EA200501818A1 - Индазолы, обладающие анальгетической активностью - Google Patents

Индазолы, обладающие анальгетической активностью

Info

Publication number
EA200501818A1
EA200501818A1 EA200501818A EA200501818A EA200501818A1 EA 200501818 A1 EA200501818 A1 EA 200501818A1 EA 200501818 A EA200501818 A EA 200501818A EA 200501818 A EA200501818 A EA 200501818A EA 200501818 A1 EA200501818 A1 EA 200501818A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indazoles
analgetic activity
indazole
activity
analgetic
Prior art date
Application number
EA200501818A
Other languages
English (en)
Other versions
EA008499B1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Гвидо Фурлотти
Анджело Гильельмотти
Лоренцо Поленцани
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA200501818A1 publication Critical patent/EA200501818A1/ru
Publication of EA008499B1 publication Critical patent/EA008499B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к индазолу, обладающему анальгетической активностью, способу его получения и содержащей его фармацевтической композиции; индазол отвечает следующей общей формуле:где X, R, R, Rи Rимеют значения, указанные в описании.
EA200501818A 2003-05-15 2004-04-23 Индазолы, обладающие анальгетической активностью EA008499B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000972A ITMI20030972A1 (it) 2003-05-15 2003-05-15 Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
PCT/EP2004/004390 WO2004101548A1 (en) 2003-05-15 2004-04-23 Indazole having analgesic activity ,

Publications (2)

Publication Number Publication Date
EA200501818A1 true EA200501818A1 (ru) 2006-06-30
EA008499B1 EA008499B1 (ru) 2007-06-29

Family

ID=33446432

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501818A EA008499B1 (ru) 2003-05-15 2004-04-23 Индазолы, обладающие анальгетической активностью

Country Status (22)

Country Link
US (2) US7662836B2 (ru)
EP (1) EP1622892B1 (ru)
JP (1) JP4865559B2 (ru)
KR (1) KR101093048B1 (ru)
CN (1) CN100364988C (ru)
AR (1) AR044317A1 (ru)
AT (1) ATE501134T1 (ru)
AU (1) AU2004238449B2 (ru)
CA (1) CA2519733C (ru)
DE (1) DE602004031726D1 (ru)
DK (1) DK1622892T3 (ru)
EA (1) EA008499B1 (ru)
ES (1) ES2359242T3 (ru)
GE (1) GEP20074183B (ru)
HK (1) HK1087705A1 (ru)
IL (1) IL170769A (ru)
IT (1) ITMI20030972A1 (ru)
MX (1) MXPA05012297A (ru)
PL (1) PL1622892T3 (ru)
SI (1) SI1622892T1 (ru)
UA (1) UA80605C2 (ru)
WO (1) WO2004101548A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ITMI20062230A1 (it) 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (ru) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, который является активным при невропатической боли
ES2399066T3 (es) 2008-07-29 2013-03-25 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compuesto con actividad serotoninérgica, procedimiento para su preparación y composición farmacéutica que lo comprende
SI2817301T1 (sl) 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A Uporaba 1H-indazol-3-karboksamidnih spojin kot inhibitorjev glikogen sintaza-kinaze-3beta
SG10201701649YA (en) 2012-02-21 2017-04-27 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
HRP20220664T1 (hr) 2018-05-07 2022-06-24 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazol-3-karboksamid spojevi kao inhibitori glikogen sintaza kinaze 3 beta

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (fr) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Derives de l'indazole a groupe amino monocyclique
US6096476A (en) * 1995-08-11 2000-08-01 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
CN1104435C (zh) 1996-08-16 2003-04-02 史密丝克莱恩比彻姆有限公司 N－[(1－正丁基－4－哌啶基)甲基]－3,4－二氢－2H－[1,3] 噁嗪并[3,2－α]吲哚－10－甲酰胺及其盐的制备方法及在本方法中的中间体的制备方法
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10132746A1 (de) 2001-07-05 2003-02-06 Gruenenthal Gmbh Substituierte 1-Phenethylpiperidinverbindungen
WO2003051847A1 (en) * 2001-12-19 2003-06-26 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors

Also Published As

Publication number Publication date
IL170769A (en) 2012-05-31
KR20060009937A (ko) 2006-02-01
US8415476B2 (en) 2013-04-09
ITMI20030972A1 (it) 2004-11-16
HK1087705A1 (en) 2006-10-20
KR101093048B1 (ko) 2011-12-13
CN100364988C (zh) 2008-01-30
AU2004238449A1 (en) 2004-11-25
JP4865559B2 (ja) 2012-02-01
DE602004031726D1 (de) 2011-04-21
US20070010555A1 (en) 2007-01-11
MXPA05012297A (es) 2006-01-30
CA2519733C (en) 2011-11-29
AU2004238449B2 (en) 2010-09-02
EA008499B1 (ru) 2007-06-29
EP1622892B1 (en) 2011-03-09
SI1622892T1 (sl) 2011-06-30
WO2004101548A1 (en) 2004-11-25
ATE501134T1 (de) 2011-03-15
US20100094015A1 (en) 2010-04-15
EP1622892A1 (en) 2006-02-08
US7662836B2 (en) 2010-02-16
PL1622892T3 (pl) 2011-08-31
GEP20074183B (en) 2007-08-10
AR044317A1 (es) 2005-09-07
CN1777597A (zh) 2006-05-24
ES2359242T3 (es) 2011-05-19
UA80605C2 (en) 2007-10-10
IL170769A0 (en) 2009-02-11
DK1622892T3 (da) 2011-06-27
JP2006528212A (ja) 2006-12-14
CA2519733A1 (en) 2004-11-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU