DE60320952D1 - Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung - Google Patents

Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung

Info

Publication number
DE60320952D1
DE60320952D1 DE60320952T DE60320952T DE60320952D1 DE 60320952 D1 DE60320952 D1 DE 60320952D1 DE 60320952 T DE60320952 T DE 60320952T DE 60320952 T DE60320952 T DE 60320952T DE 60320952 D1 DE60320952 D1 DE 60320952D1
Authority
DE
Germany
Prior art keywords
represent
alkyl group
formation method
infrared fluorescence
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60320952T
Other languages
English (en)
Inventor
Masayuki Kawakami
Hiroshi Kitaguchi
Kai Licha
Christin Perlitz
Hiroaki Eguchi
Natsuko Tsuda
Kazuhiro Aikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Fujifilm Corp
Original Assignee
Bayer Schering Pharma AG
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG, Fujifilm Corp filed Critical Bayer Schering Pharma AG
Application granted granted Critical
Publication of DE60320952D1 publication Critical patent/DE60320952D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
DE60320952T 2002-03-07 2003-03-07 Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung Expired - Fee Related DE60320952D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002109794A JP2003261464A (ja) 2002-03-07 2002-03-07 近赤外蛍光造影剤および蛍光造影法
PCT/EP2003/002358 WO2003074091A2 (en) 2002-03-07 2003-03-07 Near infrared fluorescent contrast agent and method for fluorescence imaging

Publications (1)

Publication Number Publication Date
DE60320952D1 true DE60320952D1 (de) 2008-06-26

Family

ID=27785574

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320952T Expired - Fee Related DE60320952D1 (de) 2002-03-07 2003-03-07 Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung

Country Status (20)

Country Link
US (2) US7473415B2 (de)
EP (1) EP1480683B1 (de)
JP (2) JP2003261464A (de)
KR (1) KR20040099301A (de)
CN (1) CN100340298C (de)
AT (1) ATE395088T1 (de)
AU (1) AU2003208700B2 (de)
BR (1) BR0308217A (de)
CA (1) CA2478272A1 (de)
DE (1) DE60320952D1 (de)
DK (1) DK1480683T3 (de)
ES (1) ES2305444T3 (de)
HK (1) HK1079110A1 (de)
MX (1) MXPA04008664A (de)
NO (1) NO20044244L (de)
PL (1) PL370918A1 (de)
PT (1) PT1480683E (de)
RU (1) RU2350355C9 (de)
WO (1) WO2003074091A2 (de)
ZA (1) ZA200408072B (de)

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JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
US7233392B2 (en) * 2004-03-25 2007-06-19 Opotek, Inc. Spectral imaging device with tunable light source
US7910753B2 (en) * 2004-09-10 2011-03-22 Anaspec Incorporated Cyanine dyes and their applications as luminescence quenching compounds
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US20110262354A1 (en) * 2007-07-13 2011-10-27 Emory University Cyanine-containing compounds for cancer imaging and treatment
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
US20090214436A1 (en) * 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
US20090240143A1 (en) * 2008-03-12 2009-09-24 Mauna Kea Technologies Method and an optical probe for in vivo imaging of a mucosa in a biliary or pancreatic system and a method for selectively operating a tissue sampling of a mucosa in a biliary or pancreatic system
EP2303337A4 (de) * 2008-06-13 2014-09-03 Cedars Sinai Medical Center Kleinmolekülige liganden-arzneimittel-konjugate für die gezielte krebstherapie
CN102459469A (zh) * 2009-04-17 2012-05-16 利康股份有限公司 用取代的花青染料进行荧光成像
CN101574529B (zh) * 2009-06-04 2011-04-20 中国人民解放军第三军医大学 近红外荧光化合物在制备用于淋巴结成像和血管造影的药物中的用途
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046662A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP2011046663A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
CA2810822C (en) 2009-09-22 2018-03-06 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
JP5462596B2 (ja) * 2009-11-12 2014-04-02 富士フイルム株式会社 蛍光画像撮像装置
US8273875B2 (en) 2009-11-16 2012-09-25 University Of Notre Dame Du Lac High performance luminescent compounds
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
CN103140157B (zh) 2011-03-15 2014-10-01 奥林巴斯医疗株式会社 医疗装置
EP2599429B1 (de) * 2011-03-15 2015-11-18 Olympus Corporation Medizinische vorrichtung
EP3338617B1 (de) 2012-01-23 2020-08-19 Washington University Brillenbildgebungssysteme und- vorrichtungen
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
CN106455979A (zh) 2013-12-31 2017-02-22 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
AU2015362663B2 (en) 2014-12-15 2020-07-09 Cornell University Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
KR20160086481A (ko) * 2015-01-09 2016-07-20 차의과학대학교 산학협력단 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
WO2017106525A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
CN110167601A (zh) 2016-11-30 2019-08-23 纪念斯隆凯特琳癌症中心 抑制剂-功能化超微小纳米粒子和其方法
CN115505280A (zh) 2016-12-21 2022-12-23 普罗菲尤萨股份有限公司 可聚合的近红外染料
CN109824871B (zh) * 2019-01-08 2021-04-16 南京邮电大学 一种近红外二区荧光醌式聚合物、制备方法及其应用
EP4072598A4 (de) 2019-12-13 2024-02-21 Washington University St Louis Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide
WO2023210645A1 (ja) * 2022-04-27 2023-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｉｃｇ脂質誘導体及びこれを含む脂質微粒子

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Publication number Priority date Publication date Assignee Title
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
DE19957007A1 (de) * 1999-11-26 2001-05-31 Few Chemicals Gmbh Wolfen Cyaninfarbstoffe
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
JP2001288197A (ja) * 2000-04-10 2001-10-16 Fuji Photo Film Co Ltd 蛍光ヌクレオチド
WO2002012398A1 (fr) 2000-08-08 2002-02-14 Fuji Photo Film Co., Ltd. Colorants à base de cyanine
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法

Also Published As

Publication number Publication date
RU2350355C9 (ru) 2009-05-27
CN100340298C (zh) 2007-10-03
CN1638810A (zh) 2005-07-13
WO2003074091A3 (en) 2004-03-11
BR0308217A (pt) 2004-12-21
KR20040099301A (ko) 2004-11-26
MXPA04008664A (es) 2004-12-06
RU2350355C2 (ru) 2009-03-27
JP2003261464A (ja) 2003-09-16
HK1079110A1 (en) 2006-03-31
RU2004129766A (ru) 2005-08-10
US20090041670A1 (en) 2009-02-12
JP2005519977A (ja) 2005-07-07
WO2003074091A2 (en) 2003-09-12
EP1480683A2 (de) 2004-12-01
AU2003208700A1 (en) 2003-09-16
PT1480683E (pt) 2008-07-24
NO20044244L (no) 2004-12-06
PL370918A1 (en) 2005-06-13
ATE395088T1 (de) 2008-05-15
US7473415B2 (en) 2009-01-06
DK1480683T3 (da) 2008-08-18
ZA200408072B (en) 2006-06-28
CA2478272A1 (en) 2003-09-12
ES2305444T3 (es) 2008-11-01
AU2003208700B2 (en) 2007-12-20
US20050226815A1 (en) 2005-10-13
EP1480683B1 (de) 2008-05-14

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee