DE60329325D1 - Synthese von (r) und (s)-aminocarnitin und derivaten davon ausgehend von d-und l-asparaginsäure - Google Patents

Synthese von (r) und (s)-aminocarnitin und derivaten davon ausgehend von d-und l-asparaginsäure

Info

Publication number
DE60329325D1
DE60329325D1 DE60329325T DE60329325T DE60329325D1 DE 60329325 D1 DE60329325 D1 DE 60329325D1 DE 60329325 T DE60329325 T DE 60329325T DE 60329325 T DE60329325 T DE 60329325T DE 60329325 D1 DE60329325 D1 DE 60329325D1
Authority
DE
Germany
Prior art keywords
aminocarnitine
derivatives
asparaginic
synthesis
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329325T
Other languages
German (de)
English (en)
Inventor
Fabio Giannessi
Uomo Natalina Dell
Maria Ornella Tinti
Angelis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/338,045 external-priority patent/US20030153783A1/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE60329325D1 publication Critical patent/DE60329325D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60329325T 2003-01-08 2003-12-19 Synthese von (r) und (s)-aminocarnitin und derivaten davon ausgehend von d-und l-asparaginsäure Expired - Lifetime DE60329325D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/338,045 US20030153783A1 (en) 1999-06-30 2003-01-08 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US10/372,627 US6822115B2 (en) 1999-06-30 2003-02-25 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
PCT/IT2003/000846 WO2004063143A1 (en) 2003-01-08 2003-12-19 Synthesis fo (r) and (s)-aminocarnitine and derivatives thereof from d-and l-aspartic acid

Publications (1)

Publication Number Publication Date
DE60329325D1 true DE60329325D1 (de) 2009-10-29

Family

ID=32716886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329325T Expired - Lifetime DE60329325D1 (de) 2003-01-08 2003-12-19 Synthese von (r) und (s)-aminocarnitin und derivaten davon ausgehend von d-und l-asparaginsäure

Country Status (18)

Country Link
US (1) US6822115B2 (enExample)
EP (1) EP1581475B1 (enExample)
JP (1) JP4642476B2 (enExample)
KR (1) KR20050092398A (enExample)
CN (1) CN1735588B (enExample)
AT (1) ATE443039T1 (enExample)
AU (1) AU2003295219B2 (enExample)
BR (1) BR0317956A (enExample)
CA (1) CA2512679A1 (enExample)
CY (1) CY1109545T1 (enExample)
DE (1) DE60329325D1 (enExample)
DK (1) DK1581475T3 (enExample)
ES (1) ES2333523T3 (enExample)
MX (1) MXPA05007315A (enExample)
PL (1) PL378538A1 (enExample)
PT (1) PT1581475E (enExample)
SI (1) SI1581475T1 (enExample)
WO (1) WO2004063143A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
ITRM20050090A1 (it) * 2005-03-02 2006-09-03 Sigma Tau Ind Farmaceutiche Riunite Spa Derivati dell'acido ammino-butanoico inibitore della cpt.
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
CA2680366C (en) * 2007-03-09 2016-06-21 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
WO2009015485A1 (en) * 2007-08-01 2009-02-05 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
CN115974742A (zh) * 2023-02-16 2023-04-18 中国水产科学研究院黄海水产研究所 温和条件下dmshb的制备与结构表征方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
IT1306162B1 (it) * 1999-06-30 2001-05-30 Sigma Tau Ind Farmaceuti Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
US20030153783A1 (en) * 1999-06-30 2003-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

Also Published As

Publication number Publication date
ES2333523T3 (es) 2010-02-23
KR20050092398A (ko) 2005-09-21
PL378538A1 (pl) 2006-05-02
CY1109545T1 (el) 2014-08-13
EP1581475B1 (en) 2009-09-16
HK1086254A1 (en) 2006-09-15
SI1581475T1 (sl) 2009-12-31
DK1581475T3 (da) 2010-01-25
PT1581475E (pt) 2009-11-09
CN1735588A (zh) 2006-02-15
MXPA05007315A (es) 2005-09-30
BR0317956A (pt) 2006-06-13
CN1735588B (zh) 2010-05-26
US20030153784A1 (en) 2003-08-14
JP4642476B2 (ja) 2011-03-02
AU2003295219A1 (en) 2004-08-10
AU2003295219B2 (en) 2010-08-12
WO2004063143A1 (en) 2004-07-29
CA2512679A1 (en) 2004-07-29
US6822115B2 (en) 2004-11-23
EP1581475A1 (en) 2005-10-05
ATE443039T1 (de) 2009-10-15
JP2006513243A (ja) 2006-04-20

Similar Documents

Publication Publication Date Title
DE50312946D1 (de) Difluormethyl thiazolyl carboxanilide
WO2002100844A3 (en) Hiv protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
DE50306845D1 (de) Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide
CY1108085T1 (el) Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπ-2-εν-1-ονης παρασκευη και χρησης αυτων
PT1041072E (pt) Acidos dioxociclopentil hidroxamicos
BR9508308A (pt) Derivados de benzoíla e sintese dos mesmos
CY1109545T1 (el) Συνθεση της (r) και (s)-αμινοκαρνιτινης και παραγωγων που προκυπτουν απο to d- και l- ασπαρτικο οξυ
ATE356130T1 (de) Inhibitoren von cruzipain und anderen cysteinproteasen
DE60202958D1 (de) Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten
BR0016742A (pt) Compostos e composições antipicorna virais, suas aplicações farmacêuticas, e materiais para sua sìntese
TR28332A (tr) Arilasetik asit türevleri.
SE0101038D0 (sv) Novel compounds
DE50310579D1 (de) Furancarboxamide
ATE239716T1 (de) Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-on
NO20010940L (no) TAN-1057 derivater
DE50311756D1 (de) Mikrobizide oxathiincarboxamide
IT1306162B1 (it) Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
ATE327987T1 (de) Methylthiophencarboxanilide
DE60019723D1 (de) Eine methode zur herstellung von verbindungen der formel 1 und derivaten
TR200003451T2 (tr) Pirimidin-Aminometil-Piridin Türevleri, Hazırlanmaları ve helikobakter bakterinin kontrolünde kullanımları
DK0772579T3 (da) Benzoylderivater og syntese deraf
ATE372994T1 (de) Herstellung von milchsäurederivaten und ihre anwendung
DE60128367D1 (de) Verfahren und zwischenprodukte zur herstellung von retroviralen proteaseinhibitoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition