CN1735588B - 由d-和l-天冬氨酸合成(r)和(s)-氨基肉碱及其衍生物 - Google Patents

由d-和l-天冬氨酸合成(r)和(s)-氨基肉碱及其衍生物 Download PDF

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Publication number
CN1735588B
CN1735588B CN2003801085435A CN200380108543A CN1735588B CN 1735588 B CN1735588 B CN 1735588B CN 2003801085435 A CN2003801085435 A CN 2003801085435A CN 200380108543 A CN200380108543 A CN 200380108543A CN 1735588 B CN1735588 B CN 1735588B
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CN
China
Prior art keywords
group
aspartic acid
aminocarnitine
acid
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2003801085435A
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English (en)
Chinese (zh)
Other versions
CN1735588A (zh
Inventor
F·吉安尼斯
N·德尔沃莫
M·O·替恩缇
F·德安格里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/338,045 external-priority patent/US20030153783A1/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of CN1735588A publication Critical patent/CN1735588A/zh
Application granted granted Critical
Publication of CN1735588B publication Critical patent/CN1735588B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN2003801085435A 2003-01-08 2003-12-19 由d-和l-天冬氨酸合成(r)和(s)-氨基肉碱及其衍生物 Expired - Fee Related CN1735588B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/338,045 2003-01-08
US10/338,045 US20030153783A1 (en) 1999-06-30 2003-01-08 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US10/372,627 US6822115B2 (en) 1999-06-30 2003-02-25 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US10/372,627 2003-02-25
PCT/IT2003/000846 WO2004063143A1 (en) 2003-01-08 2003-12-19 Synthesis fo (r) and (s)-aminocarnitine and derivatives thereof from d-and l-aspartic acid

Publications (2)

Publication Number Publication Date
CN1735588A CN1735588A (zh) 2006-02-15
CN1735588B true CN1735588B (zh) 2010-05-26

Family

ID=32716886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2003801085435A Expired - Fee Related CN1735588B (zh) 2003-01-08 2003-12-19 由d-和l-天冬氨酸合成(r)和(s)-氨基肉碱及其衍生物

Country Status (18)

Country Link
US (1) US6822115B2 (enExample)
EP (1) EP1581475B1 (enExample)
JP (1) JP4642476B2 (enExample)
KR (1) KR20050092398A (enExample)
CN (1) CN1735588B (enExample)
AT (1) ATE443039T1 (enExample)
AU (1) AU2003295219B2 (enExample)
BR (1) BR0317956A (enExample)
CA (1) CA2512679A1 (enExample)
CY (1) CY1109545T1 (enExample)
DE (1) DE60329325D1 (enExample)
DK (1) DK1581475T3 (enExample)
ES (1) ES2333523T3 (enExample)
MX (1) MXPA05007315A (enExample)
PL (1) PL378538A1 (enExample)
PT (1) PT1581475E (enExample)
SI (1) SI1581475T1 (enExample)
WO (1) WO2004063143A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
ITRM20050090A1 (it) * 2005-03-02 2006-09-03 Sigma Tau Ind Farmaceutiche Riunite Spa Derivati dell'acido ammino-butanoico inibitore della cpt.
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US8410150B2 (en) * 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2677049A1 (en) * 2007-08-01 2009-02-05 Sionex Corporation Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US20030153783A1 (en) * 1999-06-30 2003-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
IT1306162B1 (it) * 1999-06-30 2001-05-30 Sigma Tau Ind Farmaceuti Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.

Also Published As

Publication number Publication date
DK1581475T3 (da) 2010-01-25
BR0317956A (pt) 2006-06-13
WO2004063143A1 (en) 2004-07-29
JP2006513243A (ja) 2006-04-20
PT1581475E (pt) 2009-11-09
JP4642476B2 (ja) 2011-03-02
EP1581475A1 (en) 2005-10-05
AU2003295219A1 (en) 2004-08-10
CY1109545T1 (el) 2014-08-13
ES2333523T3 (es) 2010-02-23
EP1581475B1 (en) 2009-09-16
KR20050092398A (ko) 2005-09-21
US20030153784A1 (en) 2003-08-14
HK1086254A1 (en) 2006-09-15
DE60329325D1 (de) 2009-10-29
AU2003295219B2 (en) 2010-08-12
PL378538A1 (pl) 2006-05-02
MXPA05007315A (es) 2005-09-30
SI1581475T1 (sl) 2009-12-31
ATE443039T1 (de) 2009-10-15
CN1735588A (zh) 2006-02-15
CA2512679A1 (en) 2004-07-29
US6822115B2 (en) 2004-11-23

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