DE60331758D1 - Neue vollständige genomische rna des japanenzephalitis-virus, infektiöse jev cdna daraus und deren verwendung - Google Patents

Neue vollständige genomische rna des japanenzephalitis-virus, infektiöse jev cdna daraus und deren verwendung

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Publication number
DE60331758D1
DE60331758D1 DE60331758T DE60331758T DE60331758D1 DE 60331758 D1 DE60331758 D1 DE 60331758D1 DE 60331758 T DE60331758 T DE 60331758T DE 60331758 T DE60331758 T DE 60331758T DE 60331758 D1 DE60331758 D1 DE 60331758D1
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DE
Germany
Prior art keywords
jev
infectious
virus
japanese
cephalitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331758T
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English (en)
Inventor
Seung Han Lee
Young-Min Lee
Sang-Im Yun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CID CO Ltd
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CID CO Ltd
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Filing date
Publication date
Application filed by CID CO Ltd filed Critical CID CO Ltd
Application granted granted Critical
Publication of DE60331758D1 publication Critical patent/DE60331758D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE60331758T 2002-10-09 2003-10-09 Neue vollständige genomische rna des japanenzephalitis-virus, infektiöse jev cdna daraus und deren verwendung Expired - Lifetime DE60331758D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20020061589 2002-10-09
PCT/KR2003/002081 WO2004033690A1 (en) 2002-10-09 2003-10-09 Novel full-length genomic rna of japanese encephalitis virus, infectious jev cdna therefrom, and use thereof

Publications (1)

Publication Number Publication Date
DE60331758D1 true DE60331758D1 (de) 2010-04-29

Family

ID=36947533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331758T Expired - Lifetime DE60331758D1 (de) 2002-10-09 2003-10-09 Neue vollständige genomische rna des japanenzephalitis-virus, infektiöse jev cdna daraus und deren verwendung

Country Status (11)

Country Link
US (1) US7811579B2 (de)
EP (1) EP1556493B1 (de)
JP (1) JP4430543B2 (de)
KR (1) KR100710519B1 (de)
CN (1) CN1829796B (de)
AT (1) ATE461283T1 (de)
AU (1) AU2003267851B2 (de)
CA (1) CA2501289A1 (de)
DE (1) DE60331758D1 (de)
RU (1) RU2307872C2 (de)
WO (1) WO2004033690A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100872840B1 (ko) * 2004-07-09 2008-12-22 (주)씨아이디 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도
BRPI0504945B8 (pt) 2005-10-31 2022-08-02 Fundacao Oswaldo Cruz Método para a produção de flavivirus recombinante contendo sequências de nucleotídeos codificantes de uma proteína heteróloga, constructo de dna, flavivirus, e, composição vacinal para imunizar contra flavivirus e/ou outros patógenos.
BRPI0908936A2 (pt) * 2008-03-14 2017-03-28 Sanofi Pasteur Biologics Co vacinas de flavivírus de replicação defeituosa e vetores de vacina
US8999675B2 (en) * 2009-08-31 2015-04-07 Gen-Probe Incorporated Dengue virus assay
US9080185B2 (en) * 2010-09-21 2015-07-14 National Defensive Medical Center Recombinant flaviviral constructs and uses thereof
CN102199673A (zh) * 2010-12-24 2011-09-28 中国检验检疫科学研究院 乙型脑炎病毒荧光定量pcr检测新方法及乙型脑炎病毒检测pcr体系
WO2015157730A2 (en) * 2014-04-11 2015-10-15 Young-Min Lee Drug target and construct for japanese encephalitis virus infection
US9523093B2 (en) * 2014-05-20 2016-12-20 University Of Iowa Research Foundation Huntington's disease therapeutic compounds
WO2017059902A1 (en) 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
CN107937615B (zh) * 2017-12-20 2021-06-25 广东省农业科学院动物卫生研究所 用于区分猪乙型脑炎病毒野毒株和疫苗株的引物和探针
KR102119875B1 (ko) * 2019-03-19 2020-06-05 한국화학연구원 한국형 중동호흡기증후군 코로나바이러스 감염성 변이 유전자 및 이의 용도
CN110840908B (zh) * 2019-10-17 2021-06-01 浙江农林大学 lncRNA NONSUST0067151在抑制乙脑病毒增殖中的应用
CN111334482B (zh) * 2020-03-31 2023-03-14 华南农业大学 一种复制性增强的减毒jev及其制备方法与应用
EP4179112A2 (de) 2020-07-13 2023-05-17 The Board of Trustees of the Leland Stanford Junior University Systeme und verfahren zur beurteilung der rna-stabilität
US20220010299A1 (en) * 2020-07-13 2022-01-13 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods to Enhance RNA Stability and Translation and Uses Thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003032A1 (en) * 1986-10-27 1988-05-05 Fournier Maurielle J Diagnosis of and vaccine for japanese encephalitis virus and related viruses
KR100430960B1 (ko) * 1995-05-11 2004-10-28 거번먼트오브더유나이티드스테이츠오브아메리카,애즈리프리젠티드바이더세크러트리오브디아미 매우약독화된재조합일본뇌염바이러스를생성하는감염성일본뇌염바이러스cDNA클론및이의백신
KR0157262B1 (ko) * 1995-12-19 1998-11-16 김태구 차량용 파워 시트에서의 콘솔 박스의 무빙 시스템
KR100252379B1 (ko) * 1997-08-27 2000-04-15 대한민국 한국에서 분리된 일본뇌염 바이러스의 염기서열
AU778988B2 (en) 1998-06-04 2004-12-23 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Nucleic acid vaccines for prevention of flavivirus infection
GB2372991B (en) 2001-03-09 2004-11-17 Fiocruz Fundacao Oswaldo Cruz Flavivirus expression vector

Also Published As

Publication number Publication date
EP1556493A1 (de) 2005-07-27
RU2005114015A (ru) 2005-12-20
RU2307872C2 (ru) 2007-10-10
JP4430543B2 (ja) 2010-03-10
AU2003267851A1 (en) 2004-05-04
EP1556493A4 (de) 2006-04-26
US7811579B2 (en) 2010-10-12
AU2003267851B2 (en) 2007-07-05
CN1829796B (zh) 2010-05-26
CA2501289A1 (en) 2004-04-22
WO2004033690A1 (en) 2004-04-22
EP1556493B1 (de) 2010-03-17
JP2006501841A (ja) 2006-01-19
KR100710519B1 (ko) 2007-04-24
CN1829796A (zh) 2006-09-06
KR20040032791A (ko) 2004-04-17
ATE461283T1 (de) 2010-04-15
US20060234965A1 (en) 2006-10-19

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