PL1622892T3 - Indazole o działaniu przeciwbólowym - Google Patents

Indazole o działaniu przeciwbólowym

Info

Publication number
PL1622892T3
PL1622892T3 PL04729106T PL04729106T PL1622892T3 PL 1622892 T3 PL1622892 T3 PL 1622892T3 PL 04729106 T PL04729106 T PL 04729106T PL 04729106 T PL04729106 T PL 04729106T PL 1622892 T3 PL1622892 T3 PL 1622892T3
Authority
PL
Poland
Prior art keywords
indazoles
analgesic activity
analgesic
activity
Prior art date
Application number
PL04729106T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Guido Furlotti
Angelo Guglielmotti
Lorenzo Polenzani
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PL1622892T3 publication Critical patent/PL1622892T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL04729106T 2003-05-15 2004-04-23 Indazole o działaniu przeciwbólowym PL1622892T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000972A ITMI20030972A1 (it) 2003-05-15 2003-05-15 Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
PCT/EP2004/004390 WO2004101548A1 (en) 2003-05-15 2004-04-23 Indazole having analgesic activity ,
EP04729106A EP1622892B1 (en) 2003-05-15 2004-04-23 Indazoles having analgesic activity

Publications (1)

Publication Number Publication Date
PL1622892T3 true PL1622892T3 (pl) 2011-08-31

Family

ID=33446432

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04729106T PL1622892T3 (pl) 2003-05-15 2004-04-23 Indazole o działaniu przeciwbólowym

Country Status (22)

Country Link
US (2) US7662836B2 (pl)
EP (1) EP1622892B1 (pl)
JP (1) JP4865559B2 (pl)
KR (1) KR101093048B1 (pl)
CN (1) CN100364988C (pl)
AR (1) AR044317A1 (pl)
AT (1) ATE501134T1 (pl)
AU (1) AU2004238449B2 (pl)
CA (1) CA2519733C (pl)
DE (1) DE602004031726D1 (pl)
DK (1) DK1622892T3 (pl)
EA (1) EA008499B1 (pl)
ES (1) ES2359242T3 (pl)
GE (1) GEP20074183B (pl)
HK (1) HK1087705A1 (pl)
IL (1) IL170769A (pl)
IT (1) ITMI20030972A1 (pl)
MX (1) MXPA05012297A (pl)
PL (1) PL1622892T3 (pl)
SI (1) SI1622892T1 (pl)
UA (1) UA80605C2 (pl)
WO (1) WO2004101548A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
EA019300B1 (ru) 2008-07-29 2014-02-28 Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. Соединения с серотонинергической активностью, способ их получения и содержащие их фармацевтические композиции
SG11201403788VA (en) * 2012-02-21 2014-08-28 Acraf Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
AU2013224302B2 (en) 2012-02-21 2017-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
SG11202009230WA (en) 2018-05-07 2020-11-27 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
DE69627323T2 (de) * 1995-05-31 2004-01-15 Nisshin Seifun Group Inc Indazolderivate mit einer cyclischen aminogruppe
EP0802067B1 (en) * 1995-11-08 2002-04-24 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
ES2151743T3 (es) 1996-08-16 2001-01-01 Smithkline Beecham Plc Procedimiento para la preparacion de n-((1-n-butil-4-piperidinil)metil)-3,4-dihidro-2h-(1,3)-oxazino(3,2-a)indol-10-carboxamida y las sales y productos intermedios en el procedimiento.
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10132746A1 (de) * 2001-07-05 2003-02-06 Gruenenthal Gmbh Substituierte 1-Phenethylpiperidinverbindungen
WO2003051847A1 (en) * 2001-12-19 2003-06-26 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors

Also Published As

Publication number Publication date
AU2004238449B2 (en) 2010-09-02
DE602004031726D1 (de) 2011-04-21
AR044317A1 (es) 2005-09-07
MXPA05012297A (es) 2006-01-30
EA200501818A1 (ru) 2006-06-30
EP1622892B1 (en) 2011-03-09
ITMI20030972A1 (it) 2004-11-16
IL170769A0 (en) 2009-02-11
CA2519733C (en) 2011-11-29
GEP20074183B (en) 2007-08-10
EA008499B1 (ru) 2007-06-29
ATE501134T1 (de) 2011-03-15
CN100364988C (zh) 2008-01-30
AU2004238449A1 (en) 2004-11-25
ES2359242T3 (es) 2011-05-19
KR20060009937A (ko) 2006-02-01
JP4865559B2 (ja) 2012-02-01
US7662836B2 (en) 2010-02-16
EP1622892A1 (en) 2006-02-08
US8415476B2 (en) 2013-04-09
KR101093048B1 (ko) 2011-12-13
IL170769A (en) 2012-05-31
US20100094015A1 (en) 2010-04-15
UA80605C2 (en) 2007-10-10
US20070010555A1 (en) 2007-01-11
DK1622892T3 (da) 2011-06-27
CN1777597A (zh) 2006-05-24
JP2006528212A (ja) 2006-12-14
HK1087705A1 (en) 2006-10-20
CA2519733A1 (en) 2004-11-25
WO2004101548A1 (en) 2004-11-25
SI1622892T1 (sl) 2011-06-30

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