EA200501164A1 - Индазоламиды с аналгетической активностью - Google Patents

Индазоламиды с аналгетической активностью

Info

Publication number
EA200501164A1
EA200501164A1 EA200501164A EA200501164A EA200501164A1 EA 200501164 A1 EA200501164 A1 EA 200501164A1 EA 200501164 A EA200501164 A EA 200501164A EA 200501164 A EA200501164 A EA 200501164A EA 200501164 A1 EA200501164 A1 EA 200501164A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indasolamides
analgetic activity
analgetic
activity
indazolamide
Prior art date
Application number
EA200501164A
Other languages
English (en)
Other versions
EA009077B1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Анджело Гульельмотти
Гвидо Фурлотти
Джузеппе Луна
Лоренцо Поленцани
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA200501164A1 publication Critical patent/EA200501164A1/ru
Publication of EA009077B1 publication Critical patent/EA009077B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Индазоламид (I), в котором X, R1, R2, R3, R4, R5, R6, R7 и R8 имеют значения, представленные в описании, и его аддитивные соли с фармацевтически приемлемой кислотой, способ их получения и фармацевтическая композиция, его содержащая.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501164A 2003-02-18 2004-01-26 Индазоламиды с аналгетической активностью EA009077B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (2)

Publication Number Publication Date
EA200501164A1 true EA200501164A1 (ru) 2005-12-29
EA009077B1 EA009077B1 (ru) 2007-10-26

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501164A EA009077B1 (ru) 2003-02-18 2004-01-26 Индазоламиды с аналгетической активностью

Country Status (23)

Country Link
US (2) US7632849B2 (ru)
EP (1) EP1594859B1 (ru)
JP (1) JP4724651B2 (ru)
KR (1) KR101108222B1 (ru)
CN (2) CN101139341B (ru)
AR (1) AR043186A1 (ru)
AT (1) ATE471934T1 (ru)
AU (1) AU2004213104B2 (ru)
CA (1) CA2511984C (ru)
DE (1) DE602004027792D1 (ru)
DK (1) DK1594859T3 (ru)
EA (1) EA009077B1 (ru)
ES (1) ES2345983T3 (ru)
GE (1) GEP20074075B (ru)
HK (1) HK1079199A1 (ru)
IL (1) IL169285A (ru)
IT (1) ITMI20030287A1 (ru)
MX (1) MXPA05008730A (ru)
PL (1) PL215870B1 (ru)
PT (1) PT1594859E (ru)
SI (1) SI1594859T1 (ru)
UA (1) UA79537C2 (ru)
WO (1) WO2004074275A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
GEP20094638B (en) * 2004-06-15 2009-03-10 Pfizer Benzimidazolone carboxylic acid derivatives
BRPI0910034B1 (pt) * 2008-03-25 2022-02-08 Affectis Pharmaceuticals Ag Antagonistas do p2x7r e composições farmacêuticas que os compreendem
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
EP2243772B1 (en) * 2009-04-14 2012-01-18 Affectis Pharmaceuticals AG Novel P2X7R antagonists and their use
KR102101702B1 (ko) 2012-02-21 2020-04-20 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사미드 화합물의 용도
EA024939B1 (ru) * 2012-02-21 2016-11-30 Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. 1h-индазол-3-карбоксамидные соединения в качестве ингибиторов гликогенсинтазы киназы 3-бета
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk
PT3790873T (pt) 2018-05-07 2022-05-11 Acraf Compostos de 1h-indazole-3-carboxamida como inibidores da glicogénio sintase cinase 3 beta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
EP0802067B1 (en) * 1995-11-08 2002-04-24 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
TR199900321T2 (xx) 1996-08-16 1999-04-21 Smithkline Beecham P.L.C. N-(1-nbutil - 4 - piperidil)metil) -3,4-dihidro -2H- (1,3) oksazino (3.2A) indol-10- Karboksamit haz�rlama prosesi ve prosesteki tuzlar ve ara �r�nler.
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
AU767409B2 (en) * 1998-04-21 2003-11-06 Du Pont Pharmaceuticals Company 5-aminoindeno(1,2-C)pyrazol-4-ones as anti-cancer and anti-proliferative agents

Also Published As

Publication number Publication date
AU2004213104B2 (en) 2010-07-08
JP4724651B2 (ja) 2011-07-13
PL377236A1 (pl) 2006-01-23
CN101139341B (zh) 2010-12-08
IL169285A (en) 2012-08-30
KR20050101541A (ko) 2005-10-24
AU2004213104A1 (en) 2004-09-02
MXPA05008730A (es) 2005-09-20
WO2004074275A1 (en) 2004-09-02
AR043186A1 (es) 2005-07-20
CN101139341A (zh) 2008-03-12
KR101108222B1 (ko) 2012-02-08
GEP20074075B (en) 2007-03-26
US7632849B2 (en) 2009-12-15
PL215870B1 (pl) 2014-02-28
CN1742004A (zh) 2006-03-01
EP1594859A1 (en) 2005-11-16
CA2511984C (en) 2011-01-18
EA009077B1 (ru) 2007-10-26
HK1079199A1 (en) 2006-03-31
US20060052417A1 (en) 2006-03-09
PT1594859E (pt) 2010-07-23
US8519139B2 (en) 2013-08-27
JP2006517932A (ja) 2006-08-03
EP1594859B1 (en) 2010-06-23
CN100347168C (zh) 2007-11-07
ATE471934T1 (de) 2010-07-15
DK1594859T3 (da) 2010-10-11
SI1594859T1 (sl) 2010-10-29
DE602004027792D1 (de) 2010-08-05
UA79537C2 (en) 2007-06-25
CA2511984A1 (en) 2004-09-02
ES2345983T3 (es) 2010-10-07
US20100048907A1 (en) 2010-02-25
ITMI20030287A1 (it) 2004-08-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU