DE68903246T2 - Zusammensetzung mit anti-endotoxischer aktivitaet. - Google Patents
Zusammensetzung mit anti-endotoxischer aktivitaet.Info
- Publication number
- DE68903246T2 DE68903246T2 DE8989201329T DE68903246T DE68903246T2 DE 68903246 T2 DE68903246 T2 DE 68903246T2 DE 8989201329 T DE8989201329 T DE 8989201329T DE 68903246 T DE68903246 T DE 68903246T DE 68903246 T2 DE68903246 T2 DE 68903246T2
- Authority
- DE
- Germany
- Prior art keywords
- composition
- lactulose
- lactulose syrup
- resin
- syrup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001986 anti-endotoxic effect Effects 0.000 title claims abstract description 11
- 239000000203 mixture Substances 0.000 title claims description 8
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims abstract description 15
- 229960000511 lactulose Drugs 0.000 claims abstract description 14
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006188 syrup Substances 0.000 claims abstract description 10
- 235000020357 syrup Nutrition 0.000 claims abstract description 10
- 239000011347 resin Substances 0.000 claims abstract description 6
- 229920005989 resin Polymers 0.000 claims abstract description 6
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims abstract description 6
- 150000001768 cations Chemical class 0.000 claims abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 3
- 238000006317 isomerization reaction Methods 0.000 claims abstract description 3
- 239000008101 lactose Substances 0.000 claims abstract description 3
- 235000010265 sodium sulphite Nutrition 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims description 9
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003480 eluent Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 238000010828 elution Methods 0.000 abstract description 2
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 description 12
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 9
- 102000003390 tumor necrosis factor Human genes 0.000 description 9
- 239000000126 substance Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001529572 Chaceon affinis Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000006433 tumor necrosis factor production Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000017283 Bile Duct disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010021333 Ileus paralytic Diseases 0.000 description 1
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 description 1
- 206010023129 Jaundice cholestatic Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 201000005267 Obstructive Jaundice Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010038540 Renal tubular necrosis Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000284 endotoxic Toxicity 0.000 description 1
- 230000002346 endotoxic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 201000011200 hepatorenal syndrome Diseases 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012454 limulus amebocyte lysate test Methods 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 201000007620 paralytic ileus Diseases 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8801349 | 1988-05-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68903246D1 DE68903246D1 (de) | 1992-11-26 |
| DE68903246T2 true DE68903246T2 (de) | 1993-03-11 |
Family
ID=19852354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989201329T Expired - Fee Related DE68903246T2 (de) | 1988-05-26 | 1989-05-24 | Zusammensetzung mit anti-endotoxischer aktivitaet. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5128323A (OSRAM) |
| EP (1) | EP0345850B1 (OSRAM) |
| JP (1) | JPH0219319A (OSRAM) |
| AT (1) | ATE81590T1 (OSRAM) |
| AU (1) | AU612843B2 (OSRAM) |
| DE (1) | DE68903246T2 (OSRAM) |
| DK (1) | DK249789A (OSRAM) |
| ES (1) | ES2033076T3 (OSRAM) |
| GR (1) | GR3006759T3 (OSRAM) |
| IL (1) | IL90388A (OSRAM) |
| NZ (1) | NZ229247A (OSRAM) |
| ZA (1) | ZA893944B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034064A (en) * | 1988-09-01 | 1991-07-23 | Snow Brand Milk Products Co., Ltd. | Production process of high-purity lactulose syrup |
| AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
| RU2113466C1 (ru) * | 1997-02-28 | 1998-06-20 | Николай Яковлевич Дыкало | Способ обработки алкогольных напитков |
| US6270755B1 (en) | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
| US6290946B1 (en) * | 1999-05-13 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders and antibacterial agents |
| CA2314494A1 (en) | 2000-05-02 | 2001-11-02 | Geltex Pharmaceuticals, Inc. | Anionic polymers as species specific antibacterial agents |
| EP1542706A1 (en) * | 2002-07-22 | 2005-06-22 | Genzyme Corporation | Poly (potassium and sodium styrene sulfonate), its manufacture and its uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2524414A (en) * | 1946-06-26 | 1950-10-03 | Univ Ohio State Res Found | Chromatographic separation of carbohydrates |
| JPS522984B1 (OSRAM) * | 1971-05-22 | 1977-01-25 | ||
| GB1501700A (en) * | 1975-10-02 | 1978-02-22 | Portals Water Treatment Ltd | Lactose hydrolysis using ion exchange resins |
| US4536221A (en) * | 1982-12-17 | 1985-08-20 | Sirac Spa | Process for preparing lactulose from lactose, in the form of a syrup or a crystalline product |
| IT1163540B (it) * | 1983-06-20 | 1987-04-08 | Sirac Srl | Procedimento per la purificazione dello sciroppo di lattulosio |
| IT1206140B (it) * | 1984-03-22 | 1989-04-14 | Sirac Srl | Procedimento per la purificazione di lattulosio. |
| IT1235866B (it) * | 1987-12-01 | 1992-11-23 | Sirac Srl | Processo per la preparazione di lattolosio da lattosio mediante epimerizzazione con alluminato sodico |
| IT1223398B (it) * | 1987-12-01 | 1990-09-19 | Sirac Spa | Procedimento per la preparazione di lattulosio cristallino ad alta purezza |
| IT1224438B (it) * | 1987-12-30 | 1990-10-04 | Sirac Srl | Processo per l'ottenimento di sciroppi di lattulosio ad elevata purezza e sciroppo cosi' ottenuto |
| DK72989A (da) * | 1988-02-22 | 1989-08-23 | Duphar Int Res | Fremgangsmaade til fremstilling af en fast komposition af lactulose |
-
1989
- 1989-05-23 DK DK249789A patent/DK249789A/da not_active Application Discontinuation
- 1989-05-23 JP JP1127974A patent/JPH0219319A/ja active Pending
- 1989-05-23 US US07/355,505 patent/US5128323A/en not_active Expired - Fee Related
- 1989-05-23 IL IL90388A patent/IL90388A/xx unknown
- 1989-05-24 EP EP89201329A patent/EP0345850B1/en not_active Expired - Lifetime
- 1989-05-24 ES ES198989201329T patent/ES2033076T3/es not_active Expired - Lifetime
- 1989-05-24 AT AT89201329T patent/ATE81590T1/de active
- 1989-05-24 DE DE8989201329T patent/DE68903246T2/de not_active Expired - Fee Related
- 1989-05-24 AU AU35157/89A patent/AU612843B2/en not_active Ceased
- 1989-05-24 ZA ZA893944A patent/ZA893944B/xx unknown
- 1989-05-26 NZ NZ229247A patent/NZ229247A/en unknown
-
1993
- 1993-01-11 GR GR930400015T patent/GR3006759T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0219319A (ja) | 1990-01-23 |
| AU612843B2 (en) | 1991-07-18 |
| IL90388A0 (en) | 1989-12-15 |
| GR3006759T3 (OSRAM) | 1993-06-30 |
| EP0345850B1 (en) | 1992-10-21 |
| EP0345850A1 (en) | 1989-12-13 |
| ES2033076T3 (es) | 1993-03-01 |
| DK249789A (da) | 1989-11-27 |
| DK249789D0 (da) | 1989-05-23 |
| NZ229247A (en) | 1991-06-25 |
| IL90388A (en) | 1993-08-18 |
| ZA893944B (en) | 1990-02-28 |
| US5128323A (en) | 1992-07-07 |
| AU3515789A (en) | 1989-11-30 |
| DE68903246D1 (de) | 1992-11-26 |
| ATE81590T1 (de) | 1992-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |