2538134B2 (ja) * 1991-04-08 1996-09-25 田辺製薬株式会社 徐放性製剤およびその製造法
ATE120089T1 (de) * 1991-05-20 1995-04-15 Marion Laboratories Inc Mehrschichtige zubereitung mit kontrollierter freisetzung.
EP0520119A1 (de) * 1991-06-17 1992-12-30 Spirig Ag Pharmazeutische Präparate Neue orale Diclofenaczubereitung
KR100221695B1 (ko) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
US5160742A (en) * 1991-12-31 1992-11-03 Abbott Laboratories System for delivering an active substance for sustained release
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5523095A (en) * 1993-12-15 1996-06-04 Eastman Chemical Company Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends
US5536505A (en) * 1993-12-15 1996-07-16 Eastman Chemical Company Controlled release matrix system using cellulose acetate/poly-2-ethyl-2-oxazoline blends
ES2120354B1 (es) * 1996-02-12 1999-07-01 Univ Sevilla Dispositivo terapeutico para direccionar farmacos hacia el tramo del tracto gastrointestinal deseado en funcion de las caracteristicas fisicoquimicas del mismo.
DE19628776A1 (de) * 1996-07-17 1998-01-22 Bayer Ag Oral applizierbare Granulate von Hexahydropyrazinderivaten
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
BR9802915A (pt) * 1997-09-12 2000-01-11 Oscar Gold Procedimento para formar composições farmaceuticas em pilulas ou granulos substancialmente esfericos, de ação controlada e continuada, contendo como agente ativo o (7-bromo-1,3-diidro-5-(2-piridninilo)-2h-1,4-benzodiazep ina-2(1h)-um)
EP1030839B1 (de) 1997-11-10 2004-02-04 G.D. SEARLE & CO. Verwendung von alkylierten iminozuckern zur behandlung von multipler medikamentenresistenz
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
KR20010040937A (ko) 1998-02-12 2001-05-15 윌리암스 로저 에이 간염 바이러스 감염의 치료를 위한 ｎ-치환된1,5-디데옥시-1,5-이미노-ｄ-글루시톨 화합물의 용도
CA2327685C (en) 1998-04-03 2008-11-18 Bm Research A/S Controlled release composition
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
EP1173161A2 (de) 1999-02-12 2002-01-23 G.D. SEARLE & CO. Verwendung von glucamin derivaten zur behandlung von hepatitis infektionen
SE9903879D0 (sv) * 1999-10-28 1999-10-28 Ethical Pharmaceuticals Sweden Multipor food protection
CA2395231C (en) 1999-12-23 2006-08-15 Pfizer Products Inc. Hydrogel-driven layered drug dosage form
CA2398555C (en) * 2000-01-27 2008-04-22 Tanabe Seiyaku Co., Ltd. Sustained release preparation and method for producing the same
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
EP1429739A1 (de) 2001-09-21 2004-06-23 Egalet A/S Polymer-freigabe-system
US20040208936A1 (en) * 2002-07-22 2004-10-21 Roland Chorin Novel compositions
WO2004041252A1 (en) 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
EP1607092A4 (de) * 2003-03-17 2010-12-15 Takeda Pharmaceutical Zusammensetzungen mit kontrollierter freisetzung
EP1610767B1 (de) 2003-03-26 2011-01-19 Egalet A/S Morphin-system mit kontrollierter freisetzung
ATE399538T1 (de) * 2003-03-26 2008-07-15 Egalet As Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
US7115283B2 (en) * 2003-05-06 2006-10-03 Access Business Group International Llc Preparations for sustained release of nutraceuticals and methods of controllably releasing nutraceuticals
ATE341312T1 (de) * 2003-05-20 2006-10-15 Ethypharm Sa Orale pharmazeutische zusammensetzung mit verzögerter freisetzung
FR2855412B1 (fr) * 2003-05-27 2007-05-25 Menvielle Bourg Fabienn Joanny Composition a liberation prolongee de magnesium, et son application dans le domaine therapeutique, cosmetique et nutritionnel
WO2004112746A1 (en) * 2003-06-26 2004-12-29 Korea Research Institute Of Chemical Technology Controlled release-drug delivery system for oral administration
WO2005011637A1 (ja) * 2003-08-04 2005-02-10 Eisai Co., Ltd. 用時分散型製剤
KR100615952B1 (ko) 2004-05-27 2006-08-28 한국화학연구원 서방형 약물 전달 시스템
AU2006254554B2 (en) * 2005-06-03 2011-11-24 Egalet Ltd A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
RU2309732C1 (ru) 2006-03-13 2007-11-10 Олег Ильич Эпштейн Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата
PL1880718T3 (pl) * 2006-07-10 2012-02-29 Dr R Pfleger Chemische Fabrik Gmbh Preparat farmaceutyczny do podawania doustnego o kontrolowanym uwalnianiu w jelicie cienkim i sposób jego wytwarzania
CA2930487A1 (en) * 2007-01-16 2008-07-24 Egalet Ltd. Use of i) a polyglycol and ii) an active drug substance for the preparation of a pharmaceutical composition for i)mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse
WO2008094877A2 (en) * 2007-01-30 2008-08-07 Drugtech Corporation Compositions for oral delivery of pharmaceuticals
US8679541B2 (en) 2007-03-14 2014-03-25 Particle Dynamics International, Llc Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals
US8821928B2 (en) 2007-06-04 2014-09-02 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
BRPI0815387B8 (pt) 2007-08-13 2021-05-25 Abuse Deterrent Pharmaceutical Llc composição farmacêutica, método para fazer uma composição farmacêutica e uso da composição farmacêutica
FR2931359B1 (fr) * 2008-05-20 2012-12-21 Menvielle Bourg Fabienne Joanny Utilisation d'une matrice pour administration orale de magnesium a liberation prolongee, et composition contenant cette matrice
FR2931361B1 (fr) * 2008-05-20 2012-08-31 Menvielle Bourg Fabienne Joanny Systeme a base de magnesium et son utilisation en cosmetique
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
EP2445487A2 (de) 2009-06-24 2012-05-02 Egalet Ltd. Retard-formulierungen
US9308275B2 (en) 2010-07-15 2016-04-12 Oleg Iliich Epshtein Method of increasing the effect of an activated-potentiated form of an antibody
JP2015521988A (ja) 2012-07-06 2015-08-03 イガレット・リミテッド 制御放出用乱用防止性医薬組成物
US20140275038A1 (en) 2013-03-15 2014-09-18 Inspirion Delivery Technologies, Llc Abuse deterrent compositions and methods of use
US10729685B2 (en) 2014-09-15 2020-08-04 Ohemo Life Sciences Inc. Orally administrable compositions and methods of deterring abuse by intranasal administration
US20180344649A1 (en) 2015-09-29 2018-12-06 Acorda Therapeutics, Inc. Sustained release compositions of 4-aminopyridine

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DE2223896A1 (de) † 1972-05-17 1973-11-29 Sanol Arznei Schwarz Gmbh Verfahren zum ueberziehen von feinteiligen arzneimitteln
DD146547A5 (de) † 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
US4377568A (en) † 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
DK150008C (da) † 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
JPS5989622A (ja) † 1983-09-29 1984-05-23 Furointo Sangyo Kk 公害を生じないフイルムコ−テング法
SE457505B (sv) * 1984-01-10 1989-01-09 Lejus Medical Ab Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
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US5254347A (en) † 1988-03-31 1993-10-19 Tanabe Seiyaku Co., Ltd. Controlled release pharmaceutical preparation and method for producing the same

Also Published As

Publication number Publication date
EP0335560B1 (de) 1993-07-28
AU3227389A (en) 1989-10-05
DK156289D0 (da) 1989-03-30
US5068112A (en) 1991-11-26
ZA892131B (en) 1989-11-29
EP0335560A3 (en) 1990-12-27
DE68907762T2 (de) 1993-11-11
DK156289A (da) 1989-10-01
KR950007202B1 (ko) 1995-07-04
NO178136C (no) 1996-01-31
PT90153B (pt) 1994-07-29
ATE91888T1 (de) 1993-08-15
NO891052L (no) 1989-10-02
FR2629344A1 (fr) 1989-10-06
FI101344B1 (fi) 1998-06-15
CA1339078C (en) 1997-07-29
FI891163A (fi) 1989-10-01
NO891052D0 (no) 1989-03-13
HK76195A (en) 1995-05-26
IE64348B1 (en) 1995-07-26
EP0335560A2 (de) 1989-10-04
PT90153A (pt) 1989-11-10
NO178136B (no) 1995-10-23
FI891163A0 (fi) 1989-03-10
BG50712A3 (en) 1992-10-15
FR2629344B1 (fr) 1994-09-16
DE68907762T3 (de) 2003-11-20
PH25791A (de) 1991-11-05
HUT50050A (en) 1989-12-28
RU1836083C (ru) 1993-08-23
FI101344B (fi) 1998-06-15
EP0335560B2 (de) 2002-01-23
IL89695A0 (en) 1989-09-28
AU610711B2 (en) 1991-05-23
HU201882B (en) 1991-01-28
IE891006L (en) 1989-09-30
ES2059729T3 (es) 1994-11-16
ES2059729T5 (es) 2002-09-16
KR890014095A (ko) 1989-10-21

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8339 Ceased/non-payment of the annual fee