DE60329520D1 - Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen - Google Patents

Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen

Info

Publication number
DE60329520D1
DE60329520D1 DE60329520T DE60329520T DE60329520D1 DE 60329520 D1 DE60329520 D1 DE 60329520D1 DE 60329520 T DE60329520 T DE 60329520T DE 60329520 T DE60329520 T DE 60329520T DE 60329520 D1 DE60329520 D1 DE 60329520D1
Authority
DE
Germany
Prior art keywords
preparation
morphinan alkaloid
quaternary
alkaloid salts
alkyl morphinan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329520T
Other languages
German (de)
English (en)
Inventor
Gary L Cantrell
Robert E Halvachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE60329520D1 publication Critical patent/DE60329520D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE60329520T 2002-11-08 2003-11-05 Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen Expired - Lifetime DE60329520D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US42558002P 2002-11-12 2002-11-12
PCT/US2003/035463 WO2004043964A2 (en) 2002-11-08 2003-11-05 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Publications (1)

Publication Number Publication Date
DE60329520D1 true DE60329520D1 (de) 2009-11-12

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329520T Expired - Lifetime DE60329520D1 (de) 2002-11-08 2003-11-05 Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen

Country Status (11)

Country Link
US (1) US7285665B2 (enExample)
EP (1) EP1562953B1 (enExample)
JP (1) JP2006509745A (enExample)
AT (1) ATE444295T1 (enExample)
AU (1) AU2003290630B2 (enExample)
CA (1) CA2504262C (enExample)
DE (1) DE60329520D1 (enExample)
ES (1) ES2332453T3 (enExample)
MX (1) MXPA05004759A (enExample)
PT (1) PT1562953E (enExample)
WO (1) WO2004043964A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0409133B8 (pt) 2003-04-08 2021-05-25 Progenics Pharm Inc preparações farmacêuticas estavéis compreendendo metilnaltrexona
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
BRPI0608818A2 (pt) 2005-03-07 2010-01-26 Univ Chicago uso de antagonista opióides para atenuação de proliferação e migração de células endoteliais
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AU2013200437B2 (en) * 2005-05-25 2015-01-15 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use
TW200815451A (en) * 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
MX2009002844A (es) 2006-09-20 2009-03-30 Mallinckrodt Inc Preparacion de morfinan-6-onas sustituidas y sales e intermediarios de las mismas.
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
CA2670136A1 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
BRPI0719593A2 (pt) * 2006-11-22 2013-12-17 Progenics Pharm Inc Processos para sintetizar os análogos de 4,5-epóxi-morfinano quaternário e isolar seus n-estereoisômeros
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2682125C (en) 2007-03-29 2015-06-16 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2134718A2 (en) * 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CA2694497C (en) * 2007-08-09 2016-07-12 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
WO2009070733A1 (en) * 2007-11-26 2009-06-04 Pharmacofore, Inc. Peripheral phenolic opioid antagonist
CA2713568C (en) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2252150B1 (en) * 2008-02-14 2018-04-11 Alkermes, Inc. Selective opioid compounds
AU2009225434B2 (en) 2008-03-21 2014-05-22 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
CA2726220C (en) 2008-05-27 2017-03-28 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US8563727B2 (en) 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-morphinanium N-oxides and processes for their production
WO2010096791A1 (en) 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
AU2012304484B2 (en) 2011-09-08 2016-07-28 SpecGx LLC Production of alkaloids without the isolation of intermediates
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101339A (en) 1958-10-30 1963-08-20 Boehringer Sohn Ingelheim Quaternary salts of normorphine and its acylated derivatives
US4141897A (en) 1976-12-20 1979-02-27 Research Corporation N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof
US4176186A (en) 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
PL124001B1 (en) 1980-01-25 1982-12-31 Inst Przemyslu Zielarskiego Process for preparing quaternary halides of n-alkylor n-aralkyl- derivatives of tropanic and isoquinolylic alkaloids
US4322426A (en) 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DE4132159A1 (de) 1991-09-27 1993-04-01 Boehringer Ingelheim Kg 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
US5352680A (en) 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
SE9401728D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds II
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US5756851A (en) 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
WO2001014382A1 (en) * 1999-08-23 2001-03-01 Toray Industries, Inc. Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan
DE10229842A1 (de) 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung

Also Published As

Publication number Publication date
AU2003290630A1 (en) 2004-06-03
PT1562953E (pt) 2009-11-19
EP1562953A2 (en) 2005-08-17
JP2006509745A (ja) 2006-03-23
EP1562953B1 (en) 2009-09-30
CA2504262C (en) 2012-01-10
MXPA05004759A (es) 2005-08-02
ATE444295T1 (de) 2009-10-15
WO2004043964A3 (en) 2004-08-26
US7285665B2 (en) 2007-10-23
AU2003290630B2 (en) 2009-01-29
CA2504262A1 (en) 2004-05-27
WO2004043964A2 (en) 2004-05-27
ES2332453T3 (es) 2010-02-05
US20060014771A1 (en) 2006-01-19

Similar Documents

Publication Publication Date Title
DE60329520D1 (de) Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen
ATE258927T1 (de) Verbessertes verfahren zur herstellung von n- substituierte aminotetraline
ATE401066T1 (de) Methoden zur behandlung der essstörungen
DE60123615D1 (de) Verfahren zur herstellung von ultrahochreinem isopropanol
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
DE3880954D1 (de) Verfahren zur herstellung eines n-substituierten amins.
DE50003632D1 (de) Verfahren zur herstellung von l-phenylephrinhydrochlorid
DE60104825D1 (de) Verfahren zur herstellung von 6-substituierten (s)-nikotin-derivaten und zwischenverbindungen
DE60235331D1 (de) Verfahren zur Herstellung von quartären Ammoniumsalzen
DE602005011113D1 (de) Morphinanderivate als mittel gegen juckreiz
DE60003137D1 (de) Verfahren zu Rückgewinnung von N-Vinyl-2-Pyrrolidon
EA200501164A1 (ru) Индазоламиды с аналгетической активностью
DE60205502D1 (de) Verfahren zur herstellung von alpha-hydroxycarbonsäureamiden
ATE277887T1 (de) Verfahren zur herstellung von 1,4-bis((2- (dimethylamino)ethyl amino)-5,8- dihydroxyanthracene-9,10-dion
ATE310734T1 (de) Verfahren zur herstellung von n-substituierten 2, 6-dialkylmorpholinen
DE50003759D1 (de) Verfahren zur herstellung von n-(4,5-bis-methansulfonyl-2-methyl-benzoyl)-guanidin, hydrochlorid
DE60106778D1 (de) Verfahren zur herstellung von vitronectin-rezeptorantagonisten
ATE447563T1 (de) Verfahren zur herstellung eines immunosuppresivums
DE69907865D1 (de) Verfahren zu Herstellung von 3-Alkyl-3-Hydroxymethyloxetanen
DE69900892D1 (de) Verfahren zur Herstellung von Racemisch Sertralin
DE60331739D1 (de) Verfahren zu herstellung einer natriumglyphosat-zusammensetzung
ATE221070T1 (de) Verfahren zur herstelung von pirlindolehydrochlorid
DE50006598D1 (de) VERFAHREN ZUR HERSTELLUNG VON CYCLO-(Asp-DPhe-NMeVal-Arg-Gly)
ATA206296A (de) Verfahren zur herstellung von clavulansäure-aminsalzen
ATE264829T1 (de) Verfahren zur herstellung von acylierten 1,3- dicarbonylverbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition