DE60330468D1 - Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferase - Google Patents
Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferaseInfo
- Publication number
- DE60330468D1 DE60330468D1 DE60330468T DE60330468T DE60330468D1 DE 60330468 D1 DE60330468 D1 DE 60330468D1 DE 60330468 T DE60330468 T DE 60330468T DE 60330468 T DE60330468 T DE 60330468T DE 60330468 D1 DE60330468 D1 DE 60330468D1
- Authority
- DE
- Germany
- Prior art keywords
- galactosyltransferase
- expression
- pigs
- functional alpha
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000282887 Suidae Species 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 102000030902 Galactosyltransferase Human genes 0.000 abstract 1
- 108060003306 Galactosyltransferase Proteins 0.000 abstract 1
- 238000002689 xenotransplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40477502P | 2002-08-21 | 2002-08-21 | |
PCT/US2003/026622 WO2004028243A2 (en) | 2002-08-21 | 2003-08-21 | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60330468D1 true DE60330468D1 (de) | 2010-01-21 |
Family
ID=32043169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60330468T Expired - Lifetime DE60330468D1 (de) | 2002-08-21 | 2003-08-21 | Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferase |
Country Status (12)
Country | Link |
---|---|
US (4) | US7795493B2 (de) |
EP (3) | EP1534819B1 (de) |
JP (2) | JP2005536228A (de) |
AT (1) | ATE451448T1 (de) |
AU (2) | AU2003295322B2 (de) |
CA (2) | CA2899360A1 (de) |
DE (1) | DE60330468D1 (de) |
DK (2) | DK1534819T3 (de) |
ES (2) | ES2338111T3 (de) |
NZ (2) | NZ538464A (de) |
PT (2) | PT1534819E (de) |
WO (1) | WO2004028243A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2899360A1 (en) * | 2002-08-21 | 2004-04-08 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
CA2528500A1 (en) | 2003-06-06 | 2004-12-16 | University Of Pittsburgh | Porcine cmp-n-acetylneuraminic acid hydroxylase gene |
WO2005009134A1 (en) | 2003-07-21 | 2005-02-03 | Lifecell Corporation | ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE |
EP1734811A4 (de) | 2003-11-21 | 2009-03-25 | Revivicor Inc | Verwendung von interferierender rna bei der erzeugung transgener tiere |
KR20070002057A (ko) | 2004-03-17 | 2007-01-04 | 레비비코르 인코포레이션 | 기능성 알파 1,3 갈락토실트랜스펙션스페라제의 어떠한발현도 결여된 동물로부터 유래된 조직 산물 |
WO2005094587A1 (en) * | 2004-03-29 | 2005-10-13 | Mayo Foundation For Medical Education And Research | Genetically modified heart valve xenografts |
CA3079874C (en) * | 2004-10-22 | 2023-01-03 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
WO2010051288A1 (en) | 2008-10-27 | 2010-05-06 | Revivicor, Inc. | Immunocompromised ungulates |
US8986377B2 (en) | 2009-07-21 | 2015-03-24 | Lifecell Corporation | Graft materials for surgical breast procedures |
EP2464219B1 (de) * | 2009-08-14 | 2019-10-23 | Revivicor, Inc. | Multitransgene schweine zur diabetesbehandlung |
FR2951549B1 (fr) * | 2009-10-15 | 2013-08-23 | Olivier Schussler | Procede d'obtention de bioprotheses medicales implantables |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
US20110135706A1 (en) * | 2009-12-03 | 2011-06-09 | Lifecell Corporation | Nerve treatment devices and methods |
WO2011100505A2 (en) * | 2010-02-11 | 2011-08-18 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
ES2680636T3 (es) | 2011-02-14 | 2018-09-10 | Revivicor Inc. | Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos |
US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
CN103781900A (zh) * | 2011-06-30 | 2014-05-07 | 西格马-奥尔德里奇有限责任公司 | 缺乏CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞 |
US9549812B2 (en) | 2012-01-13 | 2017-01-24 | Lifecell Corporation | Breast prostheses, methods of manufacturing breast prostheses, and methods of treatment using breast prostheses |
WO2013169929A1 (en) * | 2012-05-08 | 2013-11-14 | The General Hospital Corporation | Reducing immunogenicity of xenogeneic transplant tissues |
EP2863840B1 (de) | 2012-06-21 | 2017-08-16 | Lifecell Corporation | Implantierbare prothese mit azellulären gewebebefestigungen |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
AU2014341866B2 (en) | 2013-11-04 | 2018-07-05 | Lifecell Corporation | Methods of removing alpha-galactose |
US20170311579A1 (en) | 2014-10-22 | 2017-11-02 | Indiana University Research & Technology Corporation | Triple transgenic pigs suitable for xenograft |
AU2015360502A1 (en) | 2014-12-10 | 2017-06-29 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
US10307237B2 (en) | 2015-05-15 | 2019-06-04 | Lifecell Corporation | Tissue matrices and methods of treatment |
WO2017034952A1 (en) | 2015-08-21 | 2017-03-02 | Lifecell Corporation | Breast treatment device |
EP3506854B1 (de) | 2016-08-31 | 2020-08-19 | LifeCell Corporation | Brustbehandlungsvorrichtung |
US10485167B2 (en) | 2016-09-21 | 2019-11-26 | Mtd Products Inc | Control assembly for a walk-behind mower |
US11026980B1 (en) | 2018-02-26 | 2021-06-08 | Triad Life Sciences, Inc. | Flowable birth tissue composition and related methods |
US11602548B1 (en) | 2018-02-26 | 2023-03-14 | Convatec, Inc | Fibrous birth tissue composition and method of use |
US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
EP3860336A1 (de) | 2018-10-05 | 2021-08-11 | Xenotherapeutics, Inc. | Xenotransplantationsprodukte und verfahren |
MX2021011709A (es) | 2019-03-25 | 2022-01-06 | Xenotherapeutics Inc | Celulas, tejidos y organos personalizados para trasplante de un donante humanizado, adaptado, designado libre de patogenos (no humano) y metodos y productos relacionados con estos. |
WO2020227095A1 (en) | 2019-05-03 | 2020-11-12 | Lifecell Corporation | Breast treatment device |
WO2021113366A1 (en) * | 2019-12-02 | 2021-06-10 | The General Hospital Corporation | Nerve xenografts and related methods |
US20220053739A1 (en) | 2020-08-24 | 2022-02-24 | Xenotherapeutics, Inc. | Immunologically compatible cells, tissues, organs, and methods for transplantation for silencing, humanization, and personalization with minimized collateral genomic disruptions |
WO2022087089A1 (en) | 2020-10-21 | 2022-04-28 | Tissue Testing Technologies Llc | Minimizing immunogenicity of decellularized tissues |
JP2023551404A (ja) | 2020-11-20 | 2023-12-08 | レビビコア, インコーポレイテッド | 異種間移植のための成長ホルモン受容体ノックアウトを有する多重トランスジェニックブタ |
WO2022256401A1 (en) * | 2021-06-01 | 2022-12-08 | Xenotherapeutics, Inc. | Xenogeneic nerve transplants and methods |
US20230255185A1 (en) | 2021-09-20 | 2023-08-17 | Revivicor, Inc. | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4863852A (en) * | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
US4994384A (en) | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
US5057420A (en) | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
US5354768A (en) * | 1988-07-26 | 1994-10-11 | Sankyo Company, Limited | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents |
NZ230723A (en) | 1988-09-21 | 1992-07-28 | Cambridge Animal Biotech | Pluripotential embryonic stem cells isolated from an embryonic disc, methods of producing transgenic cells and a chimeric foetus |
US4944384A (en) | 1989-01-30 | 1990-07-31 | Hay & Forage Industries | Trash discharge apparatus for crop transferring conveyor mechanism |
US5175383A (en) * | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
US4997384A (en) | 1989-04-17 | 1991-03-05 | Otis Engineering Corporation | Wet connector |
US5324663A (en) | 1990-02-14 | 1994-06-28 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
US5173414A (en) * | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5589582A (en) | 1992-10-27 | 1996-12-31 | Biotransplant, Inc. | Polynucleotides en coding porcine cytokines |
CA2162056A1 (en) | 1993-01-20 | 1994-11-10 | Christian A. Le Guern | Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sites |
US5496720A (en) | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
JPH06253856A (ja) | 1993-02-26 | 1994-09-13 | Amano Pharmaceut Co Ltd | ムタロターゼ遺伝子 |
EP1621627A3 (de) | 1993-03-16 | 2006-06-07 | The Austin Research Institute | Verwendung von Schwein gal-g(a)(1,3) Galaktosyltransferase für xenogene Therapien |
US6331658B1 (en) * | 1993-04-20 | 2001-12-18 | Integris Baptist Medical Center, Inc. | Genetically engineered mammals for use as organ donors |
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
US5849991A (en) * | 1994-01-27 | 1998-12-15 | Bresatch Limited | Mice homozygous for an inactivated α 1,3-galactosyl transferase gene |
WO1995020661A1 (en) | 1994-01-27 | 1995-08-03 | Bresatec Ltd. | Materials and methods for management of hyperacute rejection in human xenotransplantation |
AU2233295A (en) * | 1994-04-13 | 1995-11-10 | Biotransplant Incorporated | Alpha(1,3) galactosyltransferase negative swine |
AUPM516994A0 (en) | 1994-04-20 | 1994-05-12 | Gene Shears Pty. Limited | An in vivo gene expression system |
US5714353A (en) * | 1994-05-24 | 1998-02-03 | Research Corporation Technologies, Inc. | Safe vectors for gene therapy |
US5989808A (en) | 1994-06-14 | 1999-11-23 | American Cyanamid Company | Identification of compounds affecting specific interaction of peptide binding pairs |
AU2828595A (en) | 1994-06-15 | 1996-01-05 | Alexion Pharmaceuticals, Inc. | Methods for reducing hyperacute rejection of xenografts |
US5850004A (en) * | 1994-08-02 | 1998-12-15 | Cornell Research Foundation, Inc. | Transgenic mouse deficient in inducible nitric oxide synthase |
JPH10507906A (ja) | 1994-08-19 | 1998-08-04 | ザ ジェネラル ホスピタル コーポレイション | 遺伝子工学処理したブタ細胞 |
DK0787200T3 (da) | 1994-10-28 | 2005-08-15 | Univ Pennsylvania | Forbedret adenovirus og fremgangsmåder til anvendelse heraf |
US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
US5922601A (en) * | 1995-01-19 | 1999-07-13 | Biotransplant, Inc. | High efficiency gene trap selection of regulated genetic loci |
US5958713A (en) | 1995-01-31 | 1999-09-28 | Novo Nordisk A/S | Method of detecting biologically active substances by using green fluorescent protein |
WO1996028967A1 (fr) | 1995-03-17 | 1996-09-26 | Chihiro Koike | Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci |
AU5874896A (en) | 1995-05-26 | 1996-12-11 | Diacrin, Inc. | Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function |
US5962644A (en) | 1995-06-07 | 1999-10-05 | Biotransplant, Inc. | Porcine CD34 |
EP0851874B1 (de) | 1995-09-22 | 1999-09-15 | Novo Nordisk A/S | Varianten des grünen fluoreszenzproteins, gfp |
US5952236A (en) | 1995-10-26 | 1999-09-14 | Thompson; Richard B. | Enzyme-based fluorescence biosensor for chemical analysis |
US5856106A (en) | 1995-11-01 | 1999-01-05 | Biotransplant, Inc. | Determination of antibody production against administered therapeutic glycoproteins, especially monoclonal antibodies |
AU7668696A (en) | 1995-11-03 | 1997-05-22 | Austin Research Institute, The | Methods and compositions for the reduction of xenotransplantation rejection |
US5968738A (en) | 1995-12-06 | 1999-10-19 | The Board Of Trustees Of The Leland Stanford Junior University | Two-reporter FACS analysis of mammalian cells using green fluorescent proteins |
