DE602004031726D1 - Indazole mit analgetischer aktivität - Google Patents

Indazole mit analgetischer aktivität

Info

Publication number
DE602004031726D1
DE602004031726D1 DE602004031726T DE602004031726T DE602004031726D1 DE 602004031726 D1 DE602004031726 D1 DE 602004031726D1 DE 602004031726 T DE602004031726 T DE 602004031726T DE 602004031726 T DE602004031726 T DE 602004031726T DE 602004031726 D1 DE602004031726 D1 DE 602004031726D1
Authority
DE
Germany
Prior art keywords
indazole
analgetic activity
analgetic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004031726T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Angelo Guglielmotti
Lorenzo Polenzani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Publication of DE602004031726D1 publication Critical patent/DE602004031726D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004031726T 2003-05-15 2004-04-23 Indazole mit analgetischer aktivität Expired - Lifetime DE602004031726D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000972A ITMI20030972A1 (it) 2003-05-15 2003-05-15 Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
PCT/EP2004/004390 WO2004101548A1 (en) 2003-05-15 2004-04-23 Indazole having analgesic activity ,

Publications (1)

Publication Number Publication Date
DE602004031726D1 true DE602004031726D1 (de) 2011-04-21

Family

ID=33446432

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031726T Expired - Lifetime DE602004031726D1 (de) 2003-05-15 2004-04-23 Indazole mit analgetischer aktivität

Country Status (22)

Country Link
US (2) US7662836B2 (de)
EP (1) EP1622892B1 (de)
JP (1) JP4865559B2 (de)
KR (1) KR101093048B1 (de)
CN (1) CN100364988C (de)
AR (1) AR044317A1 (de)
AT (1) ATE501134T1 (de)
AU (1) AU2004238449B2 (de)
CA (1) CA2519733C (de)
DE (1) DE602004031726D1 (de)
DK (1) DK1622892T3 (de)
EA (1) EA008499B1 (de)
ES (1) ES2359242T3 (de)
GE (1) GEP20074183B (de)
HK (1) HK1087705A1 (de)
IL (1) IL170769A (de)
IT (1) ITMI20030972A1 (de)
MX (1) MXPA05012297A (de)
PL (1) PL1622892T3 (de)
SI (1) SI1622892T1 (de)
UA (1) UA80605C2 (de)
WO (1) WO2004101548A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ITMI20062230A1 (it) 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
AU2009276082B2 (en) 2008-07-29 2014-01-23 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it
CN104093712B (zh) 2012-02-21 2016-11-09 方济各安吉利克化学联合股份有限公司 作为糖原合酶激酶3β抑制剂的1H-吲唑-3-甲酰胺化合物
KR102101702B1 (ko) * 2012-02-21 2020-04-20 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사미드 화합물의 용도
RS63255B1 (sr) 2018-05-07 2022-06-30 Acraf 1h-indazol-3-karboksamid jedinjenja kao inhibitori glikogen sintaza kinaze 3 beta

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
CA2209831C (en) * 1995-11-08 2005-05-10 Toray Industries, Inc. Directly imageable raw plate for waterless planographic printing plate
NZ334064A (en) 1996-08-16 2000-08-25 Smithkline Beecham Plc Process for the preparation of N-[(1-nbutyl-4-piperidyl)methyl] -3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10132746A1 (de) 2001-07-05 2003-02-06 Gruenenthal Gmbh Substituierte 1-Phenethylpiperidinverbindungen
WO2003051847A1 (en) * 2001-12-19 2003-06-26 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors

Also Published As

Publication number Publication date
ES2359242T3 (es) 2011-05-19
CN1777597A (zh) 2006-05-24
GEP20074183B (en) 2007-08-10
WO2004101548A1 (en) 2004-11-25
HK1087705A1 (en) 2006-10-20
US8415476B2 (en) 2013-04-09
EP1622892A1 (de) 2006-02-08
DK1622892T3 (da) 2011-06-27
AU2004238449B2 (en) 2010-09-02
JP2006528212A (ja) 2006-12-14
KR101093048B1 (ko) 2011-12-13
JP4865559B2 (ja) 2012-02-01
US7662836B2 (en) 2010-02-16
IL170769A (en) 2012-05-31
EA200501818A1 (ru) 2006-06-30
AU2004238449A1 (en) 2004-11-25
ITMI20030972A1 (it) 2004-11-16
PL1622892T3 (pl) 2011-08-31
CA2519733A1 (en) 2004-11-25
AR044317A1 (es) 2005-09-07
US20070010555A1 (en) 2007-01-11
IL170769A0 (en) 2009-02-11
KR20060009937A (ko) 2006-02-01
MXPA05012297A (es) 2006-01-30
EP1622892B1 (de) 2011-03-09
US20100094015A1 (en) 2010-04-15
SI1622892T1 (sl) 2011-06-30
EA008499B1 (ru) 2007-06-29
CN100364988C (zh) 2008-01-30
CA2519733C (en) 2011-11-29
ATE501134T1 (de) 2011-03-15
UA80605C2 (en) 2007-10-10

Similar Documents

Publication Publication Date Title
ATE354631T1 (de) Nuancierungsmittel
DE602004031845D1 (de) Ng
DE602004017700D1 (de) Transmukosen verabreichung
DE602004016590D1 (de) Einspritzventil
DE602005019913D1 (de) Therapeutische pyrazoloä3,4-büpyridine und -indazole
DK1597171T3 (da) Terapeutisk mikroskum
DE50304722D1 (de) Fungizide Wirkstoffkombinationen
NO20034599D0 (no) Brokonstruksjon
DE602004027792D1 (de) Indazolamide mit analgetischer wirkung
DE602004018799D1 (de) Ng
DE602004031726D1 (de) Indazole mit analgetischer aktivität
NO20034600L (no) Brokonstruksjon
DE502004005095D1 (de) Einspritzdüse
DE502004009781D1 (de) Einspritzventil
DE502004005873D1 (de) Einspritzdüse
FR2852987B1 (fr) Garde-corps
ATA862002A (de) Schraubverschluss
SE0302332D0 (sv) New use I
FI5809U1 (fi) Verhouslevy
UA7330S (uk) Танк
SE0300106D0 (sv) New use
SE0301797D0 (sv) New use V
FI20031512A0 (fi) Lava
UA8008S (uk) Стілець
UA8363S (uk) Стілець