DE68902386T2 - N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. - Google Patents

N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Info

Publication number
DE68902386T2
DE68902386T2 DE8989123612T DE68902386T DE68902386T2 DE 68902386 T2 DE68902386 T2 DE 68902386T2 DE 8989123612 T DE8989123612 T DE 8989123612T DE 68902386 T DE68902386 T DE 68902386T DE 68902386 T2 DE68902386 T2 DE 68902386T2
Authority
DE
Germany
Prior art keywords
compound
formula
hydrogen
pyridinyl
carbazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989123612T
Other languages
German (de)
English (en)
Other versions
DE68902386D1 (de
Inventor
Larry Davis
Richard Charles Effland
Joseph Thomas Klein
Gordon Edward Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE68902386D1 publication Critical patent/DE68902386D1/de
Publication of DE68902386T2 publication Critical patent/DE68902386T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8989123612T 1988-12-27 1989-12-21 N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. Expired - Fee Related DE68902386T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/289,887 US4868190A (en) 1988-12-27 1988-12-27 N-pyridinyl-9H-carbazol-9-amines

Publications (2)

Publication Number Publication Date
DE68902386D1 DE68902386D1 (de) 1992-09-10
DE68902386T2 true DE68902386T2 (de) 1993-02-11

Family

ID=23113557

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989123612T Expired - Fee Related DE68902386T2 (de) 1988-12-27 1989-12-21 N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Country Status (19)

Country Link
US (1) US4868190A (https=)
EP (1) EP0376155B1 (https=)
JP (1) JPH0725749B2 (https=)
KR (1) KR900009596A (https=)
AT (1) ATE79118T1 (https=)
AU (1) AU623205B2 (https=)
CA (1) CA2006529C (https=)
DE (1) DE68902386T2 (https=)
DK (1) DK662189A (https=)
ES (1) ES2044043T3 (https=)
FI (1) FI896243A7 (https=)
GR (1) GR3006140T3 (https=)
IE (1) IE894175L (https=)
IL (1) IL92867A0 (https=)
NO (1) NO895222L (https=)
NZ (1) NZ231943A (https=)
PH (1) PH27122A (https=)
PT (1) PT92696A (https=)
ZA (1) ZA899904B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
DE69016531T2 (de) * 1989-08-02 1995-07-06 Hoechst Roussel Pharma 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
US4994472A (en) * 1989-08-02 1991-02-19 Hoechst-Roussel Pharmaceuticals Incorporated 1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5776955A (en) * 1995-07-27 1998-07-07 Hoechst Marion Roussel, Inc. Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents
DE69621617T2 (de) * 1995-07-27 2003-01-02 Aventis Pharmaceuticals Inc., Bridgewater Verwendung von substituierten und nichtsubstituierten n-(pyrrol-1-yl)pyridinaminen als antikonvulsiva
ZA989365B (en) * 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
AU7349301A (en) * 2000-07-21 2002-02-05 Ortho Mcneil Pharm Inc Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH475982A (de) * 1966-11-16 1969-07-31 Wander Ag Dr A Verfahren zur Herstellung von Carbazolderivaten
EP0073849A1 (en) * 1981-09-03 1983-03-16 Schering Corporation Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
DE69016531T2 (de) * 1989-08-02 1995-07-06 Hoechst Roussel Pharma 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.

Also Published As

Publication number Publication date
PH27122A (en) 1993-03-16
EP0376155A1 (en) 1990-07-04
ATE79118T1 (de) 1992-08-15
NO895222D0 (no) 1989-12-22
AU623205B2 (en) 1992-05-07
ZA899904B (en) 1991-02-27
IL92867A0 (en) 1990-09-17
ES2044043T3 (es) 1994-01-01
NZ231943A (en) 1992-06-25
JPH02247173A (ja) 1990-10-02
GR3006140T3 (https=) 1993-06-21
FI896243A7 (fi) 1990-06-28
CA2006529C (en) 1999-08-10
CA2006529A1 (en) 1990-06-27
DE68902386D1 (de) 1992-09-10
DK662189A (da) 1990-06-28
EP0376155B1 (en) 1992-08-05
NO895222L (no) 1990-06-28
PT92696A (pt) 1990-06-29
FI896243A0 (fi) 1989-12-22
DK662189D0 (da) 1989-12-22
US4868190A (en) 1989-09-19
JPH0725749B2 (ja) 1995-03-22
AU4720389A (en) 1990-07-05
IE894175L (en) 1990-06-27
KR900009596A (ko) 1990-07-05

Similar Documents

Publication Publication Date Title
DE3852335T2 (de) N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
DE3750596T2 (de) 1,2,3,3a,8,8a-Hexahydro-1,3a,8-Trimethylpyrrolo[2,3-b]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE69522355T2 (de) Neue N-(3,4-Dichlorphenyl-propyl)-piperidin-Derivate als selektive humane NK3-Rezeptorantagonisten
DE69323375T2 (de) Quartäre basische Amide als Antagonisten von Tachykininen
DE69518373T2 (de) Neue Zusammensetzungen, die Sertralin und einem 5-HT1D-Rezeptoragonisten oder Antagonisten enthalten
DE69032020T2 (de) N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
EP0736525B1 (de) Benzonitrile als 5-HT Agonisten und Antagonisten
DE69330926T2 (de) Isoxazolderivate zur Behandlung von Darmreizungssyndromen
DE69016530T2 (de) 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE68904586T2 (de) Histamin-derivat, verfahren zu dessen herstellung und therapeutischen anwendung.
DE69004973T2 (de) Piperidine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel.
DE69211892T2 (de) 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE68902386T2 (de) N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
DE69231817T2 (de) Carbamatderivate von 4-Amino-3-Isoxazolidinonen und 3-Amino-1-Hydroxypyrrolidinon-2-onen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69222444T2 (de) Substituierte 1,2,3,4-Tetrahydrocyclopent[b]indole, 1,2,3,3a,4,8a-Hexahydrocyclopent[b]indole und verwandte Verbindungen, Zwischenprodukte und ein Verfahren zur Herstellung derselben und ihre Verwendung als Medikamente
DE2363052A1 (de) 3-phenyl-3-aminoalkyl-2,6-dioxo-tetraund -hexahydropyridine, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zubereitungen
DE69020205T2 (de) Carbonate des Eserolins, ein Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
DE69206889T2 (de) Arylalkylpiperidine-4-yl)methyl]-2-alpha-3,4,5-tetrahydro-1-(2H)-acenaphthylene-1-Onederivate, ein Verfahren für ihre Herstellung und ihre Verwendung als Medikamente
DE69319830T2 (de) Substituierte (Pyridinylamino)-benzisoxazole und -benzisothiazole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69130196T2 (de) 1-(Substituierte Pyridinylamino)-1H-indol-5-yl substituierte Carbamate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69011013T2 (de) 1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE3780015T2 (de) Kondensierte heterocyclische tetrahydroaminochinolinole und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69016531T2 (de) 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE3851643T2 (de) 9-Amino-1,4-äthano-1,2,3,4-tetrahydroacridin und verwandte Verbindungen, Zwischenprodukte, ein Verfahren zur Herstellung davon und ihre Verwendung als Arzneimittel.
DE69403015T2 (de) Tetrahydrocyclopent[b]indole-methanamine und verwandte Verbindungen, und Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee