ES2332453T3 - Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. - Google Patents

Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. Download PDF

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Publication number
ES2332453T3
ES2332453T3 ES03783211T ES03783211T ES2332453T3 ES 2332453 T3 ES2332453 T3 ES 2332453T3 ES 03783211 T ES03783211 T ES 03783211T ES 03783211 T ES03783211 T ES 03783211T ES 2332453 T3 ES2332453 T3 ES 2332453T3
Authority
ES
Spain
Prior art keywords
quad
hydrocarbyl
quaternary
hydroxy
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03783211T
Other languages
English (en)
Spanish (es)
Inventor
Gary L. Cantrell
Robert E. Halvachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2332453T3 publication Critical patent/ES2332453T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES03783211T 2002-11-08 2003-11-05 Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. Expired - Lifetime ES2332453T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US424748P 2002-11-08
US42558002P 2002-11-12 2002-11-12
US425580P 2002-11-12

Publications (1)

Publication Number Publication Date
ES2332453T3 true ES2332453T3 (es) 2010-02-05

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03783211T Expired - Lifetime ES2332453T3 (es) 2002-11-08 2003-11-05 Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano.

Country Status (11)

Country Link
US (1) US7285665B2 (enExample)
EP (1) EP1562953B1 (enExample)
JP (1) JP2006509745A (enExample)
AT (1) ATE444295T1 (enExample)
AU (1) AU2003290630B2 (enExample)
CA (1) CA2504262C (enExample)
DE (1) DE60329520D1 (enExample)
ES (1) ES2332453T3 (enExample)
MX (1) MXPA05004759A (enExample)
PT (1) PT1562953E (enExample)
WO (1) WO2004043964A2 (enExample)

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BRPI0409133B8 (pt) 2003-04-08 2021-05-25 Progenics Pharm Inc preparações farmacêuticas estavéis compreendendo metilnaltrexona
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
BRPI0608818A2 (pt) 2005-03-07 2010-01-26 Univ Chicago uso de antagonista opióides para atenuação de proliferação e migração de células endoteliais
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AU2013200437B2 (en) * 2005-05-25 2015-01-15 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use
TW200815451A (en) * 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
MX2009002844A (es) 2006-09-20 2009-03-30 Mallinckrodt Inc Preparacion de morfinan-6-onas sustituidas y sales e intermediarios de las mismas.
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
CA2670136A1 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
BRPI0719593A2 (pt) * 2006-11-22 2013-12-17 Progenics Pharm Inc Processos para sintetizar os análogos de 4,5-epóxi-morfinano quaternário e isolar seus n-estereoisômeros
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2682125C (en) 2007-03-29 2015-06-16 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2134718A2 (en) * 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CA2694497C (en) * 2007-08-09 2016-07-12 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
WO2009070733A1 (en) * 2007-11-26 2009-06-04 Pharmacofore, Inc. Peripheral phenolic opioid antagonist
CA2713568C (en) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2252150B1 (en) * 2008-02-14 2018-04-11 Alkermes, Inc. Selective opioid compounds
AU2009225434B2 (en) 2008-03-21 2014-05-22 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
CA2726220C (en) 2008-05-27 2017-03-28 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US8563727B2 (en) 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-morphinanium N-oxides and processes for their production
WO2010096791A1 (en) 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
AU2012304484B2 (en) 2011-09-08 2016-07-28 SpecGx LLC Production of alkaloids without the isolation of intermediates
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses

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Also Published As

Publication number Publication date
AU2003290630A1 (en) 2004-06-03
PT1562953E (pt) 2009-11-19
EP1562953A2 (en) 2005-08-17
JP2006509745A (ja) 2006-03-23
EP1562953B1 (en) 2009-09-30
CA2504262C (en) 2012-01-10
MXPA05004759A (es) 2005-08-02
ATE444295T1 (de) 2009-10-15
DE60329520D1 (de) 2009-11-12
WO2004043964A3 (en) 2004-08-26
US7285665B2 (en) 2007-10-23
AU2003290630B2 (en) 2009-01-29
CA2504262A1 (en) 2004-05-27
WO2004043964A2 (en) 2004-05-27
US20060014771A1 (en) 2006-01-19

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