US6020192A (en) | 1996-01-18 | 2000-02-01 | University Of Florida | Humanized green fluorescent protein genes and methods |
US6255558B1 (en) | 1996-02-14 | 2001-07-03 | Btg International Limited | Gene expression |
US6027881A (en) | 1996-05-08 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence |
US5948889A (en) | 1996-05-21 | 1999-09-07 | Case Western Reserve University | Compositions and methods for screening antimicrobials |
US7001998B2 (en) * | 1996-08-02 | 2006-02-21 | The Austin Research Institute | Nucleic acids encoding a chimeric glycosyltransferase |
US5948681A (en) | 1996-08-14 | 1999-09-07 | Children's Hospital Of Philadelphia | Non-viral vehicles for use in gene transfer |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
EP0959899B9 (de) | 1996-08-16 | 2009-10-21 | Biotransplant, Inc | LO-CD2a Antikörper und deren Verwendung zur Hemmung der T-zellen Aktivierung und Proliferation |
EP0934403A4 (de) | 1996-08-19 | 2001-03-14 | Univ Massachusetts | Embryonische zelllinien oder stammzell-ähnliche zelllinien, die durch kerntransplantation zwischen verschiedenen spezies produziert wurden. |
AUPO182396A0 (en) * | 1996-08-23 | 1996-09-12 | Austin Research Institute, The | Improved nucleic acids for reducing carbohydrate epitopes |
US5914233A (en) | 1996-08-23 | 1999-06-22 | Osteo Screen | Screening assay for the identification of agents which alter expression of PTH-rP |
AU4153497A (en) | 1996-08-26 | 1998-03-19 | Eli Lilly And Company | Combinatorial process for preparing substituted thiophene libraries |
EP0950111A1 (de) | 1996-09-06 | 1999-10-20 | The Trustees Of The University Of Pennsylvania | Cre-lox verwendende verfahren zur herstellung von rekombinanten adeno-assoziierten viren |
US6255071B1 (en) | 1996-09-20 | 2001-07-03 | Cold Spring Harbor Laboratory | Mammalian viral vectors and their uses |
US6025192A (en) | 1996-09-20 | 2000-02-15 | Cold Spring Harbor Laboratory | Modified retroviral vectors |
US6136566A (en) | 1996-10-04 | 2000-10-24 | Lexicon Graphics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
TW371617B (en) | 1996-10-09 | 1999-10-11 | Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau | Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV |
US6455037B1 (en) * | 1996-11-01 | 2002-09-24 | Mount Sinai School Of Medicine Of The City University Of New York | Cells expressing an αgala nucleic acid and methods of xenotransplantation |
EP0943004A2 (de) | 1996-11-18 | 1999-09-22 | McGill University | Post-mitotische neuronen die adenovirusvektoren enthalten die apoptosis und wachstum modulieren |
US6235969B1 (en) * | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
US5994077A (en) | 1997-01-31 | 1999-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Flourescence-based isolation of differentially induced genes |
WO2000006194A2 (en) | 1997-02-05 | 2000-02-10 | Biotransplant, Inc. | Depletion of cells responsible for antibody-mediated graft rejection |
WO1998033528A2 (en) | 1997-02-05 | 1998-08-06 | Biotransplant, Inc. | Induction of b cell tolerance |
US6197928B1 (en) | 1997-03-14 | 2001-03-06 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
US6251384B1 (en) | 1997-04-28 | 2001-06-26 | Anticancer, Inc. | Metastasis models using green fluorescent protein (GFP) as a marker |
US5993778A (en) | 1997-05-07 | 1999-11-30 | Firestein; Stuart J. | Functional expression of, and assay for, functional cellular receptors in vivo |
US6251582B1 (en) | 1997-07-17 | 2001-06-26 | New York University | Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof |
WO1999009163A1 (en) | 1997-08-13 | 1999-02-25 | Biotransplant, Inc. | Porcine stem cell factor varients and recombinant cells expressing such polypeptides |
WO1999009141A1 (en) | 1997-08-14 | 1999-02-25 | Biotransplant, Inc. | Porcine totipotent cells and method for long-term culture |
US6251677B1 (en) | 1997-08-25 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
US6153409A (en) | 1997-09-11 | 2000-11-28 | University Of Maryland Biotechnology Institute | Process for continuous optimized protein production in insect larvae |
AU750025B2 (en) | 1997-09-26 | 2002-07-11 | Athersys, Inc. | Expression of endogenous genes by non-homologous recombination of a vector construct with cellular DNA |
US6482937B1 (en) | 1997-10-09 | 2002-11-19 | Biotransplant, Inc. | Porcine Oct-4 promoter |
AU1581899A (en) | 1997-10-28 | 1999-05-17 | Biotransplant Incorporated | Nuclear transfer for production of transgenic animal embryo |
US5968773A (en) | 1997-11-14 | 1999-10-19 | Heddle; John A. | System and method for regulation of gene expression |
US6013447A (en) | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
US5922576A (en) | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
AU2993599A (en) | 1998-03-09 | 1999-09-27 | Regents Of The University Of California, The | Regulation of the cell cycle by sterols |
ATE526406T1 (de) | 1998-03-20 | 2011-10-15 | Commw Scient Ind Res Org | Kontrolle der genexpression |
US6080576A (en) | 1998-03-27 | 2000-06-27 | Lexicon Genetics Incorporated | Vectors for gene trapping and gene activation |
US6037133A (en) | 1998-04-17 | 2000-03-14 | Clontech Laboratories, Inc. | IκBEGFP constructs, cell lines and methods of use |
US6316181B1 (en) | 1998-04-24 | 2001-11-13 | Virginia Commonwealth University | Establishment of cell lines with persistent expression of a green fluorescent protein (GFP) using a pIRES/EGFP DNA vector construct |
US6150176A (en) | 1998-06-09 | 2000-11-21 | The Regents Of The University Of California | Fluorescent protein sensors for measuring the pH of a biological sample |
WO2000011147A1 (en) | 1998-08-20 | 2000-03-02 | The General Hospital Corporation | Inbred mhc-homozygous miniature swine and uses thereof |
US6180343B1 (en) | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
US5985577A (en) | 1998-10-14 | 1999-11-16 | The Trustees Of Columbia University In The City Of New York | Protein conjugates containing multimers of green fluorescent protein |
US6203986B1 (en) | 1998-10-22 | 2001-03-20 | Robert H. Singer | Visualization of RNA in living cells |
US6268201B1 (en) | 1998-10-23 | 2001-07-31 | Albert Einstein College Of Medicine Of Yeshiva University | IniB, iniA and iniC genes of mycobacteria and methods of use |
US6270958B1 (en) | 1998-10-29 | 2001-08-07 | Washington University | Detection of negative-strand RNA viruses |
US6258998B1 (en) * | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
US6700037B2 (en) | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
US6210922B1 (en) | 1998-11-30 | 2001-04-03 | National Research Council Of Canada | Serum free production of recombinant proteins and adenoviral vectors |
ATE452973T1 (de) | 1999-03-04 | 2010-01-15 | Revivicor Inc | Genetische veränderung von somatischen zellen und deren verwendungen |
WO2001023541A2 (en) | 1999-09-30 | 2001-04-05 | Alexion Pharmaceuticals, Inc. | Compositions and methods for altering gene expression |
CA2426669A1 (en) | 1999-10-22 | 2001-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | .alpha.1-3 galactosyltransferase gene and promoter |
US7126039B2 (en) * | 2001-03-21 | 2006-10-24 | Geron Corporation | Animal tissue with carbohydrate antigens compatible for human transplantation |
EP1373498A2 (de) * | 2001-03-21 | 2004-01-02 | Geron Corporation | Tierisches gewebe mit kohlenhydratantigenen geeignet für die humantransplantation |
AU2002242854A1 (en) | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
RU2243630C2 (ru) | 2001-08-06 | 2004-12-27 | Жаров Владимир Павлович | Оптическое устройство для пространственной манипуляции объектами |
US7547816B2 (en) * | 2001-12-21 | 2009-06-16 | The Curators Of The University Of Missouri | α(1,3)-galactosyltransferase knockout swine, tissues and organs |
JP2005535343A (ja) * | 2002-08-14 | 2005-11-24 | イマージ バイオセラピューティクス,インコーポレーテッド | α(1,3)−ガラクトシルトランスフェラーゼ欠損細胞、選択する方法、およびそれらから作製されたα(1,3)−ガラクトシルトランスフェラーゼ欠損ブタ |
CA2899360A1 (en) * | 2002-08-21 | 2004-04-08 | Revivicor, Inc. | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
-
2003
- 2003-08-21 CA CA2899360A patent/CA2899360A1/en not_active Abandoned
- 2003-08-21 ES ES03786504T patent/ES2338111T3/es not_active Expired - Lifetime
- 2003-08-21 EP EP03786504A patent/EP1534819B1/de not_active Expired - Lifetime
- 2003-08-21 PT PT03786504T patent/PT1534819E/pt unknown
- 2003-08-21 NZ NZ538464A patent/NZ538464A/en not_active IP Right Cessation
- 2003-08-21 CA CA2496761A patent/CA2496761C/en not_active Expired - Lifetime
- 2003-08-21 DK DK03786504.5T patent/DK1534819T3/da active
- 2003-08-21 NZ NZ562736A patent/NZ562736A/en not_active IP Right Cessation
- 2003-08-21 EP EP09015192.9A patent/EP2163614B1/de not_active Expired - Lifetime
- 2003-08-21 US US10/646,970 patent/US7795493B2/en active Active
- 2003-08-21 JP JP2004539849A patent/JP2005536228A/ja not_active Withdrawn
- 2003-08-21 EP EP16193354.4A patent/EP3170890A1/de not_active Withdrawn
- 2003-08-21 WO PCT/US2003/026622 patent/WO2004028243A2/en active Application Filing
- 2003-08-21 ES ES09015192.9T patent/ES2609292T3/es not_active Expired - Lifetime
- 2003-08-21 AT AT03786504T patent/ATE451448T1/de active
- 2003-08-21 AU AU2003295322A patent/AU2003295322B2/en not_active Ceased
- 2003-08-21 DE DE60330468T patent/DE60330468D1/de not_active Expired - Lifetime
- 2003-08-21 PT PT90151929T patent/PT2163614T/pt unknown
- 2003-08-21 DK DK09015192.9T patent/DK2163614T3/en active
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2009
- 2009-05-28 AU AU2009202105A patent/AU2009202105B2/en not_active Ceased
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2010
- 2010-07-13 US US12/835,026 patent/US20120255047A1/en not_active Abandoned
- 2010-09-13 JP JP2010204963A patent/JP5329502B2/ja not_active Expired - Fee Related
-
2014
- 2014-05-19 US US14/281,464 patent/US20150106959A1/en not_active Abandoned
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Also Published As
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JP2005536228A (ja) | 2005-12-02 |
CA2496761C (en) | 2015-06-02 |
US20180332832A1 (en) | 2018-11-22 |
AU2009202105A1 (en) | 2009-06-18 |
DK1534819T3 (da) | 2010-04-19 |
AU2003295322A1 (en) | 2004-04-19 |
EP1534819A4 (de) | 2005-09-21 |
WO2004028243A3 (en) | 2004-08-05 |
EP2163614B1 (de) | 2016-10-12 |
CA2496761A1 (en) | 2004-04-08 |
PT2163614T (pt) | 2017-01-17 |
DK2163614T3 (en) | 2017-01-09 |
NZ538464A (en) | 2008-01-31 |
EP2163614A1 (de) | 2010-03-17 |
ES2338111T3 (es) | 2010-05-04 |
AU2003295322B2 (en) | 2009-06-18 |
AU2009202105B2 (en) | 2011-07-14 |
WO2004028243A2 (en) | 2004-04-08 |
NZ562736A (en) | 2009-07-31 |
US7795493B2 (en) | 2010-09-14 |
US11172658B2 (en) | 2021-11-16 |
US20120255047A1 (en) | 2012-10-04 |
EP3170890A1 (de) | 2017-05-24 |
US20040268424A1 (en) | 2004-12-30 |
EP1534819A2 (de) | 2005-06-01 |
ATE451448T1 (de) | 2009-12-15 |
CA2899360A1 (en) | 2004-04-08 |
US20150106959A1 (en) | 2015-04-16 |
JP2011015697A (ja) | 2011-01-27 |
JP5329502B2 (ja) | 2013-10-30 |
PT1534819E (pt) | 2010-03-11 |
ES2609292T3 (es) | 2017-04-19 |
EP1534819B1 (de) | 2009-12-09 |
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